ES261025A1 - Substituted 5h-dibenz[b,f]azepines and their 10,11-dihydro derivatives - Google Patents

Substituted 5h-dibenz[b,f]azepines and their 10,11-dihydro derivatives

Info

Publication number
ES261025A1
ES261025A1 ES0261025A ES261025A ES261025A1 ES 261025 A1 ES261025 A1 ES 261025A1 ES 0261025 A ES0261025 A ES 0261025A ES 261025 A ES261025 A ES 261025A ES 261025 A1 ES261025 A1 ES 261025A1
Authority
ES
Spain
Prior art keywords
general formula
reaction
compounds
compound
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0261025A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of ES261025A1 publication Critical patent/ES261025A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of general formula <FORM:0908788/IV (b)/1> wherein X represents -CH2-CH2-or-CH= CH- Y and Z represent hydrogen, halogen, or alkyl (1 to 4 carbon atoms) alkylene represents a straight or branched chain with 2-6 carbon atoms and R represents an alkyl, cycloalkyl or alkenyl group (maximum of 8 carbon atoms each), and processes for their production (1) by reaction of a reactive ester of a hydroxy compound of general formula <FORM:0908788/IV (b)/2> with a primary amine of general formula NH2-R III (2) by reaction of a compound of general formula <FORM:0908788/IV (b)/3> with an aliphatic oxo compound which may be saturated or may contain a double linkage, and reduction of the product, (3) by reduction of a compound of general formula <FORM:0908788/IV (b)/4> wherein alkylene1 and R1 differ from alkylene and R as defined above only in that, in at least one of these radicals, the group bound to a nitrogen atom is a carbonyl group, (4) by splitting into an acid and a secondary amine an amide of general formula <FORM:0908788/IV (b)/5> wherein Ar represents an acyl radical and (5) by catalytic reduction of a compound of general formula <FORM:0908788/IV (b)/6> wherein Av represents an arylmethyl radical. The products have antiallergic, spasmolytic, anticonvulsive and sedative activity. Acyl derivatives of general formula V are prepared, for example, by acylation of amines of general formula IV Acyl derivatives of general formula VI are prepared, for example, by reaction of alkali metal derivatives of compounds of general formula V with reactive esters (such as halides) of low molecular weight alkanols or alkenols by reaction of compounds of general formula <FORM:0908788/IV (b)/7> with reactive esters of alcohols of general formula <FORM:0908788/IV (b)/8> or by reaction of reactive esters of alcohols of general formula II with amides of general formula <FORM:0908788/IV (b)/9> Imides reducible to compounds of general formula I are prepared by reaction of appropriate oxo compounds (aldehydes or ketones) with amino compounds of general formula IV. 5-g -Chloropropyldibenz[b,f]azepine is prepared by reaction of g -chloropropyl bromide with the sodium derivative formed by reaction of sodium amide with dibenz[b,f]azepine.
ES0261025A 1959-09-04 1960-09-03 Substituted 5h-dibenz[b,f]azepines and their 10,11-dihydro derivatives Expired ES261025A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH7780659A CH374678A (en) 1959-09-04 1959-09-04 Process for the preparation of new N-heterocyclic compounds

Publications (1)

Publication Number Publication Date
ES261025A1 true ES261025A1 (en) 1961-05-16

Family

ID=4535970

Family Applications (5)

Application Number Title Priority Date Filing Date
ES0261028A Expired ES261028A1 (en) 1959-09-04 1960-09-03 Substituted 5h-dibenz[b,f]azepines and their 10,11-dihydro derivatives
ES0261026A Expired ES261026A1 (en) 1959-09-04 1960-09-03 Substituted 5h-dibenz[b,f]azepines and their 10,11-dihydro derivatives
ES0261025A Expired ES261025A1 (en) 1959-09-04 1960-09-03 Substituted 5h-dibenz[b,f]azepines and their 10,11-dihydro derivatives
ES0261027A Expired ES261027A1 (en) 1959-09-04 1960-09-03 Substituted 5h-dibenz[b,f]azepines and their 10,11-dihydro derivatives
ES0261024A Expired ES261024A1 (en) 1959-09-04 1960-09-03 Substituted 5h-dibenz[b,f]azepines and their 10,11-dihydro derivatives

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES0261028A Expired ES261028A1 (en) 1959-09-04 1960-09-03 Substituted 5h-dibenz[b,f]azepines and their 10,11-dihydro derivatives
ES0261026A Expired ES261026A1 (en) 1959-09-04 1960-09-03 Substituted 5h-dibenz[b,f]azepines and their 10,11-dihydro derivatives

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES0261027A Expired ES261027A1 (en) 1959-09-04 1960-09-03 Substituted 5h-dibenz[b,f]azepines and their 10,11-dihydro derivatives
ES0261024A Expired ES261024A1 (en) 1959-09-04 1960-09-03 Substituted 5h-dibenz[b,f]azepines and their 10,11-dihydro derivatives

Country Status (6)

Country Link
BE (1) BE594720A (en)
CH (1) CH374678A (en)
CY (1) CY340A (en)
ES (5) ES261028A1 (en)
GB (1) GB908788A (en)
MY (1) MY6600056A (en)

Also Published As

Publication number Publication date
ES261024A1 (en) 1961-05-16
CH374678A (en) 1964-01-31
ES261027A1 (en) 1961-05-16
BE594720A (en) 1961-03-06
ES261026A1 (en) 1961-05-16
MY6600056A (en) 1966-12-31
CY340A (en) 1966-02-12
GB908788A (en) 1962-10-24
ES261028A1 (en) 1961-05-16

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