ES2187079T3 - Nuevos conjugados colorante-polisacarido y su uso como agente de diagnostico. - Google Patents

Nuevos conjugados colorante-polisacarido y su uso como agente de diagnostico.

Info

Publication number
ES2187079T3
ES2187079T3 ES98965849T ES98965849T ES2187079T3 ES 2187079 T3 ES2187079 T3 ES 2187079T3 ES 98965849 T ES98965849 T ES 98965849T ES 98965849 T ES98965849 T ES 98965849T ES 2187079 T3 ES2187079 T3 ES 2187079T3
Authority
ES
Spain
Prior art keywords
conjugates
diagnostic agent
polisacarido
new colorant
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98965849T
Other languages
English (en)
Inventor
Elmar Bosies
Heinz-Michael Hein
Rudolf Reiter
Hans-Peter Josel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics GmbH filed Critical Roche Diagnostics GmbH
Application granted granted Critical
Publication of ES2187079T3 publication Critical patent/ES2187079T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0051—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Fructofuranans, e.g. beta-2,6-D-fructofuranan, i.e. levan; Derivatives thereof
    • C08B37/0054—Inulin, i.e. beta-2,1-D-fructofuranan; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Optics & Photonics (AREA)
  • Food Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Compuestos de fórmula I F-X-(espaciador)n-Y-E-(CH2)m-PS (I), en la que F = un componente colorante con un máximo de absorción comprendido entre 500 y 1300 nm, preferiblemente entre 600 y 900 nm, n = 0 ó 1, m = 0 ó 1, X, para el caso en que es n = 0, es igual a -CO, -NH-C=O, -NH-C=S, -NH-C=NH, -CONH-C=S, X, para el caso en que es n = 1, es igual a -NH, -CONH, -SO2NH, -NHCONH, -NHCSNH, espaciador = un grupo (C2-C6) alquileno o el grupo**(Fórmula)** en donde p = 0 - 4 y R1 puede ser = hidrógeno o el grupo ácido sulfónico, Y = guión de valencia, -CH2, -NHCOCH2, -NH-C=O, -NH-C=S, -NH-C=NH, E = o NH, y PS representa un polifructosano, en donde en el caso en que son E = O y m = 0, el átomo de oxígeno a través del que está unido el polisacárido es parte de este polisacárido y en el caso en que es E = NH, se trata de un polifructosano aminado o bien aminoalquilado.
ES98965849T 1997-12-17 1998-12-17 Nuevos conjugados colorante-polisacarido y su uso como agente de diagnostico. Expired - Lifetime ES2187079T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97122248A EP0934986A1 (de) 1997-12-17 1997-12-17 Farbstoff-Polyaccharid- bzw. Cyclosaccharid-Konjugate und deren Verwendung als Diagnostikum

Publications (1)

Publication Number Publication Date
ES2187079T3 true ES2187079T3 (es) 2003-05-16

Family

ID=8227817

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98965849T Expired - Lifetime ES2187079T3 (es) 1997-12-17 1998-12-17 Nuevos conjugados colorante-polisacarido y su uso como agente de diagnostico.

Country Status (8)

Country Link
US (1) US6689616B1 (es)
EP (2) EP0934986A1 (es)
JP (1) JP2003527447A (es)
AT (1) ATE227324T1 (es)
CA (1) CA2315207A1 (es)
DE (1) DE59806216D1 (es)
ES (1) ES2187079T3 (es)
WO (1) WO1999031183A1 (es)

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DE10023051B4 (de) * 2000-05-11 2004-02-19 Roche Diagnostics Gmbh Verfahren zur Herstellung von Fluoresceinisothiocyanat-Sinistrin, dessen Verwendung und Fluoresceinisothiocyanat-Sinistrin enthaltende diagnostische Zubereitung
EP1221465A1 (en) * 2001-01-03 2002-07-10 Innosense S.r.l. Symmetric, monofunctionalised polymethine dyes labelling reagents
FR2833354B1 (fr) 2001-12-06 2004-05-28 Schneider Electric Ind Sa Dispositif et procede de detection de court-circuit electrique, et disjoncteur comportant un tel dispositif
US7125644B2 (en) * 2003-08-11 2006-10-24 Hewlett-Packard Development Company, L.P. Systems and methods for storing data on an optical disk
DE102004045748A1 (de) * 2004-09-21 2006-04-06 Roche Diagnostics Gmbh Stöchiometrisch definierte farbstoffmarkierte Substanzen zur Messung der glomerulären Filtrationsrate, ihre Herstellung und Verwendung
US7198834B2 (en) * 2005-03-22 2007-04-03 Hewlett-Packard Development Company, L.P. Imaging media including interference layer for generating human-readable marking on optical media
US20070065749A1 (en) * 2005-09-21 2007-03-22 Vladek Kasperchik Radiation-markable coatings for printing and imaging
US20070065623A1 (en) * 2005-09-21 2007-03-22 Vladek Kasperchik Laser-imageable coating based on exothermic decomposition
US20070072242A1 (en) * 2005-09-22 2007-03-29 Randox Laboratories Limited Immunoassay method and kit to leucomalachite green and malachite green
US20070086308A1 (en) * 2005-10-13 2007-04-19 Gore Makarand P Systems and methods for imaging
EP2317911B8 (de) 2008-08-22 2019-03-20 MediBeacon Inc. Transkutane organfunktionsmessung
CN101709096B (zh) * 2009-11-20 2012-03-21 烟台海岸带可持续发展研究所 一种o-(氨基乙基)菊糖及其制备和应用
CN102662025B (zh) * 2012-05-22 2015-08-26 晨光生物科技集团股份有限公司 塑料包装材料中罗丹明b含量的检测方法
HUE043467T2 (hu) 2013-10-22 2019-08-28 Medibeacon Inc Javított transzkután szervmûködés mérés
US10425814B2 (en) 2014-09-24 2019-09-24 Princeton Identity, Inc. Control of wireless communication device capability in a mobile device with a biometric key
EP3227816A4 (en) 2014-12-03 2018-07-04 Princeton Identity, Inc. System and method for mobile device biometric add-on
CN105503632B (zh) * 2016-01-08 2018-02-23 广州润坤生物科技有限公司 一种可共同用于检测结晶紫和孔雀石绿的半抗原、人工抗原的制备方法及其应用
WO2017123702A1 (en) 2016-01-12 2017-07-20 Princeton Identity, Inc. Systems and methods biometric analysis
US10373008B2 (en) 2016-03-31 2019-08-06 Princeton Identity, Inc. Systems and methods of biometric analysis with adaptive trigger
US10366296B2 (en) 2016-03-31 2019-07-30 Princeton Identity, Inc. Biometric enrollment systems and methods
JP6757464B2 (ja) * 2016-07-21 2020-09-16 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 注射用組成物
MX2019009040A (es) 2017-01-30 2019-11-11 Medibeacon Inc Metodo para monitoreo no invasivo de agente trazador fluorescente con correcciones de reflejo difuso.
US10607096B2 (en) 2017-04-04 2020-03-31 Princeton Identity, Inc. Z-dimension user feedback biometric system
CN110831526A (zh) 2017-05-19 2020-02-21 波士顿科学国际有限公司 用于粘膜下组织分离的系统和方法
KR102573482B1 (ko) 2017-07-26 2023-08-31 프린스톤 아이덴티티, 인크. 생체 보안 시스템 및 방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3304297A (en) * 1959-02-12 1967-02-14 Ciba Ltd Dyestuffs consisting of organic dyestuffs bound to polyhydroxylated organic polymers
CH526298A (de) * 1968-08-19 1972-08-15 Hoffmann La Roche Verfahren zur Bestimmung des a-Amylasegehaltes eines Materials
IT1053508B (it) * 1970-07-06 1981-10-10 Searle & Co Procedimento per prepare composizioni marcate adatte a mettere in evidenza alterazioni della mucosa gastrointestinale prodotto ottenuto e relativo metodo di impiego
US3679661A (en) * 1970-12-21 1972-07-25 Warner Lambert Co Preparation of water-soluble,dyed substrates for amylase assay
JPH0735640B2 (ja) * 1988-04-18 1995-04-19 富士写真フイルム株式会社 染色された多糖類の製造方法
DE4137934A1 (de) * 1991-11-18 1993-05-19 Boehringer Mannheim Gmbh Neue pentacyklische verbindungen und ihre verwendung als absorptions- oder fluoreszenzfarbstoffe
DE4436164A1 (de) * 1994-10-10 1996-04-11 Hoechst Ag Neue Kohlenhydratkonjugate als Inhibitoren der Zelladhäsion
US5798276A (en) * 1995-06-07 1998-08-25 Molecular Probes, Inc. Reactive derivatives of sulforhodamine 101 with enhanced hydrolytic stability
FR2757162B1 (fr) * 1996-12-12 1999-03-26 Cis Bio Int Conjugues fluorescents non agreges
US6280703B1 (en) * 1997-03-13 2001-08-28 Mallinckrodt Inc. Simultaneous multimodal measurement of physiological function

Also Published As

Publication number Publication date
JP2003527447A (ja) 2003-09-16
EP0934986A1 (de) 1999-08-11
US6689616B1 (en) 2004-02-10
CA2315207A1 (en) 1999-06-24
DE59806216D1 (de) 2002-12-12
WO1999031183A1 (de) 1999-06-24
ATE227324T1 (de) 2002-11-15
EP1040168B1 (de) 2002-11-06
EP1040168A1 (de) 2000-10-04

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