ES2168314T3 - Anticuerpos monoclonales contra las celulas espumosas humanas y sus utilizaciones farmaceuticas y diagnosticas. - Google Patents
Anticuerpos monoclonales contra las celulas espumosas humanas y sus utilizaciones farmaceuticas y diagnosticas.Info
- Publication number
- ES2168314T3 ES2168314T3 ES94930226T ES94930226T ES2168314T3 ES 2168314 T3 ES2168314 T3 ES 2168314T3 ES 94930226 T ES94930226 T ES 94930226T ES 94930226 T ES94930226 T ES 94930226T ES 2168314 T3 ES2168314 T3 ES 2168314T3
- Authority
- ES
- Spain
- Prior art keywords
- foam cells
- pharmaceutical
- monoclonal antibodies
- antibodies against
- against human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000000497 foam cell Anatomy 0.000 title abstract 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 4
- 235000012000 cholesterol Nutrition 0.000 abstract 2
- 238000004128 high performance liquid chromatography Methods 0.000 abstract 2
- 230000001413 cellular effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/36—Lipids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
- Y10S530/809—Fused cells, e.g. hybridoma
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
LA INVENCION SE REFIERE A CELULAS DE ESPUMA HUMANAS GENERADAS "IN VITRO" A PARTIR DE LINEAS CELULARES RELACIONADAS CON MONOCITOS/MACROFAGOS QUE EFECTUAN UNA ELEVACION DE LA CANTIDAD MEDIA DE COLESTEROL INTRACELULAR DE AL MENOS 139+36 {MI}G/MG DE PROTEINA CELULAR SEGUN SE DETERMINA POR HPLC, ESTANDO CARACTERIZADO EL COLESTEROL POR UN GRADO DE ENTRE 46+6% DE ESTERIFICACION SEGUN SE DETERMINA POR HPLC. LA INVENCION TAMBIEN SE REFIERE A ANTICUERPOS MONOCLONALES SELECCIONADOS A PARTIR DE LAS CELULAS DE ESPUMA Y QUE PUEDEN UTILIZARSE PARA PROPOSITOS FARMACEUTICOS Y DE DIAGNOSTICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93402691 | 1993-11-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2168314T3 true ES2168314T3 (es) | 2002-06-16 |
Family
ID=8214763
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94930226T Expired - Lifetime ES2168314T3 (es) | 1993-11-02 | 1994-10-26 | Anticuerpos monoclonales contra las celulas espumosas humanas y sus utilizaciones farmaceuticas y diagnosticas. |
Country Status (10)
Country | Link |
---|---|
US (1) | US6027922A (es) |
EP (2) | EP1188824A3 (es) |
AT (1) | ATE211167T1 (es) |
AU (1) | AU7940594A (es) |
DE (1) | DE69429534T2 (es) |
DK (1) | DK0726942T3 (es) |
ES (1) | ES2168314T3 (es) |
HK (1) | HK1042726A1 (es) |
PT (1) | PT726942E (es) |
WO (1) | WO1995012666A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1474685A2 (de) * | 2002-02-12 | 2004-11-10 | Biotesys Gmbh | Analyse von vitalstoffen |
WO2006051551A2 (en) * | 2004-11-15 | 2006-05-18 | Quantomix Ltd. | Device and method for analysis of a metabolic malady |
CN106771117B (zh) * | 2016-11-25 | 2018-09-14 | 王婧 | 一种中性粒细胞抗原底片的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1340977C (en) * | 1988-11-15 | 2000-04-25 | Monty Krieger | Scavenger receptor protein and antibody thereto |
WO1992022323A1 (en) * | 1991-06-11 | 1992-12-23 | Center For Blood Research, Inc. | Intercellular adhesion molecule-3 and its binding ligands |
JP3616090B2 (ja) * | 1992-01-27 | 2005-02-02 | イコス コーポレイション | 細胞間接着分子関連タンパク質 |
-
1994
- 1994-10-26 US US08/637,669 patent/US6027922A/en not_active Expired - Fee Related
- 1994-10-26 PT PT94930226T patent/PT726942E/pt unknown
- 1994-10-26 AU AU79405/94A patent/AU7940594A/en not_active Abandoned
- 1994-10-26 DK DK94930226T patent/DK0726942T3/da active
- 1994-10-26 ES ES94930226T patent/ES2168314T3/es not_active Expired - Lifetime
- 1994-10-26 DE DE69429534T patent/DE69429534T2/de not_active Expired - Fee Related
- 1994-10-26 EP EP01202164A patent/EP1188824A3/en not_active Withdrawn
- 1994-10-26 WO PCT/EP1994/003514 patent/WO1995012666A1/en active IP Right Grant
- 1994-10-26 AT AT94930226T patent/ATE211167T1/de not_active IP Right Cessation
- 1994-10-26 EP EP94930226A patent/EP0726942B1/en not_active Expired - Lifetime
-
2002
- 2002-04-30 HK HK02103219.7A patent/HK1042726A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
WO1995012666A1 (en) | 1995-05-11 |
DE69429534T2 (de) | 2002-06-27 |
DE69429534D1 (de) | 2002-01-31 |
AU7940594A (en) | 1995-05-23 |
EP1188824A3 (en) | 2002-04-03 |
EP1188824A2 (en) | 2002-03-20 |
EP0726942B1 (en) | 2001-12-19 |
PT726942E (pt) | 2002-06-28 |
DK0726942T3 (da) | 2002-04-15 |
EP0726942A1 (en) | 1996-08-21 |
ATE211167T1 (de) | 2002-01-15 |
HK1042726A1 (zh) | 2002-08-23 |
US6027922A (en) | 2000-02-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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