ES2539520B1 - Composición farmacéutica de aplicación tópica en forma de suspensión de micronizado y método y usos correspondientes - Google Patents

Composición farmacéutica de aplicación tópica en forma de suspensión de micronizado y método y usos correspondientes Download PDF

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Publication number
ES2539520B1
ES2539520B1 ES201331939A ES201331939A ES2539520B1 ES 2539520 B1 ES2539520 B1 ES 2539520B1 ES 201331939 A ES201331939 A ES 201331939A ES 201331939 A ES201331939 A ES 201331939A ES 2539520 B1 ES2539520 B1 ES 2539520B1
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Spain
Prior art keywords
pharmaceutical composition
corresponding method
topical application
micronized
application pharmaceutical
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Active
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ES201331939A
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English (en)
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ES2539520A1 (es
Inventor
Antonio BUXADÉ VIÑAS
Montserrat Albreda Plaza
Miguel CÁNOVAS UBERA
Antonio Conchillo Teruel
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Laboratorios Vinas SA
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Laboratorios Vinas SA
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Publication date
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Priority to ES201331939A priority Critical patent/ES2539520B1/es
Publication of ES2539520A1 publication Critical patent/ES2539520A1/es
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composición farmacéutica de aplicación tópica en forma de suspensión de micronizado y método y usos correspondientes. La presente invención describe una formulación farmacéutica en forma de suspensión estable, para uso tópico, en la que se formulan ácidos orgánicos micronizados y partículas orgánicas micronizadas con efecto “soft peeling”, en un medio a base de polisiloxanos para el tratamiento de la hiperqueratosis en cuero cabelludo.

Description

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Tabla 1:
Formulación 1
Formulación 2 Formulación 3 Formulación 4
Ciclometicona (Ciclopentasiloxano)
3,3 kg 1,2 kg 3,3 kg 0,5 kg
Polisiloxano reticulado (Dimetilmetilhidroge nosiloxano/1,5hexadieno)
0,30 kg 0,25 kg
Elastómero preformulado (Dow Corning® ST Elastomer 10)
2,50 kg 3,0 kg
Ácido málico (100 %<70 µm 50 % < 25 µm)
0,30 kg 0,30 kg
Ácido salicílico (100 %<70 µm 50 % < 25 µm)
0,40 kg
Ácido mandélico (100 %<70 µm 50 % < 25 µm)
0,30 kg
PE-HD (50-200 µm)
0,10 kg 0,05 kg
Nylon® (50- 200 µm)
0,20 kg
Peso total
4,0 kg 4,0 kg 4,0 kg 4,0 kg
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Claims (1)

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ES201331939A 2013-12-30 2013-12-30 Composición farmacéutica de aplicación tópica en forma de suspensión de micronizado y método y usos correspondientes Active ES2539520B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES201331939A ES2539520B1 (es) 2013-12-30 2013-12-30 Composición farmacéutica de aplicación tópica en forma de suspensión de micronizado y método y usos correspondientes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201331939A ES2539520B1 (es) 2013-12-30 2013-12-30 Composición farmacéutica de aplicación tópica en forma de suspensión de micronizado y método y usos correspondientes

Publications (2)

Publication Number Publication Date
ES2539520A1 ES2539520A1 (es) 2015-07-01
ES2539520B1 true ES2539520B1 (es) 2016-06-06

Family

ID=53479803

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201331939A Active ES2539520B1 (es) 2013-12-30 2013-12-30 Composición farmacéutica de aplicación tópica en forma de suspensión de micronizado y método y usos correspondientes

Country Status (1)

Country Link
ES (1) ES2539520B1 (es)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5847003A (en) * 1996-06-04 1998-12-08 Avon Products, Inc. Oxa acids and related compounds for treating skin conditions
US6146664A (en) * 1998-07-10 2000-11-14 Shaklee Corporation Stable topical ascorbic acid compositions
US6200964B1 (en) * 1999-05-28 2001-03-13 Neutrogena Corporation Silicone gel containing salicylic acid
ES2322836B1 (es) * 2007-12-28 2010-04-19 Laboratorios Viñas, S.A. Composicion farmaceutica de aplicacion topica en forma de pomada anhidra que contiene acido salicilico y metodo de preparacion y uso correspondiente.

Also Published As

Publication number Publication date
ES2539520A1 (es) 2015-07-01

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