ES2548653R1 - METHOD AND KIT FOR THE CELIAQUIA DIAGNOSIS - Google Patents
METHOD AND KIT FOR THE CELIAQUIA DIAGNOSIS Download PDFInfo
- Publication number
- ES2548653R1 ES2548653R1 ES201430567A ES201430567A ES2548653R1 ES 2548653 R1 ES2548653 R1 ES 2548653R1 ES 201430567 A ES201430567 A ES 201430567A ES 201430567 A ES201430567 A ES 201430567A ES 2548653 R1 ES2548653 R1 ES 2548653R1
- Authority
- ES
- Spain
- Prior art keywords
- diagnosis
- kit
- celiaquia
- genetic markers
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Método y kit para el diagnóstico de celiaquía.#La presente invención se refiere a métodos y kits para el diagnóstico de la enfermedad celíaca mediante la combinación mediante un único kit de la detección de marcadores serológicos y genéticos. La presente invención pone de manifiesto que la presencia de anticuerpos frente a neoepítopos que surgen de la unión del complejo transglutaminasa tipo 2-péptidos deamidados de gliadina y la ausencia de los marcadores genéticos HLA-DQ2 o -DQ8, puede indicar la presencia de la enfermedad.Method and kit for the diagnosis of celiac disease # The present invention relates to methods and kits for the diagnosis of celiac disease by combining it with a single kit for the detection of serological and genetic markers. The present invention shows that the presence of antibodies against neoepitopes that arise from the union of the transglutaminase complex type 2-deamidated peptides of gliadin and the absence of the genetic markers HLA-DQ2 or -DQ8, may indicate the presence of the disease .
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201430567A ES2548653B1 (en) | 2014-04-16 | 2014-04-16 | METHOD AND KIT FOR THE CELIAQUIA DIAGNOSIS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201430567A ES2548653B1 (en) | 2014-04-16 | 2014-04-16 | METHOD AND KIT FOR THE CELIAQUIA DIAGNOSIS |
Publications (3)
Publication Number | Publication Date |
---|---|
ES2548653A2 ES2548653A2 (en) | 2015-10-19 |
ES2548653R1 true ES2548653R1 (en) | 2015-12-30 |
ES2548653B1 ES2548653B1 (en) | 2017-01-18 |
Family
ID=54292291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES201430567A Expired - Fee Related ES2548653B1 (en) | 2014-04-16 | 2014-04-16 | METHOD AND KIT FOR THE CELIAQUIA DIAGNOSIS |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2548653B1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2759342C1 (en) * | 2020-12-03 | 2021-11-12 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный педиатрический медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПбГПМУ Минздрава России) | Method for diagnosing autoimmune gastritis in children with celiac disease |
-
2014
- 2014-04-16 ES ES201430567A patent/ES2548653B1/en not_active Expired - Fee Related
Non-Patent Citations (5)
Title |
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BONAMICO MARGHERITA et al. Serologic and genetic markers of celiac disease: A sequential study in the screening of first degree relatives.JPGN Journal of Pediatric Gastroenterology and Nutrition FEB 2006 00/02/2006 VOL: 42 No: 2 Pags: 150-154 ISSN 0277-2116 todo el documento. * |
FRANK KNEEPKENS C M et al. Clinical practice ; Coeliac disease.European Journal of Pediatrics, 20120316 Springer, Berlin, DE 16/03/2012 VOL: 171 No: 7 Pags: 1011 - 1021 ISSN 1432-1076 Doi: doi:10.1007/s00431-012-1714-8 todo el documento. * |
MEGIORNI F et al. HLA-DQ and risk gradient for celiac disease.HUMAN IMMUNOLOGY, 20090101 NEW YORK, NY, US 01/01/2009 VOL: 70 No: 1 Pags: 55 - 59 ISSN 0198-8859 Doi: doi:10.1016/j.humimm.2008.10.018 Monos Dimitri; Maiers Martin J todo el documento. * |
PARTANEN JUKKA et al. HLA in coeliac disease patients not carrying the DQA1*05 DQB1*02 heterodimer: Results from the European genetics cluster on coeliac disease..Genes and Immunity May 2003 00/05/2003 VOL: 4 No: Supplement 1 Pags: S6 ISSN 1466-4879 (ISSN print) todo el documento. * |
PIETZAK M M ET AL. Stratifying Risk for Celiac Disease in a Large At-Risk United States Population by Using HLA Alleles.CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 20090901 AMERICAN GASTROENTEROLOGICAL ASSOCIATION, US 01/09/2009 VOL: 7 No: 9 Pags: 966 - 971 ISSN 1542-3565 Doi: doi:10.1016/j.cgh.2009.05.028 todo el documento. * |
Also Published As
Publication number | Publication date |
---|---|
ES2548653B1 (en) | 2017-01-18 |
ES2548653A2 (en) | 2015-10-19 |
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Legal Events
Date | Code | Title | Description |
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FG2A | Definitive protection |
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