ES2191269T3 - USE OF A CATIONIC POLYMER TO OBTAIN A NUCLEIC ACID COMPLEX AND RELATED COMPOSITIONS. - Google Patents

USE OF A CATIONIC POLYMER TO OBTAIN A NUCLEIC ACID COMPLEX AND RELATED COMPOSITIONS.

Info

Publication number
ES2191269T3
ES2191269T3 ES98402142T ES98402142T ES2191269T3 ES 2191269 T3 ES2191269 T3 ES 2191269T3 ES 98402142 T ES98402142 T ES 98402142T ES 98402142 T ES98402142 T ES 98402142T ES 2191269 T3 ES2191269 T3 ES 2191269T3
Authority
ES
Spain
Prior art keywords
nucleic acid
cationic polymer
acid complex
related compositions
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98402142T
Other languages
Spanish (es)
Inventor
Hanno V J Kolbe
Otmane Boussif
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transgene SA
Original Assignee
Transgene SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgene SA filed Critical Transgene SA
Application granted granted Critical
Publication of ES2191269T3 publication Critical patent/ES2191269T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention discloses complexes comprising a) at least one polymer of the general formula : <CHEM> wherein: the degree of polymerization p ranges from 2 to 1000000, R1, R2 and R3, independently of one another in each ÄCH - CH2Ü repeat, are selected from H, alkyl of to 20 carbon atoms or aryl of 5 to 7 carbon atoms, n is 0 or 1, with the proviso that at least one n is 1 in the full length of the polymer, and b) at least one nucleic acid. Further disclosed are pharmaceutical compositions comprising these complexes which can be used for intra cellular delivery of nucleic acids.
ES98402142T 1998-08-28 1998-08-28 USE OF A CATIONIC POLYMER TO OBTAIN A NUCLEIC ACID COMPLEX AND RELATED COMPOSITIONS. Expired - Lifetime ES2191269T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98402142A EP0987029B1 (en) 1998-08-28 1998-08-28 Use of a catonic polymer for the preparation of a complex with nucleic acid and related compositions

Publications (1)

Publication Number Publication Date
ES2191269T3 true ES2191269T3 (en) 2003-09-01

Family

ID=8235477

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98402142T Expired - Lifetime ES2191269T3 (en) 1998-08-28 1998-08-28 USE OF A CATIONIC POLYMER TO OBTAIN A NUCLEIC ACID COMPLEX AND RELATED COMPOSITIONS.

Country Status (8)

Country Link
EP (1) EP0987029B1 (en)
JP (1) JP2000135082A (en)
AT (1) ATE231399T1 (en)
AU (1) AU750696B2 (en)
CA (1) CA2281442A1 (en)
DE (1) DE69810925T2 (en)
DK (1) DK0987029T3 (en)
ES (1) ES2191269T3 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040048819A1 (en) * 2000-10-09 2004-03-11 Joachim Simon Complexes for transferring nucleic acids into cells
JP2004521109A (en) * 2001-01-17 2004-07-15 ザイコス インク． Formulation for nucleic acid transport
FR2928373B1 (en) 2008-03-05 2010-12-31 Centre Nat Rech Scient LINEAR POLYETHYLENIMINE DERIVATIVE POLYMER FOR GENE TRANSFER.
EP3235513A1 (en) * 2016-04-18 2017-10-25 Université de Liège Improvements in or relating to organic material

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0580078B1 (en) * 1992-07-22 1997-10-15 Hoechst Aktiengesellschaft Hydrophilic groups containing poly(vinylamine) derivatives, process for their manufacture and use thereof as pharmaceutical compounds, substrates for active substances and foodstuff ingredients
US5629184A (en) * 1995-01-25 1997-05-13 Amgen Inc. Cationic copolymers of vinylamine and vinyl alcohol for the delivery of oligonucleotides
FR2744453B1 (en) * 1996-02-05 1998-07-10 Transgene Sa LIPOPOLYAMINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, NUCLEIC ACID TRANSFER VECTORS AND PREPARATION METHOD

Also Published As

Publication number Publication date
CA2281442A1 (en) 2000-02-28
DK0987029T3 (en) 2003-03-31
EP0987029A1 (en) 2000-03-22
DE69810925D1 (en) 2003-02-27
AU4472799A (en) 2000-03-16
AU750696B2 (en) 2002-07-25
DE69810925T2 (en) 2004-01-08
JP2000135082A (en) 2000-05-16
ATE231399T1 (en) 2003-02-15
EP0987029B1 (en) 2003-01-22

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