ES2169089T3 - Producto de plantas para controlar las respuestas inmunes en mamiferos y procedimiento para fabricar dicho producto. - Google Patents

Producto de plantas para controlar las respuestas inmunes en mamiferos y procedimiento para fabricar dicho producto.

Info

Publication number
ES2169089T3
ES2169089T3 ES94928233T ES94928233T ES2169089T3 ES 2169089 T3 ES2169089 T3 ES 2169089T3 ES 94928233 T ES94928233 T ES 94928233T ES 94928233 T ES94928233 T ES 94928233T ES 2169089 T3 ES2169089 T3 ES 2169089T3
Authority
ES
Spain
Prior art keywords
product
plants
mammers
procedure
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94928233T
Other languages
English (en)
Inventor
Anthony M Jevnikar
Shengwu Ma
Calvin R Stiller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
London Health Services Centre
London Health Sciences Centre Research Inc
Original Assignee
London Health Services Centre
London Health Sciences Centre Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by London Health Services Centre, London Health Sciences Centre Research Inc filed Critical London Health Services Centre
Application granted granted Critical
Publication of ES2169089T3 publication Critical patent/ES2169089T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)

Abstract

SE PRESENTA UN METODO PARA EXPRESAR UN ANTIGENO A UN MAMIFERO EN PLANTAS TRANSFORMADAS PARA OBTENER UNA FUENTE DE MATERIAL VEGETAL PARA SU ADMINISTRACION ORAL O ENTERAL A UN MAMIFERO PARA PROVOCAR EN EL UNA TOLERANCIA AL ANTIGENO.
ES94928233T 1993-09-21 1994-09-21 Producto de plantas para controlar las respuestas inmunes en mamiferos y procedimiento para fabricar dicho producto. Expired - Lifetime ES2169089T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939319429A GB9319429D0 (en) 1993-09-21 1993-09-21 Methods and products for controlling immune responses in mammals

Publications (1)

Publication Number Publication Date
ES2169089T3 true ES2169089T3 (es) 2002-07-01

Family

ID=10742259

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94928233T Expired - Lifetime ES2169089T3 (es) 1993-09-21 1994-09-21 Producto de plantas para controlar las respuestas inmunes en mamiferos y procedimiento para fabricar dicho producto.

Country Status (11)

Country Link
US (2) US6338850B1 (es)
EP (1) EP0720484B1 (es)
JP (1) JP3948741B2 (es)
CN (1) CN1135718A (es)
AT (1) ATE209927T1 (es)
AU (1) AU7736794A (es)
CA (1) CA2172398C (es)
DE (1) DE69429353T2 (es)
ES (1) ES2169089T3 (es)
GB (1) GB9319429D0 (es)
WO (1) WO1995008347A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6228604B1 (en) 1996-04-10 2001-05-08 Loma Linda University Secreted renilla luciferase
AU3825497A (en) * 1996-08-15 1998-03-06 Agrivax Incorporated Delivery of tolerogenic antigens via edible plants or plant-derived products
US7361331B2 (en) * 1996-10-18 2008-04-22 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food Plant bioreactors
US7422747B2 (en) 1997-10-07 2008-09-09 Loma Linda University Transgenic plant-based vaccines
US6777546B2 (en) 1997-10-07 2004-08-17 Loma Linda University Methods and substances for preventing and treating autoimmune disease
JP2002526116A (ja) * 1998-10-07 2002-08-20 シンジェンタ・パティシペーションズ・アクチェンゲゼルシャフト 植物における治療活性タンパク質
US8622991B2 (en) * 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
CN104069567A (zh) * 2007-03-19 2014-10-01 茵苏莱恩医药有限公司 药物输送设备
US9220837B2 (en) * 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
EP2136863A2 (en) * 2007-03-19 2009-12-30 Insuline Medical Ltd. Device for drug delivery and associated connections thereto
WO2009081262A1 (en) 2007-12-18 2009-07-02 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
CA2743027C (en) 2008-11-07 2016-04-12 Insuline Medical Ltd. Device and method for drug delivery

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3854741T3 (de) 1987-06-24 2002-08-14 Autoimmune Inc Behandlung von autoimmun-erkrankungen durch orale verabreichung von autoantigenen.
EP0428572A1 (en) 1988-07-29 1991-05-29 Washington University School Of Medicine Producing commercially valuable polypeptides with genetically transformed endosperm tissue
US5202422A (en) 1989-10-27 1993-04-13 The Scripps Research Institute Compositions containing plant-produced glycopolypeptide multimers, multimeric proteins and method of their use
BR9106114A (pt) 1990-03-02 1993-03-09 Autoimmune Inc Metodo para tratar ou prevenir uma doenca auto-imune (ad) e formulacao farmaceutica
US5475086A (en) * 1990-09-21 1995-12-12 The Regents Of The University Of California Cloned glutamic acid decarboxylase peptides
US6682906B1 (en) 1990-09-21 2004-01-27 The Regents Of The University Of California Cloned glutamic acid decarboxylase
IL99699A (en) * 1990-10-10 2002-04-21 Autoimmune Inc Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
WO1992006708A1 (en) 1990-10-15 1992-04-30 Brigham And Women's Hospital Treatment of autoimmune diseases by oral administration of autoantigens
IL99864A (en) * 1990-10-31 2000-11-21 Autoimmune Inc Compositions for suppressing transplant rejection in mammals which contain tissue donor derived MHC antigens
EP0585356A1 (en) * 1991-05-15 1994-03-09 Zymogenetics, Inc. Cloning and expression of human islet glutamic acid decarboxylase autoantigen
US5612487A (en) 1991-08-26 1997-03-18 Edible Vaccines, Inc. Anti-viral vaccines expressed in plants
US5484710A (en) * 1994-01-14 1996-01-16 La Jolla Cancer Research Foundation Method of down-regulating a gene linked to a P-53 responsive element

Also Published As

Publication number Publication date
JP3948741B2 (ja) 2007-07-25
US6338850B1 (en) 2002-01-15
CN1135718A (zh) 1996-11-13
WO1995008347A1 (en) 1995-03-30
CA2172398C (en) 2010-05-04
GB9319429D0 (en) 1993-11-03
EP0720484A1 (en) 1996-07-10
DE69429353D1 (de) 2002-01-17
EP0720484B1 (en) 2001-12-05
US20020090371A1 (en) 2002-07-11
JPH09507743A (ja) 1997-08-12
AU7736794A (en) 1995-04-10
ATE209927T1 (de) 2001-12-15
CA2172398A1 (en) 1995-03-30
DE69429353T2 (de) 2002-07-11

Similar Documents

Publication Publication Date Title
ES2169089T3 (es) Producto de plantas para controlar las respuestas inmunes en mamiferos y procedimiento para fabricar dicho producto.
DE68920019D1 (de) Aloe-zusammensetzungen und deren verwendungen.
BR9611410A (pt) Método e composição farmacêutica para regular a concentração de lipídios
MX9201782A (es) Particulas de sustancias biologicamente activas, sustancialmente insolubles en agua, proceso para su produccion y composicion farmaceutica que las contiene.
PL321365A1 (en) Procedures and materials making plants resitant to plant diseases
AR224086A1 (es) Procedimiento,receptaculo final y dispositivo para acelerar la disolucion de medicamentos liofilizados poco solubles
AU2456888A (en) Monoclonal antibodies specific for HIV and hybridomas for their production
NO900380D0 (no) Formlegeme for ernaering av plantekulturer og fremgangsmaate for fremstilling av dette.
FI881097A0 (fi) Sorafeeni, menetelmä sen valmistamiseksi ja sen käyttö kasvitautien torjumiseksi
DK157035C (da) Biologisk ren mikroorganismestamme samt fremgangsmaade til fremstilling af et dyrkningsprodukt heraf til anvendelse som et hudpraeparat
DE3268159D1 (en) Medicaments based on algae, and formulations thereof
IT1245723B (it) Procedimento per la utilizzazione di rifiuti organici per la produzione di biogas e di prodotti per l'agricoltura
FR2619671B1 (fr) Procede de multiplication et de culture de plantes de la famille des bromeliacees, et plantes ainsi obtenues
IL58184A (en) Method of irrigating plant cultures and means for practising the method
AU7577091A (en) Process for the artificial stimulation of cells and cyte culture device
ATE160788T1 (de) Dextranester, verfahren zu ihrer herstellung und ihre verwendung zur umhüllung oder einbettung von arzneimitteln
AU631459B2 (en) Method of controlling plant diseases and microorganisms in the presence of plants
ES2063765T3 (es) Esteres cicloalifaticos insaturados de antibioticos macrolidicos y lincosamidicos, su procedimiento de preparacion y composiciones farmaceuticas y cosmeticas que los contienen.
ES2083932T1 (es) Familia de sustancias de nucleo porfinico, procedimiento de obtencion de dichas sustancias a partir de cianoficeas y su aplicacion en productos cosmeticos y terapeuticos.
HUT49985A (en) Process for producing and applying antidote-carrying micro- and macroorganisms suitable for reducing the harmful effect of thiolcarbamates and chloroacetanilides on cultivated plants
FR2604905B1 (fr) Procede d'obtention d'un epithelium gingival equivalent a partir de cellules humaines cultivees in vitro ainsi que les applications de cet epithelium en odontologie-stomatologie
IT1217825B (it) Procedimento ed impianto per la coltura di microorganismi
FR2655853B1 (fr) Procede de culture intensive, in vitro, de souches de babesia divergens, procede de preparation d'exoantigenes et vaccin contenant ces antigenes.
PL275724A2 (en) Method of fertilizing and watering plant cultures
DK448989A (da) Fremgangsmaade og anlaeg til fremstilling af et produkt til anvendelse som dyrkningsunderlag

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 720484

Country of ref document: ES