ES2218837T3 - Metodo para separar una sustancia fluida y dispositivo para llevarlo a cabo. - Google Patents
Metodo para separar una sustancia fluida y dispositivo para llevarlo a cabo.Info
- Publication number
- ES2218837T3 ES2218837T3 ES98930794T ES98930794T ES2218837T3 ES 2218837 T3 ES2218837 T3 ES 2218837T3 ES 98930794 T ES98930794 T ES 98930794T ES 98930794 T ES98930794 T ES 98930794T ES 2218837 T3 ES2218837 T3 ES 2218837T3
- Authority
- ES
- Spain
- Prior art keywords
- channel
- mobile
- separation
- elements
- mobile phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 58
- 239000012530 fluid Substances 0.000 title claims abstract description 44
- 239000000126 substance Substances 0.000 title claims abstract description 14
- 238000000926 separation method Methods 0.000 claims abstract description 82
- 230000033001 locomotion Effects 0.000 claims abstract description 16
- 230000001788 irregular Effects 0.000 claims abstract description 5
- 230000014759 maintenance of location Effects 0.000 claims description 64
- 238000001514 detection method Methods 0.000 claims description 36
- 239000000463 material Substances 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 14
- 238000012546 transfer Methods 0.000 claims description 14
- 230000001965 increasing effect Effects 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 230000000717 retained effect Effects 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 3
- 239000002250 absorbent Substances 0.000 claims description 2
- 230000002745 absorbent Effects 0.000 claims description 2
- 239000003463 adsorbent Substances 0.000 claims description 2
- 230000005684 electric field Effects 0.000 claims description 2
- 238000013519 translation Methods 0.000 claims description 2
- 230000000750 progressive effect Effects 0.000 claims 3
- 238000004587 chromatography analysis Methods 0.000 abstract description 9
- 230000008569 process Effects 0.000 abstract description 5
- 239000010410 layer Substances 0.000 description 68
- 239000000523 sample Substances 0.000 description 35
- 238000002347 injection Methods 0.000 description 20
- 239000007924 injection Substances 0.000 description 20
- 238000004519 manufacturing process Methods 0.000 description 18
- 230000000694 effects Effects 0.000 description 12
- 239000000758 substrate Substances 0.000 description 9
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- 230000005526 G1 to G0 transition Effects 0.000 description 4
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- 238000000151 deposition Methods 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 238000000227 grinding Methods 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 238000013375 chromatographic separation Methods 0.000 description 3
- 239000011247 coating layer Substances 0.000 description 3
- 230000008021 deposition Effects 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 238000010828 elution Methods 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
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- 238000009736 wetting Methods 0.000 description 3
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- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000003754 machining Methods 0.000 description 2
- 238000004377 microelectronic Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 2
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
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- 238000005251 capillar electrophoresis Methods 0.000 description 1
- 238000004850 capillary HPLC Methods 0.000 description 1
- 238000003965 capillary gas chromatography Methods 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000003486 chemical etching Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000012468 concentrated sample Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000005518 electrochemistry Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000013529 heat transfer fluid Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 238000010884 ion-beam technique Methods 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 238000005459 micromachining Methods 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 230000005693 optoelectronics Effects 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 238000007514 turning Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
- F04B43/04—Pumps having electric drive
- F04B43/043—Micropumps
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
- F04B43/14—Machines, pumps, or pumping installations having flexible working members having peristaltic action having plate-like flexible members
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/326—Control of physical parameters of the fluid carrier of pressure or speed pumps
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/50—Conditioning of the sorbent material or stationary liquid
- G01N30/58—Conditioning of the sorbent material or stationary liquid the sorbent moving as a whole
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
- Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Landscapes
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97201699A EP0882982A1 (en) | 1997-06-04 | 1997-06-04 | Method for separating a fluid substance and device therefor |
| EP97201699 | 1997-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2218837T3 true ES2218837T3 (es) | 2004-11-16 |
Family
ID=8228407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98930794T Expired - Lifetime ES2218837T3 (es) | 1997-06-04 | 1998-06-03 | Metodo para separar una sustancia fluida y dispositivo para llevarlo a cabo. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6565752B1 (https=) |
| EP (2) | EP0882982A1 (https=) |
| JP (1) | JP2002508840A (https=) |
| AT (1) | ATE263370T1 (https=) |
| AU (1) | AU8110598A (https=) |
| DE (1) | DE69822820T2 (https=) |
| DK (1) | DK0986749T3 (https=) |
| ES (1) | ES2218837T3 (https=) |
| PT (1) | PT986749E (https=) |
| WO (1) | WO1998055858A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001064878A2 (en) * | 2000-02-29 | 2001-09-07 | Lexicon Genetics Incorporated | Human transporter proteins and polynucleotides encoding the same |
| US6627159B1 (en) * | 2000-06-28 | 2003-09-30 | 3M Innovative Properties Company | Centrifugal filling of sample processing devices |
| US8097471B2 (en) * | 2000-11-10 | 2012-01-17 | 3M Innovative Properties Company | Sample processing devices |
| ATE337094T1 (de) * | 2001-04-26 | 2006-09-15 | Univ Bruxelles | Verfahren zur beschleunigung und verstärkung der bindung von zielkomponenten an rezeptoren und vorrichtung dafür |
| US6596140B2 (en) | 2001-05-01 | 2003-07-22 | Applera Corporation | Multi-channel capillary electrophoresis device and method |
| US7198759B2 (en) * | 2002-07-26 | 2007-04-03 | Applera Corporation | Microfluidic devices, methods, and systems |
| US7507376B2 (en) * | 2002-12-19 | 2009-03-24 | 3M Innovative Properties Company | Integrated sample processing devices |
| EP1628729A2 (en) * | 2003-05-16 | 2006-03-01 | Cryobiophysica, Inc. | External gradient chromatofocusing |
| JP2007522913A (ja) * | 2003-10-03 | 2007-08-16 | フリーイェ・ユニヴェルシテイト・ブリュッセル | 流体中に存在する粒子を粒度分離するための方法及び装置 |
| US7932090B2 (en) * | 2004-08-05 | 2011-04-26 | 3M Innovative Properties Company | Sample processing device positioning apparatus and methods |
| WO2006022822A1 (en) * | 2004-08-10 | 2006-03-02 | Prime Separations, Incorporated | Chromatographic separation member and method |
| US20090041590A1 (en) * | 2007-08-06 | 2009-02-12 | Fuetes Hernan V | Apparatus, system, and method for electrochemical pump-based chromatography separations in microfabricated devices |
| US10758840B2 (en) * | 2016-03-07 | 2020-09-01 | Mcmaster University | Laterally-fed membrane chromatography device |
| US10758841B2 (en) * | 2016-03-07 | 2020-09-01 | Mcmaster University | Laterally-fed membrane chromatography device |
| CA2969777A1 (en) * | 2016-06-07 | 2017-12-07 | Mcmaster University | Chromatography device and method for filtering a solute from a fluid |
| CN207818084U (zh) * | 2017-11-16 | 2018-09-04 | 华为技术有限公司 | 一种柔性盖板、柔性显示装置以及柔性终端产品 |
| EP4053538A1 (en) | 2021-03-01 | 2022-09-07 | Single Technologies AB | Liquid handling means for performing assays |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3449938A (en) * | 1967-08-03 | 1969-06-17 | Univ Utah | Method for separating and detecting fluid materials |
| US3417548A (en) * | 1967-09-15 | 1968-12-24 | Shell Oil Co | Apparatus and method for performing a continuous chromatographic analysis |
| NL6714123A (https=) * | 1967-10-18 | 1969-04-22 | ||
| US3511028A (en) * | 1969-01-15 | 1970-05-12 | Commerce Usa | Continuous gas-liquid chromatography method utilizing annular open columns |
| US4839032A (en) * | 1986-06-06 | 1989-06-13 | Advanced Energy Dynamics Inc. | Separating constituents of a mixture of particles |
| US4874507A (en) * | 1986-06-06 | 1989-10-17 | Whitlock David R | Separating constituents of a mixture of particles |
| DE4108820A1 (de) * | 1991-03-18 | 1992-09-24 | Karl Dr Reuter | Kontinuierliche chromatographie |
| US5770087A (en) * | 1991-03-18 | 1998-06-23 | Reuter; Karl Arnold | Continuous chromatography |
| EP0670489A3 (de) * | 1994-03-03 | 1996-03-06 | Ciba Geigy Ag | Vorrichtung und Verfahren zur Trennung fluider Substanzen. |
-
1997
- 1997-06-04 EP EP97201699A patent/EP0882982A1/en not_active Withdrawn
-
1998
- 1998-06-03 DK DK98930794T patent/DK0986749T3/da active
- 1998-06-03 JP JP50159499A patent/JP2002508840A/ja not_active Ceased
- 1998-06-03 AT AT98930794T patent/ATE263370T1/de not_active IP Right Cessation
- 1998-06-03 WO PCT/EP1998/003485 patent/WO1998055858A1/en not_active Ceased
- 1998-06-03 PT PT98930794T patent/PT986749E/pt unknown
- 1998-06-03 DE DE69822820T patent/DE69822820T2/de not_active Expired - Fee Related
- 1998-06-03 US US09/445,206 patent/US6565752B1/en not_active Expired - Fee Related
- 1998-06-03 ES ES98930794T patent/ES2218837T3/es not_active Expired - Lifetime
- 1998-06-03 EP EP98930794A patent/EP0986749B1/en not_active Expired - Lifetime
- 1998-06-03 AU AU81105/98A patent/AU8110598A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69822820D1 (de) | 2004-05-06 |
| EP0986749A1 (en) | 2000-03-22 |
| EP0986749B1 (en) | 2004-03-31 |
| JP2002508840A (ja) | 2002-03-19 |
| ATE263370T1 (de) | 2004-04-15 |
| DE69822820T2 (de) | 2005-03-17 |
| PT986749E (pt) | 2004-07-30 |
| US6565752B1 (en) | 2003-05-20 |
| DK0986749T3 (da) | 2004-08-02 |
| WO1998055858A1 (en) | 1998-12-10 |
| EP0882982A1 (en) | 1998-12-09 |
| AU8110598A (en) | 1998-12-21 |
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