ES2178342T3 - DERIVED FROM 1,2,3-TRIAZINE, ITS PREPARATION AND ITS USE AS A REFERENCE MARKER TO ANALYZE THE PURITY AND STABILITY OF LAMOTRIGINE. - Google Patents

DERIVED FROM 1,2,3-TRIAZINE, ITS PREPARATION AND ITS USE AS A REFERENCE MARKER TO ANALYZE THE PURITY AND STABILITY OF LAMOTRIGINE.

Info

Publication number
ES2178342T3
ES2178342T3 ES99200695T ES99200695T ES2178342T3 ES 2178342 T3 ES2178342 T3 ES 2178342T3 ES 99200695 T ES99200695 T ES 99200695T ES 99200695 T ES99200695 T ES 99200695T ES 2178342 T3 ES2178342 T3 ES 2178342T3
Authority
ES
Spain
Prior art keywords
triazine
purity
stability
lamotrigine
analyze
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99200695T
Other languages
Spanish (es)
Inventor
Lorraine Mary Edmeades
Nigel Arthur Griffith-Skinner
Derek Anthony Hill
Graham Thornton Hill
Terrence William Packham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10833464&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2178342(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of ES2178342T3 publication Critical patent/ES2178342T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A UN METODO PARA ENSAYAR LA PUREZA O ESTABILIDAD FRENTE A LA DEGRADACION, DE UNA MUESTRA DE LAMOTRIGINA O UNA FORMA DE DOSIFICACION FARMACEUTICA QUE CONTIENE LAMOTRIGINA. DICHO METODO CONSISTE EN ENSAYAR LA MUESTRA FLUIDA RESPECTO A LA PRESENCIA DE UN COMPUESTO SELECCIONADO A PARTIR DE 3 - AMINO- 6 (2,3 - DICLOROFENIL) - 1,2,4 - TRIAZINA - 5 (4H) - ONA (COMPUESTO A) Y DE N - [5 - AMINO - 6 - (2,3 - DICLOROFENIL) - 1,2,4 - TRIAZINA - 3 - IL] - 2,3 - DICLOROBENZAMIDA B, QUE ES NUEVO.THE INVENTION REFERS TO A METHOD FOR TESTING PURITY OR STABILITY AGAINST DEGRADATION, A SAMPLE OF LAMOTRIGIN OR A PHARMACEUTICAL DOSAGE FORM CONTAINING LAMOTRIGIN. THIS METHOD CONSISTS OF TESTING THE FLUID SAMPLE WITH REGARD TO THE PRESENCE OF A SELECTED COMPOSITE FROM 3 - AMINO- 6 (2,3 - DICLOROPHENIL) - 1,2,4 - TRIAZINE - 5 (4H) - ONA (COMPOUND A) AND FROM N - [5 - AMINO - 6 - (2,3 - DICLOROPHENIL) - 1,2,4 - TRIAZINE - 3 - IL] - 2,3 - DICLOROBENZAMIDE B, WHICH IS NEW.

ES99200695T 1998-06-10 1999-03-10 DERIVED FROM 1,2,3-TRIAZINE, ITS PREPARATION AND ITS USE AS A REFERENCE MARKER TO ANALYZE THE PURITY AND STABILITY OF LAMOTRIGINE. Expired - Lifetime ES2178342T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9812413.4A GB9812413D0 (en) 1998-06-10 1998-06-10 Compound and its use

Publications (1)

Publication Number Publication Date
ES2178342T3 true ES2178342T3 (en) 2002-12-16

Family

ID=10833464

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99200695T Expired - Lifetime ES2178342T3 (en) 1998-06-10 1999-03-10 DERIVED FROM 1,2,3-TRIAZINE, ITS PREPARATION AND ITS USE AS A REFERENCE MARKER TO ANALYZE THE PURITY AND STABILITY OF LAMOTRIGINE.

Country Status (31)

Country Link
US (1) US6333198B1 (en)
EP (2) EP1170588A1 (en)
JP (1) JP2989189B1 (en)
KR (1) KR100322354B1 (en)
CN (2) CN1238454A (en)
AP (3) AP9901481A0 (en)
AR (1) AR014074A1 (en)
AT (1) ATE218552T1 (en)
AU (1) AU2031999A (en)
BR (1) BR9900984A (en)
CA (1) CA2265194C (en)
DE (1) DE69901656T2 (en)
DK (1) DK0963980T3 (en)
EA (1) EA000666B1 (en)
ES (1) ES2178342T3 (en)
GB (1) GB9812413D0 (en)
HR (1) HRP990074A2 (en)
HU (1) HUP9900592A3 (en)
ID (1) ID22957A (en)
MA (1) MA24777A1 (en)
NO (2) NO991151L (en)
NZ (1) NZ334590A (en)
PE (1) PE20000332A1 (en)
PL (1) PL331870A1 (en)
PT (1) PT963980E (en)
SG (1) SG85628A1 (en)
SI (1) SI0963980T1 (en)
TR (1) TR199900520A3 (en)
UY (1) UY25946A1 (en)
YU (1) YU12399A (en)
ZA (1) ZA991951B (en)

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BR9900984A (en) 2000-05-02
PT963980E (en) 2002-10-31
EP0963980A2 (en) 1999-12-15
YU12399A (en) 2002-08-12
CA2265194C (en) 2000-10-10
EP0963980A3 (en) 2000-05-31
ATE218552T1 (en) 2002-06-15
US6333198B1 (en) 2001-12-25
PL331870A1 (en) 1999-12-20
NO20032753L (en) 1999-12-13
HUP9900592A3 (en) 2002-04-29
AP9901481A0 (en) 1999-03-31
EP1170588A1 (en) 2002-01-09
NZ334590A (en) 2000-07-28
AU2031999A (en) 2000-01-06
AR014074A1 (en) 2001-01-31
EA000666B1 (en) 2000-02-28
NO991151D0 (en) 1999-03-10
AP0102286A0 (en) 2000-09-10
CN1306210A (en) 2001-08-01
SG85628A1 (en) 2002-01-15
TR199900520A2 (en) 2000-01-21
DE69901656T2 (en) 2003-01-30
KR100322354B1 (en) 2002-02-07
CN1238454A (en) 1999-12-15
EA199900159A1 (en) 1999-12-29
NO991151L (en) 1999-12-13
KR20000005611A (en) 2000-01-25
JP2989189B1 (en) 1999-12-13
JP2000009714A (en) 2000-01-14
GB9812413D0 (en) 1998-08-05
HU9900592D0 (en) 1999-04-28
TR199900520A3 (en) 2000-01-21
SI0963980T1 (en) 2002-12-31
HUP9900592A2 (en) 2000-04-28
MA24777A1 (en) 1999-10-01
NO20032753D0 (en) 2003-06-17
DE69901656D1 (en) 2002-07-11
HRP990074A2 (en) 2000-10-31
PE20000332A1 (en) 2000-04-10
UY25946A1 (en) 2000-12-29
ID22957A (en) 1999-12-23
DK0963980T3 (en) 2002-09-16
ZA991951B (en) 1999-08-16
EP0963980B1 (en) 2002-06-05
AP2001002286A0 (en) 2001-12-31

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