ES2166941T3 - Un derivado de amida de amitiamicina. - Google Patents

Un derivado de amida de amitiamicina.

Info

Publication number
ES2166941T3
ES2166941T3 ES97114385T ES97114385T ES2166941T3 ES 2166941 T3 ES2166941 T3 ES 2166941T3 ES 97114385 T ES97114385 T ES 97114385T ES 97114385 T ES97114385 T ES 97114385T ES 2166941 T3 ES2166941 T3 ES 2166941T3
Authority
ES
Spain
Prior art keywords
group
sup
formula
hydrogen atom
amida
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97114385T
Other languages
English (en)
Inventor
Yasuhiko Muraoka
Hironobu Iinuma
Tomio Takeuchi
Tsuneo Okonogi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Application granted granted Critical
Publication of ES2166941T3 publication Critical patent/ES2166941T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE DESCRIBE UN NUEVO DERIVADO DE AMIDA, QUE ESTA REPRESENTADO POR LA FORMULA GENERAL (I) EN LA CUAL N ES UN NUMERO ENTERO DE 1 A 6, R SUP,1} ES UN ATOMO DE HIDROGENO, UN GRUPO CARBOXILO O UN GRUPO HIDROXILMETILO, Y R SUP,2} ES UN GRUPO DE FORMULA COOR SUP,3}, EN LA CUAL R SUP,3} ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO INFERIOR O UN GRUPO BENCILO OPCIONALMENTE SUSTITUIDO CON UN HALOGENO O UN GRUPO HIDROXILO, O R SUP,2} ES UN GRUPO DE FORMULA ES UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO INFERIOR, UN GRUPO 3 AMINOPROPILO, UN GRUPO 3 ]AMINOPROPILO O UN GRUPO 3 ES UN GRUPO METILO, UN GRUPO HIDROXILO O UN GRUPO GUANIDINO DE FORMULA TICAMENTE ACEPTABLE DEL MISMO. ESTOS COMPUESTOS DE FORMULA (I) MUESTRAN UNAS ACTIVIDADES ANTIBACTERIANAS UTILES Y SON SOLUBLES EN AGUA, Y ALGUNOS DE ELLOS DEMUESTRAN EXHIBIR UNA EXCELENTE ACTIVIDAD ANTIBACTERIANA CONTRA STAPHYLOCOCCUS AUREUS RESISTENTE A LA METICILINA (MRSA).
ES97114385T 1996-08-22 1997-08-20 Un derivado de amida de amitiamicina. Expired - Lifetime ES2166941T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8221476A JPH1059997A (ja) 1996-08-22 1996-08-22 アミチアマイシンアミド誘導体

Publications (1)

Publication Number Publication Date
ES2166941T3 true ES2166941T3 (es) 2002-05-01

Family

ID=16767319

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97114385T Expired - Lifetime ES2166941T3 (es) 1996-08-22 1997-08-20 Un derivado de amida de amitiamicina.

Country Status (6)

Country Link
US (1) US6043217A (es)
EP (1) EP0825194B1 (es)
JP (1) JPH1059997A (es)
CA (1) CA2213057A1 (es)
DE (1) DE69709802T2 (es)
ES (1) ES2166941T3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR060977A1 (es) * 2006-05-31 2008-07-23 Novartis Ag Aminotiazoles y sus usos
GB0619611D0 (en) * 2006-10-04 2006-11-15 Ark Therapeutics Ltd Compounds and their use
TW200902540A (en) * 2007-06-04 2009-01-16 Novartis Ag Macrocycles and their uses
EA020205B1 (ru) 2007-12-12 2014-09-30 Новартис Аг Аминотиазолы, фармацевтические композиции на их основе и способы лечения бактериальной инфекции
JP2011116662A (ja) * 2008-03-26 2011-06-16 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 新規抗生物質ｓｆ２８７６物質、その製造法および医薬組成物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100572A (en) * 1991-01-03 1997-01-10 Lepetit Spa Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0825194B1 (en) 2002-01-02
CA2213057A1 (en) 1998-02-22
DE69709802T2 (de) 2002-08-22
EP0825194A2 (en) 1998-02-25
US6043217A (en) 2000-03-28
EP0825194A3 (en) 1999-03-24
DE69709802D1 (de) 2002-02-28
JPH1059997A (ja) 1998-03-03

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