ES2172571T3 - 2-carboxialquil-3-(fluorofenil)-8-(3-halopropen-2-il) nortropanos sustituidos y su uso como agentes de representacion de imagenes para trastornos neurodegenerativos. - Google Patents

2-carboxialquil-3-(fluorofenil)-8-(3-halopropen-2-il) nortropanos sustituidos y su uso como agentes de representacion de imagenes para trastornos neurodegenerativos.

Info

Publication number
ES2172571T3
ES2172571T3 ES95900419T ES95900419T ES2172571T3 ES 2172571 T3 ES2172571 T3 ES 2172571T3 ES 95900419 T ES95900419 T ES 95900419T ES 95900419 T ES95900419 T ES 95900419T ES 2172571 T3 ES2172571 T3 ES 2172571T3
Authority
ES
Spain
Prior art keywords
nortropans
halopropen
carboxialquil
fluorophenil
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95900419T
Other languages
English (en)
Inventor
David R Elmaleh
Bertha K Madras
Peter Meltzer
Robert N Hanson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NORTHEASTERN, University of
Harvard College
General Hospital Corp
Organix Inc
Original Assignee
NORTHEASTERN, University of
Harvard College
General Hospital Corp
Organix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NORTHEASTERN, University of, Harvard College, General Hospital Corp, Organix Inc filed Critical NORTHEASTERN, University of
Application granted granted Critical
Publication of ES2172571T3 publication Critical patent/ES2172571T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K51/0448—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil tropane or nortropane groups, e.g. cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PRESENTAN CIERTOS ANALOGOS DE LA COCAINA UTILES PARA LA FORMACION DE IMAGENES DE LOS RECEPTORES DE LA COCAINA Y DE LOS RECEPTORES DE LA DOPAMINA. TAMBIEN SE PRESENTAN ANALOGOS UTILES PARA DIAGNOSTICOS MEDIANTE LA FORMACION DE IMAGENES PARA LA ENFERMEDAD DE PARKINSON.
ES95900419T 1993-10-25 1994-10-24 2-carboxialquil-3-(fluorofenil)-8-(3-halopropen-2-il) nortropanos sustituidos y su uso como agentes de representacion de imagenes para trastornos neurodegenerativos. Expired - Lifetime ES2172571T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/142,584 US5493026A (en) 1993-10-25 1993-10-25 Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders

Publications (1)

Publication Number Publication Date
ES2172571T3 true ES2172571T3 (es) 2002-10-01

Family

ID=22500439

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95900419T Expired - Lifetime ES2172571T3 (es) 1993-10-25 1994-10-24 2-carboxialquil-3-(fluorofenil)-8-(3-halopropen-2-il) nortropanos sustituidos y su uso como agentes de representacion de imagenes para trastornos neurodegenerativos.

Country Status (7)

Country Link
US (2) US5493026A (es)
EP (2) EP1081147A2 (es)
AT (1) ATE216385T1 (es)
DE (1) DE69430438T2 (es)
DK (1) DK0734385T3 (es)
ES (1) ES2172571T3 (es)
WO (1) WO1995011901A1 (es)

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US5750089A (en) * 1996-01-11 1998-05-12 Neuro Imaging Technologies, Llc Halogenated neuroprobe for mapping monoamine reuptake sites
US5493026A (en) * 1993-10-25 1996-02-20 Organix, Inc. Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
WO1996039198A1 (en) * 1995-06-06 1996-12-12 RESEARCH BIOCHEMICALS, LIMITED PARTNERSHIP, doing business as RESEARCH BIOCHEMICALS INTERNATIONAL, A MASSACHUSETTS LIMITED PARTNERSHIP, WHOSE SOLE GENERAL PARTNER IS RBI MANAGEMENT, INC. Iodinated neuroprobes for mapping monoamine reuptake sites
US6241963B1 (en) * 1995-10-19 2001-06-05 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
US7105678B2 (en) 1995-11-03 2006-09-12 Organix, Inc. Boat tropanes
US6171576B1 (en) * 1995-11-03 2001-01-09 Organix Inc. Dopamine transporter imaging agent
US5948933A (en) 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
US7081238B2 (en) * 1995-11-03 2006-07-25 The President And Fellows Of Harvard College Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level
FR2748475B1 (fr) * 1996-05-10 1999-04-16 Cis Bio Int Derives du tropane utilisables en particulier pour la detection in vivo des transporteurs de la dopamine
US7214686B2 (en) * 1997-06-30 2007-05-08 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
US6001330A (en) * 1997-09-12 1999-12-14 Elmaleh; David R. Diagnostic and therapeutic alkylenediamine compounds and process
US6525386B1 (en) * 1998-03-10 2003-02-25 Masimo Corporation Non-protruding optoelectronic lens
AU4974700A (en) 1999-04-22 2000-11-10 Emory University Fluoroalkenyl nortropanes
CA2721484A1 (en) 1999-05-12 2000-11-12 President And Fellows Of Harvard College Dopamine transporter imaging agents
US7553478B2 (en) * 1999-05-12 2009-06-30 President And Fellows Of Harvard College Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level
US20100143248A1 (en) * 1999-06-28 2010-06-10 President And Fellows Of Harvard College Methods for diagnosing and monitoring treatment of adhd by assessing the dopamine transporter level
DE60109924T2 (de) 2000-05-25 2006-02-09 Targacept, Inc. Heteroaryldiazabicycloalkane als liganden für den nikotinischen acetylcholin-rezeptor
US6440970B1 (en) 2000-05-25 2002-08-27 Targacept, Inc. Pharmaceutical compositions and methods for use
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
DE20120708U1 (de) 2001-10-09 2002-08-01 Meltzer Peter C Tropan-Analoga zur Inhibierung des Monoamin-Transports
AU2003265233B2 (en) * 2002-03-28 2008-05-08 Organix, Inc. Tropane compounds
AU2003231758B2 (en) * 2002-04-30 2009-10-22 Emory University Tumor imaging compounds
AU2004282201A1 (en) * 2003-10-15 2005-04-28 Targacept, Inc. Azabicycyclic compounds for relieving pain and treating central nervous system disorders
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
JP2009505947A (ja) * 2005-06-23 2009-02-12 エモリー・ユニバーシティ 画像化剤
EP1893246A4 (en) * 2005-06-23 2009-05-06 Univ Emory STEREOSELECTIVE SYNTHESIS OF AMINO ACID ANALOGUE FOR TUMOR IMAGING
DE602006017235D1 (de) * 2005-08-22 2010-11-11 Targacept Inc Heteroarylsubstituierte diazatricycloalkane, verfahren zu deren herstellung und deren anwendung
TWI389889B (zh) 2006-05-09 2013-03-21 Targacept Inc （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型
CN101528698A (zh) 2006-05-09 2009-09-09 阿斯利康公司 (2s)-(4e)-n-甲基-5-[3-(5-异丙氧基吡啶)基]-4-戊烯-2-胺的盐形式
TWI405763B (zh) 2006-11-02 2013-08-21 Targacept Inc 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺
TW200845977A (en) * 2007-03-30 2008-12-01 Targacept Inc Sub-type selective azabicycloalkane derivatives
SA08290475B1 (ar) 2007-08-02 2013-06-22 Targacept Inc (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
US20100221181A1 (en) * 2007-09-26 2010-09-02 Koninklijke Philips Electronics N.V. Method of differentially diagnosing different types of dementia
WO2009055922A1 (en) 2007-10-31 2009-05-07 Alseres Pharmaceuticals, Inc. Labeled iodinated tropane formulation
US8084018B2 (en) * 2007-10-31 2011-12-27 Alseres Pharmaceuticals, Inc. Methods for imaging dopamine transporter level
RU2010133976A (ru) * 2008-01-15 2012-02-27 Таргасепт, Инк. (Us) Получение и энантиомерное разделение 7-(3-пиридинил)-1,7-диазаспиро[4,4]нонана и новые солевые формы рацемата и энантиомеров
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US9145396B2 (en) 2008-12-01 2015-09-29 Targacept, Inc. Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine
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JP2013512922A (ja) 2009-12-07 2013-04-18 ターガセプト，インコーポレイテッド 神経型ニコチン性アセチルコリン受容体リガンドとしての３，６−ジアザビシクロ［３．１．１］ヘプタン
CN113058046A (zh) 2010-02-08 2021-07-02 兰休斯医疗成像公司 用于合成显像剂和其中间体的方法和装置
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Also Published As

Publication number Publication date
US5493026A (en) 1996-02-20
EP0734385A1 (en) 1996-10-02
DK0734385T3 (da) 2002-08-05
DE69430438T2 (de) 2002-11-21
DE69430438D1 (de) 2002-05-23
ATE216385T1 (de) 2002-05-15
WO1995011901A1 (en) 1995-05-04
EP0734385B1 (en) 2002-04-17
EP1081147A2 (en) 2001-03-07
US5853696A (en) 1998-12-29
EP0734385A4 (en) 1997-05-07

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