ES2186160T3 - Procedimiento de preparacion de ceto-enaminas sustituidas. - Google Patents

Procedimiento de preparacion de ceto-enaminas sustituidas.

Info

Publication number
ES2186160T3
ES2186160T3 ES98923656T ES98923656T ES2186160T3 ES 2186160 T3 ES2186160 T3 ES 2186160T3 ES 98923656 T ES98923656 T ES 98923656T ES 98923656 T ES98923656 T ES 98923656T ES 2186160 T3 ES2186160 T3 ES 2186160T3
Authority
ES
Spain
Prior art keywords
independently selected
hydrogen
lower alkyl
trifluoromethyl
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98923656T
Other languages
English (en)
Inventor
Anthony R Haight
Timothy L Stuk
Jerome A Menzia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2186160T3 publication Critical patent/ES2186160T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a un procedimiento para la preparación de un compuesto básicamente puro que tiene la fórmula (IV). El proceso comprende el paso de hacer reaccionar un enolato de la fórmula (A) con un reactivo de Grignard. Se forma sal de enolato in situ a partir de la reacción de un éster protegido en donde M es un metal alcalino, R{sub,6} y R{sub,7} son cada uno hidrógeno o se seleccionan independientemente entre i) en donde R{sub, a} y R{sub,b} se seleccionan independientemente entre hidrógeno, alquilo inferior y fenilo y R{sub,c}, R{sub, d} y R{sub, e} se seleccionan independientemente entre hidrógeno, alquilo inferior, trifluorometilo, alcóxido, halo y fenilo; y ii) en donde el anillo de naftilo está insustituido o sustituido con 1,2 ó 3 sustituyentes independientemente seleccionados entre alquilo inferior, trifluorometilo, alcóxido y halo. Alternativamente, R{sub,6} es según se ha definido anteriormente y R{sub,7} es R{sub, 12}OC(O)- en donde R{sub,12} es bencilo; o R{sub,6} yR{sub,7} tomados junto con el átomo de nitrógeno al cual están unidos forman (B) o (C), en donde R{sub, f}, R{sub,g}, R{sub,h} y R{sub,i} se seleccionan independientemente entre hidrógeno, alquilo inferior, alcóxido, halógeno y trifluorometilo.
ES98923656T 1997-05-30 1998-05-19 Procedimiento de preparacion de ceto-enaminas sustituidas. Expired - Lifetime ES2186160T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/862,951 US5932766A (en) 1997-05-30 1997-05-30 Process for the preparation of substituted keto-enamines

Publications (1)

Publication Number Publication Date
ES2186160T3 true ES2186160T3 (es) 2003-05-01

Family

ID=25339829

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98923656T Expired - Lifetime ES2186160T3 (es) 1997-05-30 1998-05-19 Procedimiento de preparacion de ceto-enaminas sustituidas.

Country Status (10)

Country Link
US (1) US5932766A (es)
EP (1) EP0984921B1 (es)
JP (1) JP4172660B2 (es)
AT (1) ATE224357T1 (es)
CA (1) CA2292399A1 (es)
DE (1) DE69808075T2 (es)
DK (1) DK0984921T3 (es)
ES (1) ES2186160T3 (es)
PT (1) PT984921E (es)
WO (1) WO1998054122A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1313624B1 (it) 1999-09-21 2002-09-09 Archimica Spa Ora Clariant Lif Procedimento per la sintesi del ritonavir
ZA200607637B (en) 2004-03-05 2008-05-28 Nissan Chemical Ind Ltd Isoxazoline-substituted benzamide compound and noxious organism control agent
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
US7568369B2 (en) * 2007-03-07 2009-08-04 Ball Corporation Mold construction for a process and apparatus for manufacturing shaped containers
MX2009013469A (es) 2007-06-13 2010-01-20 Du Pont Insecticidas de isoxazolina.
KR101714291B1 (ko) 2007-06-27 2017-03-08 이 아이 듀폰 디 네모아 앤드 캄파니 동물 해충 방제 방법
TWI583664B (zh) 2008-04-09 2017-05-21 杜邦股份有限公司 羰基化合物及其製備方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552558A (en) * 1989-05-23 1996-09-03 Abbott Laboratories Retroviral protease inhibiting compounds
US5491253A (en) * 1993-10-22 1996-02-13 Abbott Laboratories Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane
JP3338227B2 (ja) * 1995-02-28 2002-10-28 高砂香料工業株式会社 ケトニトリル誘導体及びヘキセノン誘導体の製造方法

Also Published As

Publication number Publication date
WO1998054122A1 (en) 1998-12-03
EP0984921B1 (en) 2002-09-18
JP4172660B2 (ja) 2008-10-29
US5932766A (en) 1999-08-03
CA2292399A1 (en) 1998-12-03
PT984921E (pt) 2003-02-28
DK0984921T3 (da) 2003-01-27
DE69808075T2 (de) 2003-05-28
EP0984921A1 (en) 2000-03-15
ATE224357T1 (de) 2002-10-15
JP2002501531A (ja) 2002-01-15
DE69808075D1 (de) 2002-10-24

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