ES2364166A1

ES2364166A1 - Genomic imprinting used to predict response to a treatment

Info

Publication number: ES2364166A1
Application number: ES200931311A
Authority: ES
Inventors: Ramon Garcia Escudero; Jesus Maria Paramio Gonzalez
Original assignee: Centro de Investigaciones Energeticas Medioambientales y Tecnologicas CIEMAT
Current assignee: Centro de Investigaciones Energeticas Medioambientales y Tecnologicas CIEMAT
Priority date: 2009-12-31
Filing date: 2009-12-31
Publication date: 2011-08-26
Anticipated expiration: 2029-12-31
Also published as: ES2364166B1; WO2011080373A1

Abstract

The invention relates to a method for predicting the response to treatment involving a taxane and chemotherapy with an antimetabolite, an intercalating agent and a DNA alkylating agent, for patients suffering from breast cancer. More specifically, a model has been developed by means of logistic regression, in which genomic testing of 40 genes, combined with clinical parameters, accurately predicts the complete pathological response (RCp) to the neoadjuvant treatment with paclitaxel and chemotherapy with fluorouracyl, adriamicine, and cyclophosphamide (T/FAC) for patients suffering from breast cancer with a normal expression of the HER-2 gene. Said model performs better than the conventionally used clinical variables.

Description

Huella genómica como predictor de respuesta a tratamiento.Genomic footprint as a predictor of response to treatment.

Field of the Invention

La presente invención se relaciona con métodos in vitro para la predicción de la respuesta de un sujeto con cáncer de mama al tratamiento de un taxano más quimioterapia con un antimetabolito, un agente intercalante y un agente alquilante.The present invention relates to in vitro methods for predicting the response of a subject with breast cancer to the treatment of a taxane plus chemotherapy with an antimetabolite, an intercalating agent and an alkylating agent.

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Background of the invention

A nivel mundial, el cáncer de mama es el segundo tipo más común de cáncer (10,4%; tras el cáncer de pulmón) y la quinta causa más común de muerte por cáncer (tras el cáncer de pulmón, cáncer de estómago, cáncer de hígado, y cáncer de colon). Entre las mujeres en el mundo, el cáncer de mama es la causa más común de muerte por cáncer. En 2005, el cáncer de mama produjo 502.000 muertes en el mundo (el 7% de las muertes por cáncer; casi el 1% de todas las muertes). El número de casos mundiales ha aumentado significativamente desde la década de 1970, un fenómeno del que se echa la culpa parcialmente a los estilos de vida modernos en el mundo occidental. Las mujeres de Norteamérica tienen la mayor incidencia de cáncer de mama en el mundo.Globally, breast cancer is the second most common type of cancer (10.4%; after lung cancer) and the fifth most common cause of cancer death (after cancer of lung, stomach cancer, liver cancer, and colon cancer). Among women in the world, breast cancer is the most common cause. common death from cancer. In 2005, breast cancer produced 502,000 deaths worldwide (7% of cancer deaths; almost 1% of all deaths). The number of global cases has significantly increased since the 1970s, a phenomenon which is partially blamed on modern lifestyles in the western world The women of North America have the highest incidence of breast cancer in the world.

Debido a que la mama está compuesta de tejidos idénticos en hombres y mujeres, el cáncer de mama también se da en hombres. La incidencia de cáncer de mama en hombres es aproximadamente 100 veces menor que en mujeres, aunque se considera que los hombres con cáncer de mama tienen estadísticamente las mismas tasas de supervivencia que las mujeres.Because the breast is composed of tissues identical in men and women, breast cancer also occurs in mens. The incidence of breast cancer in men is approximately 100 times lower than in women, although it is considered that men with breast cancer have statistically the Same survival rates as women.

El cáncer de mama se clasifica en fases según el sistema TNM. El pronóstico está íntimamente unido a los resultados de la clasificación en fases, y la clasificación en fases también se usa para asignar pacientes a tratamientos tanto en ensayos clínicos como en la práctica médica. Los diferentes estadios se pueden clasificar siguiendo el sistema TNM desarrollado por la AJCC (American Joint Committee on Cáncer) en colaboración con la UICC (Unión Internacional Contra Cáncer):Breast cancer is classified in phases according to TNM system The prognosis is closely linked to the results of phase classification, and phase classification is also used to assign patients to treatments both in clinical trials As in medical practice. The different stadiums can be classify following the TNM system developed by the AJCC (American Joint Committee on Cancer) in collaboration with the UICC (International Union Against Cancer):

\bullet?: TX: El tumor primario no se puede evaluar. T0: No hay evidencia de tumor. Tis: Carcinoma in situ, no invasión. T1: El tumor es de 2 cm o menor. T2: El tumor es mayor de 2 cm pero menor de 5 cm. T3: El tumor es mayor de 5 cm. T4: Tumor de cualquier tamaño que crece en la pared del pecho o piel, o cáncer de mama inflamatorio.TX: The primary tumor cannot be evaluated. T0: There is no evidence of tumor. Tis: Carcinoma in situ , not invasion. T1: The tumor is 2 cm or smaller. T2: The tumor is larger than 2 cm but smaller than 5 cm. T3: The tumor is larger than 5 cm. T4: Tumor of any size that grows on the chest wall or skin, or inflammatory breast cancer.

\bullet?: NX: Los ganglios linfáticos cercanos no se pueden evaluar. N0: El cáncer no se ha extendido a los ganglios linfáticos regionales. N1: El cáncer se ha extendido a 1 a 3 ganglios linfáticos de la axila o a uno mamario interno. N2: El cáncer se ha extendido a 4 a 9 ganglios linfáticos de la axila o a múltiples ganglios mamarios internos. N3: Aplica uno de los siguientes:NX: Lymph Nodes Nearby cannot be evaluated. N0: The cancer has not spread to regional lymph nodes N1: The cancer has spread to 1 to 3 lymph nodes in the armpit or one internal breast. N2: The cancer has spread to 4 to 9 lymph nodes in the armpit or to multiple internal mammary nodes. N3: Apply one of the following:

\sqbullet\ sqbullet: El cáncer se ha extendido a 10 ó más ganglios linfáticos de la axila, o el cáncer se ha extendido a los ganglios linfáticos bajo la clavícula, o el cáncer se ha extendido a los ganglios linfáticos por encima de la clavícula o el cáncer afecta a los ganglios linfáticos de la axila y se ha extendido a los ganglios linfáticos mamarios internos, o el cáncer afecta a 4 ó más ganglios linfáticos de la axila, y se encuentran cantidades mínimas de cáncer en los ganglios mamarios internos o en biopsia de ganglios linfáticos centinelas.The cancer has spread to 10 or more lymph nodes in the armpit, or the cancer has spread to lymph nodes under the collarbone, or cancer has extended to the lymph nodes above the clavicle or the cancer affects the lymph nodes in the armpit and has extended to internal mammary lymph nodes, or cancer affects 4 or more lymph nodes in the armpit, and they are found minimal amounts of cancer in the internal mammary nodes or in sentinel lymph node biopsy.

\bullet?: MX: La presencia de extensión distante (metástasis) no se puede evaluar. M0: No existe metástasis distante. M1: Se ha producido la extensión a órganos distantes, que no incluyen el ganglio linfático supraclavicular.MX: The presence of extension distant (metastasis) cannot be evaluated. M0: There is no metastasis distant. M1: Extension to distant organs has occurred, which They do not include the supraclavicular lymph node.

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Por tanto, la clasificación de los tumores de mama basada en los criterios TNM sería:Therefore, the classification of tumors from Breast based on the TNM criteria would be:

Grado 0:Grade 0:: TX, N0, M0.TX, N0, M0.

Grado I:Grade I:: T1, N0, M0.T1, N0, M0.

Grado IIA:Grade IIA:: T0, T1, N1, M0 ó T2, N0, M0.T0, T1, N1, M0 or T2, N0, M0.

Grado IIB:Grade IIB:: T2, N1, M0 ó T3, N0, M0.T2, N1, M0 or T3, N0, M0.

Grado IIIA:Grade IIIA:: T0, 1, 2, N2, M0 ó T3 N1, 2, M0.T0, 1, 2, N2, M0 or T3 N1, 2, M0.

Grado IIIB:Grade IIIB:: T4, cualquier N, M0.T4, any N, M0.

Grado IV:Grade IV:: Cualquier T, Cualquier N, M1.Any T, Any N, M1.

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El pilar principal del tratamiento de cáncer de mama es la cirugía cuando el tumor está localizado, con posible terapia adyuvante hormonal (con tamoxifeno o un inhibidor de aromatasa), quimioterapia, y/o radioterapia. En la actualidad, las recomendaciones de tratamiento después de la cirugía (terapia adyuvante) siguen un patrón. Este patrón está sujeto a cambio, ya que cada dos años, tiene lugar una conferencia mundial en St. Gallen, Suiza, para discutir los resultados reales de los estudios multicentros mundiales. Asimismo, dicho patrón también se revisa según el criterio consenso del National Institute of Health (NIH). Basándose en estos criterios, más del 85-90% de los pacientes que no presentan metástasis en nódulos linfáticos serían candidatos para recibir terapia sistémica adyuvante.The main pillar of cancer treatment of Breast is surgery when the tumor is located, with possible hormonal adjuvant therapy (with tamoxifen or an inhibitor of aromatase), chemotherapy, and / or radiotherapy. At present, the treatment recommendations after surgery (therapy adjuvant) follow a pattern. This pattern is subject to change, since Every two years, a world conference takes place in St. Gallen, Switzerland, to discuss the actual results of the studies global multicentros. Likewise, said pattern is also reviewed. according to the consensus criteria of the National Institute of Health (NIH). Based on these criteria, more than 85-90% of the patients who do not have lymph node metastases would be Candidates for receiving adjuvant systemic therapy.

La quimioterapia neoadyuvante es la administración de quimioterapia antes de cirugía de cáncer de mama, con el objetivo de reducir la extensión de la cirugía o impedir la cirugía por completo. La respuesta a quimioterapia neoadyuvante se dicotomiza usualmente como respuesta patológica completa (RCp) ó enfermedad residual (ER). RCp es un punto final clínico significativo para predecir, ya que estos pacientes poseen supervivencia global y supervivencia libre de enfermedad prolongada cuando se compara con pacientes con respuesta menor. Debido a que la terapia neoadyuvante o adyuvante con trastuzumab es efectiva en pacientes de cáncer de mama con sobreexpresión del gen HER-2 junto con quimioterapia, este régimen combinado se recomienda actualmente para pacientes positivos para HER-2.Neoadjuvant chemotherapy is the administration of chemotherapy before breast cancer surgery, with the aim of reducing the extent of surgery or preventing surgery altogether. The response to neoadjuvant chemotherapy is usually dichotomized as a complete pathological response (RCp) or residual disease (ER). RCp is a significant clinical endpoint to predict, since these patients have overall survival and prolonged disease-free survival when compared to patients with lesser response. Because neoadjuvant or adjuvant therapy with trastuzumab is effective in breast cancer patients with overexpression of the HER-2 gene along with chemotherapy, this combined regimen is currently recommended for patients positive for HER-2.

Hess et al. (Hess et al, 2006. J. Clin. Oncol. 24: 4236-44) describen el desarrollo de un "predictor" multigénico de Respuesta Patológica completa (RCp) de pacientes con cáncer de mama para tratamientos con paclitaxel/fluorouracilo, adriamicina y ciclofosfamida (T/FAC) y determinaron su precisión predictiva en casos independientes. Dicho estudio incluía 99 pacientes con niveles normales de HER-2. De esta manera, identificaron un predictor con 30 sondas que predecía la RCp a la quimioterapia T/FAC. Otros tests genómicos de cáncer de mama capaces de identificar tumores con mala prognosis basal en respuesta a quimioterapia han sido descritos conocidos en el estado de la técnica incluyen test 21-gene (Paik et al, 2004, N Engl J Med. 351: 2817-2826), intrinsic subtypes (Parker et al, 2009, J. Clin. Oncol. 27:1160-1167) o Genomic Grade Index (Liedtke et al, 2009, J. Clin. Oncol. 27: 3185-3191). Sin embargo, dichos test genómicos no presentan una alta sensibilidad ni especificidad.Hess et al . (Hess et al , 2006. J. Clin. Oncol. 24: 4236-44) describe the development of a multigenic "predictor" of complete Pathological Response (RCp) of patients with breast cancer for paclitaxel / fluorouracil, adriamycin and cyclophosphamide (T / FAC) and determined its predictive accuracy in independent cases. This study included 99 patients with normal levels of HER-2. In this way, they identified a predictor with 30 probes that predicted the RCp to T / FAC chemotherapy. Other genomic breast cancer tests capable of identifying tumors with poor baseline prognosis in response to chemotherapy have been described known in the prior art include 21-gene tests (Paik et al , 2004, N Engl J Med. 351: 2817- 2826), intrinsic subtypes (Parker et al , 2009, J. Clin. Oncol. 27: 1160-1167) or Genomic Grade Index (Liedtke et al , 2009, J. Clin. Oncol. 27: 3185-3191). However, these genomic tests do not have high sensitivity or specificity.

Por tanto, existe la necesidad de desarrollar nuevos métodos que permitan predecir la respuesta a un tratamiento con paclitaxel/fluorouracilo, adriamicina y ciclofosfamida en pacientes con cáncer de mama y que presenten mayor sensibilidad que los métodos existentes.Therefore, there is a need to develop new methods that predict the response to a treatment with paclitaxel / fluorouracil, adriamycin and cyclophosphamide in patients with breast cancer and who are more sensitive than The existing methods.

Compendium of the invention

En un primer aspecto, la presente invención se refiere a un método in vitro para predecir la respuesta de un sujeto diagnosticado con cáncer de mama al tratamiento con un taxano y quimioterapia con un antimetabolito, un agente intercalante y un agente alquilante del ADN, en adelante el método de la invención, que comprende determinar los niveles de expresión de los genes identificados en la Tabla 1 y en la Tabla 2 en una muestra de tejido tumoral procedente de dicho sujeto, en donde un aumento de la expresión de los genes identificados en la Tabla 1 y una disminución de la expresión de los genes identificados en la Tabla 2 con respecto a un valor de referencia es indicativo de una mejor respuesta al tratamiento.In a first aspect, the present invention relates to an in vitro method for predicting the response of a subject diagnosed with breast cancer to treatment with a taxane and chemotherapy with an antimetabolite, an intercalating agent and a DNA alkylating agent, hereinafter the method of the invention, which comprises determining the expression levels of the genes identified in Table 1 and in Table 2 in a sample of tumor tissue from said subject, wherein an increase in the expression of the genes identified in the Table 1 and a decrease in the expression of the genes identified in Table 2 with respect to a reference value is indicative of a better response to treatment.

Brief description of the figures

La Figura 1 muestra la relación entre el test 40 genes y la respuesta a quimioterapia T/FAC. (A) Valor de Riesgo derivado del test 40 genes frente a probabilidad de RCp. El eje Y a la derecha muestra la proporción de pacientes RCp (0) versus pacientes ER (1). (B) Valor de Riesgo derivado del test 40 genes frente a probabilidad de supervivencia libre de metástasis distante a 5 años en los datasets de Loi (GSE6532 y GSE9195). El eje Y a la derecha muestra la proporción de pacientes que desarrollaron metástasis distante a 5 años (0) versus aquellos pacientes que no (1). (C) Análisis de curvas ROC de los modelos de regresión logística para RCp a quimioterapia T/FAC.Figure 1 shows the relationship between the 40 gene test and the response to chemotherapy T / FAC. (A) Risk value derived from the test 40 genes versus probability of RCp. The Y axis on the right shows the proportion of RCp patients (0) versus ER patients (1). (B) Risk value derived from the test 40 genes versus probability of survival free of metastases distant to 5 years in Loi datasets (GSE6532 and GSE9195). The Y axis on the right shows the proportion of patients who developed metastases distant at 5 years (0) versus those patients who did not (1). (C) ROC curve analysis of logistic regression models for RCp to T / FAC chemotherapy.

Detailed description of the invention

Los autores de la presente invención han seleccionado una firma de genes que hibridan con unas sondas y cuya expresión está correlacionada con la predicción de la respuesta de un sujeto diagnosticado con cáncer de mama al tratamiento con un taxano, un antimetabolito análogo de la pirimidina, un agente intercalante y un agente alquilante del ADN.The authors of the present invention have selected a signature of genes that hybridize with probes and whose expression is correlated with the prediction of the response of a subject diagnosed with breast cancer on treatment with a taxane, a pyrimidine analog antimetabolite, an agent intercalator and a DNA alkylating agent.

Por tanto, en un primer aspecto, la invención se refiere a un método in vitro para predecir la respuesta de un sujeto diagnosticado con cáncer de mama al tratamiento con un taxano y quimioterapia con un antimetabolito, un agente intercalante y un agente alquilante del ADN, en adelante método de la invención, que comprende determinar los niveles de expresión de los genes identificados en la Tabla 1 y en la Tabla 2 en una muestra de tejido tumoral procedente de dicho sujeto, en donde un aumento de la expresión de los genes identificados en la Tabla 1 y una disminución de la expresión de los genes identificados en la Tabla 2 con respecto a un valor de referencia es indicativo de una mejor respuesta al tratamiento.Thus, in a first aspect, the invention relates to an in vitro method for predicting the response of a subject diagnosed with breast cancer to treatment with a taxane and chemotherapy with an antimetabolite, an intercalating agent and a DNA alkylating agent, hereinafter method of the invention, which comprises determining the levels of expression of the genes identified in Table 1 and Table 2 in a sample of tumor tissue from said subject, wherein an increase in the expression of the genes identified in Table 1 and a decrease in the expression of the genes identified in Table 2 with respect to a reference value is indicative of a better response to treatment.

Por "predecir la respuesta" se entiende, en el contexto de la presente invención, la determinación de la probabilidad de que el paciente responda de forma favorable o desfavorable a una terapia determinada. Especialmente, el término "predicción", como se usa aquí, se refiere a una evaluación individual de cualquier parámetro que pueda ser útil en determinar la evolución de un paciente. Como entenderán los expertos en la materia, la predicción de la respuesta clínica al tratamiento con una tirosina quinasa, aunque se prefiere que sea, no necesita ser correcta para el 100% de los sujetos a ser diagnosticados o evaluados. El término, sin embargo, requiere que se pueda identificar una parte estadísticamente significativa de los sujetos como que tienen una probabilidad aumentada de tener una respuesta positiva. El experto en la materia puede determinar fácilmente si un sujeto es estadísticamente significativo usando varias herramientas de evaluación estadística bien conocidas, por ejemplo, determinación de intervalos de confianza, determinación de los valores de p, prueba t de Student, prueba de Mann Whitney, etc. Los detalles se encuentran en Dowdy y Wearden, Statistics for Research, John Wiley & Sons, Nueva York 1983. Los intervalos de confianza preferidos son al menos del 50%, al menos del 60%, al menos del 70%, al menos del 80%, al menos del 90%, al menos del 95%. Los valores de p son, preferiblemente, 0,2, 0,1 ó 0,05.By "predicting the answer" is understood, in the context of the present invention, the determination of the probability that the patient responds favorably or unfavorable to a given therapy. Especially, the term "prediction", as used here, refers to an evaluation individual of any parameter that may be useful in determining The evolution of a patient. How will experts understand in matter, the prediction of the clinical response to treatment with a tyrosine kinase, although it is preferred, does not need to be correct for 100% of the subjects to be diagnosed or evaluated. The term, however, requires that you can identify a statistically significant part of the subjects like they have an increased chance of having an answer positive. The person skilled in the art can easily determine if a subject is statistically significant using several tools of well-known statistical evaluation, for example, determination of confidence intervals, determination of p values, Student's t-test, Mann Whitney's test, etc. The details are found in Dowdy and Wearden, Statistics for Research, John Wiley & Sons, New York 1983. Preferred confidence intervals they are at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, at least 95%. The values of p are, preferably 0.2, 0.1 or 0.05.

La predicción de la respuesta clínica se puede hacer utilizando cualquier criterio de valoración usado en oncología y conocido por el experto en la materia. Los parámetros de valoración útiles para describir la evolución de una enfermedad incluyen:The prediction of the clinical response can be do using any valuation criteria used in oncology and known to the person skilled in the art. The parameters of Useful assessment to describe the evolution of a disease include:

--: progresión libre de enfermedad que, como se usa aquí describe la proporción de pacientes en remisión completa que no han tenido recaída de la enfermedad durante el período de tiempo en estudio.disease-free progression that, like used here describes the proportion of patients in complete remission who have not had a relapse of the disease during the period of Study time

--: respuesta objetiva, que, como se usa en la presente invención, describe la proporción de gente tratada en la que se observa una respuesta completa o parcial.objective response, which, as used in The present invention describes the proportion of people treated in the that a complete or partial response is observed.

--: control tumoral, que, como se usa en la presente invención, se refiere a la proporción de gente tratada en la que se observa una respuesta completa, respuesta parcial, respuesta menor o enfermedad estable \geq 6 meses.tumor control, which, as used in the This invention refers to the proportion of people treated in which is a complete response, partial response, Minor response or stable disease? 6 months.

--: supervivencia libre de enfermedad (DFS), que, como se usa aquí, se define como el período de tiempo después del tratamiento durante el que un paciente sobrevive sin signos de crecimiento del cáncer.disease-free survival (DFS), which, as used here, is defined as the period of time after of the treatment during which a patient survives without signs of cancer growth

--: supervivencia libre de progresión de seis meses o tasa PFS6 que, como se usa aquí, se refiere al porcentaje de gente que están libres de progresión en los primeros seis meses después del inicio de la terapia yprogression free survival of six months or PFS6 rate which, as used here, refers to the percentage of people who are free from progression in the first six months after the start of therapy and

--: supervivencia mediana (MS) que, como se usa aquí, se refiere al tiempo en el que la mitad de los pacientes inscritos en el estudio están todavía vivos.median survival (MS) which, as used here, refers to the time in which half of the patients enrolled in the study are still alive.

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El término "sujeto", como se usa aquí, se refiere a todos los animales clasificados como mamíferos e incluye, pero no está restringido a, animales domésticos y de granja, primates y humanos, por ejemplo, seres humanos, primates no humanos, vacas, caballos, cerdos, ovejas, cabras, perros, gatos o roedores. Preferiblemente, el paciente es un ser humano hombre o mujer de cualquier edad o raza.The term "subject", as used herein, is refers to all animals classified as mammals and includes, but it is not restricted to domestic and farm animals, primates and humans, for example, humans, nonhuman primates, Cows, horses, pigs, sheep, goats, dogs, cats or rodents. Preferably, the patient is a human being man or woman of Any age or race.

El término "cáncer de mama" se refiere a un tumor de la mama e incluye cualquier subtipo histológico que aparece típicamente en cáncer de mama tal como carcinoma ductal, carcinoma lobulillar, hemangioma, sarcomas, etc. cualquier subtipo clínico tal como cáncer superficial, invasor de músculo o enfermedad metastásica y cualquier fase TMN incluyendo Tis, T1, T2, T3 o T4 que depende de la presencia o ausencia de cáncer invasor, las dimensiones del cáncer invasor, y la presencia o ausencia de invasión fuera de la mama, N0, N1, N2 o N3 que depende del número tamaño y localización de los depósitos de células de cáncer de mama en los ganglios linfáticos y M0 o M1 que depende de la presencia o ausencia de células de cáncer de mama en localizaciones distintas que la mama y los ganglios linfáticos (la así llamada metástasis distante, por ejemplo, al hueso, cerebro, pulmón).The term "breast cancer" refers to a breast tumor and includes any histological subtype that appears typically in breast cancer such as ductal carcinoma, carcinoma lobular, hemangioma, sarcomas, etc. any clinical subtype such such as superficial cancer, muscle invader or metastatic disease and any TMN phase including Tis, T1, T2, T3 or T4 that depends on the presence or absence of invasive cancer, the dimensions of invasive cancer, and the presence or absence of invasion outside the breast, N0, N1, N2 or N3 that depends on the number size and location of breast cancer cell deposits in the nodes lymphatic and M0 or M1 which depends on the presence or absence of breast cancer cells in locations other than the breast and lymph nodes (the so-called distant metastasis, by example, to the bone, brain, lung).

Tal como se refiere en la presente invención, los "taxanos" son un conjunto de medicamentos antineoplásicos que impiden el crecimiento celular al impedir la división de las células. Se utilizan por tanto para el tratamiento del cáncer. También son denominados antimicrotúbulos, antimitóticos e inhibidores mitóticos. Se trata de terpenos producidos por plantas del género Taxus, tal como el tejo, de ahí su nombre genérico. Son taxanos, por ejemplo, el paclitaxel y el docetaxel. Los taxanos se utilizan para realizar el tratamiento de quimioterapia en pacientes afectados de cáncer. El principal mecanismo de los taxanos es la inhibición de la función del microtúbulo, que se lleva a cabo mediante la estabilización del guanosindifosfato (GDP) unido a la tubulina impidiendo el normal funcionamiento de los microtúbulos. Los microtúbulos son esenciales para la división celular y, por ello, los taxanos paran la mitosis celular. En una realización preferida, el taxano es el paclitaxel.As referred to in the present invention, "taxanes" are a set of antineoplastic drugs that prevent cell growth by preventing cell division. They are therefore used for the treatment of cancer. They are also called antimicrotubules, antimitotic and mitotic inhibitors. These are terpenes produced by plants of the genus Taxus , such as yew, hence its generic name. They are taxanes, for example, paclitaxel and docetaxel. Taxanes are used to perform chemotherapy treatment in cancer patients. The main mechanism of the taxanes is the inhibition of the function of the microtubule, which is carried out by stabilizing the guanosindifosphate (GDP) attached to the tubulin, preventing the normal functioning of the microtubules. Microtubules are essential for cell division and, therefore, taxanes stop cell mitosis. In a preferred embodiment, the taxane is paclitaxel.

Se entiende por "antimetabolito" una sustancia que reemplaza, inhibe o compite con un compuesto químico específico en el interior de una célula, cuya función es por ende, la de desestabilizar. Debido a que su estructura se asemeja a la del compuesto, es absorbida por la célula pero no reacciona de la misma forma que con la enzima que actúa sobre la sustancia ordinaria. Puede inhibir a la enzima o ser convertida en un agente químico atípico. Muchos antimetabolitos son útiles en el tratamiento de diversos tipos de cáncer. Pueden ser análogos del ácido fólico, tal como el metotrexato; análogos de las pirimidinas, donde estarían incluidos, sin limitarse, compuestos como el 5-fluorouracilo, muy utilizado en cáncer de colon, mama y ovario; la citarabina, que se emplea en el tratamiento de las leucemias o la gemcitabina, que se emplea en el cáncer de pulmón no microcítico metastásico, en el carcinoma de páncreas y en el de vejiga o también pueden ser análogos de la purina, tal como la cladribina, la mercaptopurina o la fludarabina. En una realización preferida, el antimetabolito es un análogo de la pirimidina y en concreto el 5-fluorouracilo o 5-FU."Antimetabolite" means a substance that replaces, inhibits or competes with a chemical compound specific inside a cell, whose function is therefore, to destabilize. Because its structure resembles that of the compound, is absorbed by the cell but does not react from it form that with the enzyme that acts on the ordinary substance. It can inhibit the enzyme or be converted into a chemical agent. atypical. Many antimetabolites are useful in the treatment of Various types of cancer. They can be folic acid analogs, such like methotrexate; analogues of pyrimidines, where they would be including, without limitation, compounds such as 5-fluorouracil, widely used in colon cancer, breast and ovary; cytarabine, which is used in the treatment of leukemia or gemcitabine, which is used in non-lung cancer metastatic microcytic, in pancreatic carcinoma and in bladder or they can also be purine analogs, such as the cladribine, mercaptopurine or fludarabine. In one embodiment preferred, the antimetabolite is a pyrimidine analogue and in concrete 5-fluorouracil or 5-FU.

El 5-FU (fluorouracilo) actúa de varias formas, pero principalmente como un inhibidor de la timidilato sintasa. Interrumpir la acción de esta enzima bloquea la síntesis de la pirimidina timidina, que es un nucleótido requerido para la replicación del ADN. La timidilato sintasa metila el desoxiuracilo monofosfato (dUMP) a desoxitimidina mono fosfato (dTMP). Como muchas drogas anticáncer, los efectos del 5-FU se sienten en todo el sistema pero de forma más contundente sobre las células que se dividen rápidamente que hacen gran uso de su maquinaria de síntesis de nucleótidos. Como análogo de pirimidina, se transforma en el interior de la célula en varios metabolitos citotóxicos que después se incorporan al ADN y ARN, induciendo finalmente la parada del ciclo celular y apoptosis mediante inhibición de la capacidad de la célula de sintetizar ADN. Es una droga específica de la fase S y activa solo durante ciertos ciclos celulares. Además de ser incorporada al ADN y ARN, se ha mostrado que la droga inhibe la actividad del complejo exosoma, un complejo exoribonucleasa la actividad del cual es esencial para la supervivencia celular.5-FU (fluorouracil) acts as several ways, but mainly as an inhibitor of Thymidylate synthase. Disrupting the action of this enzyme blocks the synthesis of pyrimidine thymidine, which is a required nucleotide for DNA replication. Thymidylate synthase methylates the deoxyuracil monophosphate (dUMP) to deoxythymidine mono phosphate (dTMP). Like many anticancer drugs, the effects of 5-FU feel throughout the system but more blunt about the rapidly dividing cells that make Great use of your nucleotide synthesis machinery. As analog of pyrimidine, it is transformed inside the cell into several cytotoxic metabolites that are then incorporated into DNA and RNA, finally inducing cell cycle arrest and apoptosis by inhibiting the ability of the cell to synthesize DNA. It is a specific S phase drug and active only during certain cell cycles In addition to being incorporated into DNA and RNA, it has shown that the drug inhibits the activity of the exosome complex, a exoribonuclease complex the activity of which is essential for the cell survival

Se entiende por "agente intercalante" una molécula que es capaz de insertarse de forma reversible entre dos cadenas de ADN. En una forma preferida de realización, el agente intercalante es una antraciclina. Las "antraciclinas" son antibióticos tumorales utilizados para diferentes tipos de cáncer, derivados de la bacteria Streptomyces, específicamente de Streptomyces peucetius var. caesius. La primera antraciclina descubierta fue la daunorubicina (nombre comercial daunomicina), producida de manera natural por Streptomyces peucetius, una actinobacteria. La doxorubicina (adriamicina) se desarrolló después y posteriormente se desarrollaron otros compuestos relacionados. Ejemplos de antraciclinas incluyen, sin limitación, daunorubicina, doxorubicina, epirubicina, idarubicina, mitoxantrona, pixantrona, valrubicina. En una forma preferida de realización, el agente intercalante adriamicina."Intercalating agent" means a molecule that is capable of reversibly inserting itself between two strands of DNA. In a preferred embodiment, the intercalating agent is an anthracycline. "Anthracyclines" are tumor antibiotics used for different types of cancer, derived from the Streptomyces bacteria, specifically from Streptomyces peucetius var. Caesius The first anthracycline discovered was daunorubicin (trade name daunomycin), produced naturally by Streptomyces peucetius , an actinobacterium. Doxorubicin (adriamycin) was developed later and other related compounds subsequently developed. Examples of anthracyclines include, without limitation, daunorubicin, doxorubicin, epirubicin, idarubicin, mitoxantrone, pixantrone, valrubicin. In a preferred embodiment, the adriamycin intercalating agent.

Por "agentes alquilantes del ADN" se conoce a agentes utilizados para el tratamiento del cáncer que unen un grupo alquilo (CnH2n+1) al ADN. El grupo alquilo se une a la guanina del ADN, en concreto al átomo de nitrógeno número 7 del anillo de imidazol. Debido a que las células cancerígenas proliferan más rápido y con menor corrección de errores que las células sanas, las células cancerígenas son más sensibles a los daños en el ADN (tal como la alquilación) que las células sanas. Por ello, los agentes alquilantes se pueden utilizar para tratar varios tipos de cáncer. Ejemplos de agentes alquilantes son ciclofosfamida, iofosfamida, melfalan, mecloretamina o mustina, uramustina, clorambucil, carmustina, lomustina, estreptozocina y busulfano. En una realización preferida, el agente alquilante del ADN es la ciclofosfamida.By "DNA alkylating agents" is known to agents used to treat cancer that bind a alkyl group (CnH2n + 1) to DNA. The alkyl group binds to guanine of DNA, specifically the nitrogen atom number 7 of the ring of imidazole Because cancer cells proliferate more fast and with less error correction than healthy cells, the Cancer cells are more sensitive to DNA damage (such such as alkylation) than healthy cells. Therefore, the agents Alkylating agents can be used to treat various types of cancer. Examples of alkylating agents are cyclophosphamide, iophosphamide, melphalan, mechlorethamine or mustine, uramustine, chlorambucil, Carmustine, Lomustine, Streptozocin and Busulfan. In a preferred embodiment, the alkylating agent of DNA is the cyclophosphamide

La ciclofosfamida, también conocida como ciclofosfano, es una agente alquilante de mostaza de nitrógeno, del grupo de la oxazoforinas. Es una "prodroga"; se convierte en el hígado en las formas activas que tienen actividad quimioterapéutica. La ciclofosfamida se convierte en el hígado por las enzimas oxidasas de función mixta en metabolitos activos. El metabolito activo principal es 4-hidroxiciclofosfamida. La 4-hidroxiciclofosfamida existe en equilibrio con su tautómero, la aldofosfamida. La mayoría de la aldofosfamida es oxidada por la enzima aldehído deshidrogenasa (ALDH) para producir carboxifosfamida. Una pequeña proporción de la aldofosfamida se convierte en mostaza de fosforamida y acroleína. La acroleína es tóxica para el epitelio de la vejiga y puede conducir a cistitis hemorrágica. Esto se puede prevenir mediante el uso de hidratación agresiva y/o Mesna.Cyclophosphamide, also known as cyclophosphan, is a nitrogen mustard alkylating agent, of Oxazoforin group. It is a "prodrug"; becomes the liver in the active forms that have chemotherapeutic activity. Cyclophosphamide is converted in the liver by oxidases enzymes of mixed function in active metabolites. Active metabolite Main is 4-hydroxycyclophosphamide. The 4-hydroxycyclophosphamide exists in equilibrium with its tautomer, aldophosphamide. Most aldophosphamide is oxidized by the enzyme aldehyde dehydrogenase (ALDH) to produce carboxyphosphamide A small proportion of aldophosphamide is converts to phosphoramide and acrolein mustard. Acrolein is toxic to the bladder epithelium and may lead to cystitis hemorrhagic This can be prevented by using hydration. aggressive and / or Mesna.

El término "muestra" como se usa aquí, se refiere a cualquier muestra que se puede obtener de un paciente. El método presente se puede aplicar a cualquier tipo de muestra biológica de un paciente, tal como una muestra de biopsia, tejido, célula o fluido (suero, saliva, semen, esputo, líquido cefalorraquídeo (LCR), lágrimas, moco, sudor, leche, extractos de cerebro y similares). En una forma de realización particular, dicha muestra es una muestra de tejido tumoral o una parte del mismo. En una forma de realización más particular, dicha muestra de tejido tumoral es una muestra de tejido tumoral de mama de un paciente que padece cáncer de mama. Dicha muestra se puede obtener mediante métodos convencionales, por ejemplo, biopsia, utilizando métodos bien conocidos para los expertos en las técnicas médicas relacionadas. Los métodos para obtener una muestra de la biopsia incluyen partición en trozos grandes de una masa, o microdisección u otros métodos de separación de células conocidos en la técnica. Las células tumorales se pueden obtener de forma adicional mediante citología por aspiración con una aguja fina. Para simplificar la conservación y el manejo de las muestras, estas se pueden fijar en formalina y embeber en parafina o congelar primero y después embeber en un medio criosolidificable, tal como compuesto OCT, mediante inmersión en un medio altamente criogénico que permite la congelación rápida.The term "sample" as used here, is refers to any sample that can be obtained from a patient. He Present method can be applied to any type of sample a patient's biological, such as a biopsy sample, tissue, cell or fluid (serum, saliva, semen, sputum, liquid cerebrospinal (CSF), tears, mucus, sweat, milk, extracts of brain and the like). In a particular embodiment, said Sample is a sample of tumor tissue or a part thereof. In a more particular embodiment, said tissue sample Tumor is a sample of breast tumor tissue from a patient who suffer from breast cancer This sample can be obtained by conventional methods, for example, biopsy, using methods well known to experts in medical techniques related. The methods to obtain a biopsy sample include partitioning into large pieces of a dough, or microdissection or other cell separation methods known in the art. The tumor cells can be obtained additionally by aspiration cytology with a fine needle. To simplify the preservation and handling of samples, these can be set in formalin and soak in paraffin or freeze first and then embed in a cryosolidifiable medium, such as OCT compound, by immersion in a highly cryogenic medium that allows the quick freeze.

En una realización particular, el taxano del método de la invención es el paclitaxel. En otra realización particular, el antimetabolito es el fluorouracilo. En otra realización particular, la antraciclina es la adriamicina. Y aún en otra realización particular, el agente alquilante del ADN es la ciclofosfamida.In a particular embodiment, the taxane of the method of the invention is paclitaxel. In another embodiment In particular, the antimetabolite is fluorouracil. In other particular embodiment, anthracycline is adriamycin. And still in Another particular embodiment, the DNA alkylating agent is the cyclophosphamide

En una realización particular del método de la invención, la invención se refiere a un método in vitro para predecir la respuesta de un sujeto diagnosticado con cáncer de mama al tratamiento con paclitaxel y quimioterapia con fluorouracilo, adriamicina y ciclofosfamida, que comprende determinar los niveles de expresión de los genes identificados en la Tabla 1 y en la Tabla 2 en una muestra de tejido tumoral procedente de dicho sujeto, en donde un aumento de la expresión de los genes identificados en la Tabla 1 y una disminución de la expresión de los genes identificados en la Tabla 2 con respecto a un valor de referencia es indicativo de una mejor respuesta al tratamiento.In a particular embodiment of the method of the invention, the invention relates to an in vitro method for predicting the response of a subject diagnosed with breast cancer to treatment with paclitaxel and chemotherapy with fluorouracil, adriamycin and cyclophosphamide, which comprises determining the levels of expression of the genes identified in Table 1 and Table 2 in a sample of tumor tissue from said subject, where an increase in the expression of the genes identified in Table 1 and a decrease in the expression of the genes identified in Table 2 with respect to a reference value is indicative of a better response to treatment.

La determinación de los niveles de expresión de los genes de acuerdo al método de la invención necesita ser correlacionada con los valores de referencia que corresponden el valor mediana de los niveles de expresión de dichos genes medido en una colección de tejidos tumorales en muestras de biopsias de pacientes de cáncer, antes del tratamiento de quimioterapia neoadyuvante. Una vez que se ha establecido este valor mediana, se puede comparar el nivel de este marcador expresado en tejidos tumorales de pacientes con este valor mediana, y de esta manera ser asignado al nivel de "bajo", "normal" o "alto". La colección de muestras de las que deriva el nivel de referencia estará preferiblemente constituida por pacientes que padecen el mismo tipo de cáncer. El uso de un valor de referencia usado para determinar si la expresión de una muestra de gen está "aumentada" o "disminuida" corresponde al valor mediana de los niveles de expresión de BRCA1 medidos en una muestra de ARN obtenida juntando cantidades iguales de ARN de cada una de las muestras de tumores obtenidas mediante biopsia de pacientes de cáncer antes del tratamiento quimioterapéutico neoadyuvante. Una vez que se ha establecido este valor mediana, se puede comparar el nivel de este marcador expresado en tejidos tumorales de pacientes con este valor mediana, y de esta manera ser asignado al nivel de "aumentado" o "disminuido". Debido a la variabilidad entre sujetos (por ejemplo, aspectos referidos a la edad, raza, etc.) es muy difícil (si no prácticamente imposible) establecer valores de referencia absolutos para BRCA1. De esta manera, en una forma de realización particular, los valores de referencia para expresión de BRCA1 "aumentada" o "disminuida" se determinan calculando los percentiles por medios convencionales que implica el ensayo de un grupo de muestras aisladas de sujetos normales (es decir, gente sin diagnóstico de cáncer de mama) para los niveles de expresión del gen BRCA1. Los niveles "aumentados" se pueden entonces asignar, preferiblemente, a muestras en donde los niveles de expresión de los genes BRCA1 es igual a o supera el percentil 50 en la población normal, incluyendo, por ejemplo, niveles de expresión iguales a o en exceso al percentil 60 en la población normal, iguales a o en exceso al percentil 70 en la población normal, iguales a o en exceso al percentil 80 en la población normal, iguales a o en exceso al percentil 90 en la población normal, e iguales a o en exceso al percentil 95 en la población normal.The determination of expression levels of the genes according to the method of the invention need to be correlated with the reference values that correspond to the median value of the expression levels of these genes measured in a collection of tumor tissues in biopsy samples from cancer patients, before chemotherapy treatment neoadjuvant. Once this median value has been established, it you can compare the level of this marker expressed in tissues tumor of patients with this median value, and in this way be assigned to the level of "low", "normal" or "high". The collection of samples from which the reference level derives It will preferably consist of patients suffering from Same type of cancer. The use of a reference value used to determine if the expression of a gene sample is "increased" or "decreased" corresponds to the median value of BRCA1 expression levels measured in an RNA sample obtained by gathering equal amounts of RNA from each of the tumor samples obtained by biopsy of patients from cancer before neoadjuvant chemotherapeutic treatment. One time that this median value has been set, the level can be compared of this marker expressed in tumor tissues of patients with this median value, and thus be assigned to the level of "increased" or "decreased". Due to the variability between subjects (for example, aspects related to age, race, etc.) is very difficult (if not practically impossible) to establish values of absolute reference for BRCA1. In this way, in a way of particular embodiment, the reference values for expression of BRCA1 "increased" or "decreased" are determined by calculating the percentiles by conventional means implied by the trial of a group of isolated samples from normal subjects (i.e. people no diagnosis of breast cancer) for expression levels of the BRCA1 gene. The "increased" levels can then be assigned, preferably, to samples where the expression levels of the BRCA1 genes is equal to or exceeds the 50th percentile in the population normal, including, for example, expression levels equal to or in excess to the 60th percentile in the normal population, equal to or in excess to the 70th percentile in the normal population, equal to or in excess of 80th percentile in the normal population, equal to or in excess of 90th percentile in the normal population, and equal to or in excess of 95th percentile in the normal population.

La expresión "aumento en la expresión", como se usa aquí, se refiere a un cambio de los niveles de expresión de un gen determinado con respecto a los niveles de expresión en la muestra de referencia de al menos el 5%, en al menos el 10%, en al menos el 15%, en al menos el 20%, en al menos el 25%, en al menos el 30%, en al menos el 35%, en al menos el 40%, en al menos el 45%, en al menos el 50%, en al menos el 55%, en al menos el 60%, en al menos el 65%, en al menos el 70%, en al menos el 75%, en al menos el 80%, en al menos el 85%, en al menos el 90%, en al menos el 95%, en al menos el 100%, en al menos el 110%, en al menos el 120%, en al menos el 130%, en al menos el 140%, en al menos el 150% o más.The expression "increase in expression", as used here, it refers to a change in expression levels of a particular gene with respect to expression levels in the reference sample of at least 5%, at least 10%, at minus 15%, at least 20%, at least 25%, at least 30%, at least 35%, at least 40%, at least 45%, in at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95%, at minus 100%, at least 110%, at least 120%, at least 130%, at least 140%, at least 150% or more.

Para normalizar los valores de expresión el ARNm entre las diferentes muestras, es posible comparar los niveles de expresión del ARNm de interés en las muestras a ensayar con la expresión de un ARN control. Un "ARN control" como se usa aquí, se refiere a un ARN cuyos niveles de expresión no cambian o solo cambian en cantidades limitadas en células tumorales con respecto a células no tumorigénicas. Preferiblemente, los ARN control son ARNm derivados de genes de mantenimiento y que codifican proteínas que se expresan de forma constitutiva y que llevan a cabo funciones celulares esenciales. Los genes de mantenimiento preferidos para su uso en la presente invención incluyen \beta-2-microglobulina, ubiquitina, proteína ribosómica de 18-S, ciclofilina, GAPDH y actina. En un forma de realización preferida, el ARN control es el ARNm de la BETA-actina. En una forma de realización la cuantificación de la expresión génica relativa se calcula según el método comparativo Ct usando \beta-actina como control endógeno y controles de ARN comerciales como calibradores. Los resultados finales, se determinan según la fórmula 2-(\DeltaCt de la muestra-\DeltaCt del calibrador), donde los valores \DeltaCT del calibrador y la muestra se determinan sustrayendo el valor CT del gen diana del valor del gen de la \beta-actina.To normalize the expression values the mRNA between the different samples, it is possible to compare the levels of mRNA expression of interest in the samples to be tested with the expression of a control RNA. An "RNA control" as used here, refers to an RNA whose expression levels do not change or only they change in limited amounts in tumor cells with respect to non-tumorigenic cells Preferably, the control RNAs are mRNA. derived from maintenance genes and encoding proteins that are express constitutively and that perform functions essential cell phones. Preferred maintenance genes for your use in the present invention include β-2-microglobulin, ubiquitin, 18-S ribosomal protein, cyclophilin, GAPDH and actin. In a preferred embodiment, the control RNA is the mRNA of BETA-actin. In a embodiment of quantification of gene expression relative is calculated according to the comparative method Ct using β-actin as an endogenous control and controls of Commercial RNA as calibrators. The final results are determined according to formula 2 - (ΔCt of the sample-? DeltaCt of the calibrator), where the ΔT values of the calibrator and the sample are determined subtracting the CT value of the target gene from the gene value of the β-actin.

En una realización particular, el método de la invención predice la respuesta de un sujeto diagnosticado con cáncer de mama, que presenta además niveles normales de HER-2. Por el término "niveles normales de HER-2" se considera cuando el test de detección de HER-2 resulta negativo, es decir que no hay amplificación o expresión de HER-2. El experto en la técnica dispone de los conocimientos necesarios para determinar los niveles de HER-2. Se pueden medir, por ejemplo mediante:In a particular embodiment, the method of invention predicts the response of a subject diagnosed with cancer of breast, which also has normal levels of HER-2 By the term "normal levels of HER-2 "is considered when the screening test of HER-2 is negative, that is to say that there is no amplification or expression of HER-2. The expert in technique has the necessary knowledge to determine the HER-2 levels. They can be measured, for example through:

1)one): Test IHC (del inglés, ImmunoHistoChemistry), dicho test indica la cantidad de proteína receptora de HER-2 existente en las células cancerosas. El resultado del test IHC puede ser 0 (negativo), 1+ (negativo), 2+ (fronterizo), o 3+ (positivo) yTest IHC (of the English, ImmunoHistoChemistry), this test indicates the amount of HER-2 receptor protein existing in cancer cells The result of the IHC test can be 0 (negative), 1+ (negative), 2+ (border), or 3+ (positive) Y

2)2): Test FISH (del inglés, Fluorescence In Situ Hybridization), que indica el número de copias del gen HER-2 presente en las células cancerosas. El resultado de dicho test puede ser positivo (se amplifican más de 2 copias) o negativo (2 o menos copias, no existe amplificación).FISH Test (Fluorescence In Situ Hybridization), which indicates the number of copies of the HER-2 gene present in cancer cells. The result of this test can be positive (more than 2 copies are amplified) or negative (2 or less copies, there is no amplification).

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En otra realización particular, el método de la invención predice la respuesta de un sujeto diagnosticado con cáncer de mama avanzado. El término "cáncer de mama avanzado" se refiere a que el cáncer de mama se ha diseminado más allá de la mama y ha llegado a los ganglios linfáticos y a tejidos distales, es decir, correspondería a la fases N1, N2, N3 y las fases M de la clasificación TNM o a los grados IB, IIIA, IIIB ó IV según la clasificación del "American Joint Committee on Cancer Staging". La mayoría de los casos de cáncer de mama avanzado se encuentra en mujeres de más de 50 años. En la actualidad, existe un número creciente de opciones para el tratamiento del cáncer de mama avanzado. Los métodos tradicionales de control local incluyen cirugía (procedimientos como tumorectomía o mastectomía) y radioterapia (aplicada en el sitio del cáncer). Los tratamientos sistémicos incluyen quimioterapia y terapia hormonal.In another particular embodiment, the method of the invention predicts the response of a subject diagnosed with advanced breast cancer. The term "advanced breast cancer" refers to the fact that breast cancer has spread beyond the breast and has reached the lymph nodes and distal tissues, that is, it would correspond to phases N1, N2, N3 and phases M of the TNM classification or grades IB, IIIA, IIIB or IV according to the classification of the American Joint Committee on Cancer Staging . Most cases of advanced breast cancer are found in women over 50 years. Currently, there is a growing number of options for the treatment of advanced breast cancer. Traditional methods of local control include surgery (procedures such as lumpectomy or mastectomy) and radiation therapy (applied at the cancer site). Systemic treatments include chemotherapy and hormonal therapy.

En una realización particular del método de la invención, dicho tratamiento es un tratamiento neoadyuvante, es decir, se trata de un tratamiento que se administra como primer paso para reducir el tamaño del tumor antes del tratamiento principal que generalmente consiste en cirugía. El principal beneficio que se obtiene con la terapia neoadyuvante es que disminuye el tamaño del tumor, que ocurre en un 80-90% de los casos, y que permite evitar en muchos casos una mastectomía.In a particular embodiment of the method of invention, said treatment is a neoadjuvant treatment, it is that is, it is a treatment that is given as a first step to reduce the size of the tumor before the main treatment that It usually consists of surgery. The main benefit to be obtained with neoadjuvant therapy is that the size of the tumor, which occurs in 80-90% of cases, and that It allows to avoid in many cases a mastectomy.

En una realización particular del método de la invención, dicho método comprende además de determinar el nivel de la expresión de los genes identificados en la Tabla 1 y en la Tabla 2, determinar también al menos un parámetro clínico seleccionado entre edad del sujeto, estado del receptor de estrógenos (ER) y grado tumoral, en donde a menor edad del sujeto, sujetos negativos para receptor de estrógenos y grado tumoral más avanzado, es indicativo de una mejor respuesta al tratamiento. En concreto, sujetos menores de 50 años o con 50 años responden mejor al tratamiento. Los receptores de estrógenos están sobre-expresados en alrededor del 70% de los casos de cáncer de mama y se refiere a ellos como "ER positivos". En este caso, sujetos con tumores ER negativos, es decir que no presentan receptores de estrógenos, responderían mejor al tratamiento que sujetos con tumores ER positivos. Por último, sujetos con cáncer de mama más avanzado responden mejor al tratamiento, en concreto, los sujetos diagnosticados con cáncer de grado III responden mejor que los sujetos diagnosticados con cáncer de grado I ó II.In a particular embodiment of the method of invention, said method further comprises determining the level of the expression of the genes identified in Table 1 and in the Table 2, also determine at least one selected clinical parameter between subject's age, estrogen receptor (ER) status and tumor grade, where at the younger age of the subject, negative subjects for estrogen receptor and more advanced tumor grade, it is indicative of a better response to treatment. Specific, subjects under 50 or 50 years respond better to treatment. Estrogen receptors are overexpressed in about 70% of cases of breast cancer and refers to them as "ER positive." In this case, subjects with ER-negative tumors, that is, no they have estrogen receptors, they would respond better to treatment than subjects with ER positive tumors. By last, subjects with more advanced breast cancer respond better to treatment, specifically, subjects diagnosed with cancer of grade III respond better than subjects diagnosed with cancer Grade I or II.

En una realización particular del método de la invención, dichos genes son los genes cuyas secuencias de nucleótidos hibridan con las sondas identificadas en las Tablas 3 y 4. Los genes identificados para la firma genética o test genómico de 40 genes se corresponden con los de la Tabla 1 y la Tabla 2. Así, los inventores han demostrado que los pacientes clasificados como de mal pronóstico según el método de la presente invención responderían mejor al tratamiento por T/FAC en sujetos diagnosticados por cáncer de mama.In a particular embodiment of the method of invention, said genes are the genes whose sequences of nucleotides hybridize with the probes identified in Tables 3 and 4. The genes identified for the genetic signature or genomic test of 40 genes correspond to those in Table 1 and Table 2. Thus, the inventors have shown that patients classified as of poor prognosis according to the method of the present invention would respond better to treatment by T / FAC in subjects diagnosed with cancer of breast

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La cuantificación de los niveles de expresión de los genes identificados en la Tabla 1 y en la Tabla 2 puede realizarse a partir del ARN resultante de la transcripción de dichos genes (ARNm) o, alternativamente, a partir del ADN complementario (ADNc) de dichos genes. Por tanto, en una realización particular, la cuantificación de los niveles de expresión de los genes identificados en la Tabla 1 y en la Tabla 2 comprende la cuantificación del ARN mensajero (ARNm) de dichos genes, o un fragmento de dicho ARNm, el ADN complementario (ADNc) de dichos genes, o un fragmento de dicho ADNc, o sus mezclas.The quantification of expression levels of the genes identified in Table 1 and Table 2 can be made from the RNA resulting from the transcription of said genes (mRNA) or, alternatively, from complementary DNA (CDNA) of said genes. Therefore, in a particular embodiment, the quantification of gene expression levels identified in Table 1 and Table 2 includes the quantification of messenger RNA (mRNA) of said genes, or a fragment of said mRNA, the complementary DNA (cDNA) of said genes, or a fragment of said cDNA, or mixtures thereof.

Adicionalmente, el método de la invención puede incluir la realización de una etapa de extracción con el fin de obtener el ARN total, lo que puede realizarse mediante técnicas convencionales (Chomczynski y cols., Anal. Biochem., 1987, 162:156; Chomczynski P., Biotechniques, 1993, 15:532).Additionally, the method of the invention can include performing an extraction stage in order to get the total RNA, which can be done using techniques conventional (Chomczynski et al., Anal. Biochem., 1987, 162: 156; Chomczynski P., Biotechniques, 1993, 15: 532).

Prácticamente cualquier método convencional puede ser utilizado dentro del marco de la invención para detectar y cuantificar los niveles de ARNm codificados por los genes cuyas secuencias de nucleótidos hibridan con las sondas de las Tablas 3 y 4 o de su ADNc correspondiente. A modo ilustrativo, no limitativo, los niveles de ARNm codificados por dichos genes pueden ser cuantificados mediante el empleo de métodos convencionales, por ejemplo, métodos que comprenden la amplificación del ARNm y la cuantificación del producto de la amplificación de dicho ARNm, tales como electroforesis y tinción, o alternativamente, mediante Northern blot y empleo de sondas apropiadas, northern blot y empleo de sondas específicas del ARNm de los genes de interés o de su ADNc correspondiente, mapeo con la nucleasa S1, RT-PCR, hibridación, microarrays, etc. Análogamente, los niveles del ADNc correspondiente a dichos ARNm codificados por los genes de la Tablas 1 y 2 también pueden ser cuantificados mediante el empleo de técnicas convencionales; en este caso, el método de la invención incluye una etapa de síntesis del correspondiente ADNc mediante transcripción inversa (RT) del ARNm correspondiente seguida de amplificación y cuantificación del producto de la amplificación de dicho ADNc. Métodos convencionales de cuantificar los niveles de expresión pueden encontrarse, por ejemplo, en Sambrook y cols., 2001 "Molecular cloning: a Laboratory Manual", 3^{rd} ed., Cold Spring Harbor Laboratory Press, N.Y., Vol. 1-3.Virtually any conventional method It can be used within the framework of the invention to detect and quantify mRNA levels encoded by genes whose nucleotide sequences hybridize with the probes of Tables 3 and 4 or its corresponding cDNA. By way of illustration, not limitation, mRNA levels encoded by said genes can be quantified by using conventional methods, by example, methods that comprise mRNA amplification and quantification of the amplification product of said mRNA, such as electrophoresis and staining, or alternatively, by Northern blot and use of appropriate probes, northern blot and use of probes specific to the mRNA of the genes of interest or their cDNA corresponding, mapping with nuclease S1, RT-PCR, hybridization, microarrays, etc. Similarly, cDNA levels corresponding to said mRNAs encoded by the genes of the Tables 1 and 2 can also be quantified by using conventional techniques; in this case, the method of the invention includes a stage of synthesis of the corresponding cDNA by reverse transcription (RT) of the corresponding mRNA followed by amplification and quantification of the amplification product of said cDNA. Conventional methods of quantifying levels of expression can be found, for example, in Sambrook et al., 2001 "Molecular cloning: a Laboratory Manual", 3rd ed., Cold Spring Harbor Laboratory Press, N.Y., Vol. 1-3.

En una realización particular de la invención, la cuantificación de los niveles de expresión de los genes identificados en las Tablas 1 y 2 se realiza mediante una reacción en cadena de la polimerasa (PCR) cuantitativa multiplex.In a particular embodiment of the invention, quantification of gene expression levels identified in Tables 1 and 2 is performed by a reaction quantitative multiplex polymerase chain (PCR).

En otra realización particular de la invención, la determinación de los niveles de expresión de los genes identificados en la Tabla 1 y la Tabla 2 se realiza mediante un array de ADN que comprende las sondas identificadas en las Tablas 3 y 4. En una realización más particular de la invención, dicho array comprende, al menos, un conjunto de 11 sondas por gen para determinar los niveles de expresión de cada uno de los genes de las Tablas 1 y 2. Así, para la determinación de los niveles de expresión de cada uno de dichos genes, se tendrán en cuenta los niveles de expresión de dichas sondas.In another particular embodiment of the invention, the determination of gene expression levels identified in Table 1 and Table 2 is done through a DNA array comprising the probes identified in Tables 3 and 4. In a more particular embodiment of the invention, said array It comprises at least one set of 11 probes per gene for determine the expression levels of each of the genes of the Tables 1 and 2. Thus, for the determination of expression levels of each of these genes, the levels of expression of said probes.

Así, el método de la invención comprende la determinación de los niveles de expresión de dichos genes de las Tablas 1 y 2 con respecto a un valor de referencia. En una realización particular de la invención, dicho valor de referencia es el valor de expresión génica de dichos genes de las Tablas 1 y 2 en una muestra de tumores primarios de pacientes que no desarrollan metástasis. Preferiblemente, se considerará que los genes presentan una expresión aumentada cuando la relación de expresión de un gen es de al menos 1,5 veces con respecto a un valor de referencia, preferiblemente superior a 2 veces, más preferiblemente superior a, 3, 4, 5 y 10 veces. De igual modo, en una realización particular de la invención, se considerará que los genes presentan una expresión disminuida con respecto a un valor de referencia, cuando la relación de expresión de un gen es de al menos 1,5 veces inferior con respecto al valor de referencia.Thus, the method of the invention comprises the determination of the expression levels of said genes of the Tables 1 and 2 with respect to a reference value. In a particular embodiment of the invention, said reference value is the gene expression value of said genes from Tables 1 and 2 in a sample of primary tumors of patients who do not develop metastasis. Preferably, the genes will be considered to have an increased expression when the expression ratio of a gene is at least 1.5 times with respect to a reference value, preferably more than 2 times, more preferably more than, 3, 4, 5 and 10 times. Similarly, in a particular embodiment of the invention, genes will be considered to have an expression decreased with respect to a reference value, when the ratio expression of a gene is at least 1.5 times lower with Regarding the reference value.

En una realización particular de la invención, el método de la invención comprende la realización de un análisis de regresión de riesgos proporcionales en función de dichos valores de expresión de los genes identificados en las Tablas 1 y 2. Según los datos mostrados en el Ejemplo 1, los inventores han demostrado que, de esta forma, dicho pronóstico se realiza con una efectividad que, según las curvas ROC, tendría una sensibilidad de un 90%, así como un máximo de especificidad. Por tanto, en una realización particular de la invención, la determinación de dicho pronóstico comprende un análisis de regresión de riesgos proporcionales de dicho pronóstico en función de los niveles de expresión de los genes identificados en la Tabla 1 y en la Tabla 2.In a particular embodiment of the invention, the method of the invention comprises performing an analysis of regression of proportional risks based on these values of expression of the genes identified in Tables 1 and 2. According to the data shown in Example 1, the inventors have shown that, in this way, said forecast is made with an effectiveness that, according to the ROC curves, it would have a sensitivity of 90%, as well as a maximum of specificity Therefore, in a particular embodiment of the invention, the determination of said prognosis comprises a regression analysis of proportional risks of said forecast depending on the expression levels of the genes identified in Table 1 and Table 2.

Por tanto, en una realización particular de la invención, dicho análisis de regresión de riesgos proporcionales es un análisis de tipo Cox. Tal como se describe en el Ejemplo 1 que acompaña la presente descripción, los inventores han empleado un análisis de regresión de riesgos proporcionales de tipo Cox para la predicción de la respuesta al tratamiento de un sujeto diagnosticado de cáncer de mama. Dicho análisis de Cox asigna un coeficiente de regresión para cada gen, de tal forma que el gen cuya expresión esté directamente correlacionada con la variable pronóstico, por ejemplo con la respuesta patológica completa (RCp), es mayor que 0, y si su expresión está relacionada inversamente con dicha variable es menor que 0. En una realización más particular, en dicho análisis de tipo Cox se establece la respuesta patológica completa como variable pronóstico.Therefore, in a particular embodiment of the invention, said proportional hazards regression analysis is a Cox type analysis. As described in Example 1 that accompanies the present description, the inventors have employed a Cox-type proportional hazards regression analysis for prediction of the response to treatment of a diagnosed subject of breast cancer. Said Cox analysis assigns a coefficient of regression for each gene, so that the gene whose expression is directly correlated with the forecast variable, for example with the complete pathological response (RCp), it is greater than 0, and if your expression is inversely related to that variable is less than 0. In a more particular embodiment, in said type analysis Cox establishes the complete pathological response as a variable forecast.

Los inventores han demostrado que mediante el método de la invención es posible determinar el pronóstico de la respuesta de un paciente con cáncer de mama y con niveles normales de HER-2 con una alta sensibilidad, en concreto del 90%. Así, a partir de los valores de expresión génica de los genes de las Tablas 1 y 2 según se ha descrito anteriormente, y del valor del estadístico de Wald del análisis de regresión de riesgos proporcionales, los inventores han demostrado que es posible determinar dicho pronóstico aplicando la siguiente fórmula:The inventors have shown that by method of the invention it is possible to determine the prognosis of the response of a patient with breast cancer and with normal levels of HER-2 with high sensitivity, specifically 90% Thus, from the gene expression values of the genes of Tables 1 and 2 as described above, and of the value of the Wald statistic of the risk regression analysis proportional, the inventors have shown that it is possible determine this forecast by applying the following formula:

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33

: donde x_{i} es el valor del nivel de expresión en log_{2} de cada uno de dichos genes identificados en las Tablas 1 y 2; ywhere x_ {i} is the value of the expression level in log_ {2} of each of these genes identified in Tables 1 and 2; Y

: s_{i} es el valor del estadístico de Wald del análisis de regresión de tipo Cox para cada uno de dichos genes identificados en las Tablas 1 y 2,Yes it's him Wald statistic value of Cox regression analysis for each of said genes identified in Tables 1 and 2,

en donde si el valor obtenido es mayor que cero entonces es indicativo de una mejor respuesta al tratamiento neoadyuvante con un taxano y quimioterapia con un antimetabolito análogo de la pirimidina, una antraciclina y un agente alquilante del ADN en un paciente con cáncer de mama.where if the value obtained is greater than zero then it is indicative of a better response to treatment neoadjuvant with a taxane and chemotherapy with an antimetabolite pyrimidine analogue, an anthracycline and an alkylating agent of DNA in a patient with breast cancer.

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El valor del estadístico de Wald es un valor empleado comúnmente por el experto en la materia para saber si las variables que se introducen en el análisis estadístico son o no relevantes. Dicho valor se puede calcular según se describe en Wald A. (1943) (Transactions of the American Mathematical Society. 1943; 54:426-482) y Silvey (1959) (Silvey SD. Annals of Mathematical Statistics. 1959; 30:389-407).The value of the Wald statistic is a value commonly used by the person skilled in the art to know if the variables that are introduced in the statistical analysis are or not relevant. This value can be calculated as described in Wald A. (1943) (Transactions of the American Mathematical Society. 1943; 54: 426-482) and Silvey (1959) (Silvey SD. Annals of Mathematical Statistics. 1959; 30: 389-407).

Por otro lado, para la puesta en práctica de la invención, aparte de cuantificar los niveles de expresión de los genes identificados en las Tablas 1 y 2, también se puede cuantificar el nivel de expresión de las proteínas codificadas por dichos genes. Así, en una realización particular, la cuantificación de los niveles de las proteínas codificadas por los genes identificados en las Tablas 1 y 2 comprende la cuantificación de dichas proteínas o variables de las mismas.On the other hand, for the implementation of the invention, apart from quantifying the expression levels of genes identified in Tables 1 and 2, you can also quantify the level of expression of the proteins encoded by said genes. Thus, in a particular embodiment, the quantification of the levels of the proteins encoded by the genes identified in Tables 1 and 2 includes the quantification of said proteins or variables thereof.

El término "proteína", tal como aquí se utiliza, se refiere a una cadena molecular de aminoácidos, unidos por enlaces covalentes o no covalentes. El término incluye, además, todas las formas de modificaciones químicas post-traduccionales, relevantes fisiológicamente, por ejemplo, glicosilación, fosforilación o acetilación, etc.The term "protein", as here is used, refers to a molecular chain of amino acids, attached by covalent or non-covalent bonds. The term also includes all forms of chemical modifications post-translational, physiologically relevant, for example, glycosylation, phosphorylation or acetylation, etc.

En la presente invención se entiende por "variante", una proteína cuya secuencia de aminoácidos es sustancialmente homologa a la secuencia de aminoácidos de una proteína concreta. Una secuencia de aminoácidos es sustancialmente homologa a una secuencia de aminoácidos determinada cuando presenta un grado de identidad de, al menos, un 70%, ventajosamente de, al menos, un 75%, típicamente de, al menos, un 80%), preferentemente de, al menos, un 85%, más preferentemente de, al menos, un 90%), aún más preferentemente de, al menos, un 95%, 97%, 98% ó 99%, respecto a dicha secuencia de aminoácidos determinada. El grado de identidad entre dos secuencias de aminoácidos puede determinarse por métodos convencionales, por ejemplo, mediante algoritmos estándar de alineamiento de secuencias conocidos en el estado de la técnica, tales como, por ejemplo BLAST [Altschul S.F. et al. Basic local alignment search tool. J Mol Biol. 1990 Oct 5; 215(3):403-10].In the present invention, "variant" is understood as a protein whose amino acid sequence is substantially homologous to the amino acid sequence of a particular protein. An amino acid sequence is substantially homologous to a given amino acid sequence when it has a degree of identity of at least 70%, advantageously of at least 75%, typically at least 80%), preferably of at least 85%, more preferably of at least 90%), even more preferably of at least 95%, 97%, 98% or 99%, with respect to said determined amino acid sequence. The degree of identity between two amino acid sequences can be determined by conventional methods, for example, by standard sequence alignment algorithms known in the state of the art, such as, for example, BLAST [Altschul SF et al . Basic local alignment search tool. J Mol Biol. 1990 Oct 5; 215 (3): 403-10].

El experto en la materia entiende que, las mutaciones en la secuencia de nucleótidos de los genes que dan lugar a sustituciones conservativas de aminoácidos en posiciones no críticas para la funcionalidad de la proteína, son mutaciones evolutivamente neutras que no afectan a su estructura global ni a su funcionalidad. Dichas variantes caen dentro del ámbito de la presente invención.The person skilled in the art understands that, the mutations in the nucleotide sequence of the genes that give rise to conservative amino acid substitutions in positions not critical for protein functionality, they are mutations evolutionarily neutral that do not affect its overall structure or its functionality These variants fall within the scope of the present invention

Por tanto, tal como aquí se utiliza, el término "variante" también incluye cualquier fragmento de una de las proteínas descritas en la presente invención. El término "fragmento" se refiere a un péptido que comprende una porción de una proteína.Therefore, as used herein, the term "variant" also includes any fragment of one of the proteins described in the present invention. The term "fragment" refers to a peptide comprising a portion of a protein

El nivel de expresión de las proteínas codificadas por los genes identificados en las Tablas 1 y 2 puede ser cuantificado mediante cualquier método convencional que permita detectar y cuantificar dichas proteínas en una muestra de un sujeto. A modo ilustrativo, no limitativo, los niveles de dichas proteínas pueden cuantificarse, por ejemplo, mediante el empleo de anticuerpos con capacidad de unirse a dichas proteínas (o a fragmentos de las mismas que contenga un determinante antigénico) y la posterior cuantificación de los complejos formados. Los anticuerpos que se emplean en estos ensayos pueden estar marcados o no. Ejemplos ilustrativos de marcadores que se pueden utilizar incluyen isótopos radiactivos, enzimas, fluoróforos, reactivos quimioluminiscentes, sustratos enzimáticos o cofactores, inhibidores enzimáticos, partículas, colorantes, etc. Existe una amplia variedad de ensayos conocidos que se pueden utilizar en la presente invención, que utilizan anticuerpos no marcados (anticuerpo primario) y anticuerpos marcados (anticuerpo secundario); entre estas técnicas se incluyen el Western-blot o transferencia Western, ELISA (ensayo inmuno absorbente ligado a enzima), RIA (radioinmunoensayo), EIA competitivo (inmunoensayo enzimático competitivo), DAS-ELISA (ELISA sándwich con doble anticuerpo), técnicas inmunocitoquímicas e inmunohistoquímicas, técnicas basadas en el empleo de biochips o microarrays de proteínas que incluyan anticuerpos específicos o ensayos basados en precipitación coloidal en formatos tales como dipsticks. Otras maneras para detectar y cuantificar dichas proteínas, incluyen técnicas de cromatografía de afinidad, ensayos de unión a ligando, etc.The level of protein expression encoded by the genes identified in Tables 1 and 2 can be quantified by any conventional method that allows detect and quantify said proteins in a sample of a subject. By way of illustration, not limitation, the levels of said proteins can be quantified, for example, by the use of antibodies capable of binding to said proteins (or fragments of the same that contains an antigenic determinant) and the subsequent quantification of the complexes formed. The antibodies that are used in these tests may be marked or not. Examples Illustrative markers that can be used include isotopes radioactive, enzymes, fluorophores, chemiluminescent reagents, enzyme substrates or cofactors, enzyme inhibitors, particles, dyes, etc. There is a wide variety of trials known to be used in the present invention, which use unlabeled antibodies (primary antibody) and antibodies labeled (secondary antibody); These techniques include Western blot or Western transfer, ELISA (enzyme-linked immuno absorbent assay), RIA (radioimmunoassay), Competitive EIA (competitive enzyme immunoassay), DAS-ELISA (sandwich ELISA with double antibody), immunocytochemical and immunohistochemical techniques, based techniques in the use of biochips or protein microarrays that include specific antibodies or tests based on colloidal precipitation in formats such as dipsticks. Other ways to detect and quantify said proteins, include chromatography techniques of affinity, ligand binding assays, etc.

En una realización particular, la cuantificación de los niveles de proteína codificada por los genes identificados en las Tablas 1 y 2 se realiza mediante western blot, ELISA, inmunohistoquímica o un array de proteínas.In a particular embodiment, the quantification of protein levels encoded by the genes identified in Tables 1 and 2 are performed using western blot, ELISA, immunohistochemistry or an array of proteins.

El siguiente ejemplo ilustra la invención y no debe ser considerado como limitativo del alcance de la misma.The following example illustrates the invention and not It should be considered as limiting its scope.

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Example 1 Materials and methods

Dado que el objetivo de la invención era el analizar el valor predictivo del test genómico de 40 genes con respecto a la quimioterapia solamente, se incluyeron en este estudio únicamente los pacientes de cáncer de mama con niveles normales de HER-2.Since the aim of the invention was the analyze the predictive value of the genomic test of 40 genes with regarding chemotherapy only, they were included in this study only breast cancer patients with normal levels of HER-2

El test genómico de 40 genes se basa en la determinación de los niveles de expresión de los genes de las Tablas 1 y 2 a partir de 40 sondas de Affymetrix (Tablas 3 y 4). A partir de los niveles de dichas sondas, se obtiene mediante una fórmula un "valor de riesgo" (VR) de cada tumor. Dicha fórmula asigna un valor numérico a cada muestra (VR), basado en la suma de los productos de los valores de expresión de cada sonda y los valores del estadístico de Wald de cada gen según el modelo de Cox.The genomic test of 40 genes is based on the determination of the expression levels of the genes of the Tables 1 and 2 from 40 Affymetrix probes (Tables 3 and 4). Starting of the levels of said probes, a "risk value" (VR) of each tumor. This formula assigns a numerical value to each sample (VR), based on the sum of the products of the expression values of each probe and the values of the Wald statistic of each gene according to the Cox model.

Los datos crudos de hibridación a microarrays de tumores primarios de mama humano y sus correspondientes datos clínicos, realizados con las versiones de los GeneChips de Affymetrix Human Gene Expression U133A ó U133Plus 2.0, se descargaron desde la página web de la base de datos Gene Expression Omnibus (GEO) del NCBI, con los identificadores GSE7390 (Desmedt C. et al. Clin Cancer Res 2007; 13(11):3207-3214). (estudio que se denomina de aquí en adelante dataset Desmedt) y GSE6532 y GSE9195 (Loi S. et al. J Clin Oncol 2007; 25(10):1239-1246) (estudio que se denomina de aquí en adelante dataset Loi). Los archivos CEL se tomaron para extraer los valores de intensidad de señal usando el programa RMAExpress. Las gráficas RLE y NUSE permitieron identificar algunos microarrays de tumores que no pasaban los criterios de normalización óptima con RMA. Los correspondientes archivos CEL fueron eliminados de análisis posteriores.The raw microarray hybridization data of primary human breast tumors and their corresponding clinical data, made with the GeneChips versions of Affymetrix Human Gene Expression U133A or U133Plus 2.0, were downloaded from the Gene Expression Omnibus database website (GEO) of the NCBI, with the GSE7390 identifiers (Desmedt C. et al . Clin Cancer Res 2007; 13 (11): 3207-3214). (study hereinafter referred to as Desmedt dataset ) and GSE6532 and GSE9195 (Loi S. et al . J Clin Oncol 2007; 25 (10): 1239-1246) (study referred to hereinafter as Loi dataset ). The CEL files were taken to extract the signal strength values using the RMAExpress program. The RLE and NUSE charts allowed us to identify some tumor microarrays that did not pass the criteria of optimal normalization with RMA. The corresponding CEL files were removed from subsequent analyzes.

Un análisis de regresión de riesgos proporcionales de Cox se realizó usando metástasis distal (MD) a 5 años para las 707 sondas de U133A (y presentes también en U133Plus 2.0) correspondientes a los 427 genes humanos mapeados del análisis de expresión diferencial de los tumores de ratón, usando la utilidad de supervivencia implementada en la página web GEPAS (www.gepas.org) (Vaquerizas JM. et al. Nucleic Acids Res 2005; 33 (Web Server issue):W616-620).A Cox proportional hazards regression analysis was performed using 5-year distal metastasis (MD) for the 707 U133A probes (and also present in U133Plus 2.0) corresponding to the 427 human genes mapped from the differential expression analysis of tumor tumors. mouse, using the survival utility implemented on the GEPAS website (www.gepas.org) (Vaquerizas JM. et al . Nucleic Acids Res 2005; 33 (Web Server issue): W616-620).

Brevemente, el análisis de Cox asigna un coeficiente de regresión de Cox para cada sonda, de tal forma que una sonda cuya expresión esté directamente correlacionada con aparición de MD es mayor que 0, y si su expresión está relacionada inversamente con MD es menor que 0. Además, se aplica el test de Wald (Wald A. Transactions of the American Mathematical Society 1943; 54:426-482; Silvey SD. Annals of Mathematical Statistics 1959; 30:389-407) para analizar la hipótesis nula de que el coeficiente sea 0 (no relacionado con MD), asignándose a cada sonda un valor de estadístico de Wald, su correspondiente valor P, y valor P corregido por el método FDR. Las sondas con valores del estadístico de Wald >3 ó <-3 fueron elegidas para análisis posteriores. Estos análisis tienen como objetivo comprobar la capacidad de predicción de MD a 5 y 10 años de cáncer de mama humano.Briefly, Cox analysis assigns a Cox regression coefficient for each probe, so that a probe whose expression is directly correlated with MD occurrence is greater than 0, and if its expression is related conversely with MD it is less than 0. In addition, the test of Wald (Wald A. Transactions of the American Mathematical Society 1943; 54: 426-482; Silvey SD Annals of Mathematical Statistics 1959; 30: 389-407) to analyze the null hypothesis that the coefficient is 0 (not related to MD), assigning to each probe a Wald statistic value, its corresponding P value, and P value corrected by the FDR method. The probes with Wald statistic values> 3 or <-3 were chosen for further analysis. These analyzes have as objective to check the prediction capacity of MD at 5 and 10 years of human breast cancer

Los archivos CEL de estudios de microarrays de cáncer de mama de Hess et al. (Hess et al, 2006), Loi et al. (Loi et al, 2007. J. Clin. Oncol. 25: 1239-46) y Loi et al. (Loi et al, 2008. BMC Genomics 9:239) se tomaron desde bases de datos de libre acceso para extraer los valores de intensidad de señal usando el programa RMAExpress.The CEL files of breast cancer microarray studies by Hess et al . (Hess et al , 2006), Loi et al . (Loi et al , 2007. J. Clin. Oncol. 25: 1239-46) and Loi et al . (Loi et al , 2008. BMC Genomics 9: 239) were taken from open access databases to extract the signal strength values using the RMAExpress program.

El dataset de Hess y col (Hess et al, 2006, citado ad supra) usado para la predicción a sensibilidad a quimioterapia no se asoció con los datos de resultados a largo plazo y fue evaluado basado en la información de respuesta patológica completa (RCp). Tal como se ha mencionado anteriormente, sólo los pacientes con cáncer de mama con niveles normales de HER-2 se incluyeron en el análisis (n=99). El VR fue calculado para todos los tumores, y el VR continuo o dicotomizado fueron independientemente usados como variables para regresión logística. El VR dicotomizado fue seleccionado en base al umbral=3,53, tal que los pacientes con VR \geq 3,53 son considerados como "alto VR" y los pacientes con VR < 3,53 son considerados como "bajo VR".The Hess et al dataset (Hess et al , 2006, cited ad supra ) used for prediction of chemotherapy sensitivity was not associated with long-term outcome data and was evaluated based on complete pathological response information (RCp). . As mentioned earlier, only breast cancer patients with normal levels of HER-2 were included in the analysis (n = 99). VR was calculated for all tumors, and continuous or dichotomized VR were independently used as variables for logistic regression. The dichotomized VR was selected based on the threshold = 3.53, such that patients with VR ≥ 3.53 are considered as "high VR" and patients with VR <3.53 are considered as "low VR".

Los datasets de cáncer de mama de Loi (GSE6532 y GSE9195) fueron usados para demostrar la relación entre el VR y la probabilidad de desarrollar metástasis distal a 5 años.Loi's breast cancer datasets (GSE6532 and GSE9195) were used to demonstrate the relationship between the VR and the Probability of developing distal metastases at 5 years.

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Results Development of a mathematical model of prediction of response to treatment

Se obtuvo una fórmula para calcular un "valor de riesgo" (VR) de cada tumor basado en los genes descritos:A formula was obtained to calculate a "value of risk "(VR) of each tumor based on the genes described:

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donde s_{i} es el estadístico de Wald del análisis de regresión de tipo Cox; ywhere s _ {i} is the Wald statistic analysis Cox regression type; Y

\quadquad: x_{i} es el valor de expresión en log_{2} de la sonda de Affymetrix (media=1; desviación estándar=1) xi is the expression value in log_2 of the Affymetrix probe (mean = 1; standard deviation = 1)

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En la Tabla 5 se indican los genes de la firma de la invención, y los correspondientes valores de s_{i}.In Table 5 the signature genes of the invention, and corresponding values of s _ {i} are indicated.

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Los resultados obtenidos demuestran que la firma genética de la invención, podría ser utilizada como un predictor óptimo de la respuesta al tratamiento T/FAC de un sujeto diagnosticado con cáncer de mama humano.The results obtained show that the firm genetics of the invention, could be used as a predictor optimal response to a subject's T / FAC treatment diagnosed with human breast cancer.

Así, a partir de la fórmula descrita anteriormente, los inventores han conseguido determinar si un paciente pertenecería al grupo de mejor respuesta al tratamiento o peor respuesta a dicho tratamiento. Este método está basado en la fórmula para el cálculo del valor de riesgo (VR), y en la curva ROC de MD a 5 años del grupo de tumores Desmedt de 142 muestras (Figura 1, panel C). Según las curvas COR, el predictor tendría 90% de sensibilidad.Thus, from the formula described previously, the inventors have managed to determine if a patient would belong to the group with the best response to treatment or Worst response to such treatment. This method is based on the formula for calculating the risk value (VR), and in the ROC curve MD at 5 years of the Desmedt tumor group of 142 samples (Figure 1, panel C). According to the COR curves, the predictor would have 90% of sensitivity.

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Por otro lado, el análisis de regresión logística usando el valor continuo del Valor de Riesgo (VR) del test genómico de 40 genes demostró que cuanto más alto es el valor VR, mayor es la probabilidad de Respuesta patológica Completa (RCp) (Figura 1A). Como los pacientes que tienen altos valores de VR tienen peor pronóstico que los pacientes con valores bajos (Figura 1B), este resultado demuestra que los pacientes de mal pronóstico responderían mejor al tratamiento paclitaxel/fluorouracilo, adriamicina, ciclofosfamida (T/FAC). Además, los autores han desarrollado tres modelos usando regresión logística para predecir RCp basado en parámetros clínicos (estado del receptor de estrógenos, edad del paciente y grado tumoral) y bien el test genómico de 40 genes continuo o dicotomizado (Tabla 6). En el último caso, los pacientes fueron divididos en dos grupos (alto VR y bajo VR) basado en el test de 40 genes, usando un valor de VR umbral que muestra alta sensibilidad (90%) para predecir RCp, tal como se ha explicado en la sección de Materiales y Métodos. La figura 1C muestra las curvas operador-receptor (COR) para los distintos modelos predictivos. Los modelos que contienen el test genómico muestran mejor rendimiento (área bajo la curva ó ABC=0,897 ó 0,903) que el modelo clínico (ABC=0,871). La comparación estadística formal de las tres curvas ROC no demostró diferencias significativas entre las tres curvas. Sin embargo, los modelos que incluyen los datos genómicos tienen una sensibilidad substancialmente mayor (90%) comparado con el modelo clínico (70%) (Tabla 7). Además, la prueba de razón de verosimilitud para comparar entre el modelo clínico y los modelos completos demuestra que el test de 40 genes mejora de manera significativa el rendimiento de la predicción, tanto como variable continua como dicotomizada (Tabla 6).On the other hand, the regression analysis logistics using the continuous value of the Risk Value (VR) of the test Genomic of 40 genes showed that the higher the VR value, the greater the probability of complete pathological response (RCp) (Figure 1A). As patients who have high VR values have a worse prognosis than patients with low values (Figure 1B), this result shows that patients with poor prognosis would respond better to paclitaxel / fluorouracil treatment, Adriamycin, cyclophosphamide (T / FAC). In addition, the authors have developed three models using logistic regression to predict RCp based on clinical parameters (receptor status of estrogen, patient age and tumor grade) and well the test genomic of 40 genes continuous or dichotomized (Table 6). In the last case, the patients were divided into two groups (high VR and low VR) based on the 40 gene test, using a threshold VR value that shows high sensitivity (90%) to predict RCp, as it has been explained in the Materials and Methods section. Figure 1C shows the operator-receiver (COR) curves for Different predictive models. The models that contain the test genomic show better performance (area under the curve or ABC = 0.897 or 0.903) than the clinical model (ABC = 0.871). The comparison Formal statistics of the three ROC curves showed no differences significant between the three curves. However, the models that include genomic data have a sensitivity substantially higher (90%) compared to the clinical model (70%) (Table 7). In addition, the likelihood ratio test to compare between the clinical model and the complete models shows that the 40 gene test significantly improves the performance of the prediction, both as continuous and dichotomized variable (Table 6).

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TABLE 6 Análisis multivariado de regresión logística para la predicción de RCp tras quimioterapia neo adyuvanteMultivariate logistic regression analysis for prediction of RCp after neoadjuvant chemotherapy

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TABLE 7 Parámetros de rendimiento de los predictores clínicos y del test genómico de 40 genesPerformance parameters of clinical predictors and from the genomic test of 40 genes

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El modelo predictor completo exhibe mayor sensibilidad (90% frente a 70%) que un modelo basado en variables clínicas. El valor predictivo positivo (VPP) del modelo completo (56%; intervalo de confianza al 95%, 38% al 73%) indica que puede definir una población de pacientes que tiene más probabilidades de lograr RCp que la población general, ya que la tasa general observada de RCp es 26%, por debajo del límite inferior del intervalo de confianza del 95%. El valor predictivo negativo (VPN) del test también es alto (97%, intervalo de confianza al 95%, 89% al 99%), indicando que menos del 3% de los pacientes que testan negativo (predicho tener enfermedad residual) logran RCp. Estas estadísticas de rendimiento son similares, con respecto a VPN, y mejores con respecto a VPP, que aquellas vistas con inmunohistoquímica del receptor de estrógenos o con la amplificación génica del gen HER-2 como marcadores predictivos para terapias endocrina o de trastuzumab, respectivamente.The complete predictive model exhibits greater sensitivity (90% vs. 70%) than a model based on clinical variables. The positive predictive value (PPV) of the complete model (56%; 95% confidence interval, 38% to 73%) indicates that you can define a patient population that is more likely to achieve CRP than the general population, since the The overall observed rate of RCp is 26%, below the lower limit of the 95% confidence interval. The negative predictive value (NPV) of the test is also high (97%, 95% confidence interval, 89% to 99%), indicating that less than 3% of patients who test negative (predicted to have residual disease) achieve RCp . These performance statistics are similar, with respect to NPV, and better with respect to PPV, than those seen with estrogen receptor immunohistochemistry or with the gene amplification of the HER-2 gene as predictive markers for endocrine or trastuzumab therapies, respectively.

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<110> CENTRO DE INVESTIGACIONES ENERGÉTICAS MEDIOAMBIENTALES Y TECNOLÓGICAS<110> RESEARCH CENTER ENVIRONMENTAL AND TECHNOLOGICAL ENERGY

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<120> HUELLA GENÓMICA COMO PREDICTOR DE RESPUESTA A TRATAMIENTO<120> GENOMIC FOOTPRINT AS A PREDICTOR OF TREATMENT RESPONSE

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         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen TOP2A<223> Probe 11 for determining the TOP2A gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 11<400> 11

         \hskip1cm\ hskip1cm

twenty-one

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 12<210> 12

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen TOP2A-2<223> Probe 1 for determining the TOP2A-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 12<400> 12

         \hskip1cm\ hskip1cm

22

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 13<210> 13

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen TOP2A-2<223> Probe 2 for the determination of TOP2A-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 13<400> 13

         \hskip1cm\ hskip1cm

2. 3

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 14<210> 14

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen TOP2A-2<223> Probe 3 for determining the TOP2A-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 14<400> 14

         \hskip1cm\ hskip1cm

24

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 15<210> 15

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen TOP2A-2<223> Probe 4 for the determination of TOP2A-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 15<400> 15

         \hskip1cm\ hskip1cm

25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 16<210> 16

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen TOP2A-2<223> Probe 5 for determining the TOP2A-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 16<400> 16

         \hskip1cm\ hskip1cm

26

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 17<210> 17

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen TOP2A-2<223> Probe 6 for determining the TOP2A-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 17<400> 17

         \hskip1cm\ hskip1cm

27

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 18<210> 18

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen TOP2A-2<223> Probe 7 for determining the TOP2A-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 18<400> 18

         \hskip1cm\ hskip1cm

28

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 19<210> 19

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen TOP2A-2<223> Probe 8 for the determination of TOP2A-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 19<400> 19

         \hskip1cm\ hskip1cm

29

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 20<210> 20

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen TOP2A-2<223> Probe 9 for determining the TOP2A-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 20<400> 20

         \hskip1cm\ hskip1cm

30

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 21<210> 21

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen TOP2A-2<223> Probe 10 for determining the TOP2A-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 21<400> 21

         \hskip1cm\ hskip1cm

31

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 22<210> 22

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen TOP2A-2<223> Probe 11 for determining the TOP2A-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 22<400> 22

         \hskip1cm\ hskip1cm

32

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 23<210> 23

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen TOMM70A<223> Probe 1 for determining the TOMM70A gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 23<400> 23

         \hskip1cm\ hskip1cm

33

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 24<210> 24

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen TOMM7C1A<223> Probe 2 for the determination of TOMM7C1A gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 24<400> 24

         \hskip1cm\ hskip1cm

3. 4

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 25<210> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen TOMM7C1A<223> Probe 3 for determining the TOMM7C1A gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 25<400> 25

         \hskip1cm\ hskip1cm

35

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 26<210> 26

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen TOMM7C1A<223> Probe 4 for the determination of TOMM7C1A gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 26<400> 26

         \hskip1cm\ hskip1cm

36

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 27<210> 27

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen TOMM7C1A<223> Probe 5 for determining the TOMM7C1A gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 27<400> 27

         \hskip1cm\ hskip1cm

37

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 28<210> 28

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen TOMM70A<223> Probe 6 for determining the TOMM70A gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 28<400> 28

         \hskip1cm\ hskip1cm

38

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 29<210> 29

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen TOMM7C1A<223> Probe 7 for determining the TOMM7C1A gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 29<400> 29

         \hskip1cm\ hskip1cm

39

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 30<210> 30

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen TOMM70A<223> Probe 8 for the determination of TOMM70A gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 30<400> 30

         \hskip1cm\ hskip1cm

40

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 31<210> 31

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen TOMM70A<223> Probe 9 for determining the TOMM70A gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 31<400> 31

         \hskip1cm\ hskip1cm

41

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 32<210> 32

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen TOMM70A<223> Probe 10 for determining the TOMM70A gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 32<400> 32

         \hskip1cm\ hskip1cm

42

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 33<210> 33

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen TOMM70A<223> Probe 11 for determining the TOMM70A gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 33<400> 33

         \hskip1cm\ hskip1cm

43

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 34<210> 34

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen PLK1<223> Probe 1 for determining the PLK1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 34<400> 34

         \hskip1cm\ hskip1cm

44

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 35<210> 35

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen PLK1<223> Probe 2 for the determination of PLK1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 35<400> 35

         \hskip1cm\ hskip1cm

Four. Five

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 36<210> 36

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen PLK1<223> Probe 3 for determining the PLK1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 36<400> 36

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

46

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 37<210> 37

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen PLK1<223> Probe 4 for the determination of PLK1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 37<400> 37

         \hskip1cm\ hskip1cm

47

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 38<210> 38

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen PLK1<223> Probe 5 for determining the PLK1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 38<400> 38

         \hskip1cm\ hskip1cm

48

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 39<210> 39

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen PLK1<223> Probe 6 for determining the PLK1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 39<400> 39

         \hskip1cm\ hskip1cm

49

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 40<210> 40

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen PLK1<223> Probe 7 for determining the PLK1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 40<400> 40

         \hskip1cm\ hskip1cm

fifty

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 41<210> 41

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen PLK1<223> Probe 8 for the determination of PLK1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 41<400> 41

         \hskip1cm\ hskip1cm

51

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 42<210> 42

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen PLK1<223> Probe 9 for determining the PLK1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 42<400> 42

         \hskip1cm\ hskip1cm

52

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 43<210> 43

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen PLK1<223> Probe 10 for determining the PLK1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 43<400> 43

         \hskip1cm\ hskip1cm

53

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 44<210> 44

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen PLK1<223> Probe 11 for determining the PLK1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 44<400> 44

         \hskip1cm\ hskip1cm

54

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 45<210> 45

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen CCNB2<223> Probe 1 for determining the CCNB2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 45<400> 45

         \hskip1cm\ hskip1cm

55

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 46<210> 46

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen CCNB2<223> Probe 2 for the determination of CCNB2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 46<400> 46

         \hskip1cm\ hskip1cm

56

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 47<210> 47

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen CCNB2<223> Probe 3 for determining the CCNB2 gene expression

         \newpage\ newpage

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 47<400> 47

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

57

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 48<210> 48

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen CCNB2<223> Probe 4 for the determination of CCNB2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 48<400> 48

         \hskip1cm\ hskip1cm

58

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 49<210> 49

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen CCNB2<223> Probe 5 for determining the CCNB2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 49<400> 49

         \hskip1cm\ hskip1cm

59

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 50<210> 50

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen CCNB2<223> Probe 6 for determining the CCNB2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 50<400> 50

         \hskip1cm\ hskip1cm

60

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 51<210> 51

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen CCNB2<223> Probe 7 for determining the CCNB2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 51<400> 51

         \hskip1cm\ hskip1cm

61

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 52<210> 52

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \newpage\ newpage

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen CCNB2<223> Probe 8 for the determination of CCNB2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 52<400> 52

         \hskip1cm\ hskip1cm

62

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 53<210> 53

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen CCNB2<223> Probe 9 for determining the CCNB2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 53<400> 53

         \hskip1cm\ hskip1cm

63

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 54<210> 54

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen CCNB2<223> Probe 10 for determining the CCNB2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 54<400> 54

         \hskip1cm\ hskip1cm

64

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 55<210> 55

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen CCNB2<223> Probe 11 for determining the CCNB2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 55<400> 55

         \hskip1cm\ hskip1cm

65

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 56<210> 56

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen UBEC2C<223> Probe 1 for determining the UBEC2C gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 56<400> 56

         \hskip1cm\ hskip1cm

66

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 57<210> 57

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen UBEC2C<223> Probe 2 for the determination of UBEC2C gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 57<400> 57

         \hskip1cm\ hskip1cm

67

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 58<210> 58

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen UBEC2C<223> Probe 3 for determining the UBEC2C gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 58<400> 58

         \hskip1cm\ hskip1cm

68

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 59<210> 59

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen UBEC2C<223> Probe 4 for the determination of UBEC2C gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 59<400> 59

         \hskip1cm\ hskip1cm

69

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 60<210> 60

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen UBEC2C<223> Probe 5 for determining the UBEC2C gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 60<400> 60

         \hskip1cm\ hskip1cm

70

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 61<210> 61

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen UBEC2C<223> Probe 6 for determining the UBEC2C gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 61<400> 61

         \hskip1cm\ hskip1cm

71

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 62<210> 62

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen UBEC2C<223> Probe 7 for determining the UBEC2C gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 62<400> 62

         \hskip1cm\ hskip1cm

72

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 63<210> 63

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen UBEC2C<223> Probe 8 for the determination of UBEC2C gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 63<400> 63

         \hskip1cm\ hskip1cm

73

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 64<210> 64

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen UBEC2C<223> Probe 9 for determining the UBEC2C gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 64<400> 64

         \hskip1cm\ hskip1cm

74

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 65<210> 65

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen UBEC2C<223> Probe 10 for determining the UBEC2C gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 65<400> 65

         \hskip1cm\ hskip1cm

75

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 66<210> 66

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen UBEC2C<223> Probe 11 for determining the UBEC2C gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 66<400> 66

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

76

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 67<210> 67

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen SPAG5<223> Probe 1 for determining the SPAG5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 67<400> 67

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

77

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 68<210> 68

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen SPAG5<223> Probe 2 for the determination of SPAG5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 68<400> 68

         \hskip1cm\ hskip1cm

78

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 69<210> 69

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen SPAG5<223> Probe 3 for determining the SPAG5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 69<400> 69

         \hskip1cm\ hskip1cm

79

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 70<210> 70

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen SPAG5<223> Probe 4 for the determination of SPAG5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 70<400> 70

         \hskip1cm\ hskip1cm

80

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 71<210> 71

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen SPAG5<223> Probe 5 for determining the SPAG5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 71<400> 71

         \hskip1cm\ hskip1cm

81

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 72<210> 72

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen SPAG5<223> Probe 6 for determining the SPAG5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 72<400> 72

         \hskip1cm\ hskip1cm

82

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 73<210> 73

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen SPAG5<223> Probe 7 for determining the SPAG5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 73<400> 73

         \hskip1cm\ hskip1cm

83

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 74<210> 74

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen SPAG5<223> Probe 8 for the determination of SPAG5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 74<400> 74

         \hskip1cm\ hskip1cm

84

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 75<210> 75

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen SPAG5<223> Probe 9 for determining the SPAG5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 75<400> 75

         \hskip1cm\ hskip1cm

85

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 76<210> 76

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen SPAG5<223> Probe 10 for determining the SPAG5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 76<400> 76

         \hskip1cm\ hskip1cm

86

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 77<210> 77

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen SPAG5<223> Probe 11 for determining the SPAG5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 77<400> 77

         \hskip1cm\ hskip1cm

87

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 78<210> 78

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen CDC2<223> Probe 1 for determining the CDC2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 78<400> 78

         \hskip1cm\ hskip1cm

88

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 79<210> 79

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen CDC2<223> Probe 2 for the determination of CDC2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 79<400> 79

         \hskip1cm\ hskip1cm

89

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 80<210> 80

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen CDC2<223> Probe 3 for determining the CDC2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 80<400> 80

         \hskip1cm\ hskip1cm

90

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 81<210> 81

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen CDC2<223> Probe 4 for the determination of CDC2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 81<400> 81

         \hskip1cm\ hskip1cm

91

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 82<210> 82

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen CDC2<223> Probe 5 for determining the CDC2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 82<400> 82

         \hskip1cm\ hskip1cm

92

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 83<210> 83

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen CDC2<223> Probe 6 for determining the CDC2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 83<400> 83

         \hskip1cm\ hskip1cm

93

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 84<210> 84

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen CDC2<223> Probe 7 for determining the CDC2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 84<400> 84

         \hskip1cm\ hskip1cm

94

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 85<210> 85

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen CDC2<223> Probe 8 for the determination of CDC2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 85<400> 85

         \hskip1cm\ hskip1cm

95

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 86<210> 86

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen CDC2<223> Probe 9 for determining the CDC2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 86<400> 86

         \hskip1cm\ hskip1cm

96

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 87<210> 87

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen CDC2<223> Probe 10 for determining the CDC2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 87<400> 87

         \hskip1cm\ hskip1cm

97

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 88<210> 88

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen CDC2<223> Probe 11 for determining the CDC2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 88<400> 88

         \hskip1cm\ hskip1cm

98

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 89<210> 89

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen CDC2-2<223> Probe 1 for determining the CDC2-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 89<400> 89

         \hskip1cm\ hskip1cm

99

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 90<210> 90

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen CDC2-2<223> Probe 2 for the determination of CDC2-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 90<400> 90

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

100

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 91<210> 91

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen CDC2-2<223> Probe 3 for determining the CDC2-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 91<400> 91

         \hskip1cm\ hskip1cm

101

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 92<210> 92

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen CDC2-2<223> Probe 4 for the determination of CDC2-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 92<400> 92

         \hskip1cm\ hskip1cm

102

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 93<210> 93

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen CDC2-2<223> Probe 5 for determining the CDC2-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 93<400> 93

         \hskip1cm\ hskip1cm

103

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 94<210> 94

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen CDC2-2<223> Probe 6 for determining the CDC2-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 94<400> 94

         \hskip1cm\ hskip1cm

104

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 95<210> 95

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen CDC2-2<223> Probe 7 for determining the CDC2-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 95<400> 95

         \hskip1cm\ hskip1cm

105

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 96<210> 96

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen CDC2-2<223> Probe 8 for the determination of CDC2-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 96<400> 96

         \hskip1cm\ hskip1cm

106

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 97<210> 97

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen CDC2-2<223> Probe 9 for determining the CDC2-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 97<400> 97

         \hskip1cm\ hskip1cm

107

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 98<210> 98

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen CDC2-2<223> Probe 10 for determining the CDC2-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 98<400> 98

         \hskip1cm\ hskip1cm

108

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 99<210> 99

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen CDC2-2<223> Probe 11 for determining the CDC2-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 99<400> 99

         \hskip1cm\ hskip1cm

109

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 100<210> 100

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen MAD2L1<223> Probe 1 for determining the MAD2L1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 100<400> 100

         \hskip1cm\ hskip1cm

110

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 101<210> 101

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen MAD2L1<223> Probe 2 for the determination of MAD2L1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 101<400> 101

         \hskip1cm\ hskip1cm

111

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 102<210> 102

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen MAD2L1<223> Probe 3 for determining the MAD2L1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 102<400> 102

         \hskip1cm\ hskip1cm

112

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 103<210> 103

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen MAD2L1<223> Probe 4 for the determination of MAD2L1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 103<400> 103

         \hskip1cm\ hskip1cm

113

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 104<210> 104

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen MAD2L1<223> Probe 5 for determining the MAD2L1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 104<400> 104

         \hskip1cm\ hskip1cm

114

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 105<210> 105

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen MAD2L1<223> Probe 6 for determining the MAD2L1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 105<400> 105

         \hskip1cm\ hskip1cm

115

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 106<210> 106

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen MAD2L1<223> Probe 7 for determining the MAD2L1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 106<400> 106

         \hskip1cm\ hskip1cm

116

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 107<210> 107

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen MAD2L1<223> Probe 8 for the determination of MAD2L1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 107<400> 107

         \hskip1cm\ hskip1cm

117

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 108<210> 108

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen MAD2L1<223> Probe 9 for determining the MAD2L1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 108<400> 108

         \hskip1cm\ hskip1cm

118

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 109<210> 109

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen MAD2L1<223> Probe 10 for determining the MAD2L1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 109<400> 109

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

119

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 110<210> 110

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen MAD2L1<223> Probe 11 for determining the MAD2L1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 110<400> 110

         \hskip1cm\ hskip1cm

120

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 111<210> 111

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen BUB1B<223> Probe 1 for determining the BUB1B gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 111<400> 111

         \hskip1cm\ hskip1cm

121

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 112<210> 112

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen BUB1B<223> Probe 2 for the determination of BUB1B gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 112<400> 112

         \hskip1cm\ hskip1cm

122

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 113<210> 113

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen BUB1B<223> Probe 3 for determining the BUB1B gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 113<400> 113

         \hskip1cm\ hskip1cm

123

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 114<210> 114

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen BUB1B<223> Probe 4 for the determination of BUB1B gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 114<400> 114

         \hskip1cm\ hskip1cm

124

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 115<210> 115

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen BUB1B<223> Probe 5 for determining the BUB1B gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 115<400> 115

         \hskip1cm\ hskip1cm

125

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 116<210> 116

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen BUB1B<223> Probe 6 for determining the BUB1B gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 116<400> 116

         \hskip1cm\ hskip1cm

126

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 117<210> 117

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen BUB1B<223> Probe 7 for determining the BUB1B gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 117<400> 117

         \hskip1cm\ hskip1cm

127

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 118<210> 118

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen BUB1B<223> Probe 8 for the determination of BUB1B gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 118<400> 118

         \hskip1cm\ hskip1cm

128

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 119<210> 119

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen BUB1B<223> Probe 9 for determining the BUB1B gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 119<400> 119

         \hskip1cm\ hskip1cm

129

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 120<210> 120

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen BUB1B<223> Probe 10 for determining the BUB1B gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 120<400> 120

         \hskip1cm\ hskip1cm

130

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 121<210> 121

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen BUB1B<223> Probe 11 for determining the BUB1B gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 121<400> 121

         \hskip1cm\ hskip1cm

131

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 122<210> 122

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen TRIP13<223> Probe 1 for determining the TRIP13 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 122<400> 122

         \hskip1cm\ hskip1cm

132

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 123<210> 123

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen TRIP13<223> Probe 2 for the determination of TRIP13 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 123<400> 123

         \hskip1cm\ hskip1cm

133

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 124<210> 124

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen TRIP13<223> Probe 3 for determining the TRIP13 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 124<400> 124

         \hskip1cm\ hskip1cm

134

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 125<210> 125

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen TRIP13<223> Probe 4 for the determination of TRIP13 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 125<400> 125

         \hskip1cm\ hskip1cm

135

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 126<210> 126

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen TRIP13<223> Probe 5 for determining the TRIP13 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 126<400> 126

         \hskip1cm\ hskip1cm

136

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 127<210> 127

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen TRIP13<223> Probe 6 for determining the TRIP13 gene expression

         \newpage\ newpage

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 127<400> 127

         \hskip1cm\ hskip1cm

137

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 128<210> 128

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen TRIP13<223> Probe 7 for determining the TRIP13 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 128<400> 128

         \hskip1cm\ hskip1cm

138

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 129<210> 129

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen TRIP13<223> Probe 8 for the determination of TRIP13 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 129<400> 129

         \hskip1cm\ hskip1cm

139

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 130<210> 130

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen TRIP13<223> Probe 9 for determining the TRIP13 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 130<400> 130

         \hskip1cm\ hskip1cm

140

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 131<210> 131

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen TRIP13<223> Probe 10 for determining the TRIP13 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 131<400> 131

         \hskip1cm\ hskip1cm

141

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 132<210> 132

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen TRIP13<223> Probe 11 for determining the TRIP13 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 132<400> 132

         \hskip1cm\ hskip1cm

142

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 133<210> 133

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen AURKA<223> Probe 1 for determining the AURKA gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 133<400> 133

         \hskip1cm\ hskip1cm

143

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 134<210> 134

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen AURKA<223> Probe 2 for the determination of AURKA gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 134<400> 134

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

144

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 135<210> 135

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen AURKA<223> Probe 3 for determining the AURKA gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 135<400> 135

         \hskip1cm\ hskip1cm

145

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 136<210> 136

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen AURKA<223> Probe 4 for the determination of AURKA gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 136<400> 136

         \hskip1cm\ hskip1cm

146

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 137<210> 137

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen AURKA<223> Probe 5 for determining the AURKA gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 137<400> 137

         \hskip1cm\ hskip1cm

147

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 138<210> 138

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen AURKA<223> Probe 6 for determining the AURKA gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 138<400> 138

         \hskip1cm\ hskip1cm

148

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 139<210> 139

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen AURKA<223> Probe 7 for determining the AURKA gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 139<400> 139

         \hskip1cm\ hskip1cm

149

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 140<210> 140

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen AURKA<223> Probe 8 for the determination of AURKA gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 140<400> 140

         \hskip1cm\ hskip1cm

150

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 141<210> 141

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen AURKA<223> Probe 9 for determining the AURKA gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 141<400> 141

         \hskip1cm\ hskip1cm

151

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 142<210> 142

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen AURKA<223> Probe 10 for determining the AURKA gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 142<400> 142

         \hskip1cm\ hskip1cm

152

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 143<210> 143

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen AURKA<223> Probe 11 for determining the AURKA gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 143<400> 143

         \hskip1cm\ hskip1cm

153

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 144<210> 144

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen KIF11<223> Probe 1 for determining the KIF11 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 144<400> 144

\hskip1cm

154%

 \ hskip1cm

154 %

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 145<210> 145

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen KIF11<223> Probe 2 for the determination of KIF11 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 145<400> 145

         \hskip1cm\ hskip1cm

155

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 146<210> 146

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen KIF11<223> Probe 3 for determining the KIF11 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 146<400> 146

         \hskip1cm\ hskip1cm

156

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 147<210> 147

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen KIF11<223> Probe 4 for the determination of KIF11 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 147<400> 147

         \hskip1cm\ hskip1cm

157

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 148<210> 148

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen KIF11<223> Probe 5 for determining the KIF11 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 148<400> 148

         \hskip1cm\ hskip1cm

158

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 149<210> 149

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen KIF11<223> Probe 6 for determining the KIF11 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 149<400> 149

         \hskip1cm\ hskip1cm

159

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 150<210> 150

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen KIF11<223> Probe 7 for determining the KIF11 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 150<400> 150

         \hskip1cm\ hskip1cm

160

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 151<210> 151

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen KIF11<223> Probe 8 for the determination of KIF11 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 151<400> 151

         \hskip1cm\ hskip1cm

161

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 155<210> 155

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen KIF11<223> Probe 9 for determining the KIF11 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 152<400> 152

         \hskip1cm\ hskip1cm

162

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 153<210> 153

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen KIF11<223> Probe 10 for determining the KIF11 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 153<400> 153

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

163

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 154<210> 154

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen KIF11<223> Probe 11 for determining the KIF11 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 154<400> 154

         \hskip1cm\ hskip1cm

164

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 155<210> 155

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen BRCA1<223> Probe 1 for determining the BRCA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 155<400> 155

         \hskip1cm\ hskip1cm

166

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 156<210> 156

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen BRCA1<223> Probe 2 for the determination of BRCA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 156<400> 156

         \hskip1cm\ hskip1cm

167

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 157<210> 157

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen BRCA1<223> Probe 3 for determining the BRCA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 157<400> 157

         \hskip1cm\ hskip1cm

168

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 158<210> 158

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen BRCA1<223> Probe 4 for the determination of BRCA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 158<400> 158

         \hskip1cm\ hskip1cm

169

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 159<210> 159

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen BRCA1<223> Probe 5 for determining the BRCA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 159<400> 159

         \hskip1cm\ hskip1cm

170

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 160<210> 160

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen BRCA1<223> Probe 6 for determining the BRCA1 gene expression

         \newpage\ newpage

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 160<400> 160

         \hskip1cm\ hskip1cm

171

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 161<210> 161

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen BRCA1<223> Probe 7 for determining the BRCA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 161<400> 161

         \hskip1cm\ hskip1cm

172

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 162<210> 162

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen BRCA1<223> Probe 8 for the determination of BRCA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 162<400> 162

         \hskip1cm\ hskip1cm

173

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 163<210> 163

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen BRCA1<223> Probe 9 for determining the BRCA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 163<400> 163

         \hskip1cm\ hskip1cm

174

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 164<210> 164

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen BRCA1<223> Probe 10 for determining the BRCA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 164<400> 164

         \hskip1cm\ hskip1cm

175

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 165<210> 165

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen BRCA1<223> Probe 11 for determining the BRCA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 165<400> 165

         \hskip1cm\ hskip1cm

176

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 166<210> 166

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen HMMR<223> Probe 1 for determining the HMMR gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 166<400> 166

         \hskip1cm\ hskip1cm

177

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 167<210> 167

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen HMMR<223> Probe 2 for the determination of HMMR gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 167<400> 167

         \hskip1cm\ hskip1cm

178

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 168<210> 168

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen HMMR<223> Probe 3 for determining the HMMR gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 168<400> 168

         \hskip1cm\ hskip1cm

179

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 169<210> 169

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen HMMR<223> Probe 4 for the determination of HMMR gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 169<400> 169

         \hskip1cm\ hskip1cm

180

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 170<210> 170

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen HMMR<223> Probe 5 for determining the HMMR gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 170<400> 170

         \hskip1cm\ hskip1cm

181

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 171<210> 171

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen HMMR<223> Probe 6 for determining the HMMR gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 171<400> 171

         \hskip1cm\ hskip1cm

182

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 172<210> 172

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen HMMR<223> Probe 7 for determining the HMMR gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 172<400> 172

         \hskip1cm\ hskip1cm

183

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 173<210> 173

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen HMMR<223> Probe 8 for the determination of HMMR gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 173<400> 173

         \hskip1cm\ hskip1cm

184

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 174<210> 174

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen HMMR<223> Probe 9 for determining the HMMR gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 174<400> 174

         \hskip1cm\ hskip1cm

185

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 175<210> 175

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen HMMR<223> Probe 10 for determining the HMMR gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 175<400> 175

         \hskip1cm\ hskip1cm

186

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 176<210> 176

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen HMMR<223> Probe 11 for determining the HMMR gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 176<400> 176

         \hskip1cm\ hskip1cm

187

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 177<210> 177

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen CIAPIN1<223> Probe 1 for determining the CIAPIN1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 177<400> 177

         \hskip1cm\ hskip1cm

188

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 178<210> 178

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen CIAPIN1<223> Probe 2 for the determination of CIAPIN1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 178<400> 178

         \hskip1cm\ hskip1cm

189

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 179<210> 179

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen CIAPIN1<223> Probe 3 for determining the CIAPIN1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 179<400> 179

         \hskip1cm\ hskip1cm

190

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 180<210> 180

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen CIAPIN1<223> Probe 4 for the determination of CIAPIN1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 180<400> 180

         \hskip1cm\ hskip1cm

191

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 181<210> 181

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen CIAPIN1<223> Probe 5 for determining the CIAPIN1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 181<400> 181

         \hskip1cm\ hskip1cm

192

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 182<210> 182

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen CIAPIN1<223> Probe 6 for determining the CIAPIN1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 182<400> 182

         \hskip1cm\ hskip1cm

193

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 183<210> 183

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen CIAPIN1<223> Probe 7 for determining the CIAPIN1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 183<400> 183

         \hskip1cm\ hskip1cm

194

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 184<210> 184

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen CIAPIN1<223> Probe 8 for the determination of CIAPIN1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 184<400> 184

         \hskip1cm\ hskip1cm

195

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 185<210> 185

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen CIAPIN1<223> Probe 9 for determining the CIAPIN1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 185<400> 185

         \hskip1cm\ hskip1cm

196

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 186<210> 186

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen CIAPIN1<223> Probe 10 for determining the CIAPIN1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 186<400> 186

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

197

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 187<210> 187

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen CIAPIN1<223> Probe 11 for determining the CIAPIN1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 187<400> 187

         \hskip1cm\ hskip1cm

198

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 188<210> 188

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen LRP8<223> Probe 1 for determining the LRP8 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 188<400> 188

         \hskip1cm\ hskip1cm

199

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 189<210> 189

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen LRP8<223> Probe 2 for the determination of LRP8 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 189<400> 189

         \hskip1cm\ hskip1cm

200

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 190<210> 190

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen LRP8<223> Probe 3 for determining the LRP8 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 190<400> 190

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

201

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 191<210> 191

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen LRP8<223> Probe 4 for the determination of LRP8 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 191<400> 191

         \hskip1cm\ hskip1cm

202

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 192<210> 192

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen LRP8<223> Probe 5 for determining the LRP8 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 192<400> 192

         \hskip1cm\ hskip1cm

203

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 193<210> 193

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen LRP8<223> Probe 6 for determining the LRP8 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 193<400> 193

         \hskip1cm\ hskip1cm

204

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 194<210> 194

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen LRP8<223> Probe 7 for determining the LRP8 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 194<400> 194

         \hskip1cm\ hskip1cm

205

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 195<210> 195

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen LRP8<223> Probe 8 for the determination of LRP8 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 195<400> 195

         \hskip1cm\ hskip1cm

206

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 196<210> 196

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen LRP8<223> Probe 9 for determining the LRP8 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 196<400> 196

         \hskip1cm\ hskip1cm

207

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 197<210> 197

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen LRP8<223> Probe 10 for determining the LRP8 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 197<400> 197

         \hskip1cm\ hskip1cm

208

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 198<210> 198

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen LRP8<223> Probe 11 for determining the LRP8 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 198<400> 198

         \hskip1cm\ hskip1cm

209

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 199<210> 199

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen CIAPIN1-2<223> Probe 1 for determining the CIAPIN1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 199<400> 199

         \hskip1cm\ hskip1cm

210

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 200<210> 200

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Son 2 para la determinación de la expresión del gen CIAPIN1-2<223> There are 2 for the determination of the CIAPIN1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 200<400> 200

         \hskip1cm\ hskip1cm

211

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 201<210> 201

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen CIAPIN1-2<223> Probe 3 for determining the CIAPIN1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 201<400> 201

         \hskip1cm\ hskip1cm

212

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 202<210> 202

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen CIAPIN1-2<223> Probe 4 for the determination of CIAPIN1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 202<400> 202

         \hskip1cm\ hskip1cm

213

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 203<210> 203

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen CIAPIN1-2<223> Probe 5 for determining the CIAPIN1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 203<400> 203

         \hskip1cm\ hskip1cm

214

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 204<210> 204

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen CIAPIN1-2<223> Probe 6 for determining the CIAPIN1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 204<400> 204

         \hskip1cm\ hskip1cm

215

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 205<210> 205

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen CIAPIN1-2<223> Probe 7 for determining the CIAPIN1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 205<400> 205

         \hskip1cm\ hskip1cm

216

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 206<210> 206

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen CIAPIN1-2<223> Probe 8 for the determination of CIAPIN1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 206<400> 206

         \hskip1cm\ hskip1cm

217

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 207<210> 207

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen CIAPIN1-2<223> Probe 9 for determining the CIAPIN1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 207<400> 207

         \hskip1cm\ hskip1cm

218

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 208<210> 208

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen CIAPIN1-2<223> Probe 10 for determining the CIAPIN1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 208<400> 208

         \hskip1cm\ hskip1cm

219

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 209<210> 209

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen CIAPIN1-2<223> Probe 11 for determining the CIAPIN1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 209<400> 209

         \hskip1cm\ hskip1cm

220

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 210<210> 210

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen AURKB<223> Probe 1 for determining the AURKB gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 210<400> 210

         \hskip1cm\ hskip1cm

221

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 211<210> 211

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen AURKB<223> Probe 2 for the determination of AURKB gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 211<400> 211

         \hskip1cm\ hskip1cm

222

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 212<210> 212

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen AURKB<223> Probe 3 for determining the AURKB gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 212<400> 212

         \hskip1cm\ hskip1cm

223

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 213<210> 213

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen AURKB<223> Probe 4 for the determination of AURKB gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 213<400> 213

         \hskip1cm\ hskip1cm

224

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 214<210> 214

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen AURKB<223> Probe 5 for determining the AURKB gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 214<400> 214

         \hskip1cm\ hskip1cm

225

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 215<210> 215

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen AURKB<223> Probe 6 for determining the AURKB gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 215<400> 215

         \hskip1cm\ hskip1cm

226

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 216<210> 216

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen AURKB<223> Probe 7 for determining the AURKB gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 216<400> 216

         \hskip1cm\ hskip1cm

227

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 217<210> 217

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen AURKB<223> Probe 8 for the determination of AURKB gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 217<400> 217

         \hskip1cm\ hskip1cm

228

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 218<210> 218

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen AURKB<223> Probe 9 for determining the AURKB gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 218<400> 218

         \hskip1cm\ hskip1cm

229

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 219<210> 219

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen AURKB<223> Probe 10 for determining the AURKB gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 219<400> 219

         \hskip1cm\ hskip1cm

230

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 220<210> 220

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen AURKB<223> Probe 11 for determining the AURKB gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 220<400> 220

         \hskip1cm\ hskip1cm

231

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 221<210> 221

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen HMMR-2<223> Probe 1 for determining the HMMR-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 221<400> 221

         \hskip1cm\ hskip1cm

232

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 222<210> 222

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen HMMR-2<223> Probe 2 for the determination of HMMR-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 222<400> 222

         \hskip1cm\ hskip1cm

233

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 223<210> 223

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen HMMR-2<223> Probe 3 for determining the HMMR-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 223<400> 223

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

2. 3. 4

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 224<210> 224

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen HMMR-2<223> Probe 4 for the determination of HMMR-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 224<400> 224

         \hskip1cm\ hskip1cm

235

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 225<210> 225

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen HMMR-2<223> Probe 5 for determining the HMMR-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 225<400> 225

         \hskip1cm\ hskip1cm

236

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 226<210> 226

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen HMMR-2<223> Probe 6 for determining the HMMR-2 gene expression

         \newpage\ newpage

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 226<400> 226

         \hskip1cm\ hskip1cm

237

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 227<210> 227

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen HMMR-2<223> Probe 7 for determining the HMMR-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 227<400> 227

         \hskip1cm\ hskip1cm

238

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 228<210> 228

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen HMMR-2<223> Probe 8 for the determination of HMMR-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 228<400> 228

         \hskip1cm\ hskip1cm

239

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 229<210> 229

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen HMMR-2<223> Probe 9 for determining the HMMR-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 229<400> 229

         \hskip1cm\ hskip1cm

240

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 230<210> 230

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen HMMR-2<223> Probe 10 for determining the HMMR-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 230<400> 230

         \hskip1cm\ hskip1cm

241

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 231<210> 231

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen HMMR-2<223> Probe 11 for determining the HMMR-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 231<400> 231

         \hskip1cm\ hskip1cm

242

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 232<210> 232

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen CDKN3<223> Probe 1 for determining the CDKN3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 232<400> 232

         \hskip1cm\ hskip1cm

243

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 233<210> 233

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen CDKN3<223> Probe 2 for the determination of CDKN3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 233<400> 233

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

244

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 234<210> 234

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen CDKN3<223> Probe 3 for determining the CDKN3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 234<400> 234

         \hskip1cm\ hskip1cm

245

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 235<210> 235

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen CDKN3<223> Probe 4 for the determination of CDKN3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 235<400> 235

         \hskip1cm\ hskip1cm

246

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 236<210> 236

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen CDKN3<223> Probe 5 for determining the CDKN3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 236<400> 236

         \hskip1cm\ hskip1cm

247

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 237<210> 237

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen CDKN3<223> Probe 6 for determining the CDKN3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 237<400> 237

         \hskip1cm\ hskip1cm

248

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 238<210> 238

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen DCKN3<223> Probe 7 for determining the DCKN3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 238<400> 238

         \hskip1cm\ hskip1cm

249

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 239<210> 239

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen CDKN3<223> Probe 8 for the determination of CDKN3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 239<400> 239

         \hskip1cm\ hskip1cm

250

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 240<210> 240

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen CDKN3<223> Probe 9 for determining the CDKN3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 240<400> 240

         \hskip1cm\ hskip1cm

251

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 241<210> 241

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen CDKN3<223> Probe 10 for determining the CDKN3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 241<400> 241

         \hskip1cm\ hskip1cm

252

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 242<210> 242

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen CDKN3<223> Probe 11 for determining the CDKN3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 242<400> 242

         \hskip1cm\ hskip1cm

253

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 243<210> 243

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen HSP90AA1<223> Probe 1 for determining the HSP90AA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 243<400> 243

         \hskip1cm\ hskip1cm

254

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 244<210> 244

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen HSP90AA1<223> Probe 2 for the determination of HSP90AA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 244<400> 244

         \hskip1cm\ hskip1cm

255

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 245<210> 245

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen HSP90AA1<223> Probe 3 for determining the HSP90AA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 245<400> 245

         \hskip1cm\ hskip1cm

256

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 246<210> 246

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen HSP90AA1<223> Probe 4 for the determination of HSP90AA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 246<400> 246

         \hskip1cm\ hskip1cm

257

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 247<210> 247

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen HSP90AA1<223> Probe 5 for determining the HSP90AA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 247<400> 247

         \hskip1cm\ hskip1cm

258

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 248<210> 248

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223>Sonda 6 para la determinación de la expresión del gen HSP90AA1<223> Probe 6 for determining the HSP90AA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 248<400> 248

         \hskip1cm\ hskip1cm

259

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 249<210> 249

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen HSP90AA1<223> Probe 7 for determining the HSP90AA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 249<400> 249

         \hskip1cm\ hskip1cm

260

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 250<210> 250

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen HSP90AA1<223> Probe 8 for the determination of HSP90AA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 250<400> 250

         \hskip1cm\ hskip1cm

261

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 251<210> 251

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen HSP90AA1<223> Probe 9 for determining the HSP90AA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 251<400> 251

         \hskip1cm\ hskip1cm

262

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 252<210> 252

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen HSP90AA1<223> Probe 10 for determining the HSP90AA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 252<400> 252

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

263

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 253<210> 253

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen HSP90AA1<223> Probe 11 for determining the HSP90AA1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 253<400> 253

         \hskip1cm\ hskip1cm

264

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 254<210> 254

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen BRCA1-2<223> Probe 1 for determining the BRCA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 254<400> 254

         \hskip1cm\ hskip1cm

265

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 255<210> 255

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen BRCA1-2<223> Probe 2 for the determination of BRCA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 255<400> 255

         \hskip1cm\ hskip1cm

266

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 256<210> 256

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen BRCA1-2<223> Probe 3 for determining the BRCA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 256<400> 256

         \hskip1cm\ hskip1cm

267

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 257<210> 257

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220> Sonda 4 para la determinación de la expresión del gen BRCA1-2<220> Probe 4 for the determination of BRCA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 257<400> 257

         \hskip1cm\ hskip1cm

268

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 258<210> 258

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen BRCA1-2<223> Probe 5 for determining the BRCA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 258<400> 258

         \hskip1cm\ hskip1cm

269

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 259<210> 259

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen BRCA1-2<223> Probe 6 for determining the BRCA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 259<400> 259

         \hskip1cm\ hskip1cm

270

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 260<210> 260

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen BRCA1-2<223> Probe 7 for determining the BRCA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 260<400> 260

         \hskip1cm\ hskip1cm

271

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 261<210> 261

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen BRCA1-2<223> Probe 8 for the determination of BRCA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 261<400> 261

         \hskip1cm\ hskip1cm

272

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 262<210> 262

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen BRCA1-2<223> Probe 9 for determining the BRCA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 262<400> 262

         \hskip1cm\ hskip1cm

273

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 263<210> 263

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen BRCA1-2<223> Probe 10 for determining the BRCA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 263<400> 263

         \hskip1cm\ hskip1cm

274

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 264<210> 264

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen BRCA1-2<223> Probe 11 for determining the BRCA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 264<400> 264

         \hskip1cm\ hskip1cm

275

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 265<210> 265

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen HSP90AA1-2<223> Probe 1 for determining the HSP90AA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 265<400> 265

         \hskip1cm\ hskip1cm

276

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 266<210> 266

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen HSP90AA1-2<223> Probe 2 for the determination of HSP90AA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 266<400> 266

         \hskip1cm\ hskip1cm

277

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 267<210> 267

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen HSP90AA1-2<223> Probe 3 for determining the HSP90AA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 267<400> 267

         \hskip1cm\ hskip1cm

278

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 268<210> 268

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen HSP90AA1-2<223> Probe 4 for the determination of HSP90AA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 268<400> 268

         \hskip1cm\ hskip1cm

279

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 269<210> 269

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \newpage\ newpage

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen HSP90AA1-2<223> Probe 5 for determining the HSP90AA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 269<400> 269

         \hskip1cm\ hskip1cm

280

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 270<210> 270

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen HSP90AA1-2<223> Probe 6 for determining the HSP90AA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 270<400> 270

         \hskip1cm\ hskip1cm

281

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 271<210> 271

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen HSP90AA1-2<223> Probe 7 for determining the HSP90AA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 271<400> 271

         \hskip1cm\ hskip1cm

282

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 272<210> 272

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen HSP90AA1-2<223> Probe 8 for the determination of HSP90AA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 272<400> 272

         \hskip1cm\ hskip1cm

283

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 273<210> 273

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen HSP90AA1-2<223> Probe 9 for determining the HSP90AA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 273<400> 273

         \hskip1cm\ hskip1cm

284

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 274<210> 274

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen HSP90AA1-2<223> Probe 10 for determining the HSP90AA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 274<400> 274

         \hskip1cm\ hskip1cm

285

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 275<210> 275

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen HSP90AA1-2<223> Probe 11 for determining the HSP90AA1-2 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 275<400> 275

         \hskip1cm\ hskip1cm

286

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 276<210> 276

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen HSP90AA1-3<223> Probe 1 for determining the HSP90AA1-3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 276<400> 276

         \hskip1cm\ hskip1cm

287

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 277<210> 277

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen HSP90AA1-3<223> Probe 2 for the determination of HSP90AA1-3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 277<400> 277

         \hskip1cm\ hskip1cm

288

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 278<210> 278

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen HSP90AA1-3<223> Probe 3 for determining the HSP90AA1-3 gene expression

         \newpage\ newpage

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 278<400> 278

         \hskip1cm\ hskip1cm

289

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 279<210> 279

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen HSP90AA1-3<223> Probe 4 for the determination of HSP90AA1-3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 279<400> 279

         \hskip1cm\ hskip1cm

290

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 280<210> 280

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen HSP90AA1-3<223> Probe 5 for determining the HSP90AA1-3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 280<400> 280

         \hskip1cm\ hskip1cm

291

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 281<210> 281

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen HSP90AA1-3<223> Probe 6 for determining the HSP90AA1-3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 281<400> 281

         \hskip1cm\ hskip1cm

292

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 282<210> 282

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen HSP90AA1-3<223> Probe 7 for determining the HSP90AA1-3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 282<400> 282

         \hskip1cm\ hskip1cm

293

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 283<210> 283

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen HSP90AA1-3<223> Probe 8 for the determination of HSP90AA1-3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 283<400> 283

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

294

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 284<210> 284

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen HSP90AA1-3<223> Probe 9 for determining the HSP90AA1-3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 284<400> 284

         \hskip1cm\ hskip1cm

295

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 285<210> 285

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen HSP90AA1-3<223> Probe 10 for determining the HSP90AA1-3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 285<400> 285

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

296

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 286<210> 286

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen HSP90AA1-3<223> Probe 11 for determining the HSP90AA1-3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 286<400> 286

         \hskip1cm\ hskip1cm

297

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 287<210> 287

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen HSP90AA1-4<223> Probe 1 for determining the HSP90AA1-4 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 287<400> 287

         \hskip1cm\ hskip1cm

298

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 288<210> 288

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen HSP90AA1-4<223> Probe 2 for the determination of HSP90AA1-4 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 288<400> 288

         \hskip1cm\ hskip1cm

299

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 289<210> 289

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen HSP90AA1-4<223> Probe 3 for determining the HSP90AA1-4 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 289<400> 289

         \hskip1cm\ hskip1cm

300

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 290<210> 290

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen HSP90AA1-4<223> Probe 4 for the determination of HSP90AA1-4 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 290<400> 290

         \hskip1cm\ hskip1cm

301

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 291<210> 291

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen HSP90AA1-4<223> Probe 5 for determining the HSP90AA1-4 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 291<400> 291

         \hskip1cm\ hskip1cm

302

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 292<210> 292

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen HSP90AA1-4<223> Probe 6 for determining the HSP90AA1-4 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 292<400> 292

         \hskip1cm\ hskip1cm

303

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 293<210> 293

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen HSP90AA1-4<223> Probe 7 for determining the HSP90AA1-4 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 293<400> 293

         \hskip1cm\ hskip1cm

304

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 294<210> 294

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen HSP90AA1-4<223> Probe 8 for the determination of HSP90AA1-4 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 294<400> 294

         \hskip1cm\ hskip1cm

305

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 295<210> 295

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen HSP90AA1-4<223> Probe 9 for determining the HSP90AA1-4 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 295<400> 295

         \hskip1cm\ hskip1cm

306

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 296<210> 296

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen HSP90AA1-4<223> Probe 10 for determining the HSP90AA1-4 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 296<400> 296

         \hskip1cm\ hskip1cm

307

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 297<210> 297

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen HSP90AA1-4<223> Probe 11 for determining the HSP90AA1-4 gene expression

         \newpage\ newpage

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 297<400> 297

         \hskip1cm\ hskip1cm

308

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 298<210> 298

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen NUSAP1<223> Probe 1 for determining the NUSAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 298<400> 298

         \hskip1cm\ hskip1cm

309

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 299<210> 299

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen NUSAP1<223> Probe 2 for the determination of NUSAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 299<400> 299

         \hskip1cm\ hskip1cm

310

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 300<210> 300

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen NUSAP1<223> Probe 3 for determining the NUSAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 300<400> 300

         \hskip1cm\ hskip1cm

311

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 301<210> 301

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen NUSAP1<223> Probe 4 for the determination of NUSAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 301<400> 301

         \hskip1cm\ hskip1cm

312

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 302<210> 302

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen NUSAP1<223> Probe 5 for determining the NUSAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 302<400> 302

         \hskip1cm\ hskip1cm

313

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 303<210> 303

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen NUSAP1<223> Probe 6 for determining the NUSAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 303<400> 303

         \hskip1cm\ hskip1cm

314

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 304<210> 304

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen NUSAP1<223> Probe 7 for determining the NUSAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 304<400> 304

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

315

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 305<210> 305

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen NUSAP1<223> Probe 8 for the determination of NUSAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 305<400> 305

         \hskip1cm\ hskip1cm

316

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 306<210> 306

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen NUSAP1<223> Probe 9 for determining the NUSAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 306<400> 306

         \hskip1cm\ hskip1cm

317

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 307<210> 307

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen NUSAP1<223> Probe 10 for determining the NUSAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 307<400> 307

         \hskip1cm\ hskip1cm

318

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 308<210> 308

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen NUSAP1<223> Probe 11 for determining the NUSAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 308<400> 308

         \hskip1cm\ hskip1cm

319

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 309<210> 309

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen ERO1L<223> Probe 1 for determining the ERO1L gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 309<400> 309

         \hskip1cm\ hskip1cm

320

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 310<210> 310

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen ERO1L<223> Probe 2 for the determination of ERO1L gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 310<400> 310

         \hskip1cm\ hskip1cm

321

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 311<210> 311

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen ERO1L<223> Probe 3 for determining the ERO1L gene expression

         \newpage\ newpage

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 311<400> 311

         \hskip1cm\ hskip1cm

322

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 312<210> 312

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen ERO1L<223> Probe 4 for the determination of ERO1L gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 312<400> 312

         \hskip1cm\ hskip1cm

323

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 313<210> 313

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen ERO1L<223> Probe 5 for determining the ERO1L gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 313<400> 313

         \hskip1cm\ hskip1cm

324

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 314<210> 314

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen ERO1L<223> Probe 6 for determining the ERO1L gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 314<400> 314

         \hskip1cm\ hskip1cm

325

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 315<210> 315

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen ERO1L<223> Probe 7 for determining the ERO1L gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 315<400> 315

         \hskip1cm\ hskip1cm

326

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 316<210> 316

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen ERO1L<223> Probe 8 for the determination of ERO1L gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 316<400> 316

         \hskip1cm\ hskip1cm

327

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 317<210> 317

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen ERO1L<223> Probe 9 for determining the ERO1L gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 317<400> 317

         \hskip1cm\ hskip1cm

328

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 318<210> 318

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen ERO1L<223> Probe 10 for determining the ERO1L gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 318<400> 318

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

329

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 319<210> 319

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen ERO1L<223> Probe 11 for determining the ERO1L gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 319<400> 319

         \hskip1cm\ hskip1cm

330

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 320<210> 320

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen MLF1IP<223> Probe 1 for determining the MLF1IP gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 320<400> 320

         \hskip1cm\ hskip1cm

331

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 321<210> 321

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen MLF1IP<223> Probe 2 for the determination of MLF1IP gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 321<400> 321

         \hskip1cm\ hskip1cm

332

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 322<210> 322

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen MLF1IP<223> Probe 3 for determining the MLF1IP gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 322<400> 322

         \hskip1cm\ hskip1cm

333

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 323<210> 323

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen MLF1IP<223> Probe 4 for the determination of MLF1IP gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 323<400> 323

         \hskip1cm\ hskip1cm

334

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 324<210> 324

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen MLF1IP<223> Probe 5 for determining the MLF1IP gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 324<400> 324

         \hskip1cm\ hskip1cm

335

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 325<210> 325

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen MLF1IP<223> Probe 6 for determining the MLF1IP gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 325<400> 325

         \hskip1cm\ hskip1cm

336

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 326<210> 326

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen MLF1IP<223> Probe 7 for determining the MLF1IP gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 326<400> 326

         \hskip1cm\ hskip1cm

337

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 327<210> 327

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen MLF1IP<223> Probe 8 for the determination of MLF1IP gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 327<400> 327

         \hskip1cm\ hskip1cm

338

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 328<210> 328

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen MLF1IP<223> Probe 9 for determining the MLF1IP gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 328<400> 328

         \hskip1cm\ hskip1cm

339

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 329<210> 329

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen MLF1IP<223> Probe 10 for determining the MLF1IP gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 329<400> 329

         \hskip1cm\ hskip1cm

340

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 330<210> 330

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen MLF1IP<223> Probe 11 for determining the MLF1IP gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 330<400> 330

         \hskip1cm\ hskip1cm

341

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 331<210> 331

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen DCC1<223> Probe 1 for determining the DCC1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 331<400> 331

         \hskip1cm\ hskip1cm

342

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 332<210> 332

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen DCC1<223> Probe 2 for the determination of DCC1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 332<400> 332

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

343

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 333<210> 333

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen DCC1<223> Probe 3 for determining the DCC1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 333<400> 333

         \hskip1cm\ hskip1cm

344

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 334<210> 334

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen DCC1<223> Probe 4 for the determination of DCC1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 334<400> 334

         \hskip1cm\ hskip1cm

3. 4. 5

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 335<210> 335

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen DCC1<223> Probe 5 for determining the DCC1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 335<400> 335

         \hskip1cm\ hskip1cm

346

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 336<210> 336

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen DCC1<223> Probe 6 for determining the DCC1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 336<400> 336

         \hskip1cm\ hskip1cm

347

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 337<210> 337

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen DCC1<223> Probe 7 for determining the DCC1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 337<400> 337

         \hskip1cm\ hskip1cm

348

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 338<210> 338

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen DCC1<223> Probe 8 for the determination of DCC1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 338<400> 338

         \hskip1cm\ hskip1cm

349

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 339<210> 339

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen DCC1<223> Probe 9 for determining the DCC1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 339<400> 339

         \hskip1cm\ hskip1cm

350

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 340<210> 340

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen DCC1<223> Probe 10 for determining the DCC1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 340<400> 340

         \hskip1cm\ hskip1cm

351

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 341<210> 341

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen DCC1<223> Probe 11 for determining the DCC1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 341<400> 341

         \hskip1cm\ hskip1cm

352

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 342<210> 342

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen C21orf45<223> Probe 1 for determining the C21orf45 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 342<400> 342

         \hskip1cm\ hskip1cm

353

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 343<210> 343

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen C21orf45<223> Probe 2 for the determination of C21orf45 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 343<400> 343

         \hskip1cm\ hskip1cm

354

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 344<210> 344

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen C21orf45<223> Probe 3 for determining the C21orf45 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 344<400> 344

         \hskip1cm\ hskip1cm

355

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 345<210> 345

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen C21orf45<223> Probe 4 for the determination of C21orf45 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 345<400> 345

         \hskip1cm\ hskip1cm

356

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 346<210> 346

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen C21orf45<223> Probe 5 for determining the C21orf45 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 346<400> 346

         \hskip1cm\ hskip1cm

357

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 347<210> 347

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen C21orf45<223> Probe 6 for determining the C21orf45 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 347<400> 347

         \hskip1cm\ hskip1cm

358

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 348<210> 348

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen C21orf45<223> Probe 7 for determining the C21orf45 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 348<400> 348

         \hskip1cm\ hskip1cm

359

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 349<210> 349

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen C21orf45<223> Probe 8 for the determination of C21orf45 gene expression

         \newpage\ newpage

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 349<400> 349

         \hskip1cm\ hskip1cm

360

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 350<210> 350

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen C21orf45<223> Probe 9 for determining the C21orf45 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 350<400> 350

         \hskip1cm\ hskip1cm

361

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 351<210> 351

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen C21orf45<223> Probe 10 for determining the C21orf45 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 351<400> 351

         \hskip1cm\ hskip1cm

362

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 352<210> 352

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen C21orf45<223> Probe 11 for determining the C21orf45 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 352<400> 352

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

363

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 353<210> 353

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen PBK<223> Probe 1 for determining the PBK gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 353<400> 353

         \hskip1cm\ hskip1cm

364

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 354<210> 354

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \newpage\ newpage

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen PBK<223> Probe 2 for the determination of PBK gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 354<400> 354

         \hskip1cm\ hskip1cm

365

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 355<210> 355

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen PBK<223> Probe 3 for determining the PBK gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 355<400> 355

         \hskip1cm\ hskip1cm

366

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 356<210> 356

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen PBK<223> Probe 4 for the determination of PBK gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 356<400> 356

         \hskip1cm\ hskip1cm

367

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 357<210> 357

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen PBK<223> Probe 5 for determining the PBK gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 357<400> 357

         \hskip1cm\ hskip1cm

368

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 358<210> 358

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen PBK<223> Probe 6 for determining the PBK gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 358<400> 358

         \hskip1cm\ hskip1cm

369

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 359<210> 359

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen PBK<223> Probe 7 for determining the PBK gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 359<400> 359

         \hskip1cm\ hskip1cm

370

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 360<210> 360

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen PBK<223> Probe 8 for the determination of PBK gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 360<400> 360

         \hskip1cm\ hskip1cm

371

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 361<210> 361

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen PBK<223> Probe 9 for determining the PBK gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 361<400> 361

         \hskip1cm\ hskip1cm

372

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 362<210> 362

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen PBK<223> Probe 10 for determining the PBK gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 362<400> 362

         \hskip1cm\ hskip1cm

373

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 363<210> 363

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen PBK<223> Probe 11 for determining the PBK gene expression

         \newpage\ newpage

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 363<400> 363

         \hskip1cm\ hskip1cm

374

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 364<210> 364

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen ATAD5<223> Probe 1 for determining the ATAD5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 364<400> 364

         \hskip1cm\ hskip1cm

375

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 365<210> 365

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen ATAD5<223> Probe 2 for the determination of ATAD5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 365<400> 365

         \hskip1cm\ hskip1cm

376

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 366<210> 366

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen ATAD5<223> Probe 3 for determining the ATAD5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 366<400> 366

         \hskip1cm\ hskip1cm

377

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 367<210> 367

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen ATAD5<223> Probe 4 for the determination of ATAD5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 367<400> 367

         \hskip1cm\ hskip1cm

378

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 368<210> 368

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen ATAD5<223> Probe 5 for determining the ATAD5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 368<400> 368

         \hskip1cm\ hskip1cm

379

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 369<210> 369

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen ATAD5<223> Probe 6 for determining the ATAD5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 369<400> 369

         \hskip1cm\ hskip1cm

380

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 370<210> 370

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen ATAD5<223> Probe 7 for determining the ATAD5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 370<400> 370

         \hskip1cm\ hskip1cm

381

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 371<210> 371

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220> Sonda 8 para la determinación de la expresión del gen ATAD5<220> Probe 8 for determining the ATAD5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 371<400> 371

         \hskip1cm\ hskip1cm

382

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 372<210> 372

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen ATAD5<223> Probe 9 for determining the ATAD5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 372<400> 372

         \hskip1cm\ hskip1cm

383

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 373<210> 373

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen ATAD5<223> Probe 10 for determining the ATAD5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 373<400> 373

         \hskip1cm\ hskip1cm

384

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 374<210> 374

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen ATAD5<223> Probe 11 for determining the ATAD5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 374<400> 374

         \hskip1cm\ hskip1cm

385

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 375<210> 375

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen MCM10<223> Probe 1 for determining the MCM10 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 375<400> 375

         \hskip1cm\ hskip1cm

386

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 376<210> 376

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen MCM10<223> Probe 2 for the determination of MCM10 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 376<400> 376

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

387

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 377<210> 377

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen MCM10<223> Probe 3 for determining the MCM10 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 377<400> 377

         \hskip1cm\ hskip1cm

388

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 378<210> 378

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen MCM10<223> Probe 4 for the determination of MCM10 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 378<400> 378

         \hskip1cm\ hskip1cm

389

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 379<210> 379

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen MCM10<223> Probe 5 for determining the MCM10 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 379<400> 379

         \hskip1cm\ hskip1cm

390

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 380<210> 380

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen MCM10<223> Probe 6 for determining the MCM10 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 380<400> 380

         \hskip1cm\ hskip1cm

391

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 381<210> 381

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen MCM10<223> Probe 7 for determining the MCM10 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 381<400> 381

         \hskip1cm\ hskip1cm

392

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 382<210> 382

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen MCM10<223> Probe 8 for the determination of MCM10 gene expression

         \newpage\ newpage

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 382<400> 382

         \hskip1cm\ hskip1cm

393

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 383<210> 383

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen MCM10<223> Probe 9 for determining the MCM10 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 383<400> 383

         \hskip1cm\ hskip1cm

394

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 384<210> 384

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen MCM10<223> Probe 10 for determining the MCM10 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 384<400> 384

         \hskip1cm\ hskip1cm

395

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 385<210> 385

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen MCM10<223> Probe 11 for determining the MCM10 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 385<400> 385

         \hskip1cm\ hskip1cm

396

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 386<210> 386

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen CDCA3<223> Probe 1 for determining the CDCA3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 386<400> 386

         \hskip1cm\ hskip1cm

397

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 387<210> 387

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen CDCA3<223> Probe 2 for the determination of CDCA3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 387<400> 387

         \hskip1cm\ hskip1cm

398

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 388<210> 388

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen CDCA3<223> Probe 3 for determining the CDCA3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 388<400> 388

         \hskip1cm\ hskip1cm

399

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 389<210> 389

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen CDCA3<223> Probe 4 for the determination of CDCA3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 389<400> 389

         \hskip1cm\ hskip1cm

400

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 390<210> 390

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen CDCA3<223> Probe 5 for determining the CDCA3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 390<400> 390

         \hskip1cm\ hskip1cm

401

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 391<210> 391

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen CDCA3<223> Probe 6 for determining the CDCA3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 391<400> 391

         \hskip1cm\ hskip1cm

402

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 392<210> 392

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen CDCA3<223> Probe 7 for determining the CDCA3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 392<400> 392

         \hskip1cm\ hskip1cm

403

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 393<210> 393

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen CDCA3<223> Probe 8 for the determination of CDCA3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 393<400> 393

         \hskip1cm\ hskip1cm

404

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 394<210> 394

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen CDCA3<223> Probe 9 for determining the CDCA3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 394<400> 394

         \hskip1cm\ hskip1cm

405

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 395<210> 395

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen CDCA3<223> Probe 10 for determining the CDCA3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 395<400> 395

         \hskip1cm\ hskip1cm

406

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 396<210> 396

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen CDCA3<223> Probe 11 for determining the CDCA3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 396<400> 396

         \hskip1cm\ hskip1cm

407

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 397<210> 397

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen RACGAP1<223> Probe 1 for determining the RACGAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 397<400> 397

         \hskip1cm\ hskip1cm

408

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 398<210> 398

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen RACGAP1<223> Probe 2 for the determination of RACGAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 398<400> 398

         \hskip1cm\ hskip1cm

409

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 399<210> 399

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen RACGAP1<223> Probe 3 for determining the RACGAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 399<400> 399

         \hskip1cm\ hskip1cm

410

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 400<210> 400

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen RACGAP1<223> Probe 4 for the determination of RACGAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 400<400> 400

         \hskip1cm\ hskip1cm

411

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 401<210> 401

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen RACGAP1<223> Probe 5 for determining the RACGAP1 gene expression

         \newpage\ newpage

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 401<400> 401

         \hskip1cm\ hskip1cm

412

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 402<210> 402

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen RACGAP1<223> Probe 6 for determining the RACGAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 402<400> 402

         \hskip1cm\ hskip1cm

413

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 403<210> 403

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen RACGAP1<223> Probe 7 for determining the RACGAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 403<400> 403

         \hskip1cm\ hskip1cm

414

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 404<210> 404

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen RACGAP1<223> Probe 8 for the determination of RACGAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 404<400> 404

         \hskip1cm\ hskip1cm

415

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 405<210> 405

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen RACGAP1<223> Probe 9 for determining the RACGAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 405<400> 405

         \hskip1cm\ hskip1cm

416

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 406<210> 406

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen RACGAP1<223> Probe 10 for determining the RACGAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 406<400> 406

         \hskip1cm\ hskip1cm

417

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 407<210> 407

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen RACGAP1<223> Probe 11 for determining the RACGAP1 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 407<400> 407

         \hskip1cm\ hskip1cm

418

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 408<210> 408

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen ELOVL5<223> Probe 1 for determining the ELOVL5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 408<400> 408

         \hskip1cm\ hskip1cm

419

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 409<210> 409

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen ELOVL5<223> Probe 2 for the determination of ELOVL5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 409<400> 409

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

420

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 410<210> 410

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen ELOVL5<223> Probe 3 for determining the ELOVL5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 410<400> 410

         \hskip1cm\ hskip1cm

421

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 411<210> 411

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen ELOVL5<223> Probe 4 for the determination of ELOVL5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 411<400> 411

         \hskip1cm\ hskip1cm

422

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 412<210> 412

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen ELOVL5<223> Probe 5 for determining the ELOVL5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 412<400> 412

         \hskip1cm\ hskip1cm

423

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 413<210> 413

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen ELOVL5<223> Probe 6 for determining the ELOVL5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 413<400> 413

         \hskip1cm\ hskip1cm

424

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 414<210> 414

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen ELOVL5<223> Probe 7 for determining the ELOVL5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 414<400> 414

         \hskip1cm\ hskip1cm

425

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 415<210> 415

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen ELOVL5<223> Probe 8 for the determination of ELOVL5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 415<400> 415

         \hskip1cm\ hskip1cm

426

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 416<210> 416

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen ELOVL5<223> Probe 9 for determining the ELOVL5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 416<400> 416

         \hskip1cm\ hskip1cm

427

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 417<210> 417

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen ELOVL5<223> Probe 10 for determining the ELOVL5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 417<400> 417

         \hskip1cm\ hskip1cm

428

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 418<210> 418

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen ELOVL5<223> Probe 11 for determining the ELOVL5 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 418<400> 418

         \hskip1cm\ hskip1cm

429

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 419<210> 419

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen PARP3<223> Probe 1 for determining the PARP3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 419<400> 419

         \hskip1cm\ hskip1cm

430

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 420<210> 420

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen PARP3<223> Probe 2 for the determination of PARP3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 420<400> 420

         \hskip1cm\ hskip1cm

431

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 421<210> 421

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen PARP3<223> Probe 3 for determining the PARP3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 421<400> 421

         \hskip1cm\ hskip1cm

432

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 422<210> 422

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen PARP3<223> Probe 4 for the determination of PARP3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 422<400> 422

         \hskip1cm\ hskip1cm

433

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 423<210> 423

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen PARP3<223> Probe 5 for determining the PARP3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 423<400> 423

         \hskip1cm\ hskip1cm

434

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 424<210> 424

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen PARP3<223> Probe 6 for determining the PARP3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 424<400> 424

         \hskip1cm\ hskip1cm

435

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 425<210> 425

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen PARP3<223> Probe 7 for determining the PARP3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 425<400> 425

         \hskip1cm\ hskip1cm

436

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 426<210> 426

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen PARP3<223> Probe 8 for the determination of PARP3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 426<400> 426

         \hskip1cm\ hskip1cm

437

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 427<210> 427

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen PARP3<223> Probe 9 for determining the PARP3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 427<400> 427

         \hskip1cm\ hskip1cm

438

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 428<210> 428

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen PARP3<223> Probe 10 for determining the PARP3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 428<400> 428

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

439

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 429<210> 429

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen PARP3<223> Probe 11 for determining the PARP3 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 429<400> 429

         \hskip1cm\ hskip1cm

440

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 430<210> 430

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 1 para la determinación de la expresión del gen CBX7<223> Probe 1 for determining the CBX7 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 430<400> 430

         \hskip1cm\ hskip1cm

441

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 431<210> 431

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 2 para la determinación de la expresión del gen CBX7<223> Probe 2 for the determination of CBX7 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 431<400> 431

         \hskip1cm\ hskip1cm

442

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 432<210> 432

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 3 para la determinación de la expresión del gen CBX7<223> Probe 3 for determining the CBX7 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 432<400> 432

         \hskip1cm\ hskip1cm

443

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 433<210> 433

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 4 para la determinación de la expresión del gen CBX7<223> Probe 4 for the determination of CBX7 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 433<400> 433

         \hskip1cm\ hskip1cm

444

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 434<210> 434

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 5 para la determinación de la expresión del gen CBX7<223> Probe 5 for determining the CBX7 gene expression

         \newpage\ newpage

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 434<400> 434

         \hskip1cm\ hskip1cm

445

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 435<210> 435

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 6 para la determinación de la expresión del gen CBX7<223> Probe 6 for determining the CBX7 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 435<400> 435

         \hskip1cm\ hskip1cm

446

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 436<210> 436

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 7 para la determinación de la expresión del gen CBX7<223> Probe 7 for determining the CBX7 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 436<400> 436

         \hskip1cm\ hskip1cm

447

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 437<210> 437

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 8 para la determinación de la expresión del gen CBX7<223> Probe 8 for the determination of CBX7 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 437<400> 437

         \hskip1cm\ hskip1cm

448

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 438<210> 438

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 9 para la determinación de la expresión del gen CBX7<223> Probe 9 for determining the CBX7 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 438<400> 438

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \hskip1cm\ hskip1cm

449

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 439<210> 439

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 10 para la determinación de la expresión del gen CBX7<223> Probe 10 for determining the CBX7 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 439<400> 439

         \hskip1cm\ hskip1cm

450

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<210> 440<210> 440

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<211> 25<211> 25

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<212> DNA<212> DNA

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<213> Artificial<213> Artificial

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<220><220>

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<223> Sonda 11 para la determinación de la expresión del gen CBX7<223> Probe 11 for determining the CBX7 gene expression

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

         \vskip0.400000\baselineskip\ vskip0.400000 \ baselineskip

<400> 440<400> 440

         \hskip1cm\ hskip1cm

451

Claims

1. An in vitro method for predicting the response of a subject diagnosed with breast cancer to treatment with a taxane and chemotherapy with an antimetabolite, an intercalating agent and a DNA alkylating agent, which comprises determining the expression levels of the identified genes in Table 1 and in Table 2 in a sample of tumor tissue from said subject, where an increase in the expression of the genes identified in Table 1 and a decrease in the expression of the genes identified in Table 2 with Regarding a reference value, it is indicative of a better response to treatment.

2. Method according to claim 1, wherein the taxane is paclitaxel.

3. Method according to any of the claims 1 to 2, wherein the antimetabolite is 5-fluorouracil.

4. Method according to any of the claims 1 to 3, wherein the intercalating agent is Adriamycin

5. Method according to any of the claims 1 to 4, wherein the DNA alkylating agent is cyclophosphamide

6. Method according to any of the claims 1 to 5, wherein the subject diagnosed with cancer Breast has normal levels of HER-2.

7. Method according to any of the claims 1 to 6, wherein the breast cancer is breast cancer advanced.

8. Method according to any of the claims 1 to 7, wherein the treatment is neoadjuvant.

9. Method according to any of the claims 1 to 8, further comprising determining at least one clinical parameter selected from the subject's age, status of the estrogen receptor and tumor grade, where at a younger age of the subject, negative subjects for estrogen receptor and grade more advanced tumor, is indicative of a better response to treatment.

10. Method according to any of the claims 9, wherein the quantification of the levels of expression of the genes identified in Tables 1 and 2 comprises the quantification of messenger RNA (mRNA) of said genes, or a fragment of said mRNA, the complementary DNA (cDNA) of said genes, or a fragment of said cDNA, or mixtures thereof.

11. Method according to claim 10, wherein quantification of gene expression levels identified in Tables 1 and 2 is performed by a reaction quantitative multiplex polymerase chain (PCR) or an array of DNA or RNA.

12. Method according to claim 11, wherein the determination of expression levels of identified genes in Table 1 and Table 2 it is done by an array of DNA that It includes the probes identified in Tables 3 and 4.

13. Method according to claim 12, wherein the determination of the prediction of the response to treatment includes a regression analysis of proportional risks of said prognosis based on gene expression levels identified in Table 1 and Table 2.

14. Method according to claim 13, wherein said proportional hazards regression analysis is an analysis Cox type

15. Method according to claim 14, wherein said Cox type analysis establishes the pathological response complete (RCp) as a prognostic variable.

16. Method according to claim 15, wherein the determination of the prediction of the response to treatment is carried out by applying the following formula:

9

where x_ {i} is the level value of expression in log_ {2} of each of said identified genes in Table 1 and 2; Y

s_ {i} is the Wald statistic value of the Cox regression analysis of each of these genes identified in Table 1 and 2 according to claims 14 or fifteen,

where if said value is greater than zero then it is indicative of a better response to treatment.

         \vskip1.000000\baselineskip\ vskip1.000000 \ baselineskip

17. Method according to claim 16, wherein quantification of gene expression levels identified in Tables 1 and 2 includes the quantification of levels of protein encoded by said genes or a variant of the same.

18. Method according to claim 17, wherein quantification of protein levels is done by Western blot, ELISA or an array of proteins.