ES2178539A1 - Procedimiento para la preparacion de un compuesto de oxazolina. - Google Patents

Procedimiento para la preparacion de un compuesto de oxazolina.

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Publication number
ES2178539A1
ES2178539A1 ES200000612A ES200000612A ES2178539A1 ES 2178539 A1 ES2178539 A1 ES 2178539A1 ES 200000612 A ES200000612 A ES 200000612A ES 200000612 A ES200000612 A ES 200000612A ES 2178539 A1 ES2178539 A1 ES 2178539A1
Authority
ES
Spain
Prior art keywords
phenyl
benzoyl
oxazole
dihydro
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200000612A
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English (en)
Other versions
ES2178539B1 (es
Inventor
Jin Kyu Park
Kyung Seok Choi
Han Won Lee
Sung Ki Seo
Won Hun Ham
Chang Young Oh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dong Kook Pharmaceutical Co Ltd
Original Assignee
Dong Kook Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dong Kook Pharmaceutical Co Ltd filed Critical Dong Kook Pharmaceutical Co Ltd
Priority to ES200000612A priority Critical patent/ES2178539B1/es
Publication of ES2178539A1 publication Critical patent/ES2178539A1/es
Application granted granted Critical
Publication of ES2178539B1 publication Critical patent/ES2178539B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Procedimiento para la preparación de un compuesto de oxazolina. La presente invención se refiere a un procedimiento para la preparación de un compuesto de oxazolina que se convierte fácilmente por medios químicos en un beta-amino-alfa-hidroxiácido o un gamma-amino-beta-hidroxiácido. El procedimiento comprende la producción de un compuesto de la fórmula (4) mostrada a continuación usando un {al}-aminoácido. El compuesto (4) producido se somete a una ciclación intramolecular para producir un compuesto de oxazolina de la siguiente fórmula (3). El compuesto de oxazolina (3) se oxida a un grupo vinilo con RuCl{sub,3} o NaIO{sub,4} para producir un compuesto de oxazolina de la siguiente fórmula (1) que se convierte fácilmente por medios químicos en un beta-amino-alfa-hidroxiácido. De forma alternativa, el compuesto de oxazolina (3) también puede tratarse con 9-borabiclo [3.3.1]nonano de tal forma que se introduzca un grupo hidroxi en el extremo del grupo vinilo del compuesto de oxazolina (3). Elgrupo hidroxi terminal introducido se oxida con RuCl{sub,3} o NaIO{sub,4} para producir un compuesto de oxazolina de la siguiente fórmula (2), que se convierte fácilmente por medios químicos en un gamma-amino-hidroxiácido.
ES200000612A 2000-03-14 2000-03-14 Procedimiento para la preparacion de un compuesto de oxazolina. Expired - Lifetime ES2178539B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES200000612A ES2178539B1 (es) 2000-03-14 2000-03-14 Procedimiento para la preparacion de un compuesto de oxazolina.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200000612A ES2178539B1 (es) 2000-03-14 2000-03-14 Procedimiento para la preparacion de un compuesto de oxazolina.

Publications (2)

Publication Number Publication Date
ES2178539A1 true ES2178539A1 (es) 2002-12-16
ES2178539B1 ES2178539B1 (es) 2004-08-01

Family

ID=8492695

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200000612A Expired - Lifetime ES2178539B1 (es) 2000-03-14 2000-03-14 Procedimiento para la preparacion de un compuesto de oxazolina.

Country Status (1)

Country Link
ES (1) ES2178539B1 (es)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997015562A1 (fr) * 1995-10-27 1997-05-01 Societe D'etude Et De Recherche En Ingenierie Pharmaceutique Seripharm Intermediaires pour l'hemisynthese de taxanes et leurs procedes de preparation
US5776329A (en) * 1994-11-02 1998-07-07 H.C. Starck Gmbh & Co, Kg Method for the decomposition and recovery of metallic constituents from superalloys
WO2001030770A1 (en) * 1999-10-26 2001-05-03 Dong Kook Pharmaceutical Co., Ltd. Stereoselective synthesis of oxazoline derivative

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776329A (en) * 1994-11-02 1998-07-07 H.C. Starck Gmbh & Co, Kg Method for the decomposition and recovery of metallic constituents from superalloys
WO1997015562A1 (fr) * 1995-10-27 1997-05-01 Societe D'etude Et De Recherche En Ingenierie Pharmaceutique Seripharm Intermediaires pour l'hemisynthese de taxanes et leurs procedes de preparation
WO2001030770A1 (en) * 1999-10-26 2001-05-03 Dong Kook Pharmaceutical Co., Ltd. Stereoselective synthesis of oxazoline derivative

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Journal Organic Chemistry, Vol. 64, 1999, paginas 9450-9458. K. LEE et al. "Stereoselective intramolecular cyclization of allyl and homoallyl benzamide via pi-allyl-palladium complex catalyzed by Pd (0)". Todo el documento. *
Tetrahedron Letters, Vol. 39, no 44, 1998, paginas 8129-8132. K. LEE et al. "A highly stereocontrolled asymmetric synthesis of the Taxol C-13 side chain". Todo el documento. *

Also Published As

Publication number Publication date
ES2178539B1 (es) 2004-08-01

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