ES2180436B1 - NEW INDOLES AS INHIBITORS OF CICLOOXIGENASA- II - Google Patents

NEW INDOLES AS INHIBITORS OF CICLOOXIGENASA- II

Info

Publication number
ES2180436B1
ES2180436B1 ES200101285A ES200101285A ES2180436B1 ES 2180436 B1 ES2180436 B1 ES 2180436B1 ES 200101285 A ES200101285 A ES 200101285A ES 200101285 A ES200101285 A ES 200101285A ES 2180436 B1 ES2180436 B1 ES 2180436B1
Authority
ES
Spain
Prior art keywords
sub
compounds
present
inhibitors
cyclooxygenase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200101285A
Other languages
Spanish (es)
Other versions
ES2180436A1 (en
Inventor
Casellas David Mauleon
Perez M Luisa Garcia
Benet Albert Palomer
Avellana Jaime Pascual
Ubeda Antonio Espinosa
Rosa Joaquin Campos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Menarini SA
Original Assignee
Laboratorios Menarini SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Menarini SA filed Critical Laboratorios Menarini SA
Priority to ES200101285A priority Critical patent/ES2180436B1/en
Publication of ES2180436A1 publication Critical patent/ES2180436A1/en
Application granted granted Critical
Publication of ES2180436B1 publication Critical patent/ES2180436B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos de fórmula general I, **FIGURA** inhibidores selectivos de la ciclooxigenasa-II, en los que el grupo A es un grupo carbonilo o tiocarbonilo, o bien - CH{sub,2}- ó -CH(C{sub,1}-C{sub,12})alquil-; R{sub,3} y R{sub,4} son independientemente hidrógeno, halógeno, (C{sub,1}-C{sub,12})- alquilo, (C{sub,2}-C{sub,12})-alquenilo, (C{sub,2}-C{sub,12})- alquinilo, (C{sub,1}-C{sub,12})-haloalquilo, etc., a sus sales y solvatos farmacéuticamente aceptables, y a las composiciones farmacéuticas que las contienen. Los compuestos de la presente invención son útiles en el tratamiento de la inflamación, dolor y fiebre, así como de aquellas otras afecciones que recientemente se han asociado con las ciclooxigenasas, especialmente con la ciclooxigenasa-II, como, por ejemplo, el cáncer colorectal y la enfermedad de Alzheimer. De igual modo, la presente invención se refiere a un procedimiento para la preparación de los compuestos, así como a su utilización terapéutica.The present invention relates to compounds of general formula I, ** FIGURE ** selective inhibitors of cyclooxygenase-II, in which group A is a carbonyl or thiocarbonyl group, or - CH {sub, 2} - or - CH (C {sub, 1} -C {sub, 12}) alkyl-; R {sub, 3} and R {sub, 4} are independently hydrogen, halogen, (C {sub, 1} -C {sub, 12}) -alkyl, (C {sub, 2} -C {sub, 12 }) - alkenyl, (C {sub, 2} -C {sub, 12}) - alkynyl, (C {sub, 1} -C {sub, 12}) - haloalkyl, etc., to its pharmaceutically active salts and solvates acceptable, and the pharmaceutical compositions that contain them. The compounds of the present invention are useful in the treatment of inflammation, pain and fever, as well as those other conditions that have recently been associated with cyclooxygenases, especially with cyclooxygenase-II, such as, for example, colorectal cancer and Alzheimer's disease. Similarly, the present invention relates to a process for the preparation of the compounds, as well as to their therapeutic use.

ES200101285A 2001-06-04 2001-06-04 NEW INDOLES AS INHIBITORS OF CICLOOXIGENASA- II Expired - Fee Related ES2180436B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES200101285A ES2180436B1 (en) 2001-06-04 2001-06-04 NEW INDOLES AS INHIBITORS OF CICLOOXIGENASA- II

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200101285A ES2180436B1 (en) 2001-06-04 2001-06-04 NEW INDOLES AS INHIBITORS OF CICLOOXIGENASA- II

Publications (2)

Publication Number Publication Date
ES2180436A1 ES2180436A1 (en) 2003-02-01
ES2180436B1 true ES2180436B1 (en) 2003-11-01

Family

ID=8497946

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200101285A Expired - Fee Related ES2180436B1 (en) 2001-06-04 2001-06-04 NEW INDOLES AS INHIBITORS OF CICLOOXIGENASA- II

Country Status (1)

Country Link
ES (1) ES2180436B1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436265A (en) * 1993-11-12 1995-07-25 Merck Frosst Canada, Inc. 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents
US5639780A (en) * 1995-05-22 1997-06-17 Merck Frosst Canada, Inc. N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors
GB9716657D0 (en) * 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
ATE482945T1 (en) * 1998-05-26 2010-10-15 Chugai Pharmaceutical Co Ltd HETEROCYCLIC INDOLE DERIVATIVES AND MONO- OR DIAZAINDOLE DERIVATIVES
JP4241970B2 (en) * 1998-10-30 2009-03-18 中外製薬株式会社 Indole derivatives having amide bonds, and mono- or diazaindole derivatives

Also Published As

Publication number Publication date
ES2180436A1 (en) 2003-02-01

Similar Documents

Publication Publication Date Title
HUP0302980A2 (en) Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moeties as inhibitors of protein junkinases and pharmaceutical compositions containing them
ECSP055609A (en) "Use of IkB-kinase inhibitors for the treatment of pain"
NO20050851L (en) Caspase Inhibitors and Uses thereof
SE0104340D0 (en) New compounds
NO331166B1 (en) Inhibitors of tyrosine kinases, process for their preparation, pharmaceutical preparation and use of the compounds
UY27981A1 (en) NEW TRIAZOL COMPOUNDS AS INHIBITORS OF THE TRANSFORMING GROWTH FACTOR (TGF)
HUP0402191A2 (en) Acetylene derivatives having human matabotropic glutamate receptor antagonistic activity, process for producing them, pharmaceutical compositions containing them and use thereof
DE60226729D1 (en) HYDROXYALKYLAMINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND THEIR USE FOR THE TREATMENT OF ALZHEIMER'S DISEASE OR SIMILAR ILLNESSES
AR003220A1 (en) ACILATED MELATONIN DERIVATIVES; PHARMACEUTICAL AND COSMETIC COMPOSITION AND THE USE OF THE SAME FOR THE PREPARATION OF A MEDICINAL PRODUCT.
UY27592A1 (en) NEW USE
HUP0401192A2 (en) Use of photosenzitizing agent for preparation ot, of pharmaceutical composition for treating wounds
EA200500377A1 (en) PYRAZOL DERIVATIVES AS INHIBITORS OF THE TRANSFORMING GROWTH FACTOR (TGF)
DE60034240D1 (en) DRUGS FOR THE TREATMENT OF MALIGNER TUMORS
PA8432901A1 (en) PIRIDILPIRROL COMPOUNDS
HUP0402422A2 (en) Deuterated substituted pyrazolylbenzylsulfonamides pharmaceutical compositions containing them and use thereof
GB0112348D0 (en) Compounds
DE60045508D1 (en) DALDA ANALOGS AND THEIR USE
CY1108871T1 (en) Substituted Amino-Furan-2-yl-Acetic Acid and Amino-Thien-2-Acetic Acid Derivatives and Their Use for Home Therapy
ES2038172T3 (en) PROCEDURE FOR PREPARING HETERO CYCLIC CARBOXAMIDES.
DE60221283D1 (en) USE OF OXINDOLE DERIVATIVES FOR TREATING DISEASES RELATED TO DEMENTIA, ALZHEIMER'S DISEASE AND AIDS ASSOCIATED WITH GLYCOGENSYNTHASEKINASE-3
ATE367380T1 (en) PIPERAZINYLQUINOLINE DERIVATIVES SUITABLE FOR THE TREATMENT OF CNS DISEASES
ES2176321T3 (en) TETRASUSTITUID DERIVATIVES OF IMIDAZOL, ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICATIONS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DE60019086D1 (en) COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES
HUP0300295A2 (en) Substituted benzamide derivatives, pharmaceutical compositions containing them and their use
HUP0302616A2 (en) Dervatives of tryptamine and analogous their use, and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 20030201

Kind code of ref document: A1

FG2A Definitive protection

Ref document number: 2180436B1

Country of ref document: ES

FD1A Patent lapsed

Effective date: 20100312