ES2181602A1 - "complejo de pt (iv) con actividad antineoplasica: trans-(ptc12 (oh)2(dimetilamina) (isopropilamina)) aplicable como antitumoral. - Google Patents

"complejo de pt (iv) con actividad antineoplasica: trans-(ptc12 (oh)2(dimetilamina) (isopropilamina)) aplicable como antitumoral.

Info

Publication number
ES2181602A1
ES2181602A1 ES200101784A ES200101784A ES2181602A1 ES 2181602 A1 ES2181602 A1 ES 2181602A1 ES 200101784 A ES200101784 A ES 200101784A ES 200101784 A ES200101784 A ES 200101784A ES 2181602 A1 ES2181602 A1 ES 2181602A1
Authority
ES
Spain
Prior art keywords
complex
ptcl2
isopropylamine
dimethylamine
trans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200101784A
Other languages
English (en)
Other versions
ES2181602B1 (es
Inventor
Ranninger Carmen Navarra
Veliz Eva I Montero
Martin Jose Manuel Perez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UNIVERSIDASD AUTONOMA DE MADRI
Universidad Autonoma de Madrid
Original Assignee
UNIVERSIDASD AUTONOMA DE MADRI
Universidad Autonoma de Madrid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UNIVERSIDASD AUTONOMA DE MADRI, Universidad Autonoma de Madrid filed Critical UNIVERSIDASD AUTONOMA DE MADRI
Priority to ES200101784A priority Critical patent/ES2181602B1/es
Priority to PCT/ES2002/000383 priority patent/WO2003033511A1/es
Publication of ES2181602A1 publication Critical patent/ES2181602A1/es
Application granted granted Critical
Publication of ES2181602B1 publication Critical patent/ES2181602B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Complejo de Pt(IV) con actividad antineoplástica: trans- (PtC1{sub,2}(OH){sub,2} (dimetilamina) (isopropilamina)) aplicable como antitumoral, consiste en un complejo de Pt(IV) trans-(PtC1{sub,2}(OH){sub,2} (dimetilamina) (isopropilamina).
ES200101784A 2001-07-30 2001-07-30 "complejo de pt(iv) con actividad antineoplasica: trans-(ptcl2 (oh)2( dimetilamina) (isopropilamina)) aplicable como antitumoral. Expired - Fee Related ES2181602B1 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES200101784A ES2181602B1 (es) 2001-07-30 2001-07-30 "complejo de pt(iv) con actividad antineoplasica: trans-(ptcl2 (oh)2( dimetilamina) (isopropilamina)) aplicable como antitumoral.
PCT/ES2002/000383 WO2003033511A1 (es) 2001-07-30 2002-07-30 COMPLEJO DE Pt(IV) CON ACTIVIDAD ANTINEOPLÁSICA: TRANS-[PtCl2(OH)2 (DIMETILAMINA) (ISOPROPILAMINA)] APLICABLE COMO ANTITUMORAL

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200101784A ES2181602B1 (es) 2001-07-30 2001-07-30 "complejo de pt(iv) con actividad antineoplasica: trans-(ptcl2 (oh)2( dimetilamina) (isopropilamina)) aplicable como antitumoral.

Publications (2)

Publication Number Publication Date
ES2181602A1 true ES2181602A1 (es) 2003-02-16
ES2181602B1 ES2181602B1 (es) 2004-06-16

Family

ID=8498565

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200101784A Expired - Fee Related ES2181602B1 (es) 2001-07-30 2001-07-30 "complejo de pt(iv) con actividad antineoplasica: trans-(ptcl2 (oh)2( dimetilamina) (isopropilamina)) aplicable como antitumoral.

Country Status (2)

Country Link
ES (1) ES2181602B1 (es)
WO (1) WO2003033511A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2214138A1 (es) * 2003-02-21 2004-09-01 Universidad Autonoma De Madrid Compuestos trans de platino (iv) de formula trans, trans, trans - (ptcl2 (oh)2 (amina) (dimetilamina)) con actividad antitumoral.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4119654A (en) * 1976-02-26 1978-10-10 Rustenburg Platinum Mines Limited Compositions containing platinum
EP0503830A1 (en) * 1991-03-09 1992-09-16 Johnson Matthey Public Limited Company Trans-platinum compounds with anti-tumor activity, process for their preparation and compositions containing them

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4119654A (en) * 1976-02-26 1978-10-10 Rustenburg Platinum Mines Limited Compositions containing platinum
EP0503830A1 (en) * 1991-03-09 1992-09-16 Johnson Matthey Public Limited Company Trans-platinum compounds with anti-tumor activity, process for their preparation and compositions containing them

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KELLAND, LLOYD R. y col. Synthesis and in vitro and in vivo antitumor activity of a series of trans Platinum antitumor complexes. Journal of Medicinal Chemistry, 1995, Vol. 38, Nö 16, páginas 3016-3024, ISSN 0022-2623. Todo el documento. *
MONTERO, E.I. y col. Preparation and characterization of novel trans [PtCl2(amine)(isopropylamine)] compounds: cytotoxic activity and apoptosis induction in rats-transformed cells. J. Med. Chem., 7 Octubre 1999, Vol. 42, Nö 20, páginas 4264-4268. Todo el documento. *
REIKO KURODA y col. X-Ray and NMR studies of Trans-dihydroxo-platinum (IV) antitumor complexes. J. Inorg. Biochem., 1984, Vol. 22, Nö 3, páginas 103-177, ISSN 0162-0134. Todo el documento. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2214138A1 (es) * 2003-02-21 2004-09-01 Universidad Autonoma De Madrid Compuestos trans de platino (iv) de formula trans, trans, trans - (ptcl2 (oh)2 (amina) (dimetilamina)) con actividad antitumoral.

Also Published As

Publication number Publication date
ES2181602B1 (es) 2004-06-16
WO2003033511A1 (es) 2003-04-24

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