ES2491340B1 - New composition of chitosan conjugates or derivatives with thiolactones - Google Patents
New composition of chitosan conjugates or derivatives with thiolactones Download PDFInfo
- Publication number
- ES2491340B1 ES2491340B1 ES201300228A ES201300228A ES2491340B1 ES 2491340 B1 ES2491340 B1 ES 2491340B1 ES 201300228 A ES201300228 A ES 201300228A ES 201300228 A ES201300228 A ES 201300228A ES 2491340 B1 ES2491340 B1 ES 2491340B1
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- ES
- Spain
- Prior art keywords
- thiolactones
- derivatives
- conjugates
- properties
- new composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Birds (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a conjugados del chitosan (o sus derivados) con tiolactonas (síntesis y estructuras químicas), en las composiciones cosméticas, biomédicas-farmacéuticas que contienen dichos conjugados, y a sus aplicaciones, que presentan las siguientes propiedades: no tóxicos, biodegradables, con excelentes propiedades de mucoadhesión, cohesión e inhibición enzimática, con propiedades mejoradas de permeabilidad, captación celular y gran estabilidad como agentes de recubrimiento de cánulas y otros dispositivos médicos y como sistemas transportadores de fármacos, esto es, con largos tiempos de permanencia de los principios activos englobados, lo que garantiza un excelente control en la liberación de los fármacos incluidos en la formulación y además, capaces de gelificar en presencia de oxígeno.The present invention relates to chitosan conjugates (or their derivatives) with thiolactones (synthesis and chemical structures), in cosmetic, biomedical-pharmaceutical compositions containing said conjugates, and to their applications, which have the following properties: non-toxic, biodegradable , with excellent properties of mucoadhesion, cohesion and enzymatic inhibition, with improved properties of permeability, cellular uptake and great stability as coating agents for cannulas and other medical devices and as drug transport systems, that is, with long residence times of the active ingredients included, which guarantees excellent control in the release of the drugs included in the formulation and also capable of gelling in the presence of oxygen.
Description
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201300228A ES2491340B1 (en) | 2013-03-05 | 2013-03-05 | New composition of chitosan conjugates or derivatives with thiolactones |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201300228A ES2491340B1 (en) | 2013-03-05 | 2013-03-05 | New composition of chitosan conjugates or derivatives with thiolactones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2491340A1 ES2491340A1 (en) | 2014-09-05 |
| ES2491340B1 true ES2491340B1 (en) | 2015-03-31 |
Family
ID=51452824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES201300228A Active ES2491340B1 (en) | 2013-03-05 | 2013-03-05 | New composition of chitosan conjugates or derivatives with thiolactones |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2491340B1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10618986B2 (en) | 2016-10-19 | 2020-04-14 | Alcon Inc. | Hydrophilic copolymer with pendant thiol groups |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110217084B (en) * | 2019-06-28 | 2024-03-26 | 佛山科学技术学院 | Automobile protection fence |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATA13842001A (en) * | 2001-08-31 | 2002-10-15 | Mucobiomer Biotechnologische F | CHITOSAN-THIO-ALKYL-AMIDINE CONJUGATES AND THEIR COSMETIC AND PHARMACEUTICAL USE |
-
2013
- 2013-03-05 ES ES201300228A patent/ES2491340B1/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10618986B2 (en) | 2016-10-19 | 2020-04-14 | Alcon Inc. | Hydrophilic copolymer with pendant thiol groups |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2491340A1 (en) | 2014-09-05 |
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| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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