ES2190707B2 - Procedimiento de preparacion de talidomida mediante irradiacion en horno microondas. - Google Patents

Procedimiento de preparacion de talidomida mediante irradiacion en horno microondas.

Info

Publication number
ES2190707B2
ES2190707B2 ES200002113A ES200002113A ES2190707B2 ES 2190707 B2 ES2190707 B2 ES 2190707B2 ES 200002113 A ES200002113 A ES 200002113A ES 200002113 A ES200002113 A ES 200002113A ES 2190707 B2 ES2190707 B2 ES 2190707B2
Authority
ES
Spain
Prior art keywords
microwave oven
irradiation
preparation procedure
talidomide
thalidomide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200002113A
Other languages
English (en)
Other versions
ES2190707A1 (es
Inventor
Julio Antonio Seijas Vazquez
Maria Pilar Vazquez Tato
Cristobal Gonzalez Bande
Beatriz Pacios Lopez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidade de Santiago de Compostela
Original Assignee
Universidade de Santiago de Compostela
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade de Santiago de Compostela filed Critical Universidade de Santiago de Compostela
Priority to ES200002113A priority Critical patent/ES2190707B2/es
Publication of ES2190707A1 publication Critical patent/ES2190707A1/es
Application granted granted Critical
Publication of ES2190707B2 publication Critical patent/ES2190707B2/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento de preparación de talidomida mediante irradiación en horno microondas. Se prepara la talidomida a partir de ácido N-ftaloil-L-glutámico, mediante la formación del anillo de 2,6- piperidinodiona por ciclación con tiourea, el calentamiento de la mezcla homogénea de ambos se realiza en un horno microondas, durante 15 minutos.
ES200002113A 2000-08-22 2000-08-22 Procedimiento de preparacion de talidomida mediante irradiacion en horno microondas. Expired - Fee Related ES2190707B2 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES200002113A ES2190707B2 (es) 2000-08-22 2000-08-22 Procedimiento de preparacion de talidomida mediante irradiacion en horno microondas.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200002113A ES2190707B2 (es) 2000-08-22 2000-08-22 Procedimiento de preparacion de talidomida mediante irradiacion en horno microondas.

Publications (2)

Publication Number Publication Date
ES2190707A1 ES2190707A1 (es) 2003-08-01
ES2190707B2 true ES2190707B2 (es) 2005-03-01

Family

ID=27675877

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200002113A Expired - Fee Related ES2190707B2 (es) 2000-08-22 2000-08-22 Procedimiento de preparacion de talidomida mediante irradiacion en horno microondas.

Country Status (1)

Country Link
ES (1) ES2190707B2 (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB768821A (en) * 1954-05-17 1957-02-20 Gruenenthal Chemie Novel products of the amino-piperidine-2, 6-dione series

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A.U. RAHMAN et al. "Reactions Between Acids and Thiourea". Recl. Trav. Chim. Pays-Bas, 1960, Vol. 79, páginas 188-192, tabla 1. *
J.A. SEIJAS et al. "Direct Synthesis of Imides from Dicarboxylic Acids using Microwaves". J. Chem. Research (S), 1999, Vol. 7, páginas 420-421, esquema 1. *
N. FLAIH et al. "An Expeditious Synthesis of Cyclic Imides". Tetrahedron Letters, 1999, Vol. 40, páginas 3697-3698, compuesto 1e. *

Also Published As

Publication number Publication date
ES2190707A1 (es) 2003-08-01

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