ES2527193T3 - Copolímeros multibloque segmentados de fases separadas biodegradables y liberación de polipéptidos biológicamente activos - Google Patents
Copolímeros multibloque segmentados de fases separadas biodegradables y liberación de polipéptidos biológicamente activos Download PDFInfo
- Publication number
- ES2527193T3 ES2527193T3 ES11741302.1T ES11741302T ES2527193T3 ES 2527193 T3 ES2527193 T3 ES 2527193T3 ES 11741302 T ES11741302 T ES 11741302T ES 2527193 T3 ES2527193 T3 ES 2527193T3
- Authority
- ES
- Spain
- Prior art keywords
- prepolymer
- copolymer
- biologically active
- poly
- segments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
- A61K38/385—Serum albumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/02—Details not specific for a particular testing method
- G01N2203/026—Specifications of the specimen
- G01N2203/0262—Shape of the specimen
- G01N2203/0278—Thin specimens
- G01N2203/0282—Two dimensional, e.g. tapes, webs, sheets, strips, disks or membranes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Materials For Medical Uses (AREA)
- Polyesters Or Polycarbonates (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Biological Depolymerization Polymers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36271010P | 2010-07-09 | 2010-07-09 | |
| US362710P | 2010-07-09 | ||
| PCT/NL2011/050502 WO2012005594A2 (fr) | 2010-07-09 | 2011-07-08 | Copolymères biodégradables multiséquencés, à phases séparées et libération de polypeptides biologiquement actifs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2527193T3 true ES2527193T3 (es) | 2015-01-21 |
Family
ID=44629868
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14195906.4T Active ES2628931T3 (es) | 2010-07-09 | 2011-07-08 | Copolímeros multibloque segmentados de fases separadas biodegradables y liberación de polipétidos biológicamente activos |
| ES11741302.1T Active ES2527193T3 (es) | 2010-07-09 | 2011-07-08 | Copolímeros multibloque segmentados de fases separadas biodegradables y liberación de polipéptidos biológicamente activos |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14195906.4T Active ES2628931T3 (es) | 2010-07-09 | 2011-07-08 | Copolímeros multibloque segmentados de fases separadas biodegradables y liberación de polipétidos biológicamente activos |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9364442B2 (fr) |
| EP (2) | EP2859887B1 (fr) |
| CA (1) | CA2804601C (fr) |
| DK (2) | DK2859887T3 (fr) |
| ES (2) | ES2628931T3 (fr) |
| HU (1) | HUE033386T2 (fr) |
| PL (2) | PL2859887T3 (fr) |
| WO (1) | WO2012005594A2 (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2628931T3 (es) | 2010-07-09 | 2017-08-04 | Innocore Technologies B.V. | Copolímeros multibloque segmentados de fases separadas biodegradables y liberación de polipétidos biológicamente activos |
| FI128487B (en) * | 2013-05-06 | 2020-06-15 | Teknologian Tutkimuskeskus Vtt Oy | Glycolic acid polymers and process for their preparation |
| GB201405874D0 (en) * | 2014-04-01 | 2014-05-14 | Aga Nanotech Ltd | A therapeutic agent for use in the treatment of infections |
| US10353503B2 (en) * | 2015-10-29 | 2019-07-16 | Texas Instruments Incorporated | Integrated force sensing element |
| HUE058207T2 (hu) | 2017-01-31 | 2022-07-28 | Veru Inc | Készítmények és módszerek gonadotropin felszabadító hormon (GNRH) antagonisták elnyújtott idejû felszabadítására |
| US11911476B2 (en) * | 2017-07-25 | 2024-02-27 | Pk Med | Process for preparing a drug delivery composition |
| EP3628698A1 (fr) | 2018-09-26 | 2020-04-01 | Covidien LP | Copolymères triblocs biodégradables et dispositifs médicaux implantables fabriqués à partir de ceux-ci |
| WO2020087203A1 (fr) * | 2018-10-29 | 2020-05-07 | Pujing Chemical Industry Co., Ltd | Copolymère polyglycolide résistant à la chaleur et au vieillissement et composition associée |
| US20210395516A1 (en) * | 2018-10-29 | 2021-12-23 | Pujing Chemical Industry Co., Ltd. | Polyglycolide Copolymer and Preparation Thereof |
| US20220371277A1 (en) | 2019-09-25 | 2022-11-24 | Carbon, Inc. | Particle coating methods for additively manufactured products |
| WO2021064550A1 (fr) * | 2019-09-30 | 2021-04-08 | Tolmar International Limited | Compositions polymères liquides et systèmes d'administration prolongée de peptides en tant qu'ingrédients pharmaceutiques actifs |
| US20220331258A1 (en) | 2019-10-01 | 2022-10-20 | Allergan Sales, Llc | Poly-Dioxanone Multi-Block Copolymer for Ocular Protein Delivery |
| BR112022006024A2 (pt) | 2019-10-01 | 2022-07-12 | Innocore Tech Holding B V | Copolímero em multi-bloco, termoplástico, biodegradável, separado por fase |
| EP4051233A1 (fr) | 2019-11-01 | 2022-09-07 | InnoCore Technologies Holding B.V. | Forme posologique pour libération prolongée d'un anticorps ou d'une protéine de grande taille |
| CN114621450B (zh) * | 2021-04-07 | 2023-05-05 | 江苏睿安应用生物技术股份有限公司 | 一种扩链改性生物降解聚酯的方法及其应用 |
| AU2023235001A1 (en) | 2022-03-17 | 2024-10-17 | InnoCore Technologies Holding B.V. | Biodegradable thermoplastic poly(ortho ester) based multiblock copolymers |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4429080A (en) | 1982-07-01 | 1984-01-31 | American Cyanamid Company | Synthetic copolymer surgical articles and method of manufacturing the same |
| US4643734A (en) | 1983-05-05 | 1987-02-17 | Hexcel Corporation | Lactide/caprolactone polymer, method of making the same, composites thereof, and prostheses produced therefrom |
| US5066772A (en) | 1987-12-17 | 1991-11-19 | Allied-Signal Inc. | Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides |
| US5324519A (en) * | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| US5133739A (en) | 1990-02-06 | 1992-07-28 | Ethicon, Inc. | Segmented copolymers of ε-caprolactone and glycolide |
| US5236444A (en) | 1992-10-27 | 1993-08-17 | United States Surgical Corporation | Absorbable polymers and surgical articles made therefrom |
| US5403347A (en) | 1993-05-27 | 1995-04-04 | United States Surgical Corporation | Absorbable block copolymers and surgical articles fabricated therefrom |
| US5980948A (en) | 1996-08-16 | 1999-11-09 | Osteotech, Inc. | Polyetherester copolymers as drug delivery matrices |
| US6255408B1 (en) | 1998-11-06 | 2001-07-03 | Poly-Med, Inc. | Copolyesters with minimized hydrolytic instability and crystalline absorbable copolymers thereof |
| EP1382628A1 (fr) * | 2002-07-16 | 2004-01-21 | Polyganics B.V. | Segment- ou block-copolyester phase-separée |
| EP1555278A1 (fr) * | 2004-01-15 | 2005-07-20 | Innocore Technologies B.V. | Copolymères biodégradables en block multiples |
| NL1026261C2 (nl) | 2004-05-25 | 2005-11-28 | Nanomi B V | Sproei inrichting met een nozzleplaat voorzien van structuren ter bevordering van self-breakup, een nozzleplaat, alsmede werkwijzen ter vervaardiging en toepassing van een dergelijke nozzleplaat. |
| JP5203695B2 (ja) | 2007-12-28 | 2013-06-05 | ヤマハ発動機株式会社 | 遠心クラッチ、エンジンユニット及び鞍乗型車両 |
| ES2628931T3 (es) | 2010-07-09 | 2017-08-04 | Innocore Technologies B.V. | Copolímeros multibloque segmentados de fases separadas biodegradables y liberación de polipétidos biológicamente activos |
-
2011
- 2011-07-08 ES ES14195906.4T patent/ES2628931T3/es active Active
- 2011-07-08 PL PL14195906T patent/PL2859887T3/pl unknown
- 2011-07-08 DK DK14195906.4T patent/DK2859887T3/en active
- 2011-07-08 US US13/808,492 patent/US9364442B2/en active Active
- 2011-07-08 CA CA2804601A patent/CA2804601C/fr active Active
- 2011-07-08 ES ES11741302.1T patent/ES2527193T3/es active Active
- 2011-07-08 EP EP14195906.4A patent/EP2859887B1/fr active Active
- 2011-07-08 EP EP11741302.1A patent/EP2590629B1/fr active Active
- 2011-07-08 PL PL11741302T patent/PL2590629T3/pl unknown
- 2011-07-08 HU HUE14195906A patent/HUE033386T2/en unknown
- 2011-07-08 WO PCT/NL2011/050502 patent/WO2012005594A2/fr active Application Filing
- 2011-07-08 DK DK11741302.1T patent/DK2590629T3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2804601C (fr) | 2020-05-19 |
| EP2859887B1 (fr) | 2017-03-22 |
| WO2012005594A2 (fr) | 2012-01-12 |
| DK2859887T3 (en) | 2017-06-26 |
| ES2628931T3 (es) | 2017-08-04 |
| CA2804601A1 (fr) | 2012-01-12 |
| PL2590629T3 (pl) | 2015-04-30 |
| EP2590629A2 (fr) | 2013-05-15 |
| WO2012005594A3 (fr) | 2012-07-05 |
| DK2590629T3 (en) | 2015-01-12 |
| US20130209568A1 (en) | 2013-08-15 |
| US9364442B2 (en) | 2016-06-14 |
| EP2859887A1 (fr) | 2015-04-15 |
| EP2590629B1 (fr) | 2014-12-03 |
| HUE033386T2 (en) | 2017-11-28 |
| PL2859887T3 (pl) | 2017-10-31 |
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