ES2176302T3 - Sitios de union upa en el dominio 2+3 de upar y anticuerpos reactivos con los mismos. - Google Patents
Sitios de union upa en el dominio 2+3 de upar y anticuerpos reactivos con los mismos.Info
- Publication number
- ES2176302T3 ES2176302T3 ES95610039T ES95610039T ES2176302T3 ES 2176302 T3 ES2176302 T3 ES 2176302T3 ES 95610039 T ES95610039 T ES 95610039T ES 95610039 T ES95610039 T ES 95610039T ES 2176302 T3 ES2176302 T3 ES 2176302T3
- Authority
- ES
- Spain
- Prior art keywords
- par
- antibody
- dsm
- relates
- upar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
EL INVENTO SE REFIERE A UN ANTICUERPO QUE INHIBE LA UNION ENTRE U-PA Y U-PAR HASTA UN PORCENTAJE DE UN 90% COMO MINIMO EN UN ENSAYO COMO EL DEFINIDO EN LA ESPECIFICACION, O UN FRAGMENTO ACTIVO O EQUIVALENTE INMUNOLOGICO DE DICHO ANTICUERPO. SE HAN DEPOSITADO MUESTRAS DE LOS CITADOS ANTICUERPOS EL 7 DE JULIO EN EL DEUTSCHE SAMMLUNG VON MIKROORGANISMEN UND ZELLKULTUREN (DSM) CON LOS NUMEROS DE REFERENCIA DSM ACC2178 Y DSM ACC2179 BAJO LOS TERMINOS Y CONDICIONES ESTABLECIDOS EN EL TRATADO DE BUDAPEST. EL INVENTO SE REFIERE ADEMAS A UN METODO PARA DETECTAR O CUANTIFICAR U-PAR O UNA VARIANTE DE GLUCOSILACION DE U-PAR EN UNA MUESTRA, MEDIANTE EL USO DE UN ANTICUERPO SEGUN EL INVENTO. ADEMAS, EL INVENTO SE REFIERE A UN METODO PARA LA FABRICACION DE UN AGENTE TERAPEUTICO PARA PREVENIR O CONTRARRESTAR LA ACTIVIDAD PROTEOLITICA UTILIZANDO EL ANTICUERPO DEL INVENTO, ASI COMO EL USO DE UN ANTICUERPO SEGUN EL INVENTO PARA LA PREPARACION DE UN AGENTE DE DIAGNOSTICO QUE SEA CAPAZ DE DETERMINAR EL DIAGNOSTICO DE UNA CELULA QUE CONTENGA U-PAR EN LA SUPERFICIE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK83194 | 1994-07-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2176302T3 true ES2176302T3 (es) | 2002-12-01 |
Family
ID=8098050
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95610039T Expired - Lifetime ES2176302T3 (es) | 1994-07-08 | 1995-06-22 | Sitios de union upa en el dominio 2+3 de upar y anticuerpos reactivos con los mismos. |
Country Status (7)
Country | Link |
---|---|
US (1) | US6025142A (es) |
EP (1) | EP0691350B1 (es) |
JP (1) | JP2852192B2 (es) |
AT (1) | ATE217013T1 (es) |
CA (1) | CA2153208A1 (es) |
DE (1) | DE69526542T2 (es) |
ES (1) | ES2176302T3 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6077508A (en) * | 1998-03-23 | 2000-06-20 | American Diagnostica Inc. | Urokinase plasminogen activator receptor as a target for diagnosis of metastases |
WO2002009753A1 (en) * | 2000-08-02 | 2002-02-07 | H:S Hvidovre Hospital | Composition and method for the treatment or prevention of hiv infection |
EP1393743A1 (en) * | 2001-01-25 | 2004-03-03 | Fondazione Centro San Raffaele Del Monte Tabor | Agents modulating UPA/UPAR activity for the treatment of AIDS |
ATE361096T1 (de) * | 2001-01-25 | 2007-05-15 | San Raffaele Centro Fond | Antikörper zur modulierung der upa/upar interaktion und deren verwendungen |
WO2004037286A2 (en) * | 2002-10-23 | 2004-05-06 | F. Hoffmann-La Roche Ag | Combination of a trioxopyrimidine compound inhibitor and an anti-tumor agent, and uses thereof |
DE10323898A1 (de) | 2003-05-26 | 2004-12-23 | Wilex Ag | Hydroxyamidin- und Hydroxyguanidin-Verbindungen als Urokinase-Hemmstoffe |
TW200813091A (en) * | 2006-04-10 | 2008-03-16 | Amgen Fremont Inc | Targeted binding agents directed to uPAR and uses thereof |
PL2117571T3 (pl) * | 2006-12-08 | 2017-08-31 | Monopar Therapeutics Inc. | Epitop receptora aktywatora plazminogenu typu urokinazy |
WO2011123029A1 (en) | 2010-03-30 | 2011-10-06 | Ge Healthcare Bio-Sciences Ab | Method for determination of binding stoichiometry |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5327493A (en) | 1976-08-27 | 1978-03-14 | Risei Ui | Ultra micro analysis for acetone and kit for carrying out the analysis |
US5519120A (en) * | 1989-04-07 | 1996-05-21 | Cancerforskningsfondet Af 1989 | Urokinase-type plasminogen activator receptor antibodies |
WO1992007083A1 (en) * | 1990-10-18 | 1992-04-30 | Cancerforskningsfondet Af 1989 | Antibodies against the urokinase receptor and their use |
DE69033653T2 (de) * | 1989-04-07 | 2001-06-07 | Cancerforskningsfonden Af 1989 | Plasminogen-aktivator-rezeptor vom urokinasetyp |
JPH07501524A (ja) * | 1991-11-18 | 1995-02-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | uPA−Rの検出・分離方法及びuPAのuPA−Rへの結合阻止方法 |
-
1995
- 1995-01-06 JP JP7000631A patent/JP2852192B2/ja not_active Expired - Fee Related
- 1995-06-02 US US08/458,585 patent/US6025142A/en not_active Expired - Lifetime
- 1995-06-22 ES ES95610039T patent/ES2176302T3/es not_active Expired - Lifetime
- 1995-06-22 DE DE69526542T patent/DE69526542T2/de not_active Expired - Lifetime
- 1995-06-22 AT AT95610039T patent/ATE217013T1/de not_active IP Right Cessation
- 1995-06-22 EP EP95610039A patent/EP0691350B1/en not_active Expired - Lifetime
- 1995-07-04 CA CA002153208A patent/CA2153208A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US6025142A (en) | 2000-02-15 |
ATE217013T1 (de) | 2002-05-15 |
JPH0859700A (ja) | 1996-03-05 |
DE69526542T2 (de) | 2003-01-09 |
CA2153208A1 (en) | 1996-01-09 |
EP0691350B1 (en) | 2002-05-02 |
EP0691350A3 (en) | 1996-11-27 |
EP0691350A2 (en) | 1996-01-10 |
DE69526542D1 (de) | 2002-06-06 |
JP2852192B2 (ja) | 1999-01-27 |
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