ES2164564A1 - Bencenos trisustituidos unidos a amidas, esteres y acidos carboxilicos como nuevos inhibidores de la ciclooxigenasa ii. - Google Patents
Bencenos trisustituidos unidos a amidas, esteres y acidos carboxilicos como nuevos inhibidores de la ciclooxigenasa ii.Info
- Publication number
- ES2164564A1 ES2164564A1 ES009902287A ES9902287A ES2164564A1 ES 2164564 A1 ES2164564 A1 ES 2164564A1 ES 009902287 A ES009902287 A ES 009902287A ES 9902287 A ES9902287 A ES 9902287A ES 2164564 A1 ES2164564 A1 ES 2164564A1
- Authority
- ES
- Spain
- Prior art keywords
- amides
- inhibitors
- cancer
- esters
- combined
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
Bencenos trisustituidos unidos a amidas, ésteres y ácidos carboxílicos como nuevos inhibidores de la ciclooxigenasa II. La presente invención se refiere a compuesto de fórmula general I, **FORMULA** inhibidores selectivos de la ciclooxigenasa-II, en los que el grupo D es un grupo - C(R{sup,2}) (R{sup,3}) -C(R{sup,4}) (R{sup,5})-, - C(R{sup,2})=C(R{sup,4}- ó -C C-; A es un birradical -CO-, -O-, -S-, ó -NH-; X es un átomo de oxígeno o un grupo -N(R{sup,6})- y E es halógeno, (C{sub,1}-C{sub,6})-alquilo, (C{sub,2}- C{sub,6})-alquenilo, C{sub,2}-C{sub,6 })-alquinilo, etc., a sus sales y solvatos farmacéuticamente aceptables, y a las composiciones farmacéuticas que las contiene. Los compuestos de la presente invención son útiles en el tratamiento de la inflamación, dolor y fiebre, así como de aquellas otras afecciones que recientemente se han asociado con las cilooxigenasas, especialmente con la ciclooxigenasa-II, como ejemplo el cáncer colorectal y Alzheimer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9902287A ES2164564B1 (es) | 1999-10-18 | 1999-10-18 | Bencenos trisustituidos unidos a amidas, esteres y acidos carboxilicos como nuevos inhibidores de la ciclooxigenasa ii. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9902287A ES2164564B1 (es) | 1999-10-18 | 1999-10-18 | Bencenos trisustituidos unidos a amidas, esteres y acidos carboxilicos como nuevos inhibidores de la ciclooxigenasa ii. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2164564A1 true ES2164564A1 (es) | 2002-02-16 |
| ES2164564B1 ES2164564B1 (es) | 2003-02-16 |
Family
ID=8310284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9902287A Expired - Fee Related ES2164564B1 (es) | 1999-10-18 | 1999-10-18 | Bencenos trisustituidos unidos a amidas, esteres y acidos carboxilicos como nuevos inhibidores de la ciclooxigenasa ii. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2164564B1 (es) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0436199A1 (en) * | 1989-12-28 | 1991-07-10 | Abbott Laboratories | Cyclopropyl derivative lipoxygenase inhibitors |
| EP0527458A1 (de) * | 1991-08-13 | 1993-02-17 | Roche Diagnostics GmbH | Neue 3,5-Di-tert.butyl-4-hydroxyphenyl-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel |
| US5604253A (en) * | 1995-05-22 | 1997-02-18 | Merck Frosst Canada, Inc. | N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors |
| JPH10182583A (ja) * | 1996-12-25 | 1998-07-07 | Mitsui Chem Inc | 新規ヒドロキサム酸誘導体 |
-
1999
- 1999-10-18 ES ES9902287A patent/ES2164564B1/es not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0436199A1 (en) * | 1989-12-28 | 1991-07-10 | Abbott Laboratories | Cyclopropyl derivative lipoxygenase inhibitors |
| EP0527458A1 (de) * | 1991-08-13 | 1993-02-17 | Roche Diagnostics GmbH | Neue 3,5-Di-tert.butyl-4-hydroxyphenyl-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel |
| US5604253A (en) * | 1995-05-22 | 1997-02-18 | Merck Frosst Canada, Inc. | N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors |
| JPH10182583A (ja) * | 1996-12-25 | 1998-07-07 | Mitsui Chem Inc | 新規ヒドロキサム酸誘導体 |
Non-Patent Citations (1)
| Title |
|---|
| STANKEVICIUS, A. y col. "Synthesis and spectral properties of phthalimidines and phthalides". Khim. Geterotsikl. Soedin., 1992, No 4, paginas 472-6 (resumen) HCAPLUS [en linea]. Londres (Reino Unido) [recuperado el 12.11.2001]. Recuperado de STN International, Columbus, Ohio (EE.UU) No acceso 1992:633774. RN 144402-64-2 y RN 119935-62-5 * |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2164564B1 (es) | 2003-02-16 |
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Legal Events
| Date | Code | Title | Description |
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| EC2A | Search report published |
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