ES2628210T3 - Poliuretano que tiene un revestimiento antitrombogénico - Google Patents

Poliuretano que tiene un revestimiento antitrombogénico Download PDF

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Publication number
ES2628210T3
ES2628210T3 ES14801976.3T ES14801976T ES2628210T3 ES 2628210 T3 ES2628210 T3 ES 2628210T3 ES 14801976 T ES14801976 T ES 14801976T ES 2628210 T3 ES2628210 T3 ES 2628210T3
Authority
ES
Spain
Prior art keywords
pur
antithrombogenic
polyurethane
antithrombogenic coating
pei
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES14801976.3T
Other languages
English (en)
Inventor
Karin STADTHERR
Christof SCHMID
Karla LEHLE
Karin LUKAS
Hanngörg ZIMMERMANN
Daniel Wehner
Thomas Schmid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFM Medical Titanium GmbH
Original Assignee
PFM Medical Titanium GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFM Medical Titanium GmbH filed Critical PFM Medical Titanium GmbH
Application granted granted Critical
Publication of ES2628210T3 publication Critical patent/ES2628210T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0094—Physical treatment, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Materials For Medical Uses (AREA)
  • Laminated Bodies (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)

Abstract

Poliuretano (PUR) que tiene un revestimiento antitrombogénico, en donde el revestimiento antitrombogénico comprende al menos una sustancia antitrombogénica covalentemente unida a una superficie del PUR mediante al menos dos enlaces, en donde un primero de dichos enlaces es un enlace amida entre la superficie del PUR y una polietilenimina (PEI) y un segundo de dichos enlaces está entre la PEI y la sustancia antitrombogénica, en donde la superficie del PUR se ha activado mediante el uso de un plasma de dióxido de carbono o un plasma modificado por adición de dióxido de carbono antes de que se forme el primero de dichos enlaces.

Description

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Claims (1)

  1. imagen1
ES14801976.3T 2013-11-14 2014-11-12 Poliuretano que tiene un revestimiento antitrombogénico Active ES2628210T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13192956 2013-11-14
EP13192956 2013-11-14
PCT/EP2014/074380 WO2015071313A1 (en) 2013-11-14 2014-11-12 Polyurethane having an antithrombogenic coating

Publications (1)

Publication Number Publication Date
ES2628210T3 true ES2628210T3 (es) 2017-08-02

Family

ID=49582641

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14801976.3T Active ES2628210T3 (es) 2013-11-14 2014-11-12 Poliuretano que tiene un revestimiento antitrombogénico

Country Status (5)

Country Link
US (1) US9867912B2 (es)
EP (1) EP3068454B1 (es)
CN (1) CN105899244B (es)
ES (1) ES2628210T3 (es)
WO (1) WO2015071313A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019042261A1 (zh) * 2017-08-28 2019-03-07 武汉杨森生物技术有限公司 复合肝素抗凝涂层液、涂层用微球及制备方法与应用
CN110028692B (zh) * 2019-03-14 2020-11-03 江苏赛腾医疗科技有限公司 一种基于离子键-共价键协同表面肝素化抗凝血医用装置的制备方法
JP2022528428A (ja) * 2019-03-19 2022-06-10 ジェイメドテック・コーティング・テクノロジーズ・プライベイト・リミテッド 共有結合したヘパリン・コーティングを備える医療デバイス
CN113350580A (zh) * 2021-06-11 2021-09-07 海思盖德(苏州)生物医学科技有限公司 一种应用于医疗器械中的肝素涂层制备方法
CN114306758A (zh) * 2021-12-28 2022-04-12 上海宏创医疗科技有限公司 一种长效抗凝血涂层、制备方法及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4521564A (en) * 1984-02-10 1985-06-04 Warner-Lambert Company Covalent bonded antithrombogenic polyurethane material
CN85108692A (zh) * 1985-12-21 1987-06-24 南京大学 聚乙二醇醚在聚氨酯表面的接枝共聚方法
US5132108A (en) * 1990-11-08 1992-07-21 Cordis Corporation Radiofrequency plasma treated polymeric surfaces having immobilized anti-thrombogenic agents
US5405919A (en) * 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
CN1057540C (zh) * 1995-09-26 2000-10-18 财团法人工业技术研究院 含酰胺键的聚氨酯制品
US6491965B1 (en) 1995-11-30 2002-12-10 Hamilton Civic Hospitals Research Development, Inc. Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US6033582A (en) * 1996-01-22 2000-03-07 Etex Corporation Surface modification of medical implants
DE19902948A1 (de) * 1999-01-26 2000-07-27 Creavis Tech & Innovation Gmbh Verfahren zur Modifizierung von Polymersubstraten durch Oberflächenfixierung eigenschaftsbestimmende Makromoleküle
US7456025B2 (en) * 2001-08-28 2008-11-25 Porex Corporation Sintered polymer membrane for analyte detection device
BR0213279A (pt) 2001-10-15 2004-10-26 Hemoteq Gmbh Revestimento de stents para impedir a restenose
US8383156B2 (en) * 2007-04-30 2013-02-26 Cordis Corporation Coating for a medical device having an anti-thrombotic conjugate
KR101132732B1 (ko) * 2008-11-26 2012-04-06 한국과학기술연구원 인 시튜 조직재생용 지능형 다공성 생분해 고분자 지지체 및 이의 제조방법
AU2011257663A1 (en) 2010-05-27 2012-10-04 Hemoteq Ag Coating of endoprostheses with a coating consisting of a tight mesh of polymer fibres

Also Published As

Publication number Publication date
US9867912B2 (en) 2018-01-16
EP3068454A1 (en) 2016-09-21
US20160279304A1 (en) 2016-09-29
CN105899244B (zh) 2019-02-19
EP3068454B1 (en) 2017-04-19
WO2015071313A1 (en) 2015-05-21
CN105899244A (zh) 2016-08-24

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