ES2537905B2 - Uso de 12- desoxiforboles para promover la proliferación de las células madre neurales - Google Patents

Uso de 12- desoxiforboles para promover la proliferación de las células madre neurales Download PDF

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Publication number
ES2537905B2
ES2537905B2 ES201301153A ES201301153A ES2537905B2 ES 2537905 B2 ES2537905 B2 ES 2537905B2 ES 201301153 A ES201301153 A ES 201301153A ES 201301153 A ES201301153 A ES 201301153A ES 2537905 B2 ES2537905 B2 ES 2537905B2
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Prior art keywords
proliferation
stem cells
neural stem
promote
deoxiforboles
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Active
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ES201301153A
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English (en)
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ES2537905R2 (es
ES2537905A2 (es
Inventor
Carmen Castro González
Noelia GERIBALDI DOLDÁN
Maribel MURILLO CARRETERO
Jesús DOMINGUEZ RISCART
Purificación ORTIZ CUELLAR
Francisco GARCÍA BERNAL
Eugenia FLORES GIUBI
Rosario HERNÁNDEZ GALÁN
Antonio José MACÍAS SÁNCHEZ
Cristina VERÁSTEGUI ESCOLANO
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Universidad de Cadiz
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Universidad de Cadiz
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Priority to ES201301153A priority Critical patent/ES2537905B2/es
Priority to PCT/ES2014/000180 priority patent/WO2015086866A1/es
Publication of ES2537905A2 publication Critical patent/ES2537905A2/es
Publication of ES2537905R2 publication Critical patent/ES2537905R2/es
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Uso de 12-desoxiforboles para promover la proliferación de células madre neurales.#Esta invención está relacionada con el empleo de compuestos de la familia 12-desoxiforboles o una sal farmacológicamente activa de dichos compuestos, para favorecer la proliferación de precursores neurales o células madre neurales en cultivo. Adicionalmente, también se relaciona con el empleo de esta familia de compuestos para la elaboración de una composición farmacéutica útil en el tratamiento de enfermedades del sistema nervioso central que cursen con perdida neuronal.

Description

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Claims (1)

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ES201301153A 2013-12-11 2013-12-11 Uso de 12- desoxiforboles para promover la proliferación de las células madre neurales Active ES2537905B2 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES201301153A ES2537905B2 (es) 2013-12-11 2013-12-11 Uso de 12- desoxiforboles para promover la proliferación de las células madre neurales
PCT/ES2014/000180 WO2015086866A1 (es) 2013-12-11 2014-10-24 Uso de 12-desoxiforboles para promover la expansión de células madre neurales

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201301153A ES2537905B2 (es) 2013-12-11 2013-12-11 Uso de 12- desoxiforboles para promover la proliferación de las células madre neurales

Publications (3)

Publication Number Publication Date
ES2537905A2 ES2537905A2 (es) 2015-06-15
ES2537905R2 ES2537905R2 (es) 2015-06-29
ES2537905B2 true ES2537905B2 (es) 2015-10-14

Family

ID=53290863

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201301153A Active ES2537905B2 (es) 2013-12-11 2013-12-11 Uso de 12- desoxiforboles para promover la proliferación de las células madre neurales

Country Status (2)

Country Link
ES (1) ES2537905B2 (es)
WO (1) WO2015086866A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2916383B2 (es) * 2020-12-29 2023-12-13 Univ Cadiz Derivados de 12-desoxiforboles y usos de los mismos

Also Published As

Publication number Publication date
ES2537905R2 (es) 2015-06-29
ES2537905A2 (es) 2015-06-15
WO2015086866A1 (es) 2015-06-18

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