ES2549132T3 - 2-Aril-3,5-diciano-4-indazolil-6-metil-1,4-dihidropiridinas sustituidas con fluoro y usos de las mismas - Google Patents

2-Aril-3,5-diciano-4-indazolil-6-metil-1,4-dihidropiridinas sustituidas con fluoro y usos de las mismas Download PDF

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Publication number
ES2549132T3
ES2549132T3 ES10775812.0T ES10775812T ES2549132T3 ES 2549132 T3 ES2549132 T3 ES 2549132T3 ES 10775812 T ES10775812 T ES 10775812T ES 2549132 T3 ES2549132 T3 ES 2549132T3
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Spain
Prior art keywords
formula
compound
fluoro
methyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10775812.0T
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English (en)
Spanish (es)
Inventor
Alexandros Vakalopoulos
Martin Michels
Katja Zimmermann
Nicole Teusch
Mario Lobell
Karen Engel
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Bayer Intellectual Property GmbH
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Bayer Intellectual Property GmbH
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Publication of ES2549132T3 publication Critical patent/ES2549132T3/es
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES10775812.0T 2009-11-11 2010-11-08 2-Aril-3,5-diciano-4-indazolil-6-metil-1,4-dihidropiridinas sustituidas con fluoro y usos de las mismas Active ES2549132T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09175642 2009-11-11
EP09175642 2009-11-11
PCT/EP2010/066983 WO2011069761A1 (en) 2009-11-11 2010-11-08 Fluoro-substituted 2-aryl-3,5-dicyano-4-indazolyl-6-methyl-1,4-dihydropyridines and uses thereof

Publications (1)

Publication Number Publication Date
ES2549132T3 true ES2549132T3 (es) 2015-10-23

Family

ID=43629143

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10775812.0T Active ES2549132T3 (es) 2009-11-11 2010-11-08 2-Aril-3,5-diciano-4-indazolil-6-metil-1,4-dihidropiridinas sustituidas con fluoro y usos de las mismas

Country Status (7)

Country Link
US (1) US9018234B2 (enExample)
EP (1) EP2499124B1 (enExample)
JP (1) JP5753182B2 (enExample)
CN (1) CN102666525B (enExample)
CA (1) CA2777907C (enExample)
ES (1) ES2549132T3 (enExample)
WO (1) WO2011069761A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104513253A (zh) 2013-10-01 2015-04-15 南京波尔泰药业科技有限公司 用于治疗增殖性疾病的大环化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635977A (en) 1969-11-03 1972-01-18 American Cyanamid Co Certain 6-trifluoromethylcytosines and thiocytosines their synthesis and their use in the synthesis of uracisls and thiouracil
WO2005085227A1 (en) 2004-03-02 2005-09-15 Smithkline Beecham Corporation Inhibitors of akt activity
EP1828135A4 (en) 2004-12-13 2009-08-12 Irm Llc COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROIDAL RECEPTORS AND CALCIUM CHANNEL ACTIVITIES
EP1858325A4 (en) 2005-01-07 2010-06-30 Roskamp Res Llc COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS FOR IDENTIFYING THESE COMPOUNDS
ES2396160T3 (es) * 2006-12-14 2013-02-19 Bayer Intellectual Property Gmbh Derivados de DIHIDROPIRIDINA que utiliza como inhibidores de la proteina quinasa

Also Published As

Publication number Publication date
EP2499124B1 (en) 2015-08-19
EP2499124A1 (en) 2012-09-19
CA2777907A1 (en) 2011-06-16
CN102666525A (zh) 2012-09-12
HK1177452A1 (en) 2013-08-23
WO2011069761A1 (en) 2011-06-16
US20130005773A1 (en) 2013-01-03
JP5753182B2 (ja) 2015-07-22
JP2013510814A (ja) 2013-03-28
CA2777907C (en) 2017-08-29
CN102666525B (zh) 2015-01-28
US9018234B2 (en) 2015-04-28

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