ES266752A1 - Un procedimiento para la preparaciën de un derivado de sulfanilamidoquinazolina - Google Patents
Un procedimiento para la preparaciën de un derivado de sulfanilamidoquinazolinaInfo
- Publication number
- ES266752A1 ES266752A1 ES0266752A ES266752A ES266752A1 ES 266752 A1 ES266752 A1 ES 266752A1 ES 0266752 A ES0266752 A ES 0266752A ES 266752 A ES266752 A ES 266752A ES 266752 A1 ES266752 A1 ES 266752A1
- Authority
- ES
- Spain
- Prior art keywords
- quinazoline
- alkoxy
- methyl
- treating
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 2-substituted sulphanilamidoquinazolines Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 125000001931 aliphatic group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 4
- 125000004414 alkyl thio group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- TUQSVSYUEBNNKQ-UHFFFAOYSA-N 2,4-dichloroquinazoline Chemical compound C1=CC=CC2=NC(Cl)=NC(Cl)=C21 TUQSVSYUEBNNKQ-UHFFFAOYSA-N 0.000 abstract 2
- CIAADIPJOLLZFK-UHFFFAOYSA-N 2-chloro-4-methoxyquinazoline Chemical compound C1=CC=C2C(OC)=NC(Cl)=NC2=C1 CIAADIPJOLLZFK-UHFFFAOYSA-N 0.000 abstract 2
- FBROSDXALSKXIB-UHFFFAOYSA-N 4-amino-n-quinazolin-2-ylbenzenesulfonamide Chemical class C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=C(C=CC=C2)C2=N1 FBROSDXALSKXIB-UHFFFAOYSA-N 0.000 abstract 2
- OXVPNGBFUAIXTE-UHFFFAOYSA-N 6-methyl-1h-quinazoline-2,4-dione Chemical compound N1C(=O)NC(=O)C2=CC(C)=CC=C21 OXVPNGBFUAIXTE-UHFFFAOYSA-N 0.000 abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 2
- 229910019213 POCl3 Inorganic materials 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 229910052801 chlorine Chemical group 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- GKKCIDNWFBPDBW-UHFFFAOYSA-M potassium cyanate Chemical compound [K]OC#N GKKCIDNWFBPDBW-UHFFFAOYSA-M 0.000 abstract 2
- 239000011734 sodium Substances 0.000 abstract 2
- 229910052708 sodium Inorganic materials 0.000 abstract 2
- ABJUVWDYXGOLJZ-UHFFFAOYSA-N 2,4,7-trimethoxyquinazoline Chemical compound COC1=NC(OC)=NC2=CC(OC)=CC=C21 ABJUVWDYXGOLJZ-UHFFFAOYSA-N 0.000 abstract 1
- VZDVVLXYAOVNRW-UHFFFAOYSA-N 2,4-dichloro-6-methylquinazoline Chemical compound N1=C(Cl)N=C(Cl)C2=CC(C)=CC=C21 VZDVVLXYAOVNRW-UHFFFAOYSA-N 0.000 abstract 1
- DJLGBZOLTZXCHN-UHFFFAOYSA-N 2,4-dichloro-7-methoxyquinazoline Chemical compound ClC1=NC(Cl)=NC2=CC(OC)=CC=C21 DJLGBZOLTZXCHN-UHFFFAOYSA-N 0.000 abstract 1
- NIPORGZEMSOJEK-UHFFFAOYSA-N 2,4-dimethoxy-6-methylquinazoline Chemical compound C1=C(C)C=CC2=NC(OC)=NC(OC)=C21 NIPORGZEMSOJEK-UHFFFAOYSA-N 0.000 abstract 1
- RVZMPNMUBCAPQO-UHFFFAOYSA-N 2,4-dimethoxyquinazoline Chemical compound C1=CC=CC2=NC(OC)=NC(OC)=C21 RVZMPNMUBCAPQO-UHFFFAOYSA-N 0.000 abstract 1
- HHNWXQCVWVVVQZ-UHFFFAOYSA-N 2-amino-4-methoxybenzoic acid Chemical compound COC1=CC=C(C(O)=O)C(N)=C1 HHNWXQCVWVVVQZ-UHFFFAOYSA-N 0.000 abstract 1
- NBUUUJWWOARGNW-UHFFFAOYSA-N 2-amino-5-methylbenzoic acid Chemical compound CC1=CC=C(N)C(C(O)=O)=C1 NBUUUJWWOARGNW-UHFFFAOYSA-N 0.000 abstract 1
- LUANCFNZZLKBOQ-UHFFFAOYSA-N 2-ethyl-1h-quinazolin-4-one Chemical compound C1=CC=C2NC(CC)=NC(=O)C2=C1 LUANCFNZZLKBOQ-UHFFFAOYSA-N 0.000 abstract 1
- JHGVAZCNMCJXSO-UHFFFAOYSA-N 2-ethyl-1h-quinazoline-4-thione Chemical compound C1=CC=C2NC(CC)=NC(=S)C2=C1 JHGVAZCNMCJXSO-UHFFFAOYSA-N 0.000 abstract 1
- MPFMDBDLIURSOD-UHFFFAOYSA-N 2-methyl-1h-quinazoline-4-thione Chemical compound C1=CC=C2NC(C)=NC(=S)C2=C1 MPFMDBDLIURSOD-UHFFFAOYSA-N 0.000 abstract 1
- XVVUFHKVQZEEJZ-UHFFFAOYSA-N 2-methyl-4-methylsulfanylquinazoline Chemical compound C1=CC=C2C(SC)=NC(C)=NC2=C1 XVVUFHKVQZEEJZ-UHFFFAOYSA-N 0.000 abstract 1
- PPYUJFILUZPYPY-UHFFFAOYSA-N 6-chloro-2,4-dimethoxyquinazoline Chemical compound COC1=NC2=CC=C(C=C2C(=N1)OC)Cl PPYUJFILUZPYPY-UHFFFAOYSA-N 0.000 abstract 1
- BTEAXSZDTYHOGC-UHFFFAOYSA-N 7-methoxy-1h-quinazoline-2,4-dione Chemical compound N1C(=O)NC(=O)C=2C1=CC(OC)=CC=2 BTEAXSZDTYHOGC-UHFFFAOYSA-N 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 150000002440 hydroxy compounds Chemical class 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000002960 penicillins Chemical class 0.000 abstract 1
- CYQAYERJWZKYML-UHFFFAOYSA-N phosphorus pentasulfide Chemical compound S1P(S2)(=S)SP3(=S)SP1(=S)SP2(=S)S3 CYQAYERJWZKYML-UHFFFAOYSA-N 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
- 229940040944 tetracyclines Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22D—CASTING OF METALS; CASTING OF OTHER SUBSTANCES BY THE SAME PROCESSES OR DEVICES
- B22D19/00—Casting in, on, or around objects which form part of the product
- B22D19/04—Casting in, on, or around objects which form part of the product for joining parts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2852260A | 1960-05-12 | 1960-05-12 | |
| US93035A US3155650A (en) | 1961-03-03 | 1961-03-03 | 2-substituted-4-sulfanilamidoquinazolines and process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES266752A1 true ES266752A1 (es) | 1961-09-16 |
Family
ID=26703793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0266752A Expired ES266752A1 (es) | 1960-05-12 | 1961-04-20 | Un procedimiento para la preparaciën de un derivado de sulfanilamidoquinazolina |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE603719A (h) |
| CH (1) | CH422803A (h) |
| ES (1) | ES266752A1 (h) |
| FR (1) | FR1132M (h) |
| GB (1) | GB920019A (h) |
| SE (1) | SE311364B (h) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2160201B (en) * | 1984-06-14 | 1988-05-11 | Wyeth John & Brother Ltd | Quinazoline and cinnoline derivatives |
| GB0007657D0 (en) | 2000-03-29 | 2000-05-17 | Celltech Therapeutics Ltd | Chemical compounds |
| WO2003055866A1 (en) * | 2001-12-21 | 2003-07-10 | Bayer Pharmaceuticals Corporation | Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents |
-
1961
- 1961-04-20 GB GB14271/61A patent/GB920019A/en not_active Expired
- 1961-04-20 ES ES0266752A patent/ES266752A1/es not_active Expired
- 1961-05-10 FR FR861496A patent/FR1132M/fr active Active
- 1961-05-10 CH CH552161A patent/CH422803A/de unknown
- 1961-05-12 BE BE603719A patent/BE603719A/fr unknown
- 1961-05-12 SE SE4978/61A patent/SE311364B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH422803A (de) | 1966-10-31 |
| SE311364B (h) | 1969-06-09 |
| BE603719A (fr) | 1961-11-13 |
| GB920019A (en) | 1963-03-06 |
| FR1132M (fr) | 1962-02-19 |
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