ES2549132T3 - 2-Aril-3,5-diciano-4-indazolil-6-metil-1,4-dihidropiridinas sustituidas con fluoro y usos de las mismas - Google Patents

2-Aril-3,5-diciano-4-indazolil-6-metil-1,4-dihidropiridinas sustituidas con fluoro y usos de las mismas Download PDF

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Publication number
ES2549132T3
ES2549132T3 ES10775812.0T ES10775812T ES2549132T3 ES 2549132 T3 ES2549132 T3 ES 2549132T3 ES 10775812 T ES10775812 T ES 10775812T ES 2549132 T3 ES2549132 T3 ES 2549132T3
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Spain
Prior art keywords
formula
compound
fluoro
methyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10775812.0T
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English (en)
Spanish (es)
Inventor
Alexandros Vakalopoulos
Martin Michels
Katja Zimmermann
Nicole Teusch
Mario Lobell
Karen Engel
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Bayer Intellectual Property GmbH
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Bayer Intellectual Property GmbH
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Publication of ES2549132T3 publication Critical patent/ES2549132T3/es
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES10775812.0T 2009-11-11 2010-11-08 2-Aril-3,5-diciano-4-indazolil-6-metil-1,4-dihidropiridinas sustituidas con fluoro y usos de las mismas Active ES2549132T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09175642 2009-11-11
EP09175642 2009-11-11
PCT/EP2010/066983 WO2011069761A1 (en) 2009-11-11 2010-11-08 Fluoro-substituted 2-aryl-3,5-dicyano-4-indazolyl-6-methyl-1,4-dihydropyridines and uses thereof

Publications (1)

Publication Number Publication Date
ES2549132T3 true ES2549132T3 (es) 2015-10-23

Family

ID=43629143

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10775812.0T Active ES2549132T3 (es) 2009-11-11 2010-11-08 2-Aril-3,5-diciano-4-indazolil-6-metil-1,4-dihidropiridinas sustituidas con fluoro y usos de las mismas

Country Status (7)

Country Link
US (1) US9018234B2 (cg-RX-API-DMAC10.html)
EP (1) EP2499124B1 (cg-RX-API-DMAC10.html)
JP (1) JP5753182B2 (cg-RX-API-DMAC10.html)
CN (1) CN102666525B (cg-RX-API-DMAC10.html)
CA (1) CA2777907C (cg-RX-API-DMAC10.html)
ES (1) ES2549132T3 (cg-RX-API-DMAC10.html)
WO (1) WO2011069761A1 (cg-RX-API-DMAC10.html)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104513253A (zh) 2013-10-01 2015-04-15 南京波尔泰药业科技有限公司 用于治疗增殖性疾病的大环化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635977A (en) 1969-11-03 1972-01-18 American Cyanamid Co Certain 6-trifluoromethylcytosines and thiocytosines their synthesis and their use in the synthesis of uracisls and thiouracil
JP2007526324A (ja) 2004-03-02 2007-09-13 スミスクライン・ビーチャム・コーポレイション Ａｋｔ活性のある阻害剤
US20090298872A1 (en) 2004-12-13 2009-12-03 Irm Llc Compounds and compositions as modulators of steroidal receptors and calcium channel activities
EP1858325A4 (en) 2005-01-07 2010-06-30 Roskamp Res Llc COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS FOR IDENTIFYING THESE COMPOUNDS
CA2672167C (en) * 2006-12-14 2016-01-26 Bayer Schering Pharma Aktiengesellschaft Dihydropyridine derivatives useful as protein kinase inhibitors

Also Published As

Publication number Publication date
JP5753182B2 (ja) 2015-07-22
EP2499124A1 (en) 2012-09-19
CN102666525B (zh) 2015-01-28
JP2013510814A (ja) 2013-03-28
US20130005773A1 (en) 2013-01-03
CN102666525A (zh) 2012-09-12
HK1177452A1 (en) 2013-08-23
US9018234B2 (en) 2015-04-28
EP2499124B1 (en) 2015-08-19
CA2777907C (en) 2017-08-29
WO2011069761A1 (en) 2011-06-16
CA2777907A1 (en) 2011-06-16

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