ES2463365A1 - Aortic endoprosthesis for the treatment of an aneurysm - Google Patents
Aortic endoprosthesis for the treatment of an aneurysm Download PDFInfo
- Publication number
- ES2463365A1 ES2463365A1 ES201231638A ES201231638A ES2463365A1 ES 2463365 A1 ES2463365 A1 ES 2463365A1 ES 201231638 A ES201231638 A ES 201231638A ES 201231638 A ES201231638 A ES 201231638A ES 2463365 A1 ES2463365 A1 ES 2463365A1
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- Prior art keywords
- tubular body
- aneurysm
- bag
- intended
- aortic endoprosthesis
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
- A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
- A61B17/12118—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm for positioning in conjunction with a stent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12136—Balloons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2002/065—Y-shaped blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
- A61F2250/0031—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts
Abstract
Description
Endoprótesis aórtica para tratamiento de aneurisma. Aortic endoprosthesis for aneurysm treatment.
La presente invención pertenece al campo de las endoprótesis, más concretamente se trata de un modelo de endoprótesis para el tratamiento de los aneurismas de aorta abdominal, aunque asimismo se contempla que variaciones de este diseño inicial podrían ser útiles para tratar otras patologías arteriales o venosas. The present invention belongs to the field of stents, more specifically it is a stent model for the treatment of abdominal aortic aneurysms, although it is also contemplated that variations of this initial design could be useful for treating other arterial or venous pathologies.
La patología arterial tiene un denominador común que es la respuesta inflamatoria que se produce en sus paredes en respuesta a diferentes noxas. Esta respuesta se puede traducir en el acúmulo de sustancias y productos de degradación en la región subendotelial (patología obstructiva, hiperplasia intimal) o en la degradación y debilitamiento de la pared que se dilata (aneurismas). Arterial pathology has a common denominator that is the inflammatory response that occurs on its walls in response to different noxas. This response can be translated into the accumulation of substances and degradation products in the subendothelial region (obstructive pathology, intimal hyperplasia) or in the degradation and weakening of the dilated wall (aneurysms).
Diferentes estudios van explicando las bases y mecanismos de este proceso inflamatorio, y aunque no se conocen Different studies explain the basis and mechanisms of this inflammatory process, and although they are not known
con exactitud los mecanismos inicializadores o regulatorios del proceso, se conoce que las células madre juegan un papel que parece crucial en los procesos de reparación y “cicatrización” de las lesiones inducidas en la pared arterial. Exactly the initializing or regulatory mechanisms of the process, it is known that stem cells play a role that seems crucial in the processes of repair and "scarring" of induced lesions in the arterial wall.
Se define como una dilatación focal y persistente del diámetro de una arteria del 150% o más que el diámetro de la arteria adyacente no patológica. It is defined as a persistent focal dilation of the diameter of an artery of 150% or more than the diameter of the adjacent non-pathological artery.
Hay evidencias de que el desarrollo de los aneurismas de aorta se asocia con la inflamación, la disfunción endotelial y la proteolisis, consecuencia de la disfunción de las proteasas y sus inhibidores en la pared arterial, que lleva a la destrucción de la túnica media. There is evidence that the development of aortic aneurysms is associated with inflammation, endothelial dysfunction and proteolysis, a consequence of the dysfunction of proteases and their inhibitors in the arterial wall, which leads to the destruction of the middle tunic.
Se desconoce la secuencia exacta de sucesos que llevan a la progresión y rotura de un aneurisma pero lo que han demostrado los últimos estudios publicados es que se produce una inflamación y proteolisis de la túnica media que provoca una reducción crítica en la resistencia tensil de la pared. The exact sequence of events that lead to the progression and rupture of an aneurysm is unknown but what recent studies have shown is that there is an inflammation and proteolysis of the middle tunic that causes a critical reduction in tensile strength of the wall .
Por su situación anatómica, la aorta infrarrenal tiene una mayor resistencia periférica, un mayor estrés de su pared y un menor flujo en reposo que otros tramos de aorta. Estas condiciones hemodinámicas especiales la hacen ser más propensa a degenerar en aneurisma que otras arterias. Due to its anatomical situation, the infrarenal aorta has a greater peripheral resistance, a greater stress on its wall and a lower fl ow at rest than other sections of aorta. These special hemodynamic conditions make it more prone to degenerate into aneurysm than other arteries.
Estudios y registros internacionales han demostrado los beneficios a corto plazo de las endoprótesis aórticas frente a la cirugía abierta. International studies and registries have demonstrated the short-term benefits of aortic stents versus open surgery.
Es conocido el empleo de endoprótesis de material elástico y configuración tubular autoexpandibles que se adaptan al diámetro de la aorta pasando a ser el conducto de paso de la sangre, de forma que se disminuye la presión sobre el aneurisma. Estas prótesis disponen de medios de fijación distal y proximal que establecen el anclaje de la endoprótesis. It is known to use stents of elastic material and self-expanding tubular configuration that adapt to the diameter of the aorta becoming the passage of blood, so that the pressure on the aneurysm is reduced. These prostheses have distal and proximal fixation means that establish the stent anchor.
Sin embargo las migraciones de la endoprótesis o la aparición de fugas (relleno del saco aneurismático de sangre, con la consiguiente re-presurización del aneurisma) condicionan un riesgo de rotura y obligan a realizar un seguimiento estrecho de por vida de estos pacientes con repetidas pruebas de imagen. However, endoprosthesis migrations or the appearance of leaks (filling of the aneurysmal blood sac, with the consequent re-pressurization of the aneurysm) condition a risk of rupture and force a close follow-up of these patients with repeated tests. of image.
En definitiva la fuga de sangre en el espacio definido entre la superficie exterior de la prótesis y la pared interior del saco aneurismático es uno de los problemas que se ha intentado resolver. El titular de la presente invención plantea una solución de ingeniería tisular para tratar este problema mediante el uso de células. In short, blood leakage in the defined space between the outer surface of the prosthesis and the inner wall of the aneurysm sac is one of the problems that has been tried to solve. The holder of the present invention proposes a tissue engineering solution to treat this problem through the use of cells.
Se conoce el empleo de aparatos para tratamiento de aneurismas que comprenden una endoprótesis, y el empleo de un catéter u otros medios de suministro que podrían introducir células en el aneurisma una vez excluido de la circulación por la propia endoprótesis. The use of aneurysm treatment devices comprising a stent, and the use of a catheter or other means of delivery that could introduce cells into the aneurysm once excluded from circulation by the stent itself, is known.
El empleo de las células con este aparato sin embargo no está del todo optimizado debido a que la porción tubular de la endoprotesis ajustada al vaso no es suficiente para garantizar la hermeticidad, y por tanto podría haber una fuga importante de las células introducidas en el aneurisma que van en detrimento del tratamiento y complicaciones graves derivadas de su embolización. However, the use of the cells with this device is not fully optimized because the tubular portion of the stent adjusted to the vessel is not sufficient to guarantee airtightness, and therefore there could be a significant leakage of the cells introduced into the aneurysm. that are detrimental to the treatment and serious complications derived from its embolization.
La presente invención resuelve la problemática anteriormente expuesta de forma satisfactoria mediante una endoprótesis que comprende básicamente un cuerpo tubular adaptado para su acoplamiento en la aorta abdominal y medios de fijación extremos destinados a asegurar la posición de dicho cuerpo tubular, y que incorpora adicionalmente una bolsa que está unida y circunda el cuerpo tubular definiendo un compartimento. Esta bolsa está adaptada para expandirse en el saco del aneurisma, contando a tal efecto la bolsa con un pequeño orificio que da paso a un catéter mediante el que se introducen las células en el compartimento, lo que ocasiona la expansión de la bolsa en forma de globo dentro del saco del aneurisma excluido de la circulación por el cuerpo tubular. The present invention solves the aforementioned problem satisfactorily by means of an endoprosthesis that basically comprises a tubular body adapted for coupling in the abdominal aorta and extreme fixing means intended to ensure the position of said tubular body, and which additionally incorporates a bag that It is attached and surrounds the tubular body defining a compartment. This bag is adapted to expand in the aneurysm sac, with the bag having a small hole that gives way to a catheter through which the cells are introduced into the compartment, which causes the bag to expand balloon inside the aneurysm sac excluded from circulation through the tubular body.
Una vez introducidas las células en la bolsa, el orificio se cierra por la propia presión que ejerce la endoprótesis sobre la arteria, de esta forma la bolsa garantiza el confinamiento de las células en su interior y evita su fuga, resolviéndose así la problemática anteriormente descrita. Once the cells are introduced into the bag, the hole is closed by the same pressure that the stent exerts on the artery, in this way the bag guarantees the confinement of the cells inside and prevents their leakage, thus solving the problem described above .
Esta bolsa está hecha preferiblemente de un material bioabsorbible, por ejemplo de una combinación de ácido poliláctico y poliglicólico, que se reabsorberá normalmente días después del implante, de manera que el contenido que se introduzca tenga tiempo para “estabilizarse” en su interior. El tiempo de reabsorción será variable en función del grosor de la pared y de su composición. This bag is preferably made of a bioabsorbable material, for example a combination of polylactic and polyglycolic acid, which will normally be reabsorbed days after implantation, so that the content introduced has time to "stabilize" inside. The reabsorption time will vary depending on the thickness of the wall and its composition.
Asimismo al rellenar el saco del aneurisma con una sustancia semisólida contenida en la bolsa, ésta actúa como un sólido en conjunto, que se amolda al saco del aneurisma y confiere con ello un nuevo anclaje en su posición, de manera que la fijación de la endoprótesis se realiza no sólo en sus extremos, donde se pega a una pared arterial Likewise, by filling the aneurysm sac with a semi-solid substance contained in the bag, it acts as a solid as a whole, which conforms to the aneurysm sac and thereby con fi rms a new anchor in its position, so that the stent fixation It is performed not only at its ends, where it sticks to an arterial wall
sana, sino también en el propio aneurisma. Este anclaje doble da mucha más estabilidad al conjunto y podría permitir el tratamiento de aneurismas con zonas de anclaje proximal (cuellos) más cortos, es decir, anatómicamente peores. heals, but also in the aneurysm itself. This double anchorage gives the whole much more stability and could allow the treatment of aneurysms with shorter proximal anchorage zones (necks), that is, anatomically worse.
El cuerpo tubular puede disponer de un único tramo o bien puede disponer de un tramo proximal que se bifurca en dos tramos distales, en el que el tramo proximal está destinado a su fijación en la aorta abdominal infrarrenal y los tramos distales están destinados a su fijación en las arterias iliacas. The tubular body may have a single section or it may have a proximal section that branches into two distal sections, in which the proximal section is intended for fixation in the infrarenal abdominal aorta and the distal sections are intended for fixation. in the iliac arteries.
En el caso de que el cuerpo tubular presente la mencionada bifurcación, el proceso de colocación de la endoprótesis constará de los siguientes pasos: 1º cateterización de la aorta abdominal desde la arteria femoral derecha o izquierda. 2º despliegue del cuerpo tubular principal de la endoprótesis en posición infrarrenal hasta la iliaca contralateral. 3º cateterización del orificio del cuerpo principal para meter dentro el tramo correspondiente a la iliaca izquierda, hasta aquí el procedimiento es igual al de una endoprótesis bifurcada convencional. 4º A continuación se utiliza el catéter pre-insertado en la bolsa para rellenar la bolsa del contenido celular elegido. 5º seguidamente se retira el catéter, cuya entrada queda sellada por la propia presión que ejerce el conjunto de la endoprótesis sobre la arteria iliaca por la que se introdujo el cuerpo principal. In the event that the tubular body presents the aforementioned bifurcation, the stent placement process will consist of the following steps: 1st catheterization of the abdominal aorta from the right or left femoral artery. 2nd deployment of the main tubular body of the stent in the infrarenal position to the contralateral iliac. 3rd catheterization of the opening of the main body to insert the section corresponding to the left iliac, so far the procedure is the same as a conventional bifurcated stent. 4th The catheter pre-inserted into the bag is then used to refill the bag of the chosen cellular content. 5th, the catheter is removed, the entrance of which is sealed by the pressure of the stent assembly on the iliac artery through which the main body was introduced.
Preferentemente se utilizan células madre de estirpe mesenquimal obtenida mediante lipoaspirado, pero esta invención permite el uso de cualquier tejido o sustancia para rellenar el saco del aneurisma de forma segura. Por ejemplo podría tener una utilidad especial en el caso de los aneurismas de aorta rotos, al conferir un poder de hemostasia extra para cohibir la hemorragia que se produce en estos casos. Preferably mesenchymal line stem cells obtained by lipoaspirate are used, but this invention allows the use of any tissue or substance to fill the aneurysm sac safely. For example, it could have a special utility in the case of broken aortic aneurysms, by conferring an extra hemostasis power to inhibit the bleeding that occurs in these cases.
Se contempla asimismo la posibilidad de fabricar el cuerpo tubular en material también bioreabsorbible, ya que se ha comprobado que existen signos de regeneración de la arquitectura normal de la arteria tratada (aneurisma) en estudios de experimentación animal. The possibility of manufacturing the tubular body in bioreabsorbable material is also contemplated, since it has been proven that there are signs of regeneration of the normal architecture of the treated artery (aneurysm) in animal experimentation studies.
De acuerdo con el concepto aquí planteado se abre la posibilidad de diseñar materiales tales como por ejemplo tejidos, mallas de endoprótesis, capaces de albergar células para conseguir con ellas el efecto regenerador y reparador de la arquitectura vascular en esta y otras patologías vasculares. In accordance with the concept presented here, the possibility of designing materials such as tissues, stent meshes, capable of housing cells to achieve the regenerative and restorative effect of vascular architecture in this and other vascular pathologies is opened.
Para complementar la descripción que se está realizando y con objeto de ayudar a una mejor comprensión de las características de la invención, de acuerdo con un ejemplo preferente de realización práctica de la misma, se acompaña como parte integrante de dicha descripción, un juego de dibujos en donde con carácter ilustrativo y no limitativo, se ha representado lo siguiente: To complement the description that is being made and in order to help a better understanding of the characteristics of the invention, according to a preferred example of practical implementation thereof, a set of drawings is attached as an integral part of said description. where, for illustrative and non-limiting purposes, the following has been represented:
Figura 1.- Muestra un corte sagital de aorta abdominal por debajo de las arterias renales, en el que se aprecia la endoprótesis de la invención seccionada, para la realización en la que el cuerpo tubular de la endoprótesis presenta una bifurcación, que está fijada por sus extremos proximal y distal en aorta abdominal infrarrenal e iliacas, representándose la bolsa en su situación expandida sobre el aneurisma. Figure 1.- Shows a sagittal section of the abdominal aorta below the renal arteries, in which the stent of the invention can be seen, for the embodiment in which the tubular body of the stent has a bifurcation, which is fixed by its proximal and distal ends in the infrarenal and iliac abdominal aorta, representing the pouch in its expanded position on the aneurysm.
Figura 2.- Muestra una vista en perspectiva de la endoprótesis de la figura anterior. Figure 2.- Shows a perspective view of the stent of the previous figure.
Figura 3.- Muestra un corte sagital de aorta abdominal por debajo de las arterias renales, en el que se aprecia la endoprótesis de la invención seccionada, para la realización en la que el cuerpo tubular presenta un único tramo tubular, representándose la situación en la que la bolsa comienza su expansión dentro del saco del aneurisma. Figure 3.- Shows a sagittal section of the abdominal aorta below the renal arteries, in which the stent of the invention can be seen, for the embodiment in which the tubular body has a single tubular section, representing the situation in the that the bag begins its expansion into the aneurysm sac.
Se describen a continuación dos ejemplos de realizaciones preferidas, haciendo mención a las figuras arriba citadas, sin que ello suponga limitación alguna en el ámbito de protección de la presente invención. Two examples of preferred embodiments are described below, with reference to the aforementioned figures, without any limitation in the scope of protection of the present invention.
Tal y como se observa en las figuras 1 o 3 la endoprótesis aórtica para tratamiento de aneurisma (7) está formada por un cuerpo tubular (1) y medios de fijación extremos (2) destinados a asegurar la posición de dicho cuerpo tubular (1), y por una bolsa (3) que está unida y circunda al cuerpo tubular (1), definiendo un compartimento (4) cerrado entre la bolsa (3) y el cuerpo tubular (1) que está dotado de un orificio (5) que da paso a un catéter (6) destinado a la introducción de células en el mencionado compartimento (4) para su expansión y adaptación al saco del aneurisma (7). As can be seen in figures 1 or 3, the aortic stent for aneurysm treatment (7) is formed by a tubular body (1) and extreme fixing means (2) designed to ensure the position of said tubular body (1) , and by a bag (3) that is attached and surrounds the tubular body (1), defining a closed compartment (4) between the bag (3) and the tubular body (1) that is provided with a hole (5) that It gives way to a catheter (6) intended for the introduction of cells into said compartment (4) for expansion and adaptation to the aneurysm sac (7).
En la figura 2 se observa con mayor detalle como se ha expandido la bolsa (3) con forma de globo quedando adaptada al saco del aneurisma, así como se aprecia que la bolsa (3) colabora en la fijación de la endoprótesis. Figure 2 shows in greater detail how the balloon-shaped bag (3) has been expanded being adapted to the aneurysm sac, as well as it is appreciated that the bag (3) collaborates in the fixation of the stent.
En el caso de la figura 1 se muestra una primera realización en la que el cuerpo tubular (1) está configurado por un tramo proximal (8) fijado a la aorta abdominal infrarrenal (9) que se bifurca en dos tramos distales (10) fijados en las aortas iliacas (11). En este caso se aprecia las líneas de sellado (12) que establecen la unión de la bolsa (3) con dichos tramos (8, 10), definiendo entre ambos el compartimento (4) cerrado que alberga las células introducidas mediante el catéter (6). In the case of Figure 1, a first embodiment is shown in which the tubular body (1) is configured by a proximal section (8) fixed to the infrarenal abdominal aorta (9) that branches into two distal sections (10) fixed in the iliac aortas (11). In this case, the sealing lines (12) that establish the union of the bag (3) with said sections (8, 10) can be seen, defining between them the closed compartment (4) that houses the cells introduced by the catheter (6) ).
En la figura 3 se ha representado otra realización alternativa en la que el cuerpo tubular está configurado por un único tramo que se prolonga por una de las arterias iliacas (11) y continúa por la aorta abdominal infrarrenal (9), mostrándose la bolsa (3) fijada por líneas de sellado a este único tramo en la situación en la que se acaba de introducir y se está rellenado de células que van a dar lugar a su posterior expansión. In Figure 3 another alternative embodiment is shown in which the tubular body is configured by a single section that extends through one of the iliac arteries (11) and continues through the infrarenal abdominal aorta (9), showing the bag (3 ) fixed by sealing lines to this single section in the situation in which it has just been introduced and is filled with cells that will lead to its subsequent expansion.
Claims (5)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201231638A ES2463365B1 (en) | 2012-10-24 | 2012-10-24 | AORTIC ENDOPROTESIS FOR ANEURISM TREATMENT |
| PCT/ES2013/070712 WO2014064311A1 (en) | 2012-10-24 | 2013-10-17 | Aortic endoprosthesis for the treatment of an aneurysm |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201231638A ES2463365B1 (en) | 2012-10-24 | 2012-10-24 | AORTIC ENDOPROTESIS FOR ANEURISM TREATMENT |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2463365A1 true ES2463365A1 (en) | 2014-05-27 |
| ES2463365B1 ES2463365B1 (en) | 2015-05-28 |
Family
ID=50544070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES201231638A Expired - Fee Related ES2463365B1 (en) | 2012-10-24 | 2012-10-24 | AORTIC ENDOPROTESIS FOR ANEURISM TREATMENT |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES2463365B1 (en) |
| WO (1) | WO2014064311A1 (en) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5665117A (en) * | 1995-11-27 | 1997-09-09 | Rhodes; Valentine J. | Endovascular prosthesis with improved sealing means for aneurysmal arterial disease and method of use |
| US6729356B1 (en) * | 2000-04-27 | 2004-05-04 | Endovascular Technologies, Inc. | Endovascular graft for providing a seal with vasculature |
| US20020165601A1 (en) * | 2001-05-04 | 2002-11-07 | Clerc Claude O. | Bioabsorbable stent-graft and covered stent |
| FR2834199B1 (en) * | 2001-12-27 | 2004-10-15 | Doron Carmi | ENDOPROSTHESIS ADAPTED TO THE ENDOLUMINAL ENVIRONMENT |
| US20040098096A1 (en) * | 2002-10-22 | 2004-05-20 | The University Of Miami | Endograft device to inhibit endoleak and migration |
| US7387645B2 (en) * | 2003-04-25 | 2008-06-17 | Medtronic Vascular, Inc. | Cellular therapy to heal vascular tissue |
| US20100256728A1 (en) * | 2009-04-07 | 2010-10-07 | Medtronic Vascular, Inc. | Semi-Permiable Biodegradable Stent Graft and Uses Thereof |
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2012
- 2012-10-24 ES ES201231638A patent/ES2463365B1/en not_active Expired - Fee Related
-
2013
- 2013-10-17 WO PCT/ES2013/070712 patent/WO2014064311A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014064311A1 (en) | 2014-05-01 |
| ES2463365B1 (en) | 2015-05-28 |
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