ES2196263T3 - ANTIHIPERTENSION AGENT. - Google Patents

ANTIHIPERTENSION AGENT.

Info

Publication number
ES2196263T3
ES2196263T3 ES97305820T ES97305820T ES2196263T3 ES 2196263 T3 ES2196263 T3 ES 2196263T3 ES 97305820 T ES97305820 T ES 97305820T ES 97305820 T ES97305820 T ES 97305820T ES 2196263 T3 ES2196263 T3 ES 2196263T3
Authority
ES
Spain
Prior art keywords
antihipertension
agent
effective amount
pro
day
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97305820T
Other languages
Spanish (es)
Inventor
Naoyuki Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Soft Drinks Co Ltd
Original Assignee
Calpis Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calpis Co Ltd filed Critical Calpis Co Ltd
Application granted granted Critical
Publication of ES2196263T3 publication Critical patent/ES2196263T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/80—Antihypertensive peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A method for producing an antihypertensive agent containing an effective amount of dipeptide Tyr-Pro and/or a pharmaceutically acceptable salt thereof, the effective amount being from 0.05 to 10mg/kg body weight/day.
ES97305820T 1996-08-02 1997-08-01 ANTIHIPERTENSION AGENT. Expired - Lifetime ES2196263T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20466596 1996-08-02

Publications (1)

Publication Number Publication Date
ES2196263T3 true ES2196263T3 (en) 2003-12-16

Family

ID=16494265

Family Applications (2)

Application Number Title Priority Date Filing Date
ES97305820T Expired - Lifetime ES2196263T3 (en) 1996-08-02 1997-08-01 ANTIHIPERTENSION AGENT.
ES02080463T Expired - Lifetime ES2291417T3 (en) 1996-08-02 1997-08-01 METHOD FOR PREPARING AN ANTIHIPERTENSOR AGENT THAT CONTAINS A DIPEPTIDE AS ACTIVE INGREDIENT.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES02080463T Expired - Lifetime ES2291417T3 (en) 1996-08-02 1997-08-01 METHOD FOR PREPARING AN ANTIHIPERTENSOR AGENT THAT CONTAINS A DIPEPTIDE AS ACTIVE INGREDIENT.

Country Status (8)

Country Link
US (1) US5854029A (en)
EP (2) EP1302207B1 (en)
JP (2) JP3364579B2 (en)
AT (2) ATE374617T1 (en)
DE (2) DE69721407T2 (en)
DK (2) DK0821968T3 (en)
ES (2) ES2196263T3 (en)
PT (1) PT1302207E (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6998259B1 (en) 1999-05-20 2006-02-14 Davisco Foods International Enzymatic treatment of whey proteins for the production of antihypertensive peptides and the resulting products
US6630320B1 (en) 2000-05-08 2003-10-07 Devisco Foods International, Inc. Treatment of hypertension in mammals with hydrolyzed whey proteins
FI113741B (en) * 1999-11-01 2004-06-15 Valio Oy Process for the preparation of a product containing peptides with antihypertensive effect
TWI225070B (en) 1999-12-01 2004-12-11 Food Industry Res & Dev Inst Novel peptides used as angiotensin converting enzyme inhibitor and preparation process thereof
AU2001245537A1 (en) * 2000-03-10 2001-09-24 Monsanto Company Anti-hypertensive peptides
WO2001068114A1 (en) * 2000-03-10 2001-09-20 Monsanto Company Novel peptides with anti-hypertensive activity
EP1287159A4 (en) * 2000-05-08 2005-02-09 Davisco Foods Int Inc ENZYMATIC TREATMENT OF LACTOSERUM PROTEINS FOR OBTAINING ANTI-HYPERTENSION PEPTIDES, PRODUCTS OBTAINED AND TREATMENT OF HYPERTENSION IN MAMMALS
EP1529114A1 (en) 2002-08-09 2005-05-11 Chr. Hansen A/S Process for preparing peptides with anti-hypertensive properties
US7718171B2 (en) 2003-04-07 2010-05-18 Chr. Hansen A/S Reducing heart rate in mammals using milk derived fermentation products produced using Lactobacillus helveticus
EP1466529A1 (en) * 2003-04-07 2004-10-13 Chr. Hansen A/S Composition with heart rate reducing properties
JP4680571B2 (en) * 2003-12-25 2011-05-11 カルピス株式会社 Moisturizer for ingestion
JP2008511593A (en) 2004-09-03 2008-04-17 セーホーエル．ハンセン アクティーゼルスカブ Fermented milk or vegetable protein containing receptor ligand and use thereof
JP4868619B2 (en) * 2005-09-05 2012-02-01 独立行政法人農業・食品産業技術総合研究機構 Edible plant containing high concentration of vitamin U, taurine, carnosine, Tyr-Pro and / or L-carnitine and method for producing the same
JP4635159B2 (en) * 2005-09-05 2011-02-16 独立行政法人農業・食品産業技術総合研究機構 Edible plant body containing GABA in high concentration and method for producing the same
ATE493999T1 (en) * 2008-09-09 2011-01-15 Unilever Nv FOODS CONTAINING DIPEPTIDES WITH BLOOD PRESSURE-LOWERING PROPERTIES.
EP2161029A1 (en) * 2008-09-09 2010-03-10 Unilever N.V. Composition comprising peptides
TW201039839A (en) * 2009-03-27 2010-11-16 Calpis Co Ltd Composition for regulating antonomic nervous activity and method for regulating autonomic nervous
WO2012063826A1 (en) * 2010-11-09 2012-05-18 カルピス株式会社 Bacterium lactobacillus helveticus having high proteolysis activity
US8673862B1 (en) 2012-09-06 2014-03-18 Food Industry Research And Development Institute Peptides and use thereof in the inhibition of angiotensin converting enzyme
US10780127B2 (en) 2016-06-23 2020-09-22 National University Corporation Tottori University Method for producing fermented milk having high angiotensin converting enzyme inhibitory activity and method for producing physiologically active peptide
JP7453665B2 (en) * 2019-01-29 2024-03-21 国立大学法人鳥取大学 Fermented milk with high dipeptidyl peptidase IV inhibitory activity and method for producing the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3047596A1 (en) * 1980-12-17 1982-07-22 Victor Dipl.- Chem. 8000 München Brantl Neuroleptic tyrosyl-proline di:peptide derivs. - prepd. by conventional linking of the component aminoacid(s)
JP3782837B2 (en) * 1995-04-10 2006-06-07 カルピス株式会社 Antihypertensive agent and method for producing the same

Also Published As

Publication number Publication date
DE69721407D1 (en) 2003-06-05
ATE374617T1 (en) 2007-10-15
US5854029A (en) 1998-12-29
ES2291417T3 (en) 2008-03-01
PT1302207E (en) 2007-11-08
EP1302207A2 (en) 2003-04-16
JP2003048849A (en) 2003-02-21
DK1302207T3 (en) 2007-11-05
EP0821968B1 (en) 2003-05-02
JP4713053B2 (en) 2011-06-29
ATE238825T1 (en) 2003-05-15
DK0821968T3 (en) 2003-06-02
DE69721407T2 (en) 2004-05-06
EP1302207B1 (en) 2007-10-03
DE69738185D1 (en) 2007-11-15
JP3364579B2 (en) 2003-01-08
JPH1095736A (en) 1998-04-14
EP1302207A3 (en) 2003-04-23
EP0821968A2 (en) 1998-02-04
DE69738185T2 (en) 2008-07-10
EP0821968A3 (en) 1999-07-14

Similar Documents

Publication Publication Date Title
ES2196263T3 (en) ANTIHIPERTENSION AGENT.
PL323152A1 (en) Derivatives of 1,3-propanodiole as biologically active compounds
EP0248594A3 (en) Pharmacologically active 1,5-diaryl-3-substituted-pyrazopharmacologically active 1,5-diaryl-3-substituted-pyrazoles and method for synthesizing the same les and method for synthesizing the same
AU3215597A (en) Method of inhibiting fibrosis with a somatostatin agonist
IT1299982B1 (en) METHOD FOR THE CREATION OF CIGARETTE PACKAGES AND PLANT FOR THE IMPLEMENTATION OF THIS METHOD.
GR3036669T3 (en) O-carbamoyl-phenylalaninol having substituent at benzene ring, its pharmaceutically useful salts and method for preparing the same
WO1993000094A3 (en) Use of tetrahydrobenzazepine derivatives for the treatment of portal hypertension and migraine
PL309259A1 (en) Insecticidal derivatives of 5-substituted 2,4-diamine pyride
FI941776A7 (en) Method for the preparation of 1,2,4-thiadiazoles
PL322802A1 (en) Derivatives of 10,13,15-trioxatricyclo[9.2.1.1]-pentadecanone, method of obtaining them and therapeutic agents containing such compounds
CS440889A2 (en) Method of bu-3608 antibiotics' complex n-alkyl derivatives production
ITMI913465A1 (en) PROCEDURE FOR THE PURIFICATION OF 1, 1, 1-TRIFLUORO-2-FLUOROETANO
ZA933151B (en) Cycloheptimidazole derivatives, method of manufacturing the same and therapeutic agents containing these compounds.
IT1274859B (en) METHOD AND DEVICE FOR THE PNEUMATIC SUPPLY OF CIGARETTE PACKAGES.
EP0127124A3 (en) Compounds for treating hypertension
FR2630907B1 (en) SCREWED COTYL, ESPECIALLY FOR "HIP" TYPE PROSTHESIS
UA29461C2 (en) An agent for treatment of amyloidosis, a method for treatment of amyloidosis
EP0846465A4 (en) REMEDY FOR ANXIETY NEVROSIS
GB2218453B (en) "method of construction."
IT1252659B (en) PROCEDURE FOR THE PURIFICATION OF 1,1,1-TRIFLUORO-2-FLUOROETANO AND 1,1,1-TRIFLUORO-2,2-DICHLOROETANO
ZA974929B (en) New forms of organic salts of N'N-diacetylcystine.
IT1282639B1 (en) DEVICE FOR THE STORAGE OF CIGARETTES OR SIMILAR
IL116262A0 (en) Processes for preparing ranitidine
IT1296613B1 (en) DRUG FOR THE TREATMENT OF IRCISM CONTAINING AN ADRENOCORTICOSTEROID.
ITMI931371A1 (en) PROCEDURE FOR THE PREPARATION OF ERDOSTEIN