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Wyeth Holdings LLC
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American Cyanamid Co
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Publication date
Application filed by American Cyanamid CofiledCriticalAmerican Cyanamid Co
Publication of ES229596A1publicationCriticalpatent/ES229596A1/en
Preparation Of Compounds By Using Micro-Organisms
(AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
A tetracycline refining method that includes the acidification of the fermentation must to solubilize the tetracycline contained in it, the operations that include adjusting the content of calcium ion in order to reduce the concentration of the calcium ion, adding an ammonium compound quaternary selected from the group consisting of the alkytrimethylammonium halides and the dialkyl-dimethyl-ammonium halides, adjust the ph of the aqueous solution between 8 and 12, extract the tetracycline from the aqueous solution with an organic solvent and then isolate the tetracycline of the organic solvent extract. (Machine-translation by Google Translate, not legally binding)
ES0229596A1956-05-111956-07-03A tetracycline refining method (Machine-translation by Google Translate, not legally binding)
ExpiredES229596A1
(en)