ES2492015B1 - Hidrogeles de poloxamina y su uso para la regeneración o reparación ósea - Google Patents

Hidrogeles de poloxamina y su uso para la regeneración o reparación ósea Download PDF

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Publication number
ES2492015B1
ES2492015B1 ES201330135A ES201330135A ES2492015B1 ES 2492015 B1 ES2492015 B1 ES 2492015B1 ES 201330135 A ES201330135 A ES 201330135A ES 201330135 A ES201330135 A ES 201330135A ES 2492015 B1 ES2492015 B1 ES 2492015B1
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ES
Spain
Prior art keywords
poloxamine
hydrogels
repair
bone regeneration
regeneration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES201330135A
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English (en)
Other versions
ES2492015A1 (es
Inventor
Carmen Alvarez Lorenzo
Angel Concheiro Nine
Susana SIMOES
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidade de Santiago de Compostela
Original Assignee
Universidade de Santiago de Compostela
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade de Santiago de Compostela filed Critical Universidade de Santiago de Compostela
Priority to ES201330135A priority Critical patent/ES2492015B1/es
Priority to PCT/ES2014/070070 priority patent/WO2014122345A1/es
Publication of ES2492015A1 publication Critical patent/ES2492015A1/es
Application granted granted Critical
Publication of ES2492015B1 publication Critical patent/ES2492015B1/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Hidrogeles de poloxamina y su uso para la regeneración o reparación ósea.#La presente invención se relaciona con hidrogeles de poloxamina y ciclodextrina que pueden incorporar una estatina. La incorporación de ciclodextrinas permite disminuir la concentración de poloxamina necesaria para dar lugar a la formación de geles y aumenta además la actividad osteogénica/osteoinductiva de la poloxamina. Dichos hidrogeles promueven la diferenciación de células madre mesenquimales a osteoblastos y pueden utilizarse para la reparación, regeneración o aumento de la formación de hueso.

Description

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Claims (1)

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ES201330135A 2013-02-05 2013-02-05 Hidrogeles de poloxamina y su uso para la regeneración o reparación ósea Active ES2492015B1 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES201330135A ES2492015B1 (es) 2013-02-05 2013-02-05 Hidrogeles de poloxamina y su uso para la regeneración o reparación ósea
PCT/ES2014/070070 WO2014122345A1 (es) 2013-02-05 2014-02-03 Hidrogeles de poloxamina y su uso para la regeneración o reparación ósea

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201330135A ES2492015B1 (es) 2013-02-05 2013-02-05 Hidrogeles de poloxamina y su uso para la regeneración o reparación ósea

Publications (2)

Publication Number Publication Date
ES2492015A1 ES2492015A1 (es) 2014-09-08
ES2492015B1 true ES2492015B1 (es) 2015-09-04

Family

ID=51299257

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201330135A Active ES2492015B1 (es) 2013-02-05 2013-02-05 Hidrogeles de poloxamina y su uso para la regeneración o reparación ósea

Country Status (2)

Country Link
ES (1) ES2492015B1 (es)
WO (1) WO2014122345A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015035996A1 (en) * 2013-09-11 2015-03-19 Amphidex A/S Cell culture products for adherent cell cultures and manufacture thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2370205B2 (es) * 2010-05-18 2012-07-04 Universidad De Santiago De Compostela Uso de poloxaminas como inductoras de la diferenciacion osteogenica de celulas mesenquimales

Also Published As

Publication number Publication date
ES2492015A1 (es) 2014-09-08
WO2014122345A1 (es) 2014-08-14

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