ES2181706T3 - Oxidacion de taxanos sustituidos de glucosidos a taxol o precursores de taxol, y compuestos de taxano formados como productos intermedios. - Google Patents
Oxidacion de taxanos sustituidos de glucosidos a taxol o precursores de taxol, y compuestos de taxano formados como productos intermedios.Info
- Publication number
- ES2181706T3 ES2181706T3 ES94900515T ES94900515T ES2181706T3 ES 2181706 T3 ES2181706 T3 ES 2181706T3 ES 94900515 T ES94900515 T ES 94900515T ES 94900515 T ES94900515 T ES 94900515T ES 2181706 T3 ES2181706 T3 ES 2181706T3
- Authority
- ES
- Spain
- Prior art keywords
- taxol
- oxidation
- substituted
- precursors
- glucosids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
UN PROCESO PARA LA CONVERSION DE TAXANOS SUSTITUIDOS DE GLUCOSIDOS A TAXOL Y LOS COMPONENTES RELACIONADOS QUE PUEDEN SERVIR PARA TAXOL. EL PROCESO INCLUYE LA OXIDACION DE LOS TAXANOS SUSTITUIDOS DE GLUCOSIDO PARA CONVERTIR EL GLUCOSIDO AL GRUPO HIDROXIL. LA OXIDACION PUEDE SUCEDER EN PRESENCIA DE UN ACIDO O SEGUIDO POR EL TRATAMIENTO CON ACIDO. LA APLICACION DEL PROCESO AL TAXOL XILOSILO-7 ( XY ) PRODUCE TAXOL; LA APLICACION DE OTROS TAXANOS SUSTITUIDOS DE GLUCOSIDO FORMA COMPONENTES QUE PUEDEN SERVIR COMO PRECURSORES PARA TAXOL. EL PROCESO INCLUYE LA FORMACION DE CIERTOS NUEVOS COMPONENTES INTERMEDIARIOS RELACIONADOS DE TAXOL QUE TIENEN UN HEMIALDAL EN LA POSICION 7 EN EL ANILLO DE TAXANO, CUYO HEMIALDAL PUEDE LUEGO SER CONVERTIDO A TAXOL O PRECURSORES DE TAXOL. DESDE QUE LOS TAXANOS SUSTITUIDOS DE GLUCOSIDO ESTAN AISLADOS CON TAXOL DESDE LA BIOMASA QUE SURGE NATURALMENTE, SU CONVERSION A TAXOL USANDO EL PROCESO DE LA PRESENTE INVENCION SIGNIFICATIVAMENTE MEJORA LA PRODUCCION TOTAL DE TAXOL DESDE FUENTES NATURALES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97307692A | 1992-11-06 | 1992-11-06 | |
US08/133,449 US5412116A (en) | 1992-11-06 | 1993-10-07 | Oxidation of glycoside substituted taxanes to taxol or taxol precursors and new taxane compounds formed as intermediates |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2181706T3 true ES2181706T3 (es) | 2003-03-01 |
Family
ID=26831389
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94900515T Expired - Lifetime ES2181706T3 (es) | 1992-11-06 | 1993-11-02 | Oxidacion de taxanos sustituidos de glucosidos a taxol o precursores de taxol, y compuestos de taxano formados como productos intermedios. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5412116A (es) |
EP (1) | EP0668862B1 (es) |
JP (1) | JP3878204B2 (es) |
AU (1) | AU5547694A (es) |
CA (1) | CA2148943C (es) |
DE (1) | DE69332223T2 (es) |
ES (1) | ES2181706T3 (es) |
WO (1) | WO1994011366A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5856532A (en) * | 1996-08-14 | 1999-01-05 | Council Of Scientific & Industrial Research | Process for the production of taxol |
US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
US6002025A (en) * | 1999-02-24 | 1999-12-14 | Bcm Developement Inc. | Method for the purification of taxanes |
EP2289549A3 (en) | 1999-10-01 | 2011-06-15 | Immunogen, Inc. | Immunoconjugates for treating cancer |
EP1298128B1 (en) * | 2001-09-28 | 2005-03-02 | Council Of Scientific And Industrial Research | Process for the preparation of 10-deacetylbaccatin III |
US6437154B1 (en) | 2001-09-28 | 2002-08-20 | Council Of Scientific And Industrial Research | Process for the preparation of 10-deacetylbaccatin III |
WO2004033442A2 (en) * | 2002-10-09 | 2004-04-22 | Chatham Biotec Ltd. | Novel taxanes and methods related to use and preparation thereof |
US7202370B2 (en) * | 2003-10-27 | 2007-04-10 | Conor Medsystems, Inc. | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III |
CN101391989B (zh) * | 2008-08-29 | 2010-12-01 | 华中科技大学 | 一种制备多羟基紫杉烷及紫杉醇的方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2629818B1 (fr) * | 1988-04-06 | 1990-11-16 | Centre Nat Rech Scient | Procede de preparation du taxol |
US4960790A (en) * | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
US5200534A (en) * | 1992-03-13 | 1993-04-06 | University Of Florida | Process for the preparation of taxol and 10-deacetyltaxol |
-
1993
- 1993-10-07 US US08/133,449 patent/US5412116A/en not_active Expired - Lifetime
- 1993-11-02 JP JP51219094A patent/JP3878204B2/ja not_active Expired - Fee Related
- 1993-11-02 ES ES94900515T patent/ES2181706T3/es not_active Expired - Lifetime
- 1993-11-02 WO PCT/US1993/010580 patent/WO1994011366A1/en active IP Right Grant
- 1993-11-02 CA CA002148943A patent/CA2148943C/en not_active Expired - Fee Related
- 1993-11-02 AU AU55476/94A patent/AU5547694A/en not_active Abandoned
- 1993-11-02 DE DE69332223T patent/DE69332223T2/de not_active Expired - Lifetime
- 1993-11-02 EP EP94900515A patent/EP0668862B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69332223D1 (de) | 2002-09-26 |
DE69332223T2 (de) | 2003-04-17 |
WO1994011366A1 (en) | 1994-05-26 |
CA2148943A1 (en) | 1994-05-26 |
JPH08503214A (ja) | 1996-04-09 |
EP0668862B1 (en) | 2002-08-21 |
CA2148943C (en) | 2006-04-18 |
EP0668862A4 (en) | 1995-12-13 |
AU5547694A (en) | 1994-06-08 |
EP0668862A1 (en) | 1995-08-30 |
US5412116A (en) | 1995-05-02 |
JP3878204B2 (ja) | 2007-02-07 |
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