ES2196263T3 - ANTIHIPERTENSION AGENT. - Google Patents

ANTIHIPERTENSION AGENT.

Info

Publication number
ES2196263T3
ES2196263T3 ES97305820T ES97305820T ES2196263T3 ES 2196263 T3 ES2196263 T3 ES 2196263T3 ES 97305820 T ES97305820 T ES 97305820T ES 97305820 T ES97305820 T ES 97305820T ES 2196263 T3 ES2196263 T3 ES 2196263T3
Authority
ES
Spain
Prior art keywords
antihipertension
agent
effective amount
pro
day
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97305820T
Other languages
Spanish (es)
Inventor
Naoyuki Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Soft Drinks Co Ltd
Original Assignee
Calpis Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calpis Co Ltd filed Critical Calpis Co Ltd
Application granted granted Critical
Publication of ES2196263T3 publication Critical patent/ES2196263T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/80—Antihypertensive peptides

Abstract

A method for producing an antihypertensive agent containing an effective amount of dipeptide Tyr-Pro and/or a pharmaceutically acceptable salt thereof, the effective amount being from 0.05 to 10mg/kg body weight/day.
ES97305820T 1996-08-02 1997-08-01 ANTIHIPERTENSION AGENT. Expired - Lifetime ES2196263T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20466596 1996-08-02

Publications (1)

Publication Number Publication Date
ES2196263T3 true ES2196263T3 (en) 2003-12-16

Family

ID=16494265

Family Applications (2)

Application Number Title Priority Date Filing Date
ES02080463T Expired - Lifetime ES2291417T3 (en) 1996-08-02 1997-08-01 METHOD FOR PREPARING AN ANTIHIPERTENSOR AGENT THAT CONTAINS A DIPEPTIDE AS ACTIVE INGREDIENT.
ES97305820T Expired - Lifetime ES2196263T3 (en) 1996-08-02 1997-08-01 ANTIHIPERTENSION AGENT.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES02080463T Expired - Lifetime ES2291417T3 (en) 1996-08-02 1997-08-01 METHOD FOR PREPARING AN ANTIHIPERTENSOR AGENT THAT CONTAINS A DIPEPTIDE AS ACTIVE INGREDIENT.

Country Status (8)

Country Link
US (1) US5854029A (en)
EP (2) EP1302207B1 (en)
JP (2) JP3364579B2 (en)
AT (2) ATE238825T1 (en)
DE (2) DE69738185T2 (en)
DK (2) DK0821968T3 (en)
ES (2) ES2291417T3 (en)
PT (1) PT1302207E (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6998259B1 (en) 1999-05-20 2006-02-14 Davisco Foods International Enzymatic treatment of whey proteins for the production of antihypertensive peptides and the resulting products
US6630320B1 (en) 2000-05-08 2003-10-07 Devisco Foods International, Inc. Treatment of hypertension in mammals with hydrolyzed whey proteins
FI113741B (en) 1999-11-01 2004-06-15 Valio Oy Process for the preparation of a product containing peptides with antihypertensive effect
TWI225070B (en) 1999-12-01 2004-12-11 Food Industry Res & Dev Inst Novel peptides used as angiotensin converting enzyme inhibitor and preparation process thereof
WO2001068113A1 (en) * 2000-03-10 2001-09-20 Monsanto Technology Llc Anti-hypertensive peptides
AU2001247334A1 (en) * 2000-03-10 2001-09-24 Monsanto Company Novel peptides with anti-hypertensive activity
CA2415688A1 (en) * 2000-05-08 2001-11-15 Anand Rao Enzymatic treatment of whey proteins for the production of antihypertensive peptides, the resulting products and treatment of hypertension in mammals
JP4499564B2 (en) 2002-08-09 2010-07-07 セーホーエル．ハンセン アクティーゼルスカブ Method for producing peptides having antihypertensive properties
US7718171B2 (en) 2003-04-07 2010-05-18 Chr. Hansen A/S Reducing heart rate in mammals using milk derived fermentation products produced using Lactobacillus helveticus
EP1466529A1 (en) * 2003-04-07 2004-10-13 Chr. Hansen A/S Composition with heart rate reducing properties
JP4680571B2 (en) * 2003-12-25 2011-05-11 カルピス株式会社 Moisturizer for ingestion
JP2008511593A (en) 2004-09-03 2008-04-17 セーホーエル．ハンセン アクティーゼルスカブ Fermented milk or vegetable protein containing receptor ligand and use thereof
JP4635159B2 (en) * 2005-09-05 2011-02-16 独立行政法人農業・食品産業技術総合研究機構 Edible plant body containing GABA in high concentration and method for producing the same
JP4868619B2 (en) * 2005-09-05 2012-02-01 独立行政法人農業・食品産業技術総合研究機構 Edible plant containing high concentration of vitamin U, taurine, carnosine, Tyr-Pro and / or L-carnitine and method for producing the same
ATE493999T1 (en) * 2008-09-09 2011-01-15 Unilever Nv FOODS CONTAINING DIPEPTIDES WITH BLOOD PRESSURE-LOWERING PROPERTIES.
EP2161029A1 (en) * 2008-09-09 2010-03-10 Unilever N.V. Composition comprising peptides
CN102448480A (en) * 2009-03-27 2012-05-09 可尔必思株式会社 Composition for regulating autonomic nervous activity and method for regulating autonomic nerve
MY160992A (en) * 2010-11-09 2017-03-31 Asahi Group Holdings Ltd Lactobacillus helveticus having high proteolysis activity
US8673862B1 (en) 2012-09-06 2014-03-18 Food Industry Research And Development Institute Peptides and use thereof in the inhibition of angiotensin converting enzyme
JP6923882B2 (en) * 2016-06-23 2021-08-25 国立大学法人鳥取大学 Method for producing fermented milk and bioactive peptide having high angiotensin converting enzyme inhibitory activity
JP7453665B2 (en) 2019-01-29 2024-03-21 国立大学法人鳥取大学 Fermented milk with high dipeptidyl peptidase IV inhibitory activity and method for producing the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3047596A1 (en) * 1980-12-17 1982-07-22 Victor Dipl.- Chem. 8000 München Brantl Neuroleptic tyrosyl-proline di:peptide derivs. - prepd. by conventional linking of the component aminoacid(s)
JP3782837B2 (en) * 1995-04-10 2006-06-07 カルピス株式会社 Antihypertensive agent and method for producing the same

Also Published As

Publication number Publication date
JP2003048849A (en) 2003-02-21
EP0821968A3 (en) 1999-07-14
ATE238825T1 (en) 2003-05-15
ES2291417T3 (en) 2008-03-01
DK1302207T3 (en) 2007-11-05
DE69738185T2 (en) 2008-07-10
EP0821968B1 (en) 2003-05-02
US5854029A (en) 1998-12-29
JP4713053B2 (en) 2011-06-29
DE69721407D1 (en) 2003-06-05
DE69738185D1 (en) 2007-11-15
EP1302207A3 (en) 2003-04-23
EP1302207A2 (en) 2003-04-16
EP1302207B1 (en) 2007-10-03
EP0821968A2 (en) 1998-02-04
DE69721407T2 (en) 2004-05-06
JP3364579B2 (en) 2003-01-08
PT1302207E (en) 2007-11-08
DK0821968T3 (en) 2003-06-02
ATE374617T1 (en) 2007-10-15
JPH1095736A (en) 1998-04-14

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