ES2167817T3 - Procedimiento para la preparacion de diesteres del acido 3-hidroxioctandioico enantiomericamente puros por hidrogenacion catalitica asimetrica. - Google Patents

Procedimiento para la preparacion de diesteres del acido 3-hidroxioctandioico enantiomericamente puros por hidrogenacion catalitica asimetrica.

Info

Publication number
ES2167817T3
ES2167817T3 ES98103245T ES98103245T ES2167817T3 ES 2167817 T3 ES2167817 T3 ES 2167817T3 ES 98103245 T ES98103245 T ES 98103245T ES 98103245 T ES98103245 T ES 98103245T ES 2167817 T3 ES2167817 T3 ES 2167817T3
Authority
ES
Spain
Prior art keywords
preparation
diesters
acid
hydroxioctandioic
enantiomerally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98103245T
Other languages
English (en)
Inventor
Rainer Dr Gewald
Gunter Dr Laban
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meda Pharma GmbH and Co KG
Original Assignee
Viatris GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viatris GmbH and Co KG filed Critical Viatris GmbH and Co KG
Application granted granted Critical
Publication of ES2167817T3 publication Critical patent/ES2167817T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

LA INVENCION TRATA DE UN PROCEDIMIENTO PARA LA PRODUCCION DE COMPOSICIONES DE FORMULA GENERAL I, EN LA CUAL R 1 Y R2 SON IGUALES O DIFERENTES Y SIGNIFICAN UN GRUPO ALQUILO C 1 C 20 , UN GRUPO CICLOALQUILO C 3 C 12 , UN GRUPO ARALQUILO C 7 C 12 O UN GRUPO ARILO DE UNO O DOS NUCLEOS, EN EL QUE SE HIDROGENA DE FORMA ASIMETRICA UNA QUETONA DE FORMULA III O IV, EN LA CUAL R 1 Y R 2 TIENEN LA SIGNIFICACION DADA ARRIBA.
ES98103245T 1997-03-06 1998-02-25 Procedimiento para la preparacion de diesteres del acido 3-hidroxioctandioico enantiomericamente puros por hidrogenacion catalitica asimetrica. Expired - Lifetime ES2167817T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19709069A DE19709069C2 (de) 1997-03-06 1997-03-06 Enantiomerenreine 3-Hydroxyoctandisäurediester, Verfahren zur Herstellung derselben durch asymmetrische katalytische Hydrierung sowie Verfahren zur Herstellung von R-(+)- und S-(-)-alpha-Liponsäure

Publications (1)

Publication Number Publication Date
ES2167817T3 true ES2167817T3 (es) 2002-05-16

Family

ID=7822377

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98103245T Expired - Lifetime ES2167817T3 (es) 1997-03-06 1998-02-25 Procedimiento para la preparacion de diesteres del acido 3-hidroxioctandioico enantiomericamente puros por hidrogenacion catalitica asimetrica.

Country Status (9)

Country Link
US (2) US6013833A (es)
EP (1) EP0863125B1 (es)
JP (1) JPH10273476A (es)
AT (1) ATE209623T1 (es)
CA (1) CA2231093C (es)
DE (2) DE19709069C2 (es)
DK (1) DK0863125T3 (es)
ES (1) ES2167817T3 (es)
PT (1) PT863125E (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19845517A1 (de) 1998-10-02 2000-04-06 Basf Ag Verfahren zur asymmetrische Hydrierung von beta-Ketoestern
DE10036516A1 (de) 2000-07-27 2002-02-07 Asta Medica Ag Verfahren zur Herstellung von enantiomerenreinen 6,8-Dihydroxyoctansäureestern durch assymetrische katalytische Hydrierung
DE10137381A1 (de) 2001-07-31 2003-02-13 Viatris Gmbh Neue Modifikationen des Trometamolsalzes der R-Thioctsäure sowie Verfahren zu ihrer Herstellung
DE10160149A1 (de) * 2001-12-07 2003-06-18 Basf Ag Verfahren zur Herstellung von Dihydroxycarbonsäureestern in Abwesenheit von Lösungsmitteln
DE10201464B4 (de) 2002-01-16 2005-06-16 Viatris Gmbh & Co. Kg Verfahren zur Herstellung reiner Thioctsäure

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883580A (en) * 1972-02-09 1975-05-13 Monsanto Co Asymmetric reduction of ketones to form optically active alcohols
DE3629116A1 (de) * 1986-08-27 1988-03-10 Asta Pharma Ag Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer
JPH0699367B2 (ja) * 1987-06-11 1994-12-07 高砂香料工業株式会社 光学活性アルコ−ルの製法
JPH064543B2 (ja) * 1987-06-18 1994-01-19 高砂香料工業株式会社 光学活性アルコ−ルの製造法
DE4037440A1 (de) * 1990-11-24 1992-05-27 Basf Ag Verfahren zur herstellung von (6s)-6,8-dihydroxyoctansaeureestern
US5508435A (en) * 1992-07-29 1996-04-16 Merck & Co., Inc. Asymmetric hydrogenation of beta- or gamma-ketoesters and beta- or gamma-ketoamides

Also Published As

Publication number Publication date
DK0863125T3 (da) 2002-02-25
EP0863125A1 (de) 1998-09-09
DE19709069C2 (de) 2000-04-06
CA2231093C (en) 2007-01-02
US6013833A (en) 2000-01-11
ATE209623T1 (de) 2001-12-15
PT863125E (pt) 2002-05-31
DE19709069A1 (de) 1998-09-17
DE59802194D1 (de) 2002-01-10
US6229042B1 (en) 2001-05-08
EP0863125B1 (de) 2001-11-28
JPH10273476A (ja) 1998-10-13
CA2231093A1 (en) 1998-09-06

Similar Documents

Publication Publication Date Title
ES2099758T3 (es) Procedimiento para preparar catalizadores para polimerizacion por adicion mediante oxidacion del nucleo metalico.
ATE76069T1 (de) 5-nitrobenzo(de>isochinolin-1,3-dione, ihre herstellung und verwendung.
DK172089D0 (da) 1,3-dioxolanderivater samt fremgangsmaade til fremstilling deraf
IT1223309B (it) Lampada di segnalazione, specialmente per autoveicoli
HUT44470A (en) Process for selective amination of diamides
DK164557C (da) Derivater af cis,endo-2-azabicyclo-oe5.3.0aa-decan-3-carboxylsyre samt laegemiddel indeholdende dem
FI860842A0 (fi) Labdan-derivat, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
GR3004139T3 (es)
ES2167817T3 (es) Procedimiento para la preparacion de diesteres del acido 3-hidroxioctandioico enantiomericamente puros por hidrogenacion catalitica asimetrica.
MX9300875A (es) Procedimiento para la preparacion de compuestos azabiciclicos.
DK131084A (da) Egolinderivater, fremgangsmaade til fremstilling heraf samt anvendelsen heraf som laegemiddel
DE59303616D1 (de) Verfahren zur Herstellung von Isoprenderivaten
EP0203382A3 (en) Process for the preparation and purification of alpha-interferon
HU9202489D0 (en) Method for producing new n-alkylated 1,4-dihydro-pyridine-dicarboxylic acid esters and pharmaceutical preparatives containing said compounds
EP0274064A3 (en) 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene pgi2 derivatives
DE3763413D1 (en) Erythromycylamin-derivate.
ES2096388T3 (es) Procedimiento para la hidrogenacion enantioselectiva de derivados de 2h-piran-2-ona.
DE3778809D1 (de) Gen fuer a-typ-einschliesskoerper des poxvirus, seine herstellung und verwendung.
ATE167863T1 (de) Verfahren zur herstellung von (1h-tetrazol-5- yl)tetrazolo(1,5-a>quinolinen und naphthridinen
DE69711506D1 (de) Methylsulfomycin 1, Verfahren zu dessen Herstellung und Verwendung
TW234715B (es)
DE3875937D1 (de) Verwendung von lactamgruppe-enthaltenden verbindungen zur herstellung eines antiviralen wirkstoffes.
DE69322218D1 (de) Heteroarenylpiperazine, Verfahren zu ihrer Herstellung und ihre Anwendung als Medikamente
ES2043896T3 (es) Procedimiento para la preparacion de derivados de tetrahidropiridina.
ES2037191T3 (es) Procedimiento para la fabricacion de las dialquilamino-etilaminas.