ES2197790A1 - Macrolide intermediates - Google Patents

Macrolide intermediates

Info

Publication number
ES2197790A1
ES2197790A1 ES200150042A ES200150042A ES2197790A1 ES 2197790 A1 ES2197790 A1 ES 2197790A1 ES 200150042 A ES200150042 A ES 200150042A ES 200150042 A ES200150042 A ES 200150042A ES 2197790 A1 ES2197790 A1 ES 2197790A1
Authority
ES
Spain
Prior art keywords
macrolide
intermediates
macrolide intermediates
homoerythromycin
deoxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200150042A
Other languages
Spanish (es)
Other versions
ES2197790B1 (en
Inventor
Immaculada Bosch
Victor Centellas
Jose Diago
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz Industrial Products SA
Original Assignee
Biochemie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie SA filed Critical Biochemie SA
Publication of ES2197790A1 publication Critical patent/ES2197790A1/en
Application granted granted Critical
Publication of ES2197790B1 publication Critical patent/ES2197790B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

The present invention relates to the preparation of 9-deoxo-6-deoxy-6,9-epoxy-9,9a-didehydro-9a-aza-9a-homoerythromycin A, of Formula (I) in the form of a stable hydrate and its use as an intermediate in the production of azithromycin.
ES200150042A 1998-11-10 1999-11-09 INTERMEDIATE COMPOSITE OF UTILITY IN THE SYNTHESIS OF MACROLIDOS. Expired - Fee Related ES2197790B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9824580.6A GB9824580D0 (en) 1998-11-10 1998-11-10 Organic compounds
GB9824580 1998-11-10

Publications (2)

Publication Number Publication Date
ES2197790A1 true ES2197790A1 (en) 2004-01-01
ES2197790B1 ES2197790B1 (en) 2005-03-16

Family

ID=10842151

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200150042A Expired - Fee Related ES2197790B1 (en) 1998-11-10 1999-11-09 INTERMEDIATE COMPOSITE OF UTILITY IN THE SYNTHESIS OF MACROLIDOS.

Country Status (4)

Country Link
AU (1) AU1161500A (en)
ES (1) ES2197790B1 (en)
GB (1) GB9824580D0 (en)
WO (1) WO2000027856A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001000640A1 (en) 1999-06-29 2001-01-04 Biochemie S.A. Macrolides
WO2002010144A1 (en) * 2000-07-25 2002-02-07 Laboratorio Silanes, S.A. De C.V. Single-step process for preparing 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle (11.2.1)hexadeca-1(2)-en-8-ona and obtaining a new form of 9-desoxo-9a-methyl-9a-aza-9a-homoerythromycin a
US7683162B2 (en) 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
CN105481913B (en) * 2014-09-19 2019-01-08 宁夏启元药业有限公司 A method of synthesis azithromycin
CN104892697A (en) * 2015-05-05 2015-09-09 黄石世星药业有限责任公司 Azithromycin production technology
CN106432370A (en) * 2016-09-12 2017-02-22 上海现代制药海门有限公司 Preparation method of high-purity erythromycin 6,9-imino ether

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0137132A2 (en) * 1983-07-18 1985-04-17 SOUR PLIVA farmaceutska, Kemijska prehrambena i kozmeticka industrija, n.sol.o. Process for the manufacture of 7,16-dioxa-2-aza-10-0-cladinosyl-12-0-desosaminyl-4,5-dihydroxy-6-ethyl-3,5,9,11,13,15-hexamethyl-bicyclo(11.2.1)-hexadeca-1(2)-ene-8-one and novel intermediate used in this process
WO1994026758A1 (en) * 1993-05-19 1994-11-24 Pfizer Inc. Intermediate for azithromycin
WO1998041532A1 (en) * 1997-03-14 1998-09-24 Biochemie S.A. Erythromycin a oxime dihydrate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0137132A2 (en) * 1983-07-18 1985-04-17 SOUR PLIVA farmaceutska, Kemijska prehrambena i kozmeticka industrija, n.sol.o. Process for the manufacture of 7,16-dioxa-2-aza-10-0-cladinosyl-12-0-desosaminyl-4,5-dihydroxy-6-ethyl-3,5,9,11,13,15-hexamethyl-bicyclo(11.2.1)-hexadeca-1(2)-ene-8-one and novel intermediate used in this process
WO1994026758A1 (en) * 1993-05-19 1994-11-24 Pfizer Inc. Intermediate for azithromycin
WO1998041532A1 (en) * 1997-03-14 1998-09-24 Biochemie S.A. Erythromycin a oxime dihydrate

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BAYOD-JASANADA, M. et al. Synthesis of 9-deoxo-9a-aza-9a- homoerythromycin A 11,12-hydrogen borate and Azithromycin 11,12-hydrogen borate. A new procedure to obtain Azithromycin dihydrate. J. Org. Chem., 1997, Vol. 62, paginas 7479-7481. *
WILKENING, R.R. et al. Novel transannular rearrangements of Azalide Iminoethers. Tetrahedron 1997, Vol. 53, nº 50, paginas 16923-16944. *

Also Published As

Publication number Publication date
GB9824580D0 (en) 1999-01-06
WO2000027856A1 (en) 2000-05-18
AU1161500A (en) 2000-05-29
ES2197790B1 (en) 2005-03-16

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