ES255871A1 - Tablet coating composition and method of applying - Google Patents

Tablet coating composition and method of applying

Info

Publication number
ES255871A1
ES255871A1 ES0255871A ES255871A ES255871A1 ES 255871 A1 ES255871 A1 ES 255871A1 ES 0255871 A ES0255871 A ES 0255871A ES 255871 A ES255871 A ES 255871A ES 255871 A1 ES255871 A1 ES 255871A1
Authority
ES
Spain
Prior art keywords
oil
water
vinyl acetate
waxes
grms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0255871A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of ES255871A1 publication Critical patent/ES255871A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
    • C08L39/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
    • C08L39/06—Homopolymers or copolymers of N-vinyl-pyrrolidones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

A fluid composition suitable for coating tablets consists essentially of about 10 to 25 parts by weight of a "water-soluble" wax as hereinafter defined and about 2 to 10 parts by weight of a polyvinylpyrrolidone-vinyl acetate copolymer per 100 ml. of the composition and a non-aqueous solvent for said wax and said copolymer. The waxes are polyethylene glycols of melting point of at least 50 DEG C., glyceryl monostearate and diglycol stearate, or mixtures thereof. The copolymers contain 30-70, and preferably 60% of vinylpyrrolidone and 70 to 30% and preferably 40% of vinyl acetate. Optional ingredients are (a) dyes, lakes and pigments (b) water-insoluble waxes such as beeswax, lanolin, stearic acid, cocoa butter and cetyl alcohol (c) plasticizers such as castor oil, mineral oil, corn oil, sesame oil and propylene glycol, alone or in admixture with a drying oil such as soybean oil (d) surface-active ingredients such as polyoxyethylene sorbitan derivatives and sulphated fatty alcohols and (e) cellulose acetate. Specifications 762,229 and 764,342 are referred to.ALSO:A coated solid medicament has the coating material in the form of a physiologically acceptable composition consisting essentially of a water permeable combination of a water-soluble or water-dispersible wax (A) and a polyvinylpyrrolidone vinyl acetate copolymer (B). The waxes are polyethylene glycols of melting point at least 50 DEG C., glyceryl monostearate and diglycol stearate, or mixtures thereof. The copolymers contain 30-70, and preferably 60% of polyvinylpyrrolidone and 70 to 30%, and preferably 40% of vinyl acetate. Optional ingredients are (a) dyes, lakes and pigments, (b) water-insoluble waxes such as beeswax, lanolin, stearic acid, cocoa butter and cetyl alcohol (C) (c) plasticizers such as castor oil, mineral oil, corn oil, sesame oil and propylene glycol, alone or in admixture with a drying oil such as soybean oil (D) (d) surface-active agents such as polyoxyethylene sorbitan derivatives and sulphated fatty alcohols and (e) an antisticking agent which is cellulose acetate. The compositions contain 10 to 25 grms. of (A), 2 to 10 grms. of (B), not more than 1 grm. of (C) and not more than 2 grms. of (D) per 100 ml. of the fluid composition which is prepared by dissolving the components in a non-aqueous solvent such as acetone, ethanol or mixtures thereof. The finished coat contains 50-92% of (A), 8 to 50% of (B) and not more than 5% of the optional components. Specifications 762,229 and 764,342 are referred to.
ES0255871A 1959-02-18 1960-02-18 Tablet coating composition and method of applying Expired ES255871A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79394659A 1959-02-18 1959-02-18

Publications (1)

Publication Number Publication Date
ES255871A1 true ES255871A1 (en) 1960-10-01

Family

ID=25161236

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0255871A Expired ES255871A1 (en) 1959-02-18 1960-02-18 Tablet coating composition and method of applying

Country Status (4)

Country Link
BE (1) BE593354A (en)
ES (1) ES255871A1 (en)
GB (1) GB907310A (en)
NL (1) NL248553A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436011A (en) * 1993-04-16 1995-07-25 Bristol-Myers Squibb Company Solid pharmaceutical dosage form and a method for reducing abrasion
CA2434835A1 (en) * 2001-02-13 2002-08-22 Astrazeneca Ab Novel modified released formulation

Also Published As

Publication number Publication date
BE593354A (en)
NL248553A (en)
GB907310A (en) 1962-10-03

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