ES2302590B1 - BLISTER FILLING PROCEDURE. - Google Patents

BLISTER FILLING PROCEDURE. Download PDF

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Publication number
ES2302590B1
ES2302590B1 ES200503079A ES200503079A ES2302590B1 ES 2302590 B1 ES2302590 B1 ES 2302590B1 ES 200503079 A ES200503079 A ES 200503079A ES 200503079 A ES200503079 A ES 200503079A ES 2302590 B1 ES2302590 B1 ES 2302590B1
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Prior art keywords
filling
blister
product
ampoule
nozzles
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Withdrawn - After Issue
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ES200503079A
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ES2302590A1 (en
Inventor
Jose Martinez Nieto
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06Ampoules or carpules
    • A61J1/065Rigid ampoules, e.g. glass ampoules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/09Ampoules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00Closures not otherwise provided for
    • B65D51/002Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means

Abstract

Procedimiento de llenado de ampollas.Blister filling procedure.

Convencionalmente las ampollas contenedoras de productos bebibles se esterilizan tras su llenado, mediante un choque térmico a alta temperatura que a veces hace que el producto pierda parte de sus propiedades. Para evitar éste problema la invención consiste en esterilizar el producto previamente al envasado, introducirlo en las ampollas (1) a través de boquillas (6) que mantienen las condiciones de esterilización, y tras la introducción de la dosis (7) del producto, eliminar el aire residual mediante la introducción de nitrógeno a través de boquillas (6'), procediéndose finalmente al cierre de la ampolla mediante corte de su cuello (2) con una llama (9) que funde el material constitutivo de la ampolla.Conventionally the blisters containing drinkable products are sterilized after filling, by high temperature thermal shock that sometimes causes the product lose part of its properties. To avoid this problem the invention consists in sterilizing the product prior to packaging, insert it in the ampoules (1) through nozzles (6) that maintain sterilization conditions, and after introduction of the dose (7) of the product, remove the air residual by introducing nitrogen through nozzles (6 '), finally closing the blister by Cut your neck (2) with a flame (9) that melts the material constitutive of the blister.

Description

Procedimiento de llenado de ampollas.Blister filling procedure.

Objeto de la invenciónObject of the invention

La presente invención se refiere a un nuevo procedimiento para la fabricación de ampollas sin fondo de vidrio, con fondo de aluminio pegado, y el llenado de ampollas contenedoras de productos bebibles, tales como productos medicamentosos o dietéticos, o con productos cosméticos, ampollas comúnmente denominadas "securviales", que incorporan en su seno una dosis del producto en estado líquido de que se trate.The present invention relates to a new procedure for manufacturing glass bottomless ampoules, with glued aluminum bottom, and filling of container blisters of drinkable products, such as medicated products or dietary, or with cosmetic products, ampoules commonly denominated "securviales", that incorporate in their breast a dose of the product in liquid state in question.

El objeto de la invención es conseguir una utilización más fiable por parte del consumidor final del envase de vidrio, sin que este tenga que romper vidrio alguno para poder acceder al contenido del mismo y aumentando así su seguridad, utilizando la misma maquinaria de llenado y conservando las condiciones de asepsia que el producto requiere.The object of the invention is to achieve a more reliable use by the final consumer of the packaging of glass, without this having to break any glass to be able to access its content and thus increase its security, using the same filling machinery and keeping the aseptic conditions that the product requires.

La invención se sitúa pues en el ámbito de los productos farmacológicos, dietéticos y cosméticos, más concretamente en la sustitución del material de acondicionamiento (envase que llamaremos securvial) en lugar de la ampolla rompible de una punta tradicional. La maquinaria de llenado y las instalaciones no necesitarían de ninguna modificación.The invention thus falls within the scope of the Pharmacological, dietary and cosmetic products, more specifically in the replacement of the conditioning material (container that we will call securvial) instead of the breakable blister of a traditional tip. The filling machinery and facilities would not need any modification.

Antecedentes de la invenciónBackground of the invention

Son conocidas ampollas para la comercialización de productos medicamentosos bebibles, que inicialmente presentan un cuerpo de vidrio, abierto por sus extremos, en uno de los cuales se define una acusada estrangulación rematada en un largo y fino cuello, para el llenado de la ampolla, mientras que su base, es decir su otro extremo, está sellado mediante una tapa de aluminio desprendible en el momento del consumo del contenido de la ampolla, mediante tracción de la misma sobre una pequeña lengüeta radial.Blisters for marketing are known of drinkable medicinal products, which initially have a glass body, open at its ends, in one of which defines a sharp strangulation topped in a long and fine neck, for filling the blister, while its base, is say its other end, it is sealed by an aluminum cover removable at the time of consumption of the blister contents, by pulling it on a small tongue radial.

El procedimiento convencional para el llenado de estas ampollas consiste en introducir las mismas en el producto líquido que han de contener, llenándose por diferencia de presión, procediéndose seguidamente al cierre unitario de las ampollas mediante la aplicación de calor, concretamente en la zona próxima a su cuello, produciéndose simultáneamente el corte de dicho cuello y la fusión del vidrio para cierre de la ampolla, procediéndose finalmente a un proceso de esterilización de choque, aplicando altas temperaturas durante poco tiempo. Este choque térmico hace que en ocasiones el producto contenido en la ampolla pierda parte de sus propiedades. En el momento que el consumo de su contenido la tapa de aluminio se limita mediante tracción manual sobre la misma, como anteriormente se ha dicho, cada ampolla se convierte en una especie de pequeño vaso que permite beber su contenido.The conventional procedure for filling These ampoules consist of introducing them in the product liquid to be contained, filling by pressure difference, then proceed to the unit closure of the ampoules by applying heat, specifically in the area near its neck, simultaneously producing the cut of said neck and the fusion of the glass to close the blister, proceeding finally to a shock sterilization process, applying high  temperatures for a short time. This thermal shock causes that in Sometimes the product contained in the blister loses part of its properties. At the moment that the consumption of its contents the cover of  Aluminum is limited by manual traction on it, as previously said, each blister becomes a species Small glass that allows you to drink its contents.

Descripción de la invenciónDescription of the invention

El procedimiento que la invención propone resuelve de forma plenamente satisfactoria la problemática expuesta, eliminando cualquier riesgo de que el producto bebible pueda perder parte de sus propiedades, y ello porque durante dicho procedimiento no se aplica una esterilización por choque térmico a elevada temperatura.The procedure that the invention proposes solves the problem fully satisfactorily exposed, eliminating any risk of the drinkable product may lose part of its properties, and this because during said procedure does not apply a thermal shock sterilization to high temperature

De forma más concreta en el procedimiento de la invención se parte de una ampolla similar a las anteriormente citadas, cuyo cuerpo presenta su base mayor abierta y sellada con una tapa de aluminio, pero con la particularidad de que dicha tapa no está provista de una lengüeta radial por cuanto que tampoco está prevista para ser desprendida en el momento del consumo de su contenido, sino prevista para ser perforada por la "pajita".More specifically in the procedure of the invention is based on a blister similar to those above cited, whose body has its main base open and sealed with an aluminum lid, but with the particularity that said lid it is not provided with a radial tongue because it is not planned to be detached at the time of consumption of your content, but intended to be pierced by the "straw".

El procedimiento centra sus características en el hecho de que el producto de que se trate llega a la cápsula ya tratado y esterilizado, convenientemente alojado en tanques que mantienen las condiciones asépticas.The procedure focuses its characteristics on the fact that the product in question reaches the capsule already treated and sterilized, conveniently housed in tanks that maintain aseptic conditions.

El producto esterilizado es suministrado, mediante boquillas apropiadas, directamente al interior de las ampollas, en las dosis preestablecidas.The sterilized product is supplied, by appropriate nozzles, directly inside the ampoules, in the pre-established doses.

Finalizada la fase de llenado de las ampollas se inyecta en el interior de las mismas nitrógeno para expulsar el aire contenido en tales ampollas.Once the blister filling phase is finished, injected into the same nitrogen to expel the air contained in such blisters.

Finalmente se cierra la ampolla mediante proceso de sellado por calor, como en el sistema convencional, quedando la ampolla en condiciones de ser envasada conjuntamente con la pajita prevista para el consumo de la misma, como por ejemplo en el seno de sendas cápsulas de plástico termo-retráctil.Finally the blister is closed by process heat sealing, as in the conventional system, leaving the blister able to be packaged together with the straw planned for its consumption, such as within of two thermo-retractable plastic capsules.

Se consigue de esta manera, al no ser necesario un tratamiento esterilizante post-llenado, que el producto contenido en la ampolla mantenga íntegramente sus propiedades en el seno de un envase higiénico, resistente y limpio, ya que mediante el consumo con pajita se evitan derrames accidentales de dicho producto en el momento de consumirlo.It is achieved in this way, not being necessary a post-filling sterilizing treatment, which the product contained in the blister fully keep your properties within a hygienic, resistant and clean container, since spillage consumption prevents spillage accidentals of said product at the time of consumption.

Descripción de los dibujosDescription of the drawings

Para complementar la descripción que se está realizando y con objeto de ayudar a una mejor comprensión de las características del invento, de acuerdo con un ejemplo preferente de realización práctica del mismo, se acompaña como parte integrante de dicha descripción, un juego de dibujos en donde con carácter ilustrativo y no limitativo, se ha representado lo siguiente:To complement the description that is being performing and in order to help a better understanding of the characteristics of the invention, according to a preferred example of practical realization of it, is accompanied as part member of that description, a set of drawings where with illustrative and non-limiting nature, what has been represented next:

La figura 1.- Muestra una representación esquemática de las diferentes fases del procedimiento desde que se inicia el llenado de la ampolla hasta que se produce el consumo de su contenido.Figure 1.- Shows a representation schematic of the different phases of the procedure since it starts filling the blister until the consumption of its content

La figura 2.- Muestra un detalle en perspectiva de una ampolla bebible a término del proceso de llenado de la invención y en condiciones de comercialización para la misma.Figure 2.- Shows a detail in perspective of a drinkable blister at the end of the filling process of the invention and in marketing conditions for it.

Realización preferente de la invenciónPreferred Embodiment of the Invention

A la vista de las figuras reseñadas y en especial de la figura 1, se observa como el procedimiento de la invención parte de la utilización de ampollas (1), tubulares, abiertas por sus extremos, con uno de ellos determinando un estrecho cuello (2), y el otro cerrado mediante una tapa (3) de aluminio, sellada sobre el fondo (1) y con un debilitamiento central (4) que permite su fácil perforación con una pajita (5).In view of the figures outlined and in special of figure 1, it is observed as the procedure of the invention part of the use of ampoules (1), tubular, open at its ends, with one of them determining a narrow neck (2), and the other closed by a cover (3) of aluminum, sealed on the bottom (1) and with a central weakening (4) that allows easy drilling with a straw (5).

Opcionalmente el citado cuello (2) puede estar inicialmente cerrado, para ser abierto por la maquinaria de llenado, si ésta dispone de esta posibilidad operativa.Optionally said neck (2) may be initially closed, to be opened by the machinery of filled, if it has this operational possibility.

Tal como anteriormente se ha dicho el procedimiento, a partir de la utilización de ampollas de éste tipo, consiste en la paralela utilización del producto bebible de que se trate, ya tratado y esterilizado, convenientemente almacenado en tanques desde que a través de conducciones apropiadas y rematadas en boquillas (6) se suministra dicho producto dosificado al interior de las ampollas (1) a través de su cuello (2), tal como muestra la segunda secuencia de la citada figura 1.As previously stated on procedure, from the use of ampoules of this type, it consists of the parallel use of the drinkable product of which treat, already treated and sterilized, conveniently stored in tanks from that through appropriate and topped pipes in nozzles (6) said dosed product is supplied inside  of the blisters (1) through your neck (2), as shown by the second sequence of the aforementioned figure 1.

A continuación y siempre manteniendo las condiciones de esterilización iniciales, una vez que la ampolla (1) ha recibido toda la dosis de producto (7) prevista, recibe a través de la boquilla (6') la cantidad de nitrógeno (8) necesaria para expulsar del interior de la ampolla todo el aire, concretamente el oxígeno (O_{2}) que inicialmente pudiera pertenecer en la misma, tal como muestra la tercera secuencia de la figura 1, con la evidente finalidad de que dicho oxígeno no pueda actuar como oxidante del producto (7) en cuestión.Then and always keeping the Initial sterilization conditions, once the blister (1) has received all the expected product dose (7), receives through from the nozzle (6 ') the amount of nitrogen (8) needed to expel all the air from the inside of the vial, specifically the oxygen (O2) that might initially belong therein, as shown in the third sequence of figure 1, with the obvious purpose that said oxygen cannot act as oxidizer of the product (7) in question.

Finalmente se procede al cierre de la ampolla, mediante corte del cuello (2) con llama (9), que simultáneamente provoca la fusión del material cerrando el cuerpo (1) a nivel del inicio del citado cuello (2), concretamente por la zona en la que se produce el corte.Finally, the blister is closed, by cutting the neck (2) with flame (9), which simultaneously causes the fusion of the material by closing the body (1) at the level of beginning of said neck (2), specifically by the area in which the cut occurs.

Tal como muestra la figura 2, la ampolla (1) con su contenido (7), se comercializará en el seno de un envase (10) apropiado, como por ejemplo una cápsula termo-retráctil, que será eliminada en el momento del consumo del contenido de la ampolla, a la vez que la complementaria pajita (5) está igualmente protegida en el seno de una cápsula (11) hasta el momento de su utilización, en la que dicha pajita (5) perforará la tapa de aluminio (3) de la ampolla, por su zona debilitada (4), tal como muestra la última secuencia de la figura 1.As shown in Figure 2, the vial (1) with its content (7), will be marketed in a container (10) appropriate, such as a capsule heat shrink, which will be removed at the time of the consumption of the blister contents, while the complementary straw (5) is also protected within a capsule (11) until the moment of its use, in which said straw (5) will pierce the aluminum cap (3) of the vial, for its weakened area (4), as shown in the last sequence of Figure 1

Lógicamente la citada pajita (5) se utiliza cuando se trata de productos medicamentosos o dietéticos, pero cuando se trate de productos cosméticos dicha pajita será sustituida por un aplicador apropiado, que puede actuar simultáneamente como dosificador.Logically the mentioned straw (5) is used when it comes to medicinal or dietary products, but when it comes to cosmetic products, that straw will be replaced by an appropriate applicator, which can act simultaneously as a dispenser.

Claims (2)

1. Procedimiento de llenado de ampollas, concretamente de ampollas contenedoras de productos medicamentosos, dietéticos o cosméticos, provistas de un cuerpo de vidrio abierto por sus extremos, cuya base se cierra mediante una tapa de aluminio, mientras que su extremo opuesto se remata en un cuello de llenado inicialmente abierto, que se cierra mediante sellado por calor tras la fase de llenado, caracterizado porque consiste en tratar y esterilizar convenientemente el producto bebible de que se trate previamente a su envasado en la ampolla (1), procediéndose seguidamente al llenado de dicha ampolla (1) desde los tanques de almacenamiento del producto a través de boquillas (6) que depositan en cada ampolla (1) la dosis preestablecida al efecto, procediéndose seguidamente a la eliminación del aire residual en el interior de la ampolla (1) mediante aportación al interior de la misma, con la colaboración de boquillas, de nitrógeno que desplaza hacia el exterior el aire y consecuentemente al oxígeno contenido en el mismo, procediéndose finalmente al clásico sellado mediante corte por calor del cuello de la ampolla.1. Procedure for filling ampoules, specifically of ampoules containing medicinal, dietary or cosmetic products, provided with a glass body open at its ends, whose base is closed by an aluminum lid, while its opposite end is finished off in a Initially open filling neck, which is closed by heat sealing after the filling phase, characterized in that it consists of conveniently treating and sterilizing the beverage product in question prior to its packaging in the vial (1), then filling said ampoule (1) from the product storage tanks through nozzles (6) that deposit in each ampoule (1) the pre-established dose for this purpose, then eliminating residual air inside the ampoule (1) by means of contribution to the interior of the same, with the collaboration of nozzles, of nitrogen that displaces the air outside and achieves Add to the oxygen contained in it, finally proceeding to the classic sealing by heat cutting of the neck of the blister. 2. Procedimiento de llenado de ampollas, según reivindicación 1ª, caracterizado porque como tapa de aluminio (3) para el cierre de la base del cuerpo (1) de la ampolla se utiliza una lámina de aluminio dotado de un debilitamiento (4) en su zona central, y la ampolla (1), tras su llenado se introduce en el seno de un envase (10) al igual que se hace con una pajita (5) para consumo de su contenido, en un envase (11), o con un aplicador en el caso de un producto cosmético.2. Method for filling blisters, according to claim 1, characterized in that an aluminum foil provided with a weakening (4) is used as an aluminum cover (3) for closing the base of the body (1) of the vial. central area, and the ampoule (1), after filling it is introduced into a container (10) as is done with a straw (5) for consumption of its contents, in a container (11), or with an applicator in the case of a cosmetic product.
ES200503079A 2005-12-14 2005-12-14 BLISTER FILLING PROCEDURE. Withdrawn - After Issue ES2302590B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES200503079A ES2302590B1 (en) 2005-12-14 2005-12-14 BLISTER FILLING PROCEDURE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200503079A ES2302590B1 (en) 2005-12-14 2005-12-14 BLISTER FILLING PROCEDURE.

Publications (2)

Publication Number Publication Date
ES2302590A1 ES2302590A1 (en) 2008-07-16
ES2302590B1 true ES2302590B1 (en) 2009-05-05

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ES200503079A Withdrawn - After Issue ES2302590B1 (en) 2005-12-14 2005-12-14 BLISTER FILLING PROCEDURE.

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Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB737242A (en) * 1952-10-16 1955-09-21 Novo Terapeutisk Labor As Process of increasing the physical stability of aqueous suspensions of penicillin compounds
US3012386A (en) * 1958-11-22 1961-12-12 Strunck & Co Maschf H Process and apparatus for the filling, sealing and permanent marking of ampoules andthe like
US4208852A (en) * 1974-11-08 1980-06-24 Pont-A-Mousson S.A. Process for the aseptic packing of products and machine employing said process
US5662230A (en) * 1990-07-13 1997-09-02 J. G. Finneran Associates Crimp top seal for vials
AU9004598A (en) * 1997-08-26 1999-03-16 Choa Pharmaceutical Co., Ltd. Ampule and method for manufacturing the same
IT1300052B1 (en) * 1998-05-20 2000-04-04 Corazza Natalino Spa SINGLE-DOSE PACKAGE FOR A FOOD PRODUCT AND PROCEDURE FOR OBTAINING THIS PACKAGE.

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