ES2219102T3 - Composiciones de acido fenilacetico para tratar o prevenir aterosclerosis u reestenosis. - Google Patents
Composiciones de acido fenilacetico para tratar o prevenir aterosclerosis u reestenosis.Info
- Publication number
- ES2219102T3 ES2219102T3 ES99965840T ES99965840T ES2219102T3 ES 2219102 T3 ES2219102 T3 ES 2219102T3 ES 99965840 T ES99965840 T ES 99965840T ES 99965840 T ES99965840 T ES 99965840T ES 2219102 T3 ES2219102 T3 ES 2219102T3
- Authority
- ES
- Spain
- Prior art keywords
- phenylacetic acid
- aterosclerosis
- reset
- treat
- prevent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 title 2
- 229960003424 phenylacetic acid Drugs 0.000 title 1
- 239000003279 phenylacetic acid Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 201000001320 Atherosclerosis Diseases 0.000 abstract 2
- 208000037803 restenosis Diseases 0.000 abstract 2
- WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 abstract 1
- AEFLONBTGZFSGQ-VKHMYHEASA-N L-isoglutamine Chemical compound NC(=O)[C@@H](N)CCC(O)=O AEFLONBTGZFSGQ-VKHMYHEASA-N 0.000 abstract 1
- JFLIEFSWGNOPJJ-JTQLQIEISA-N N(2)-phenylacetyl-L-glutamine Chemical compound NC(=O)CC[C@@H](C(O)=O)NC(=O)CC1=CC=CC=C1 JFLIEFSWGNOPJJ-JTQLQIEISA-N 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Uso de una composición farmacéutica que comprende ácido fenilacético, una de sus sales, uno de sus precursores, o uno de sus análogos, en el que dicho análogo es fenilacetilglutamina, iso-fenilacetilglutamina o la **fórmula** en la que R se selecciona del grupo formado por H y C3H7; R1 se selecciona del grupo formado por H, CH3, CH3-O-, C2H5 y C3H7; y R2 se selecciona del grupo formado por: en la que X se selecciona el grupo formado por CH3, CI, F y -OH; y n es 0, 1, 2, 3 ó 4; para la fabricación de un medicamento para el tratamiento o inhibición de reestenosis.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/197,903 US6127419A (en) | 1998-11-23 | 1998-11-23 | Phenylacetic acid compositions for treating or preventing atherosclerosis and restenosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2219102T3 true ES2219102T3 (es) | 2004-11-16 |
Family
ID=22731212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99965840T Expired - Lifetime ES2219102T3 (es) | 1998-11-23 | 1999-11-19 | Composiciones de acido fenilacetico para tratar o prevenir aterosclerosis u reestenosis. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6127419A (es) |
| EP (1) | EP1171110B1 (es) |
| JP (1) | JP4536258B2 (es) |
| AT (1) | ATE263556T1 (es) |
| AU (1) | AU757114B2 (es) |
| CA (1) | CA2345409C (es) |
| DE (1) | DE69916330T2 (es) |
| ES (1) | ES2219102T3 (es) |
| HK (1) | HK1045253B (es) |
| WO (1) | WO2000030627A2 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6987131B1 (en) * | 2000-06-26 | 2006-01-17 | Burzynski Stanislaw R | Phenylacetic acid compositions for treating or preventing hypercholesterolemia |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53113032A (en) * | 1977-03-09 | 1978-10-03 | Mitsubishi Chem Ind Ltd | Immune depresants |
| JPS54160740A (en) * | 1978-06-09 | 1979-12-19 | Takeda Chem Ind Ltd | Anti-fibrotic agent |
| US4470970A (en) * | 1981-07-02 | 1984-09-11 | Burzynski Stanislaw R | Purified antineoplaston fractions and methods of treating neoplastic disease |
| US5089508A (en) * | 1990-09-04 | 1992-02-18 | Burzynski Stanislaw R | Methods for treating aids |
| AU655780B2 (en) * | 1990-10-30 | 1995-01-12 | Clintec Nutrition Company | A method and composition for the protection of a metabolic recovery of ischemic cardiac tissue |
| GB9027200D0 (en) * | 1990-12-14 | 1991-02-06 | Smithkline Beecham Plc | Medicaments |
| US5605930A (en) * | 1991-10-21 | 1997-02-25 | The United States Of America As Represented By The Department Of Health And Human Services | Compositions and methods for treating and preventing pathologies including cancer |
| US5646182A (en) * | 1992-06-15 | 1997-07-08 | Burzynski; Stanislaw R. | Methods for treating autoimmune diseases |
| US5391575A (en) * | 1994-05-04 | 1995-02-21 | Burzynski; Stanislaw R. | Method for treating neurofibromatosis |
| US5705507A (en) * | 1995-03-10 | 1998-01-06 | Eli Lilly And Company | Aplha-substituted-3-benzyl-benzofurans |
| US6258849B1 (en) * | 1998-07-23 | 2001-07-10 | Stanislaw R. Burzynski | Treatment regimen for administration of phenylacetylglutamine, phenylacetylisoglutamine, and/or phenylacetate |
-
1998
- 1998-11-23 US US09/197,903 patent/US6127419A/en not_active Expired - Fee Related
-
1999
- 1999-11-19 ES ES99965840T patent/ES2219102T3/es not_active Expired - Lifetime
- 1999-11-19 WO PCT/US1999/027480 patent/WO2000030627A2/en active IP Right Grant
- 1999-11-19 AU AU21528/00A patent/AU757114B2/en not_active Ceased
- 1999-11-19 JP JP2000583510A patent/JP4536258B2/ja not_active Expired - Fee Related
- 1999-11-19 CA CA002345409A patent/CA2345409C/en not_active Expired - Fee Related
- 1999-11-19 DE DE69916330T patent/DE69916330T2/de not_active Expired - Lifetime
- 1999-11-19 EP EP99965840A patent/EP1171110B1/en not_active Expired - Lifetime
- 1999-11-19 AT AT99965840T patent/ATE263556T1/de active
-
2002
- 2002-07-16 HK HK02105280.6A patent/HK1045253B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP4536258B2 (ja) | 2010-09-01 |
| WO2000030627A3 (en) | 2000-11-23 |
| WO2000030627A2 (en) | 2000-06-02 |
| DE69916330T2 (de) | 2005-03-17 |
| ATE263556T1 (de) | 2004-04-15 |
| CA2345409C (en) | 2008-09-09 |
| EP1171110A2 (en) | 2002-01-16 |
| CA2345409A1 (en) | 2000-06-02 |
| US6127419A (en) | 2000-10-03 |
| DE69916330D1 (de) | 2004-05-13 |
| EP1171110B1 (en) | 2004-04-07 |
| HK1045253B (zh) | 2004-08-13 |
| HK1045253A1 (en) | 2002-11-22 |
| AU2152800A (en) | 2000-06-13 |
| AU757114B2 (en) | 2003-02-06 |
| JP2002530328A (ja) | 2002-09-17 |
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