ES2179671T3 - Rapamicinas fotociclizadas. - Google Patents
Rapamicinas fotociclizadas.Info
- Publication number
- ES2179671T3 ES2179671T3 ES99941166T ES99941166T ES2179671T3 ES 2179671 T3 ES2179671 T3 ES 2179671T3 ES 99941166 T ES99941166 T ES 99941166T ES 99941166 T ES99941166 T ES 99941166T ES 2179671 T3 ES2179671 T3 ES 2179671T3
- Authority
- ES
- Spain
- Prior art keywords
- rapamicines
- photociclized
- antiproliferative
- antiinflammatory
- immunosuppressive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Rapamicinas fotociclizadas. Esta invención se refiere a rapamicinas fotociclizadas y a un método para utilizarlas en la inducción de la inmunosupresión y en el tratamiento del rechazo de trasplantes, enfermedad del injerto contra el huésped, enfermedades autoinmunitarias, enfermedades inflamatorias, leucemia/linfoma de células T adultas, tumores sólidos, micosis y trastornos vasculares hiperproliferativos. La rapamicina es un antibiótico triénico macrocíclico producido por Streptomyces hygroscopicus, del que se encontró que tenía actividad antifúngica, especialmente contra Candida albicans, tanto in vitro como in vivo. La rapamicina sola o en combinación con picibanil ha demostrado tener actividad antitumoral. R. Martel y cols. describieron cómo la rapamicina es eficaz en el modelo de encefalomielitis alérgica experimental, un modelo de esclerosis múltiple; en el modelo de artritis con adyuvantes, un modelo de artritis reumatoide; e inhibe de forma eficaz la formación de anticuerpos de tipoIgE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13542198A | 1998-08-17 | 1998-08-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2179671T3 true ES2179671T3 (es) | 2003-01-16 |
Family
ID=22468034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99941166T Expired - Lifetime ES2179671T3 (es) | 1998-08-17 | 1999-08-16 | Rapamicinas fotociclizadas. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1105395B1 (es) |
| JP (1) | JP2002522543A (es) |
| CN (1) | CN1323310A (es) |
| AT (1) | ATE219492T1 (es) |
| AU (1) | AU5487499A (es) |
| BR (1) | BR9913052A (es) |
| CA (1) | CA2340700A1 (es) |
| DE (1) | DE69901907T2 (es) |
| DK (1) | DK1105395T3 (es) |
| ES (1) | ES2179671T3 (es) |
| PT (1) | PT1105395E (es) |
| WO (1) | WO2000009510A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
| ES2380779T3 (es) | 2004-12-20 | 2012-05-18 | Wyeth Llc | Análogos de rapamicina y usos de los mismos en el tratamiento de trastornos neurológicos, proliferativos e inflamatorios |
| MX2007007409A (es) | 2004-12-20 | 2007-07-12 | Wyeth Corp | Derivados de rapamicina y los usos de los mismos en el tratamiento de trastornos neurologicos. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
-
1999
- 1999-08-16 AU AU54874/99A patent/AU5487499A/en not_active Abandoned
- 1999-08-16 DE DE69901907T patent/DE69901907T2/de not_active Expired - Fee Related
- 1999-08-16 CN CN99812174A patent/CN1323310A/zh active Pending
- 1999-08-16 EP EP99941166A patent/EP1105395B1/en not_active Expired - Lifetime
- 1999-08-16 JP JP2000564961A patent/JP2002522543A/ja active Pending
- 1999-08-16 CA CA002340700A patent/CA2340700A1/en not_active Abandoned
- 1999-08-16 BR BR9913052-1A patent/BR9913052A/pt not_active IP Right Cessation
- 1999-08-16 ES ES99941166T patent/ES2179671T3/es not_active Expired - Lifetime
- 1999-08-16 DK DK99941166T patent/DK1105395T3/da active
- 1999-08-16 WO PCT/US1999/018564 patent/WO2000009510A1/en active IP Right Grant
- 1999-08-16 PT PT99941166T patent/PT1105395E/pt unknown
- 1999-08-16 AT AT99941166T patent/ATE219492T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK1105395T3 (da) | 2002-10-14 |
| PT1105395E (pt) | 2002-09-30 |
| CA2340700A1 (en) | 2000-02-24 |
| CN1323310A (zh) | 2001-11-21 |
| DE69901907D1 (de) | 2002-07-25 |
| EP1105395A1 (en) | 2001-06-13 |
| WO2000009510A1 (en) | 2000-02-24 |
| JP2002522543A (ja) | 2002-07-23 |
| AU5487499A (en) | 2000-03-06 |
| ATE219492T1 (de) | 2002-07-15 |
| DE69901907T2 (de) | 2002-12-19 |
| BR9913052A (pt) | 2001-05-08 |
| EP1105395B1 (en) | 2002-06-19 |
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