ES2180629T3 - Usos terapeuticos de productos dimeros de proteina bactericida/aumentadora de la permeabilidad. - Google Patents
Usos terapeuticos de productos dimeros de proteina bactericida/aumentadora de la permeabilidad.Info
- Publication number
- ES2180629T3 ES2180629T3 ES95913668T ES95913668T ES2180629T3 ES 2180629 T3 ES2180629 T3 ES 2180629T3 ES 95913668 T ES95913668 T ES 95913668T ES 95913668 T ES95913668 T ES 95913668T ES 2180629 T3 ES2180629 T3 ES 2180629T3
- Authority
- ES
- Spain
- Prior art keywords
- protein
- therapeutic uses
- bactericide
- permeability increased
- bpi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4742—Bactericidal/Permeability-increasing protein [BPI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
COMPOSICIONES TERAPEUTICAS MEJORADAS, METODOS Y USOS DE PRODUCTOS DE PROTEINAS BACTERICIDAS O QUE AUMENTAN LA PERMEABILIDAD (BPI) QUE CONLLEVAN EL USO DE FORMAS DIMERICAS DE PRODUCTOS MONOMERICOS DE PROTEINAS (BPI) CARACTERIZADOS POR UNA ACTIVIDAD BIOLOGICA IN VIVO MEJORADA. LAS FORMULACIONES PREFERENTES INCLUYEN 50% O MAS, POR PESO, DEL PRODUCTO DIMERICO Y LOS USOS TERAPEUTICOS PREFERENTES INCLUYEN LA NEUTRALIZACION DE HEPARINA Y DE ENDOTOXINAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/212,132 US5447913A (en) | 1994-03-11 | 1994-03-11 | Therapeutic uses of bactericidal/permeability-increasing protein dimer products |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2180629T3 true ES2180629T3 (es) | 2003-02-16 |
Family
ID=22789691
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95913668T Expired - Lifetime ES2180629T3 (es) | 1994-03-11 | 1995-03-13 | Usos terapeuticos de productos dimeros de proteina bactericida/aumentadora de la permeabilidad. |
Country Status (12)
Country | Link |
---|---|
US (4) | US5447913A (es) |
EP (1) | EP0749317B1 (es) |
JP (1) | JPH09510217A (es) |
AT (1) | ATE218879T1 (es) |
AU (1) | AU703134B2 (es) |
CA (1) | CA2185155C (es) |
DE (1) | DE69527049T2 (es) |
DK (1) | DK0749317T3 (es) |
ES (1) | ES2180629T3 (es) |
HK (1) | HK1014159A1 (es) |
PT (1) | PT749317E (es) |
WO (1) | WO1995024209A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5198541A (en) * | 1987-08-11 | 1993-03-30 | New York University | Dna encoding bactericidal/permeability-increasing proteins |
US5652332A (en) * | 1993-03-12 | 1997-07-29 | Xoma | Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof |
AU703211B2 (en) * | 1994-01-14 | 1999-03-18 | Xoma Corporation | Anti-fungal methods and materials |
US5447913A (en) | 1994-03-11 | 1995-09-05 | Xoma Corporation | Therapeutic uses of bactericidal/permeability-increasing protein dimer products |
US5912228A (en) * | 1995-01-13 | 1999-06-15 | Xoma Corporation | Therapeutic compositions comprising bactericidal/permeability-increasing (BPI) protein products |
WO1997004008A1 (en) * | 1995-07-20 | 1997-02-06 | Xoma Corporation | Anti-fungal peptides |
AU730307B2 (en) * | 1995-11-14 | 2001-03-01 | Xoma Corporation | Bactericidal permeability increasing protein (BPI) for treating conditions associated with corneal injury |
US5686414A (en) * | 1995-11-14 | 1997-11-11 | Xoma Corporation | Methods of treating conditions associated with corneal transplantation |
EP0914144B1 (en) * | 1996-05-10 | 2000-12-13 | XOMA Technology Ltd. | Therapeutic uses of bpi protein products for human meningococcemia |
US5741779A (en) * | 1996-05-10 | 1998-04-21 | Xoma Corporation | Antithrombotic materials and methods |
US5945399A (en) * | 1996-05-23 | 1999-08-31 | Xoma Corporation | Therapeutic uses of BPI protein products in humans with hemorrhage due to trauma |
WO1997044354A2 (en) * | 1996-05-24 | 1997-11-27 | Regents Of The University Of Minnesota | Synthesis of soluble beta-sheet forming peptides |
US5888973A (en) * | 1996-08-09 | 1999-03-30 | Xoma Corporation | Anti-chlamydial uses of BPI protein products |
JP2002509527A (ja) * | 1996-11-01 | 2002-03-26 | ゾーマ コーポレイション | 嚢胞性線維症におけるbpiタンパク質産物の治療用途 |
US6482796B2 (en) * | 1996-11-01 | 2002-11-19 | Xoma Corporation | Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients |
US6093573A (en) * | 1997-06-20 | 2000-07-25 | Xoma | Three-dimensional structure of bactericidal/permeability-increasing protein (BPI) |
US6013631A (en) | 1998-06-19 | 2000-01-11 | Xoma Corporation | Bactericidal/permeability-increasing protein (BPI) deletion analogs |
US20050159343A1 (en) * | 1999-03-26 | 2005-07-21 | Board Of Regents, University Of Texas System | Inhibitors of glycosaminoglycans |
WO2001003724A1 (en) * | 1999-07-12 | 2001-01-18 | Xoma Technology Ltd. | Therapeutic uses of bpi protein products for inhibiting h+/k+ atpase activity |
CA2397835A1 (en) * | 2000-01-20 | 2001-07-26 | Regents Of The University Of Minnesota | Polypeptides with therapeutic activity and methods of use |
US6686180B2 (en) * | 2000-04-04 | 2004-02-03 | Baxter International Inc. | Method for the production of bacterial toxins |
US20020173464A1 (en) * | 2000-12-01 | 2002-11-21 | King George L. | Modulation of pericyte proliferation |
EP1572719A4 (en) | 2002-02-20 | 2007-11-14 | Univ Minnesota | PARTIAL PEPTIDE MIMETICS AND METHOD |
DE60335794D1 (de) | 2002-03-29 | 2011-03-03 | Xoma Technology Ltd | Multigene vectoren und methoden für eine erhöhte expression von rekombinanten polypeptiden |
US20040037895A1 (en) * | 2002-08-23 | 2004-02-26 | Alex Zhu | Methods of treating involuntary facial spasms and facial wrinkles |
EP1741440A1 (en) | 2005-07-08 | 2007-01-10 | Mellitus S.L. | Use of BPI protein for the treatment of disorders of the metabolism and cardiovascular disorders |
KR101367479B1 (ko) * | 2008-07-21 | 2014-03-14 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 귀 질병 치료를 위한 제어 방출형 항미생물성 조성물 및 방법 |
GB201319621D0 (en) | 2013-11-06 | 2013-12-18 | Norwegian University Of Science And Technology | Antimicrobial agents and their use in therapy |
GB201319620D0 (en) | 2013-11-06 | 2013-12-18 | Norwegian University Of Science And Technology | Immunosuppressive agents and their use in therapy |
CN117686438A (zh) * | 2024-02-02 | 2024-03-12 | 东北大学秦皇岛分校 | 一种基于红外偏振光的远程材料鉴别方法 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5198541A (en) * | 1987-08-11 | 1993-03-30 | New York University | Dna encoding bactericidal/permeability-increasing proteins |
US5089274A (en) * | 1989-02-14 | 1992-02-18 | Incyte Pharmaceuticals, Inc. | Use of bactericidal/permeability increasing protein or biologically active analogs thereof to treat endotoxin-related disorders |
US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
WO1993023434A2 (en) * | 1992-05-19 | 1993-11-25 | Xoma Corporation | Bpi-immunoglobulin fusion proteins |
ATE178652T1 (de) * | 1992-05-19 | 1999-04-15 | Xoma Corp | Verbessertes verfahren zur herstellung von endotoxinbindungsproteinen |
US5420019A (en) * | 1993-02-02 | 1995-05-30 | Xoma Corporation | Stable bactericidal/permeability-increasing protein muteins |
CA2155005C (en) * | 1993-02-02 | 1999-04-06 | Weldon Courtney Mcgregor | Pharmaceutical compositions containing bactericidal permeability increasing protein and a surfactant |
US5348942A (en) * | 1993-03-12 | 1994-09-20 | Xoma Corporation | Therapeutic uses of bactericidal/permeability increasing protein products |
US5733872A (en) * | 1993-03-12 | 1998-03-31 | Xoma Corporation | Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof |
ATE169304T1 (de) * | 1993-03-12 | 1998-08-15 | Xoma Corp | Biologisch aktive peptide aus funktionellen domaenen des bakteriziden/ die permeabilitaet erhoehenden proteins und ihre verwendung |
AU6361894A (en) * | 1993-03-12 | 1994-09-26 | Xoma Corporation | Treatment of mycobacterial diseases by administration of bactericidal/permeability-increasing protein products |
ATE202482T1 (de) * | 1993-03-12 | 2001-07-15 | Xoma Technology Ltd | Therapeutische verwendungen von antibakteriellen/durchlässigkeitserhöhenden proteinprodukten |
AU7330994A (en) * | 1993-07-14 | 1995-02-13 | Xoma Corporation | Method for potentiating bpi protein product bactericidal activity by administration of lbp protein products |
NZ275205A (en) * | 1993-09-22 | 1998-03-25 | Xoma Corp | Use of bactericidal/permeability-increasing protein in treating gram-negative bacterial infection |
CA2173611C (en) * | 1993-10-05 | 2005-07-26 | Paul A. M. Van Leeuwen | Method of treating depressed reticuloendothelial system function |
AU703211B2 (en) * | 1994-01-14 | 1999-03-18 | Xoma Corporation | Anti-fungal methods and materials |
PT754050E (pt) * | 1994-01-14 | 2002-11-29 | Xoma Technology Ltd | Metodos e materiais contra bacterias gram-positivas |
US5643875A (en) * | 1994-01-24 | 1997-07-01 | Friedmann; Nadav | Human therapeutic uses of bactericidal/permeability increasing (BPI) protein products |
US5447913A (en) * | 1994-03-11 | 1995-09-05 | Xoma Corporation | Therapeutic uses of bactericidal/permeability-increasing protein dimer products |
US5578568A (en) * | 1994-04-22 | 1996-11-26 | Xoma Corporation | Method of treating conditions associated with intestinal ischemia/reperfusion |
US5912228A (en) * | 1995-01-13 | 1999-06-15 | Xoma Corporation | Therapeutic compositions comprising bactericidal/permeability-increasing (BPI) protein products |
US5494896A (en) * | 1995-03-31 | 1996-02-27 | Xoma Corporation | Method of treating conditions associated with burn injuries |
-
1994
- 1994-03-11 US US08/212,132 patent/US5447913A/en not_active Expired - Lifetime
-
1995
- 1995-03-13 DE DE69527049T patent/DE69527049T2/de not_active Expired - Fee Related
- 1995-03-13 US US08/704,504 patent/US5856302A/en not_active Expired - Fee Related
- 1995-03-13 ES ES95913668T patent/ES2180629T3/es not_active Expired - Lifetime
- 1995-03-13 PT PT95913668T patent/PT749317E/pt unknown
- 1995-03-13 JP JP7523700A patent/JPH09510217A/ja not_active Ceased
- 1995-03-13 AT AT95913668T patent/ATE218879T1/de not_active IP Right Cessation
- 1995-03-13 WO PCT/US1995/003125 patent/WO1995024209A1/en active IP Right Grant
- 1995-03-13 EP EP95913668A patent/EP0749317B1/en not_active Expired - Lifetime
- 1995-03-13 AU AU19969/95A patent/AU703134B2/en not_active Ceased
- 1995-03-13 DK DK95913668T patent/DK0749317T3/da active
- 1995-03-13 CA CA002185155A patent/CA2185155C/en not_active Expired - Fee Related
- 1995-06-06 US US08/470,366 patent/US5703038A/en not_active Expired - Fee Related
-
1998
- 1998-12-24 HK HK98115460A patent/HK1014159A1/xx not_active IP Right Cessation
- 1998-12-30 US US09/223,342 patent/US6277821B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69527049D1 (de) | 2002-07-18 |
US5703038A (en) | 1997-12-30 |
US5447913A (en) | 1995-09-05 |
JPH09510217A (ja) | 1997-10-14 |
AU1996995A (en) | 1995-09-25 |
ATE218879T1 (de) | 2002-06-15 |
DE69527049T2 (de) | 2003-03-06 |
CA2185155A1 (en) | 1995-09-14 |
US5856302A (en) | 1999-01-05 |
WO1995024209A1 (en) | 1995-09-14 |
EP0749317B1 (en) | 2002-06-12 |
PT749317E (pt) | 2002-11-29 |
DK0749317T3 (da) | 2002-10-07 |
US6277821B1 (en) | 2001-08-21 |
AU703134B2 (en) | 1999-03-18 |
HK1014159A1 (en) | 1999-09-24 |
CA2185155C (en) | 2001-08-14 |
EP0749317A1 (en) | 1996-12-27 |
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