ES2189597A1 - Derivados de 12,13-dihidro-5h-indolo(2,3-a)pirrolo(3,4-c)carbazol-5,7(6h)-diona como agentes antineoplasicos. - Google Patents

Derivados de 12,13-dihidro-5h-indolo(2,3-a)pirrolo(3,4-c)carbazol-5,7(6h)-diona como agentes antineoplasicos.

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Publication number
ES2189597A1
ES2189597A1 ES200001782A ES200001782A ES2189597A1 ES 2189597 A1 ES2189597 A1 ES 2189597A1 ES 200001782 A ES200001782 A ES 200001782A ES 200001782 A ES200001782 A ES 200001782A ES 2189597 A1 ES2189597 A1 ES 2189597A1
Authority
ES
Spain
Prior art keywords
anhydride
dione
synthesised
dihydro
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200001782A
Other languages
English (en)
Other versions
ES2189597B2 (es
Inventor
Brana Miguel Fernandez
Diaz Loreto Anorbe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fundacion Universitaria San Pablo CEU
Original Assignee
Fundacion Universitaria San Pablo CEU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacion Universitaria San Pablo CEU filed Critical Fundacion Universitaria San Pablo CEU
Priority to ES200001782A priority Critical patent/ES2189597B2/es
Publication of ES2189597A1 publication Critical patent/ES2189597A1/es
Application granted granted Critical
Publication of ES2189597B2 publication Critical patent/ES2189597B2/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Nuevos derivados de 12, 13-dihidro-5H-indolo[2,3-a]pirrolo[3,4- c]carbazol-5,7(6H)-diona de fórmula general I, donde Q'', Y, Y'', R''`, R''`'', X y Z pueden ser diferentes tipos de átomos, cadenas y grupos de química orgánica, caracterizados por su actividad antiproliferativa celular, en particular, de células cancerosas y endoteliales humanas, en unos valores comprendidos entre 0.00001 y 0,0000001 M. Estos compuestos son sintetizados a partir de un anhídrido mono o disustituido, que se transforma en la correspondiente imida, la cual, una vez purificada y sustituido el OH por un buen grupo saliente, se convierte en el amino derivado, del que se obtienen las diferentes sales, profármacos de sales y medicamentos para su utilización como agentes antineoplásicos en la terapia anticancerosa, por cualquier medio disponible en clínica.
ES200001782A 2000-07-18 2000-07-18 Derivados de 12,13-dihidro-5h-indolo(2,3-a)pirrolo(3,4-c)carbazol-5,7(6h)-diona como agentes antineoplasicos. Expired - Fee Related ES2189597B2 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES200001782A ES2189597B2 (es) 2000-07-18 2000-07-18 Derivados de 12,13-dihidro-5h-indolo(2,3-a)pirrolo(3,4-c)carbazol-5,7(6h)-diona como agentes antineoplasicos.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200001782A ES2189597B2 (es) 2000-07-18 2000-07-18 Derivados de 12,13-dihidro-5h-indolo(2,3-a)pirrolo(3,4-c)carbazol-5,7(6h)-diona como agentes antineoplasicos.

Publications (2)

Publication Number Publication Date
ES2189597A1 true ES2189597A1 (es) 2003-07-01
ES2189597B2 ES2189597B2 (es) 2004-06-16

Family

ID=8494310

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200001782A Expired - Fee Related ES2189597B2 (es) 2000-07-18 2000-07-18 Derivados de 12,13-dihidro-5h-indolo(2,3-a)pirrolo(3,4-c)carbazol-5,7(6h)-diona como agentes antineoplasicos.

Country Status (1)

Country Link
ES (1) ES2189597B2 (es)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018766A1 (en) * 1992-03-20 1993-09-30 The Wellcome Foundation Limited Further indole derivatives with antiviral activity
WO1993024491A1 (de) * 1992-05-30 1993-12-09 Gödecke Aktiengesellschaft Indolocarbazol-imide und deren verwendung
EP0675125A1 (en) * 1994-03-18 1995-10-04 Kyowa Hakko Kogyo Co., Ltd. A therapeutic agent for thrombocytopenia and indolocarbazole derivatives
WO1996004906A1 (en) * 1994-08-13 1996-02-22 The Wellcome Foundation Limited Compounds for the treatment of restenosis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018766A1 (en) * 1992-03-20 1993-09-30 The Wellcome Foundation Limited Further indole derivatives with antiviral activity
WO1993024491A1 (de) * 1992-05-30 1993-12-09 Gödecke Aktiengesellschaft Indolocarbazol-imide und deren verwendung
EP0675125A1 (en) * 1994-03-18 1995-10-04 Kyowa Hakko Kogyo Co., Ltd. A therapeutic agent for thrombocytopenia and indolocarbazole derivatives
WO1996004906A1 (en) * 1994-08-13 1996-02-22 The Wellcome Foundation Limited Compounds for the treatment of restenosis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Bioorganic Medicinal Chemistry Letters, Vol. 5, nö 1, páginas 55-60, 1995. KLEINSCHROTH et al. "Novel indolocarbazole protein Kinase C inhibitors with improved biochemical properties". Todo el documento. *

Also Published As

Publication number Publication date
ES2189597B2 (es) 2004-06-16

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