ES2364166B1 - GENOMIC FOOTPRINT AS A PREDICTOR OF TREATMENT RESPONSE. - Google Patents

GENOMIC FOOTPRINT AS A PREDICTOR OF TREATMENT RESPONSE. Download PDF

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Publication number
ES2364166B1
ES2364166B1 ES200931311A ES200931311A ES2364166B1 ES 2364166 B1 ES2364166 B1 ES 2364166B1 ES 200931311 A ES200931311 A ES 200931311A ES 200931311 A ES200931311 A ES 200931311A ES 2364166 B1 ES2364166 B1 ES 2364166B1
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Spain
Prior art keywords
treatment
response
predictor
genomic
breast cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200931311A
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Spanish (es)
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ES2364166A1 (en
Inventor
Ramon Garcia Escudero
Jesus Maria Paramio Gonzalez
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Centro de Investigaciones Energeticas Medioambientales y Tecnologicas CIEMAT
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Centro de Investigaciones Energeticas Medioambientales y Tecnologicas CIEMAT
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Application filed by Centro de Investigaciones Energeticas Medioambientales y Tecnologicas CIEMAT filed Critical Centro de Investigaciones Energeticas Medioambientales y Tecnologicas CIEMAT
Priority to ES200931311A priority Critical patent/ES2364166B1/en
Priority to PCT/ES2010/070874 priority patent/WO2011080373A1/en
Publication of ES2364166A1 publication Critical patent/ES2364166A1/en
Application granted granted Critical
Publication of ES2364166B1 publication Critical patent/ES2364166B1/en
Expired - Fee Related legal-status Critical Current
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G01N33/57415—
    • G01N33/57484—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57515—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the breast
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G06F19/20—
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Huella genómica como predictor de respuesta a tratamiento.#La invención se relaciona con un método de predicción de la respuesta al tratamiento con un taxano más quimioterapia con un antimetabolito, un agente intercalante y un agente alquilante del ADN, en pacientes con cáncer de mama. En concreto, los autores han desarrollado un modelo mediante regresión logística en que el test genómico de 40 genes, combinado con parámetros clínicos, predice con precisión la respuesta patológica completa (RCp) al tratamiento neoadyuvante de paclitaxel más quimioterapia con fluorouracilo, adriamicina y ciclofosfamida (T/FAC) en pacientes de cáncer de mama con una expresión normal del gen HER-2. Dicho modelo tiene mejor rendimiento que las variables clínicas utilizadas rutinariamente.Genomic footprint as a predictor of treatment response. # The invention relates to a method of predicting the response to treatment with a taxane plus chemotherapy with an antimetabolite, an intercalating agent and a DNA alkylating agent, in patients with breast cancer. Specifically, the authors have developed a model through logistic regression in which the genomic test of 40 genes, combined with clinical parameters, accurately predicts the complete pathological response (RCp) to the neoadjuvant treatment of paclitaxel plus chemotherapy with fluorouracil, adriamycin and cyclophosphamide ( T / FAC) in breast cancer patients with a normal expression of the HER-2 gene. This model has better performance than the clinical variables used routinely.

ES200931311A 2009-12-31 2009-12-31 GENOMIC FOOTPRINT AS A PREDICTOR OF TREATMENT RESPONSE. Expired - Fee Related ES2364166B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES200931311A ES2364166B1 (en) 2009-12-31 2009-12-31 GENOMIC FOOTPRINT AS A PREDICTOR OF TREATMENT RESPONSE.
PCT/ES2010/070874 WO2011080373A1 (en) 2009-12-31 2010-12-30 Genomic imprinting used to predict response to a treatment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200931311A ES2364166B1 (en) 2009-12-31 2009-12-31 GENOMIC FOOTPRINT AS A PREDICTOR OF TREATMENT RESPONSE.

Publications (2)

Publication Number Publication Date
ES2364166A1 ES2364166A1 (en) 2011-08-26
ES2364166B1 true ES2364166B1 (en) 2012-07-10

Family

ID=44226196

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Application Number Title Priority Date Filing Date
ES200931311A Expired - Fee Related ES2364166B1 (en) 2009-12-31 2009-12-31 GENOMIC FOOTPRINT AS A PREDICTOR OF TREATMENT RESPONSE.

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ES (1) ES2364166B1 (en)
WO (1) WO2011080373A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012344676A1 (en) * 2011-11-28 2014-06-19 National Research Council Of Canada Paclitaxel response markers for cancer
WO2014080060A1 (en) * 2012-11-23 2014-05-30 Servicio Andaluz De Salud Method for predicting the response to chemotherapy treatment in patients with cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002357606A (en) * 2000-11-21 2002-12-13 Affymetrix Inc Methods and computer software products for predicting the hybridization affinity of nucleic acids
ES2905579T3 (en) * 2003-07-10 2022-04-11 Genomic Health Inc Expression profiling algorithm and test for prognosis of breast cancer relapse
US20060121511A1 (en) * 2004-11-30 2006-06-08 Hyerim Lee Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents
WO2008060376A2 (en) * 2006-10-04 2008-05-22 The Johns Hopkins University Algorithims for multivariant models to combine a panel of biomarkers for assessing the risk of developing ovarian cancer
US20110014191A1 (en) * 2007-12-28 2011-01-20 Ipsogen Breast cancer expression profiling

Also Published As

Publication number Publication date
WO2011080373A1 (en) 2011-07-07
ES2364166A1 (en) 2011-08-26

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