ES2165747A1 - Depsipeptides are used as inhibitors of bone resorption by human osteoclasts - Google Patents
Depsipeptides are used as inhibitors of bone resorption by human osteoclastsInfo
- Publication number
- ES2165747A1 ES2165747A1 ES009900103A ES9900103A ES2165747A1 ES 2165747 A1 ES2165747 A1 ES 2165747A1 ES 009900103 A ES009900103 A ES 009900103A ES 9900103 A ES9900103 A ES 9900103A ES 2165747 A1 ES2165747 A1 ES 2165747A1
- Authority
- ES
- Spain
- Prior art keywords
- inhibitors
- depsipeptides
- bone resorption
- propanidiol
- human osteoclasts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Depsipeptides are used as inhibitors of bone resorption by human osteoclasts and are represented by an overall formula (A) in which R1 represents -CH(CH3) (C2H5) and R2 represents -CH2CH(C1-)CH2 - OH2, R1 represents -CH(CH3)2 and R2 represents 2S, 3-propanidiol, R1 represents CH(CH3) (C2H5) and R2 represents 2R,3-propanidiol or R1 represents CH(CH3)(C2H5) and R2 represents 2R,3 - propanidiol. Also involved are the known constituents of the formula (A) where R1 represents - CH(CH3)(C2H5) and R2 represents -CH2-CH=CH2, R1 represents CH(CH3)2 and R2 represents - CH2-CH(CH32, R1 represents - CH(CH3)2 and R2 represents 2,3-epoxipropyl, R1 represents -CH(CH3)(C2H5) and R2 represents - CH2CH(OH)CH2Cl or R1 represents -CH(CH3)(C2H5) and R2 represents 2S,3 propanidiol, as inhibitors of vacuolar H+-ATPasa. These constituents and those of formula (A) where R1 represents - CH(CH3)(C2H5) and R2 represents O CH2-CH(CH3)2 or R1 represents - CH(CH3)(C2H5) and R2 represents 2,3-epoxypropyl are obtained by means of cultivation of the fungus Metarhizium anisopliae.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009900103A ES2165747A1 (en) | 1999-01-20 | 1999-01-20 | Depsipeptides are used as inhibitors of bone resorption by human osteoclasts |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009900103A ES2165747A1 (en) | 1999-01-20 | 1999-01-20 | Depsipeptides are used as inhibitors of bone resorption by human osteoclasts |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2165747A1 true ES2165747A1 (en) | 2002-03-16 |
Family
ID=8306980
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009900103A Pending ES2165747A1 (en) | 1999-01-20 | 1999-01-20 | Depsipeptides are used as inhibitors of bone resorption by human osteoclasts |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2165747A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007048848A2 (en) * | 2005-10-28 | 2007-05-03 | Brane Discovery S.R.L. | V-atpase inhibitors for use in the treatment of septic shock |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991006296A1 (en) * | 1989-10-24 | 1991-05-16 | Aktiebolaget Astra | Bafilomycine macrolides for treatment of bone affecting diseases |
-
1999
- 1999-01-20 ES ES009900103A patent/ES2165747A1/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991006296A1 (en) * | 1989-10-24 | 1991-05-16 | Aktiebolaget Astra | Bafilomycine macrolides for treatment of bone affecting diseases |
Non-Patent Citations (2)
Title |
---|
MUROI, M. et al. "Dextrusin B, a specific and readily reversible inhibitor of vacuolar-type H+-translocating ATPase". BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol. 205, no 2, 15 diciembre 1994. Todo el documento. * |
PAIS, M. et al. "Depsipeptides from Metarhizium Anisopliae". PHYTOCHEMISTRY, Vol. 20, no 4, 1981, paginas 715-723 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007048848A2 (en) * | 2005-10-28 | 2007-05-03 | Brane Discovery S.R.L. | V-atpase inhibitors for use in the treatment of septic shock |
WO2007048848A3 (en) * | 2005-10-28 | 2007-06-14 | Nikem Research Srl | V-atpase inhibitors for use in the treatment of septic shock |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20020316 Kind code of ref document: A1 Effective date: 20020316 |
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FC2A | Grant refused |
Effective date: 20040116 |