ES2180436B1 - NEW INDOLES AS INHIBITORS OF CICLOOXIGENASA- II - Google Patents
NEW INDOLES AS INHIBITORS OF CICLOOXIGENASA- IIInfo
- Publication number
- ES2180436B1 ES2180436B1 ES200101285A ES200101285A ES2180436B1 ES 2180436 B1 ES2180436 B1 ES 2180436B1 ES 200101285 A ES200101285 A ES 200101285A ES 200101285 A ES200101285 A ES 200101285A ES 2180436 B1 ES2180436 B1 ES 2180436B1
- Authority
- ES
- Spain
- Prior art keywords
- sub
- compounds
- present
- inhibitors
- cyclooxygenase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a compuestos de fórmula general I, **FIGURA** inhibidores selectivos de la ciclooxigenasa-II, en los que el grupo A es un grupo carbonilo o tiocarbonilo, o bien - CH{sub,2}- ó -CH(C{sub,1}-C{sub,12})alquil-; R{sub,3} y R{sub,4} son independientemente hidrógeno, halógeno, (C{sub,1}-C{sub,12})- alquilo, (C{sub,2}-C{sub,12})-alquenilo, (C{sub,2}-C{sub,12})- alquinilo, (C{sub,1}-C{sub,12})-haloalquilo, etc., a sus sales y solvatos farmacéuticamente aceptables, y a las composiciones farmacéuticas que las contienen. Los compuestos de la presente invención son útiles en el tratamiento de la inflamación, dolor y fiebre, así como de aquellas otras afecciones que recientemente se han asociado con las ciclooxigenasas, especialmente con la ciclooxigenasa-II, como, por ejemplo, el cáncer colorectal y la enfermedad de Alzheimer. De igual modo, la presente invención se refiere a un procedimiento para la preparación de los compuestos, así como a su utilización terapéutica.The present invention relates to compounds of general formula I, ** FIGURE ** selective inhibitors of cyclooxygenase-II, in which group A is a carbonyl or thiocarbonyl group, or - CH {sub, 2} - or - CH (C {sub, 1} -C {sub, 12}) alkyl-; R {sub, 3} and R {sub, 4} are independently hydrogen, halogen, (C {sub, 1} -C {sub, 12}) -alkyl, (C {sub, 2} -C {sub, 12 }) - alkenyl, (C {sub, 2} -C {sub, 12}) - alkynyl, (C {sub, 1} -C {sub, 12}) - haloalkyl, etc., to its pharmaceutically active salts and solvates acceptable, and the pharmaceutical compositions that contain them. The compounds of the present invention are useful in the treatment of inflammation, pain and fever, as well as those other conditions that have recently been associated with cyclooxygenases, especially with cyclooxygenase-II, such as, for example, colorectal cancer and Alzheimer's disease. Similarly, the present invention relates to a process for the preparation of the compounds, as well as to their therapeutic use.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200101285A ES2180436B1 (en) | 2001-06-04 | 2001-06-04 | NEW INDOLES AS INHIBITORS OF CICLOOXIGENASA- II |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200101285A ES2180436B1 (en) | 2001-06-04 | 2001-06-04 | NEW INDOLES AS INHIBITORS OF CICLOOXIGENASA- II |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2180436A1 ES2180436A1 (en) | 2003-02-01 |
ES2180436B1 true ES2180436B1 (en) | 2003-11-01 |
Family
ID=8497946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200101285A Expired - Fee Related ES2180436B1 (en) | 2001-06-04 | 2001-06-04 | NEW INDOLES AS INHIBITORS OF CICLOOXIGENASA- II |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2180436B1 (en) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5436265A (en) * | 1993-11-12 | 1995-07-25 | Merck Frosst Canada, Inc. | 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents |
US5639780A (en) * | 1995-05-22 | 1997-06-17 | Merck Frosst Canada, Inc. | N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors |
GB9716657D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
ATE482945T1 (en) * | 1998-05-26 | 2010-10-15 | Chugai Pharmaceutical Co Ltd | HETEROCYCLIC INDOLE DERIVATIVES AND MONO- OR DIAZAINDOLE DERIVATIVES |
JP4241970B2 (en) * | 1998-10-30 | 2009-03-18 | 中外製薬株式会社 | Indole derivatives having amide bonds, and mono- or diazaindole derivatives |
-
2001
- 2001-06-04 ES ES200101285A patent/ES2180436B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2180436A1 (en) | 2003-02-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0302980A2 (en) | Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moeties as inhibitors of protein junkinases and pharmaceutical compositions containing them | |
ECSP055609A (en) | "Use of IkB-kinase inhibitors for the treatment of pain" | |
NO20050851L (en) | Caspase Inhibitors and Uses thereof | |
SE0104340D0 (en) | New compounds | |
NO331166B1 (en) | Inhibitors of tyrosine kinases, process for their preparation, pharmaceutical preparation and use of the compounds | |
UY27981A1 (en) | NEW TRIAZOL COMPOUNDS AS INHIBITORS OF THE TRANSFORMING GROWTH FACTOR (TGF) | |
HUP0402191A2 (en) | Acetylene derivatives having human matabotropic glutamate receptor antagonistic activity, process for producing them, pharmaceutical compositions containing them and use thereof | |
DE60226729D1 (en) | HYDROXYALKYLAMINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND THEIR USE FOR THE TREATMENT OF ALZHEIMER'S DISEASE OR SIMILAR ILLNESSES | |
AR003220A1 (en) | ACILATED MELATONIN DERIVATIVES; PHARMACEUTICAL AND COSMETIC COMPOSITION AND THE USE OF THE SAME FOR THE PREPARATION OF A MEDICINAL PRODUCT. | |
UY27592A1 (en) | NEW USE | |
HUP0401192A2 (en) | Use of photosenzitizing agent for preparation ot, of pharmaceutical composition for treating wounds | |
EA200500377A1 (en) | PYRAZOL DERIVATIVES AS INHIBITORS OF THE TRANSFORMING GROWTH FACTOR (TGF) | |
DE60034240D1 (en) | DRUGS FOR THE TREATMENT OF MALIGNER TUMORS | |
PA8432901A1 (en) | PIRIDILPIRROL COMPOUNDS | |
HUP0402422A2 (en) | Deuterated substituted pyrazolylbenzylsulfonamides pharmaceutical compositions containing them and use thereof | |
GB0112348D0 (en) | Compounds | |
DE60045508D1 (en) | DALDA ANALOGS AND THEIR USE | |
CY1108871T1 (en) | Substituted Amino-Furan-2-yl-Acetic Acid and Amino-Thien-2-Acetic Acid Derivatives and Their Use for Home Therapy | |
ES2038172T3 (en) | PROCEDURE FOR PREPARING HETERO CYCLIC CARBOXAMIDES. | |
DE60221283D1 (en) | USE OF OXINDOLE DERIVATIVES FOR TREATING DISEASES RELATED TO DEMENTIA, ALZHEIMER'S DISEASE AND AIDS ASSOCIATED WITH GLYCOGENSYNTHASEKINASE-3 | |
ATE367380T1 (en) | PIPERAZINYLQUINOLINE DERIVATIVES SUITABLE FOR THE TREATMENT OF CNS DISEASES | |
ES2176321T3 (en) | TETRASUSTITUID DERIVATIVES OF IMIDAZOL, ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICATIONS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
DE60019086D1 (en) | COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES | |
HUP0300295A2 (en) | Substituted benzamide derivatives, pharmaceutical compositions containing them and their use | |
HUP0302616A2 (en) | Dervatives of tryptamine and analogous their use, and pharmaceutical compositions containing them |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20030201 Kind code of ref document: A1 |
|
FG2A | Definitive protection |
Ref document number: 2180436B1 Country of ref document: ES |
|
FD1A | Patent lapsed |
Effective date: 20100312 |