ES2418032R1 - Derivados de 2-(1-fenil-4,5,6,7-tetrahidro-1h-indazol-4-il)etilamina utiles como inhibidores de receptores sigma - Google Patents
Derivados de 2-(1-fenil-4,5,6,7-tetrahidro-1h-indazol-4-il)etilamina utiles como inhibidores de receptores sigmaInfo
- Publication number
- ES2418032R1 ES2418032R1 ES201390057A ES201390057A ES2418032R1 ES 2418032 R1 ES2418032 R1 ES 2418032R1 ES 201390057 A ES201390057 A ES 201390057A ES 201390057 A ES201390057 A ES 201390057A ES 2418032 R1 ES2418032 R1 ES 2418032R1
- Authority
- ES
- Spain
- Prior art keywords
- indazol
- phenyl
- derivatives
- ethylamine
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Derivados de 2-(1-fenil-4,5,6,7-tetrahidro-1H-indazol-4-IL)etilamina útiles como inhibidores de receptores sigma. La invención se refiere a compuestos que tienen actividad farmacológica frente al receptor sigma, y más particularmente a derivados de indazol de fórmula I ****IMAGEN**** y a procedimientos de preparación de tales compuestos, a composiciones farmacéuticas que los comprenden, y a su uso en terapia y/o profilaxis, en particular para el tratamiento de psicosis o dolor.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10382327A EP2468728A1 (en) | 2010-12-03 | 2010-12-03 | 2-(1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-YL)ethylamine derivatives useful as sigma receptor inhibitors |
EP10382327 | 2010-12-03 | ||
PCT/EP2011/071613 WO2012072791A2 (en) | 2010-12-03 | 2011-12-02 | 2-(1-phenyl-4,5,6,7-tetrahydro-1h-indazol-4-yl)ethylamine derivatives useful as sigma receptor inhibitors |
Publications (3)
Publication Number | Publication Date |
---|---|
ES2418032A2 ES2418032A2 (es) | 2013-08-09 |
ES2418032R1 true ES2418032R1 (es) | 2013-11-07 |
ES2418032B1 ES2418032B1 (es) | 2014-10-06 |
Family
ID=43501083
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES201390057A Withdrawn - After Issue ES2418032B1 (es) | 2010-12-03 | 2011-12-02 | Derivados de 2-(1-fenil-4,5,6,7-tetrahidro-1h-indazol-4-il)etilamina útiles como inhibidores de receptores sigma |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2468728A1 (es) |
ES (1) | ES2418032B1 (es) |
WO (1) | WO2012072791A2 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TN2016000254A1 (en) * | 2013-12-20 | 2017-10-06 | Esteve Labor Dr | Fused imidazolyl derivatives, their preparation and use as medicaments. |
WO2024105225A1 (en) | 2022-11-18 | 2024-05-23 | Universitat De Barcelona | Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006021463A1 (en) * | 2004-08-27 | 2006-03-02 | Laboratorios Del Dr. Esteve, S.A. | Sigma receptor inhibitors |
EP2196458A1 (en) * | 2008-12-10 | 2010-06-16 | Laboratorios Del. Dr. Esteve, S.A. | Process for obtaining enantiomerically enriched pyrazole derivatives |
WO2011018488A1 (en) * | 2009-08-14 | 2011-02-17 | Laboratorios Del Dr. Esteve, S.A. | Sigma ligands for the prevention or treatment of pain induced by chemotherapy |
-
2010
- 2010-12-03 EP EP10382327A patent/EP2468728A1/en not_active Withdrawn
-
2011
- 2011-12-02 WO PCT/EP2011/071613 patent/WO2012072791A2/en active Application Filing
- 2011-12-02 ES ES201390057A patent/ES2418032B1/es not_active Withdrawn - After Issue
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006021463A1 (en) * | 2004-08-27 | 2006-03-02 | Laboratorios Del Dr. Esteve, S.A. | Sigma receptor inhibitors |
EP2196458A1 (en) * | 2008-12-10 | 2010-06-16 | Laboratorios Del. Dr. Esteve, S.A. | Process for obtaining enantiomerically enriched pyrazole derivatives |
WO2011018488A1 (en) * | 2009-08-14 | 2011-02-17 | Laboratorios Del Dr. Esteve, S.A. | Sigma ligands for the prevention or treatment of pain induced by chemotherapy |
Non-Patent Citations (1)
Title |
---|
CORBERA, J. et al. ¿A Medicinal-Chemistry-Guided Approach to Selective and Druglike Sigma 1 Ligands¿ ChemMedChem 2006, Volumen 1, páginas 140-154. Ver página 140, resumen, página 142, esquema 1; página 143, tabla 1. * |
Also Published As
Publication number | Publication date |
---|---|
EP2468728A1 (en) | 2012-06-27 |
WO2012072791A2 (en) | 2012-06-07 |
WO2012072791A3 (en) | 2012-09-13 |
ES2418032B1 (es) | 2014-10-06 |
ES2418032A2 (es) | 2013-08-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 2418032 Country of ref document: ES Kind code of ref document: B1 Effective date: 20141006 |
|
FA2A | Application withdrawn |
Effective date: 20150209 |