ES2183221T3 - INTRACELLULAR ADMINISTRATION THROUGH PRESSURE, MOLECULES OR MICROPARTICLES. - Google Patents

INTRACELLULAR ADMINISTRATION THROUGH PRESSURE, MOLECULES OR MICROPARTICLES.

Info

Publication number
ES2183221T3
ES2183221T3 ES97948268T ES97948268T ES2183221T3 ES 2183221 T3 ES2183221 T3 ES 2183221T3 ES 97948268 T ES97948268 T ES 97948268T ES 97948268 T ES97948268 T ES 97948268T ES 2183221 T3 ES2183221 T3 ES 2183221T3
Authority
ES
Spain
Prior art keywords
cell
microparticles
molecules
pressure
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97948268T
Other languages
Spanish (es)
Inventor
Micheal J Mann
Victor J Dzau
Gary H Gibbons
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Application granted granted Critical
Publication of ES2183221T3 publication Critical patent/ES2183221T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C12M3/04—Tissue, human, animal or plant cell, or virus culture apparatus with means providing thin layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/14—Bags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/1052—Balloon catheters with special features or adapted for special applications for temporarily occluding a vessel for isolating a sector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1011—Multiple balloon catheters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3517—Marker; Tag
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

Abstract

The invention provides a method of enhancing the uptake by a cell of an atom, a molecule, or particle of <10 mu m. The method involves (a) bringing into contact a cell and a liquid medium containing the atom, molecule, or particle, (b) maintaining the cell and the liquid medium in an enclosed space, and (c) subjecting the enclosed cell and liquid medium to an incubation pressure sufficient to enhance the uptake by the cell of the atom, molecule, or particle. <IMAGE>
ES97948268T 1996-11-07 1997-11-07 INTRACELLULAR ADMINISTRATION THROUGH PRESSURE, MOLECULES OR MICROPARTICLES. Expired - Lifetime ES2183221T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/745,023 US5922687A (en) 1995-05-04 1996-11-07 Intracellular delivery of nucleic acids using pressure

Publications (1)

Publication Number Publication Date
ES2183221T3 true ES2183221T3 (en) 2003-03-16

Family

ID=24994918

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97948268T Expired - Lifetime ES2183221T3 (en) 1996-11-07 1997-11-07 INTRACELLULAR ADMINISTRATION THROUGH PRESSURE, MOLECULES OR MICROPARTICLES.

Country Status (16)

Country Link
US (1) US5922687A (en)
EP (2) EP1279412A3 (en)
JP (3) JP2001505419A (en)
KR (1) KR100449330B1 (en)
CN (1) CN1109749C (en)
AT (1) ATE223967T1 (en)
AU (1) AU736298B2 (en)
BR (1) BR9713334A (en)
CA (1) CA2271244C (en)
DE (1) DE69715449T2 (en)
DK (1) DK0944715T3 (en)
ES (1) ES2183221T3 (en)
HK (1) HK1022711A1 (en)
IL (1) IL129808A (en)
PT (1) PT944715E (en)
WO (1) WO1998020109A1 (en)

Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7803782B2 (en) * 2003-05-28 2010-09-28 Roche Madison Inc. Intravenous delivery of polynucleotides to cells in mammalian limb
US6627616B2 (en) * 1995-12-13 2003-09-30 Mirus Corporation Intravascular delivery of non-viral nucleic acid
US20020001574A1 (en) * 1995-12-13 2002-01-03 Jon A. Woiff Process of delivering a polynucleotide to a muscle cell via the vascular system
US7507722B1 (en) 1999-11-05 2009-03-24 Roche Madison Inc. Intravascular delivery of nucleic acid
US20040259828A1 (en) * 1995-12-13 2004-12-23 Wolff Jon A. Intravascular delivery of non-viral nucleic acid
US6379966B2 (en) * 1999-02-26 2002-04-30 Mirus Corporation Intravascular delivery of non-viral nucleic acid
US6676626B1 (en) 1998-05-01 2004-01-13 Ekos Corporation Ultrasound assembly with increased efficacy
US6582392B1 (en) 1998-05-01 2003-06-24 Ekos Corporation Ultrasound assembly for use with a catheter
US7435723B2 (en) * 1997-11-21 2008-10-14 Mirus Bio Corporation Process for delivery of polynucleotides to the prostate
US6699231B1 (en) 1997-12-31 2004-03-02 Heartport, Inc. Methods and apparatus for perfusion of isolated tissue structure
US6722370B1 (en) * 1998-07-17 2004-04-20 Corgentech, Inc. Delivery of a composition to the liver by utilizing the portal vein
WO2000015285A1 (en) * 1998-09-14 2000-03-23 Mirus Corporation A process for delivering nucleic acids to cardiac tissue
WO2000050617A1 (en) * 1999-02-26 2000-08-31 Mirus Corporation Intravascular delivery of non-viral nucleic acid
AU5771500A (en) * 1999-06-28 2001-01-31 Oklahoma Medical Research Foundation Catalytically active recombinant memapsin and methods of use thereof
ES2269199T3 (en) 1999-11-05 2007-04-01 Mirus Bio Corporation INTRAVASCULAR SUPPLY OF NUCLEIC ACID.
US7214369B2 (en) * 2003-05-05 2007-05-08 Mirus Bio Corporation Devices and processes for distribution of genetic material to mammalian limb
US7642248B2 (en) * 1999-11-05 2010-01-05 Roche Madison Inc Devices and processes for distribution of genetic material to mammalian limb
JP4776131B2 (en) 1999-11-18 2011-09-21 エピミューン インコーポレイテッド Heteroclitic analogs and related methods
US20040072785A1 (en) * 1999-11-23 2004-04-15 Wolff Jon A. Intravascular delivery of non-viral nucleic acid
US6346098B1 (en) 2000-03-07 2002-02-12 The Board Of Trustees Of The Leland Stanford Junior University Methods and kits for locally administering an active agent to an interstitial space of a host
JP2003531865A (en) * 2000-04-28 2003-10-28 アメリカ合衆国 Improving immunogenicity using a combination of DNA and vaccinia virus vector vaccines
EP2075582A3 (en) 2000-07-12 2010-01-06 Agensys, Inc. Novel tumor antigen useful in diagnosis and therapy of bladder, ovary, lung and kidney cancers
WO2002008448A2 (en) * 2000-07-25 2002-01-31 The Board Of Trustees Of The Leland Stanford Junior University Non-viral linear dna vectors and methods for using the same
PT1313850E (en) 2000-08-28 2008-11-18 Agensys Inc Nucleic acid and corresponding protein entitled 85p1b3 useful in treatment and detection of cancer
AU2001298049A1 (en) 2000-10-19 2003-05-19 Epimmune Inc. Hla class i and ii binding peptides and their uses
AU2002306539A1 (en) * 2001-02-16 2002-09-04 The Board Of Trustees Of The Leland Stanford Junior University Minimal plasmid vectors that provide for persistent and high level gene expression and methods for using the same
US6924358B2 (en) 2001-03-05 2005-08-02 Agensys, Inc. 121P1F1: a tissue specific protein highly expressed in various cancers
US7271240B2 (en) 2001-03-14 2007-09-18 Agensys, Inc. 125P5C8: a tissue specific protein highly expressed in various cancers
US20030191073A1 (en) 2001-11-07 2003-10-09 Challita-Eid Pia M. Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer
CA2443123A1 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
US10590418B2 (en) * 2001-07-23 2020-03-17 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for RNAi mediated inhibition of gene expression in mammals
CA2936534C (en) 2001-07-23 2021-01-26 The Board Of Trustees Of Leland Stanford Junior University Methods and compositions for rnai mediated inhibition of gene expression in mammals
AU2002336446B2 (en) 2001-09-06 2008-03-06 Agensys, Inc. Nucleic acid and corresponding protein entitled STEAP-1 useful in treatment and detection of cancer
EP1721977A3 (en) 2001-09-17 2008-10-15 PDL BioPharma, Inc. Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer
AU2002359576A1 (en) 2001-12-03 2003-06-17 Ekos Corporation Catheter with multiple ultrasound radiating members
US7141044B2 (en) * 2001-12-11 2006-11-28 Ekos Corporation Alternate site gene therapy
DE10211589A1 (en) * 2002-03-15 2003-10-02 Steffen-Sebastian Bolz In vitro transfection and long-term cultivation of isolated organs
US8226629B1 (en) 2002-04-01 2012-07-24 Ekos Corporation Ultrasonic catheter power control
US20030204167A1 (en) * 2002-04-24 2003-10-30 Johnson Lanny L. Device for delivering liquid medications, nutrients or gases to local tissue
US20060094006A1 (en) * 2002-05-01 2006-05-04 Genoveffa Franchini Immunotherapy regimens in hiv-infected patients
US20030228691A1 (en) * 2002-05-17 2003-12-11 Lewis David L. Processes for inhibiting gene expression using polynucleotides
JP4643255B2 (en) 2002-06-10 2011-03-02 バクシネックス インコーポレーティッド Differentially expressed genes and encoded polypeptides in breast and bladder cancer
US7589059B2 (en) * 2002-07-26 2009-09-15 Roche Madison Inc. Delivery of molecules and complexes to mammalian cells in vivo
US20040081653A1 (en) 2002-08-16 2004-04-29 Raitano Arthur B. Nucleic acids and corresponding proteins entitled 251P5G2 useful in treatment and detection of cancer
EP2801614B1 (en) * 2002-08-29 2019-05-15 The Board of Trustees of the Leland Stanford Junior University Circular nucleic acid vectors and methods for making and using the same
US6921371B2 (en) 2002-10-14 2005-07-26 Ekos Corporation Ultrasound radiating members for catheter
JP2006508163A (en) 2002-11-27 2006-03-09 アジェンシス， インコーポレイテッド Nucleic acids and corresponding proteins referred to as 24P4C12 useful in the treatment and detection of cancer
EP1903056A3 (en) 2002-12-10 2008-05-07 Idm Pharma, Inc. HLA-A1, -A2 -A3, -A24, -B7, and -B44 binding peptides comprising tumor associated antigen epitopes, and compositions thereof
US7781415B2 (en) * 2003-02-07 2010-08-24 Roche Madison Inc. Process for delivering sirna to cardiac muscle tissue
EP2343315A3 (en) 2003-02-10 2011-11-23 Agensys, Inc. Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers
US20070037151A1 (en) * 2003-04-28 2007-02-15 Babe Lilia M Cd4+ human papillomavirus (hpv) epitopes
ATE541052T1 (en) 2003-05-30 2012-01-15 Agensys Inc VARIANTS OF PROSTATE STEM CELL ANTIGEN (PSCA) AND PARTIAL SEQUENCES THEREOF
CN1846000B (en) * 2003-09-05 2012-10-03 金克克国际有限公司 HPV CD8+ T-cell epitopes
US20050164240A1 (en) * 2003-10-06 2005-07-28 Corgentech, Inc. E2F oligonucleotide decoy molecules
EP1709175A2 (en) * 2003-12-03 2006-10-11 Corgentech, Inc. Hif oligonucleotide decoy molecules
KR20060103957A (en) * 2004-01-15 2006-10-04 알자 코포레이션 Liposome composition for delivery of therapeutic agents
GB0406728D0 (en) * 2004-03-25 2004-04-28 Hydrodynamic Gene Delivery Ltd Gene therapy
DK1747023T4 (en) 2004-05-04 2016-05-02 Univ Leland Stanford Junior Methods and compositions for reducing the HCV viral genome amounts in a target cell
US20050289659A1 (en) * 2004-05-18 2005-12-29 Jacks E T Cre-lox based method for conditional RNA interference
EP2583981A3 (en) 2004-05-28 2013-07-31 Agensys, Inc. Antibodies and related molecules that bind to PSCA proteins
US7482158B2 (en) * 2004-07-01 2009-01-27 Mathison Brian H Composite polynucleic acid therapeutics
TW200626724A (en) * 2004-08-23 2006-08-01 Paik Medicine International Inc Method for gene transfer into the organelles of cells: direct gene transfer to mitochondria
US20070036740A1 (en) * 2004-10-06 2007-02-15 Reed Kenneth C Modulation of hair growth
EP1807514A1 (en) * 2004-10-22 2007-07-18 Benitec, Inc. Therapeutic rnai agents for treating psoriasis
US20060115462A1 (en) * 2004-12-01 2006-06-01 Vladimir Subbotin Direct DNA delivery to bone cells
JP2008526229A (en) * 2005-01-06 2008-07-24 ベニテック，インコーポレーテッド RNAi agents for stem cell maintenance
ES2459466T3 (en) 2005-02-25 2014-05-09 Oncotherapy Science, Inc. Peptide vaccines for lung cancers expressing TTK, URLC10 or KOC1 polypeptides
DK2289533T3 (en) 2005-02-28 2013-12-02 Oncotherapy Science Inc Epitope peptides derived from carendothelial growth factor receptor-1 as well as vaccines containing these peptides
AU2006230563B8 (en) 2005-03-31 2010-06-17 Agensys, Inc. Antibodies and related molecules that bind to 161P2F10B proteins
US20060292159A1 (en) * 2005-06-08 2006-12-28 Ranscht Barbara E Methods for the inhibition of neovascularization and cancer metastasis
JP5095603B2 (en) 2005-07-27 2012-12-12 オンコセラピー・サイエンス株式会社 Colon cancer-related gene TOM34
CA2618508A1 (en) * 2005-08-10 2007-02-22 Oklahoma Medical Research Foundation Truncated memapsin 2 for use for treating alzheimer's disease
US20070143195A1 (en) * 2005-12-15 2007-06-21 Bell Ryan B Systems and methods for evaluating terms of a deal to purchase a vehicle
US20070173470A1 (en) * 2006-01-23 2007-07-26 Chi-Hung Lin Methods for delivering extracellular target into cells
CN101568550B (en) 2006-10-17 2012-12-26 肿瘤疗法科学股份有限公司 Peptide vaccines for cancers expressing mphosph1 or depdc1 polypeptides
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
TWI494319B (en) 2007-02-21 2015-08-01 Oncotherapy Science Inc Peptide vaccines for cancers expressing tumor-associated antigens
WO2008112226A2 (en) * 2007-03-13 2008-09-18 Massachusetts Institute Of Technology Cre-lox based gene knockdown constructs and methods of use thereof
TW201425333A (en) 2007-04-11 2014-07-01 Oncotherapy Science Inc TEM8 peptides and vaccines comprising the same
US8202983B2 (en) 2007-05-10 2012-06-19 Agilent Technologies, Inc. Thiocarbon-protecting groups for RNA synthesis
EP2494932B1 (en) 2007-06-22 2020-05-20 Ekos Corporation Apparatus for treatment of intracranial hemorrhages
US20100310640A1 (en) * 2007-11-01 2010-12-09 Knutson Keith L Hla-dr binding peptides and their uses
EP2612868B1 (en) 2007-11-01 2018-08-15 Astellas Pharma Inc. Immunosuppressive polypeptides and nucleic acids
EP2288379A4 (en) 2008-05-19 2012-08-08 Advaxis Dual delivery system for heterologous antigens
US9017660B2 (en) 2009-11-11 2015-04-28 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
US9650639B2 (en) 2008-05-19 2017-05-16 Advaxis, Inc. Dual delivery system for heterologous antigens
JP5676436B2 (en) 2008-06-17 2015-02-25 ザ ガヴァーニング カウンシル オブ ザ ユニヴァーシティ オブ トロント Device for investigation of flow conduits
CA2728291C (en) * 2008-07-03 2017-06-20 The Board Of Trustees Of The Leland Stanford Junior University Minicircle dna vector preparations and methods of making and using the same
US8945885B2 (en) 2008-07-03 2015-02-03 The Board Of Trustees Of The Leland Stanford Junior University Minicircle DNA vector preparations and methods of making and using the same
JP5764822B2 (en) 2008-08-27 2015-08-19 オンコセラピー・サイエンス株式会社 PRMT1 as a target gene for cancer treatment and diagnosis
JP2012506858A (en) * 2008-10-23 2012-03-22 インターベット インターナショナル ベー． フェー． Lawsonia intracellularis vaccine
WO2010061881A1 (en) 2008-11-26 2010-06-03 中外製薬株式会社 Oligoribonucleotide or peptide nucleic acid capable of inhibiting activity of hepatitis c virus
KR101727333B1 (en) 2008-11-26 2017-04-14 추가이 세이야쿠 가부시키가이샤 Vesicle preparation
TWI500932B (en) 2008-12-05 2015-09-21 Oncotherapy Science Inc Wdrpuh epitope peptides and vaccines containing the same
TWI469791B (en) 2009-02-18 2015-01-21 Oncotherapy Science Inc Foxm1 peptides and vaccines containing the same
WO2010105135A1 (en) 2009-03-13 2010-09-16 Tufts University Methods, apparatuses, and kits for introducing genetic material into living cells
US9017991B2 (en) * 2009-03-13 2015-04-28 Tufts University Methods tip assemblies and kits for introducing material into cells
CN105601725B (en) 2009-03-18 2019-08-09 肿瘤疗法科学股份有限公司 NEIL3 peptide and vaccine comprising it
TWI507204B (en) 2009-05-26 2015-11-11 Oncotherapy Science Inc Cdc45l peptides and vaccines including the same
US10016617B2 (en) 2009-11-11 2018-07-10 The Trustees Of The University Of Pennsylvania Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers
TW201136604A (en) 2009-12-14 2011-11-01 Oncotherapy Science Inc TMEM22 peptides and vaccines including the same
WO2011106705A2 (en) 2010-02-26 2011-09-01 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Dna-protein vaccination protocols
AU2011225577B2 (en) 2010-03-11 2017-01-19 Oncotherapy Science, Inc. HJURP peptides and vaccines including the same
US11020444B2 (en) * 2010-04-23 2021-06-01 Scicotec Gmbh Transluminal delivery of viruses for treatment of diseased tissue
EP2621527A4 (en) 2010-10-01 2015-12-09 Univ Pennsylvania The use of listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals
AU2012229218B2 (en) 2011-03-11 2017-03-02 Advaxis, Inc. Listeria-based adjuvants
UA113413C2 (en) 2011-08-12 2017-01-25 Онкотерапі Саєнс, Інк. Mphosph1 peptides and vaccines including the same
SG10201913173SA (en) 2011-10-28 2020-03-30 Oncotherapy Science Inc Topk Peptides And Vaccines Including The Same
BR112014022662A2 (en) 2012-03-12 2017-10-03 Advaxis Inc INHIBITION OF SUPPRESSOR CELL FUNCTION FOLLOWING LISTERIA VACCINE TREATMENT
JP6255594B2 (en) 2012-07-10 2018-01-10 オンコセラピー・サイエンス株式会社 LY6K epitope peptide of Th1 cell and vaccine containing the same
EP2872530A4 (en) 2012-07-10 2016-04-06 Oncotherapy Science Inc Kif20a epitope peptides for th1 cells and vaccines containing the same
AU2013317194B2 (en) 2012-09-11 2018-07-12 Oncotherapy Science, Inc. UBE2T peptides and vaccines containing the same
CA2895791A1 (en) 2013-01-25 2014-07-31 Xcell Biosciences, Inc. Methods, compositions, kits, and systems for selective enrichment of target cells
TWI658049B (en) 2013-03-12 2019-05-01 腫瘤療法 科學股份有限公司 Kntc2 peptides and vaccines containing the same
US10982217B2 (en) 2013-03-15 2021-04-20 The Regents Of The University Of California High-throughput cargo delivery into live cells using photothermal platforms
ES2702622T3 (en) 2013-03-27 2019-03-04 Immunovaccine Technologies Inc Method to improve the effectiveness of a survivin vaccine in the treatment of cancer
CA2947539C (en) * 2014-03-28 2022-10-04 The Regents Of The University Of California Efficient delivery of large cargos into cells on a porous substrate
US10760040B1 (en) 2014-07-03 2020-09-01 NanoCav, LLC Mechanical transfection devices and methods
US10081816B1 (en) 2014-07-03 2018-09-25 Nant Holdings Ip, Llc Mechanical transfection devices and methods
ES2856834T3 (en) 2014-08-04 2021-09-28 Oncotherapy Science Inc URLC10 derived peptide and vaccine containing the same
JP6754958B2 (en) 2014-08-04 2020-09-16 オンコセラピー・サイエンス株式会社 KOC1-derived peptide and vaccine containing it
WO2016021508A1 (en) 2014-08-04 2016-02-11 オンコセラピー・サイエンス株式会社 Cdca1-derived peptide and vaccine containing same
JP2018509384A (en) 2015-01-06 2018-04-05 イミューノヴァクシーン テクノロジーズ インコーポレイテッドＩｍｍｕｎｏｖａｃｃｉｎｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． Lipid A mimics, methods of preparation, and uses thereof
WO2016183420A1 (en) 2015-05-13 2016-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods and compositions for inducing an immune response using conserved element constructs
EP3307388B1 (en) 2015-06-10 2022-06-22 Ekos Corporation Ultrasound catheter
CA3000810A1 (en) 2015-10-08 2017-04-13 Oncotherapy Science, Inc. Foxm1-derived peptide, and vaccine including same
WO2017223199A1 (en) * 2016-06-22 2017-12-28 Xcell Biosciences, Inc. Methods for increasing cell culture transfection efficiency and cellular reprogramming
US10533189B2 (en) * 2016-09-20 2020-01-14 The Chinese University Of Hong Kong Highly specific delivery of polynucleotides to the cell nucleus via compression
CN111032134B (en) * 2017-06-30 2024-02-13 阿维塔斯有限公司 electrospray catheter
TW202023581A (en) 2018-08-02 2020-07-01 日商腫瘤療法 科學股份有限公司 Cdca1-derived peptide and vaccine containing same
AU2022299660A1 (en) * 2021-06-24 2024-01-18 Avectas Limited Spray nozzle
WO2023122797A1 (en) * 2021-12-23 2023-06-29 Intergalactic Therapeutics, Inc. Devices and methods for hollow tissue electrotransfer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698531A (en) * 1989-03-31 1997-12-16 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5328470A (en) * 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5674192A (en) * 1990-12-28 1997-10-07 Boston Scientific Corporation Drug delivery
US5584803A (en) * 1991-07-16 1996-12-17 Heartport, Inc. System for cardiac procedures
US5766901A (en) * 1995-05-04 1998-06-16 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for delivering a nucleotide into cell nuclei

Also Published As

Publication number Publication date
EP1279412A2 (en) 2003-01-29
JP2001505419A (en) 2001-04-24
KR20000053164A (en) 2000-08-25
PT944715E (en) 2003-01-31
EP0944715A1 (en) 1999-09-29
AU7002098A (en) 1998-05-29
KR100449330B1 (en) 2004-09-18
BR9713334A (en) 2000-05-09
AU736298B2 (en) 2001-07-26
WO1998020109A1 (en) 1998-05-14
EP1279412A3 (en) 2003-12-17
EP0944715B1 (en) 2002-09-11
CN1109749C (en) 2003-05-28
JP2008237221A (en) 2008-10-09
HK1022711A1 (en) 2000-08-18
DK0944715T3 (en) 2002-12-30
CA2271244A1 (en) 1998-05-14
ATE223967T1 (en) 2002-09-15
US5922687A (en) 1999-07-13
IL129808A0 (en) 2000-02-29
EP0944715A4 (en) 1999-12-22
CN1244213A (en) 2000-02-09
CA2271244C (en) 2008-09-02
IL129808A (en) 2004-06-20
JP2008054681A (en) 2008-03-13
DE69715449D1 (en) 2002-10-17
DE69715449T2 (en) 2003-07-31

Similar Documents

Publication Publication Date Title
ES2183221T3 (en) INTRACELLULAR ADMINISTRATION THROUGH PRESSURE, MOLECULES OR MICROPARTICLES.
ATE218066T1 (en) VACCINE CONTAINING NUCLEIC ACID
DE69616606T2 (en) Polymer stabilization through a stable free radical
DE69114649D1 (en) In-line gas / liquid dispersion.
ATE242317T1 (en) METHOD FOR PURIFYING VIRUSES USING CHROMATOGRAPHY
GR3026658T3 (en) Hydrazino-type radionuclide chelators having an n 3?s configuration
DK0593624T3 (en) Improvements to or in relation to contrast agents
DE69938170D1 (en) MIXING PROCESS
SE9801287D0 (en) Incorporation of active substances into carrier matrixes
EP1158320A3 (en) Dichroic light polarizers
DE69024002D1 (en) Device for coding two-dimensional information and corresponding decoding device.
ZA966118B (en) Interseparation of platinum group metals.
NZ305188A (en) DNA encoding Human Papilloma Virus (hPV)type 18
NO931689D0 (en) DEVICE FOR ELECTROCHEMICAL SYNTHESIS FOR &#34;IN-LINE&#34; AND &#34;OFF-LINE&#34;, WHEATING, OXIDATION AND DISINFECTION OF ORGANIC SUBSTANCES IN LIQUID.
ATE209486T1 (en) LIQUID MEDICINAL COMPOSITIONS CONTAINING IBUPROFEN
Evans Front Cover-" But now, I am found"
KR920004281A (en) Solid-Liquid Separation and Concentration Methods in Wastewater Treatment
RU96108731A (en) METHOD FOR PRODUCING FIRE-PROTECTED CHEMICAL FIBERS
Occulto Writing in the biology classroom
ES2120916A1 (en) Instrument for qualifying the mechanical preservation status of biological surfaces
Scheidt Teacher immediacy and student communication apprehension in the college classroom
Sawvel Analysis of immunogenicity of cellular envelope proteins (CEP) isolated from Pseudomonas aeruginosa
UA29496C2 (en) rotor for mixing devices
Tobias Reading Trends
Abou Jaoude Plastic analysis of rigid frames using micro computer graphics