ES2436344B1 - Pharmaceutical composition of diacetylmorphine and naloxone for oral administration - Google Patents
Pharmaceutical composition of diacetylmorphine and naloxone for oral administration Download PDFInfo
- Publication number
- ES2436344B1 ES2436344B1 ES201230814A ES201230814A ES2436344B1 ES 2436344 B1 ES2436344 B1 ES 2436344B1 ES 201230814 A ES201230814 A ES 201230814A ES 201230814 A ES201230814 A ES 201230814A ES 2436344 B1 ES2436344 B1 ES 2436344B1
- Authority
- ES
- Spain
- Prior art keywords
- diacetylmorphine
- naloxone
- oral administration
- pharmaceutical composition
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Composición farmacéutica de diacetilmorfina y naloxona para administración oral; que comprende diacetilmorfina o una de sus sales farmacéuticamente aceptables, naloxona o una de sus sales farmacéuticamente aceptables y al menos un excipiente farmacéuticamente aceptable, con una relación ponderal entre diacetilmorfina:naloxona está comprendida entre 24:1 y 26:1. La invención también comprende un comprimido con esta composición y el uso de dicha composición o comprimido para la preparación de un medicamento para el tratamiento de la adicción a sustancias opioides.Pharmaceutical composition of diacetylmorphine and naloxone for oral administration; comprising diacetylmorphine or one of its pharmaceutically acceptable salts, naloxone or one of its pharmaceutically acceptable salts and at least one pharmaceutically acceptable excipient, with a weight ratio between diacetylmorphine: naloxone is between 24: 1 and 26: 1. The invention also comprises a tablet with this composition and the use of said composition or tablet for the preparation of a medicament for the treatment of addiction to opioid substances.
Description
Claims (1)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201230814A ES2436344B1 (en) | 2012-05-29 | 2012-05-29 | Pharmaceutical composition of diacetylmorphine and naloxone for oral administration |
PCT/ES2013/070272 WO2013178846A1 (en) | 2012-05-29 | 2013-04-30 | Pharmaceutical composition comprising diacetylmorphine and naloxone for oral administration |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201230814A ES2436344B1 (en) | 2012-05-29 | 2012-05-29 | Pharmaceutical composition of diacetylmorphine and naloxone for oral administration |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2436344A1 ES2436344A1 (en) | 2013-12-30 |
ES2436344B1 true ES2436344B1 (en) | 2014-08-07 |
Family
ID=49672511
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES201230814A Expired - Fee Related ES2436344B1 (en) | 2012-05-29 | 2012-05-29 | Pharmaceutical composition of diacetylmorphine and naloxone for oral administration |
Country Status (2)
Country | Link |
---|---|
ES (1) | ES2436344B1 (en) |
WO (1) | WO2013178846A1 (en) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0212019A (en) * | 2001-08-06 | 2005-08-09 | Euro Celtique Sa | Dosage forms, methods for treating pain, methods of preparing a dosage form and methods for preventing abuse of a dosage form. |
PT1551372T (en) * | 2002-09-20 | 2018-07-23 | Alpharma Pharmaceuticals Llc | Sequestering subunit and related compositions and metohds |
EP1810714A1 (en) * | 2006-01-19 | 2007-07-25 | Holger Lars Hermann | Use of a combination of heroin and naloxon for drug substitution |
EP1813276A1 (en) * | 2006-01-27 | 2007-08-01 | Euro-Celtique S.A. | Tamper resistant dosage forms |
EP1897544A1 (en) * | 2006-09-05 | 2008-03-12 | Holger Lars Hermann | Opioid agonist and antagonist combinations |
-
2012
- 2012-05-29 ES ES201230814A patent/ES2436344B1/en not_active Expired - Fee Related
-
2013
- 2013-04-30 WO PCT/ES2013/070272 patent/WO2013178846A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2013178846A1 (en) | 2013-12-05 |
ES2436344A1 (en) | 2013-12-30 |
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