ES2572355R1 - Combinación de aad para uso en el tratamiento del vhc - Google Patents
Combinación de aad para uso en el tratamiento del vhc Download PDFInfo
- Publication number
- ES2572355R1 ES2572355R1 ES201431521A ES201431521A ES2572355R1 ES 2572355 R1 ES2572355 R1 ES 2572355R1 ES 201431521 A ES201431521 A ES 201431521A ES 201431521 A ES201431521 A ES 201431521A ES 2572355 R1 ES2572355 R1 ES 2572355R1
- Authority
- ES
- Spain
- Prior art keywords
- combination
- treatment
- adb
- hcv
- antiviral agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Combinación de AAD para uso en el tratamiento del VHC.#La presente invención presenta combinaciones de agentes antivirales para uso en terapias sin interferón y ribavirina en el tratamiento de VHC. Preferentemente, el tratamiento es durante un tiempo de tratamiento corto, tal como no más de 12 semanas. En un aspecto, el uso de las combinaciones de agentes antivirales en las terapias comprende administrar al menos dos agentes antivirales de acción directa sin interferón y ni ribavirina a un sujeto con infección por VHC.
Applications Claiming Priority (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161055036P | 2011-10-21 | 2011-10-21 | |
US61/55036 | 2011-10-21 | ||
US201161056217P | 2011-11-21 | 2011-11-21 | |
US61/56217 | 2011-11-21 | ||
US201261058719P | 2012-01-17 | 2012-01-17 | |
US61/58719 | 2012-01-17 | ||
US201261060046P | 2012-02-17 | 2012-02-17 | |
US61/60046 | 2012-02-17 | ||
US201261061988P | 2012-04-03 | 2012-04-03 | |
US61/61988 | 2012-04-03 | ||
US201261065625P | 2012-06-06 | 2012-06-06 | |
US61/65625 | 2012-06-06 | ||
US201261071179P | 2012-10-10 | 2012-10-10 | |
US61/71179 | 2012-10-10 |
Publications (3)
Publication Number | Publication Date |
---|---|
ES2572355A2 ES2572355A2 (es) | 2016-05-31 |
ES2572355R1 true ES2572355R1 (es) | 2016-11-03 |
ES2572355B1 ES2572355B1 (es) | 2017-08-24 |
Family
ID=52465028
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES201431520A Withdrawn - After Issue ES2572330B1 (es) | 2011-10-21 | 2012-10-19 | Combinación de al menos dos agentes antivirales de acción directa (aad) para su uso en el tratamiento del vhc |
ES201490005A Expired - Fee Related ES2529144B1 (es) | 2011-10-21 | 2012-10-19 | Combinación de aad para uso en el tratamiento del vhc |
ES201431521A Withdrawn - After Issue ES2572355B1 (es) | 2011-10-21 | 2012-10-19 | Combinación de aad para uso en el tratamiento del vhc |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES201431520A Withdrawn - After Issue ES2572330B1 (es) | 2011-10-21 | 2012-10-19 | Combinación de al menos dos agentes antivirales de acción directa (aad) para su uso en el tratamiento del vhc |
ES201490005A Expired - Fee Related ES2529144B1 (es) | 2011-10-21 | 2012-10-19 | Combinación de aad para uso en el tratamiento del vhc |
Country Status (1)
Country | Link |
---|---|
ES (3) | ES2572330B1 (es) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY32699A (es) * | 2009-06-11 | 2010-12-31 | Abbott Lab | Compuestos antivirales eficaces para inhibir la replicación del virus de la hepatitis c ("hcv"), procesos, composiciones, y métodos relacionados |
CN104771364B (zh) * | 2010-03-10 | 2018-05-25 | 艾伯维巴哈马有限公司 | 固体组合物 |
-
2012
- 2012-10-19 ES ES201431520A patent/ES2572330B1/es not_active Withdrawn - After Issue
- 2012-10-19 ES ES201490005A patent/ES2529144B1/es not_active Expired - Fee Related
- 2012-10-19 ES ES201431521A patent/ES2572355B1/es not_active Withdrawn - After Issue
Non-Patent Citations (2)
Title |
---|
JAZWINSKI ALISON B et al. Direct-acting antiviral medications for chronic hepatitis C virus infection..Gastroenterology & hepatology United States Mar 2011 00/03/2011 VOL: 7 No: 3 Pags: 154 - 162 ISSN 1554-7914 (Print) Doi: pubmed:21528041, página, 160 ultimo párrafo y 161 * |
LOK ANNA S et al. COMBINATION THERAPY WITH BMS-790052 AND BMS-650032 ALONE OR WITH PEGIFN/RBV RESULTS IN UNDETECTABLE HCV RNA THROUGH 12 WEEKS OF THERAPY IN HCV GENOTYPE 1 NULL RESPONDERS.Hepatology, 20101001 01/10/2010 VOL: 52 No: 4, Suppl Pags: 877A ISSN 0270-9139, resumen * |
Also Published As
Publication number | Publication date |
---|---|
ES2572355A2 (es) | 2016-05-31 |
ES2529144B1 (es) | 2015-10-26 |
ES2529144R1 (es) | 2015-03-10 |
ES2529144A2 (es) | 2015-02-17 |
ES2572330R1 (es) | 2016-11-03 |
ES2572355B1 (es) | 2017-08-24 |
ES2572330B1 (es) | 2017-08-24 |
ES2572330A2 (es) | 2016-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 2572355 Country of ref document: ES Kind code of ref document: B1 Effective date: 20170824 |
|
FA2A | Application withdrawn |
Effective date: 20180212 |