ES2194988T3 - Inhibidor de infecciones por c. difficile con la ayuda de oligosacaridos indigeribles. - Google Patents

Inhibidor de infecciones por c. difficile con la ayuda de oligosacaridos indigeribles.

Info

Publication number
ES2194988T3
ES2194988T3 ES96912568T ES96912568T ES2194988T3 ES 2194988 T3 ES2194988 T3 ES 2194988T3 ES 96912568 T ES96912568 T ES 96912568T ES 96912568 T ES96912568 T ES 96912568T ES 2194988 T3 ES2194988 T3 ES 2194988T3
Authority
ES
Spain
Prior art keywords
difficile
diarrhea
microflora
inhibit
oligosacarids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96912568T
Other languages
English (en)
Inventor
Keith Allen Garleb
Brian Warren Wolf
Jonathan Allan Meulbroek
Keith Brian Wheeler
Shelia Martinson Campbell
Joseph Edward Walton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/417,413 external-priority patent/US5688777A/en
Priority claimed from US08/417,411 external-priority patent/US5733579A/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2194988T3 publication Critical patent/ES2194988T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA ETIOLOGIA PRINCIPAL DE LA DIARREA ASOCIADA A ANTIBIOTICOS (TAMBIEN CONOCIDA COMO COLITIS PSEUDOMEMBRANOSA) SE HA DESCUBIERTO QUE ES DEBIDA A CLOSTRIDIUM DIFFICILE. SE CREE QUE LA MICROFLORA NATIVA DE UN INDIVIDUO SANO SUPRIME EL C. DIFFICILE PRESENTE NORMALMENTE. SIN EMBARGO, CUANDO LA MICROFLORA NATIVA SE VE ALTERADA (POR EJEMPLO DURANTE EL TRATAMIENTO CON ANTIBIOTICO), PUEDE PRODUCIRSE UN CRECIMIENTO EXCESIVO DE C. DIFFICILE, LO QUE PRODUCE DIARREA Y COLITIS. EL TRATAMIENTO DE C. DIFFICILE CON ANTIBIOTICOS HA DEMOSTRADO SER EFICAZ, SI BIEN SE PRODUCEN RECAIDAS FRECUENTES, Y LA DESHIDRATACION DEBIDA A LA DIARREA CONSTITUYE UN PROBLEMA EXACERBADOR. SE HA SUGERIDO QUE LA NORMALIZACION DE LA MICROFLORA INHIBIRIA LA RECAIDA POR C. DIFFICILE. LOS OLIGOSACARIDOS INDIGERIBLES HAN DEMOSTRADO INHIBIR LA INFECCION POR C. DIFFICILE. UNA SOLUCION ORAL DE REHIDRATACION QUE CONTIENE DICHOS OLIGOSACARIDOS INDIGERIBLES TAMBIEN PROPORCIONA SUMINISTRO DE LIQUIDOS Y ELECTROLITOS.
ES96912568T 1995-04-05 1996-04-04 Inhibidor de infecciones por c. difficile con la ayuda de oligosacaridos indigeribles. Expired - Lifetime ES2194988T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/417,413 US5688777A (en) 1995-04-05 1995-04-05 Inhibition of C. difficile infections by indigestible oligosaccharides
US08/417,411 US5733579A (en) 1995-04-05 1995-04-05 Oral rehydration solution containing indigestible oligosaccharides

Publications (1)

Publication Number Publication Date
ES2194988T3 true ES2194988T3 (es) 2003-12-01

Family

ID=27023728

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96912568T Expired - Lifetime ES2194988T3 (es) 1995-04-05 1996-04-04 Inhibidor de infecciones por c. difficile con la ayuda de oligosacaridos indigeribles.

Country Status (14)

Country Link
EP (1) EP0820292B1 (es)
JP (1) JPH11503168A (es)
AT (1) ATE232389T1 (es)
AU (1) AU704004B2 (es)
CA (1) CA2217157C (es)
DE (1) DE69626200T2 (es)
DK (1) DK0820292T3 (es)
ES (1) ES2194988T3 (es)
HK (1) HK1008492A1 (es)
MX (1) MX9707631A (es)
NO (1) NO313685B1 (es)
NZ (1) NZ306712A (es)
PT (1) PT820292E (es)
WO (1) WO1996031219A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60031385D1 (de) * 2000-06-28 2006-11-30 B S D Bio Science Dev Snc Di O Pharmazeutische Zusammensetzungen von Antibiotika und Fruktan-Gemische
EP1243273A1 (en) † 2001-03-22 2002-09-25 Societe Des Produits Nestle S.A. Composition comprising a prebiotic for decreasing infammatory process and abnormal activation of non-specific immune parameters
AU2005289330A1 (en) * 2004-09-30 2006-04-06 Ab Biopharma Inc. Rehydration compositions comprising epidermal growth factor
CN101668437A (zh) * 2007-03-13 2010-03-10 N.V.努特里奇亚 使用含有非消化性糖的组合物改善能力的方法
EP3431090A4 (en) * 2016-03-14 2020-04-15 B Food Science Co., Ltd. PROLIFERATIVE AGENT FOR BACTERIA OF THE GENE FAECALIBACTERIUM

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902674A (en) * 1987-10-13 1990-02-20 Coors Biotech, Inc. Method for inhibiting the growth of salmonella
NZ232346A (en) * 1989-02-07 1992-03-26 Duphar Int Res Effervescent oral rehydration solution comprising saccharides, amino acids and bicarbonate salts
US5397786A (en) * 1993-01-08 1995-03-14 Simone; Charles B. Rehydration drink

Also Published As

Publication number Publication date
JPH11503168A (ja) 1999-03-23
NO313685B1 (no) 2002-11-18
ATE232389T1 (de) 2003-02-15
NO974490L (no) 1997-09-29
NO974490D0 (no) 1997-09-29
EP0820292A1 (en) 1998-01-28
DK0820292T3 (da) 2003-05-19
AU704004B2 (en) 1999-04-01
MX9707631A (es) 1998-04-30
CA2217157C (en) 2002-07-30
DE69626200T2 (de) 2003-12-18
DE69626200D1 (de) 2003-03-20
CA2217157A1 (en) 1996-10-10
PT820292E (pt) 2003-06-30
EP0820292B1 (en) 2003-02-12
WO1996031219A1 (en) 1996-10-10
HK1008492A1 (en) 1999-05-14
NZ306712A (en) 1999-10-28
AU5534296A (en) 1996-10-23

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