ES2160827T3 - Procedimiento para la preparacion de peptidos y peptidos n-carbamoil protegidos. - Google Patents
Procedimiento para la preparacion de peptidos y peptidos n-carbamoil protegidos.Info
- Publication number
- ES2160827T3 ES2160827T3 ES96923933T ES96923933T ES2160827T3 ES 2160827 T3 ES2160827 T3 ES 2160827T3 ES 96923933 T ES96923933 T ES 96923933T ES 96923933 T ES96923933 T ES 96923933T ES 2160827 T3 ES2160827 T3 ES 2160827T3
- Authority
- ES
- Spain
- Prior art keywords
- peptides
- carbamoil
- protected
- procedure
- well
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 238000000926 separation method Methods 0.000 abstract 3
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 230000001681 protective effect Effects 0.000 abstract 2
- 102000015636 Oligopeptides Human genes 0.000 abstract 1
- 108010038807 Oligopeptides Proteins 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000012039 electrophile Substances 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000012038 nucleophile Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE DESCRIBE UN PROCEDIMIENTO PARA LA PRODUCCION ENZIMATICA DE DI Y OLIGOPEPTIDOS PROTEGIDOS, ASI COMO LA SEPARACION DE LOS GRUPOS PROTECTORES UTILIZADOS. EL PROCEDIMIENTO SEGUN LA INVENCION PERMITE UNA SINTESIS SENCILLA Y BARATA DE PEPTIDOS, ASI COMO UNA SEPARACION CUIDADOSA DE LOS GRUPOS PROTEGIDOS. EL PROCEDIMIENTO INCLUYE TRES PASOS DE REACCION: 1. LA OBTENCION DE LOS N - CARBAMOIL - AMINOACIDOS O DE LOS DERIVADOS DE LOS N CARBAMOIL - AMINOACIDOS. 2. LA FORMACION DE UN ENLACE PEPTIDICO ENTRE EL ELECTROFILO PROTEGIDO CON CARBAMOILO Y EL NUCLEOFILO, ASI COMO LA SEPARACION DEL GRUPO PROTECTOR DE CARBAMOLILO.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19524710 | 1995-07-11 | ||
| DE19603844 | 1996-02-05 | ||
| DE19607100A DE19607100C2 (de) | 1995-07-11 | 1996-02-26 | Verfahren zur Herstellung von Peptiden und N-Carbamoyl-geschützten Peptiden |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2160827T3 true ES2160827T3 (es) | 2001-11-16 |
Family
ID=27215260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96923933T Expired - Lifetime ES2160827T3 (es) | 1995-07-11 | 1996-06-26 | Procedimiento para la preparacion de peptidos y peptidos n-carbamoil protegidos. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6251625B1 (es) |
| EP (1) | EP0839153B1 (es) |
| JP (1) | JPH11508452A (es) |
| CN (1) | CN1190406A (es) |
| AR (1) | AR002798A1 (es) |
| AT (1) | ATE204291T1 (es) |
| AU (1) | AU6416596A (es) |
| CA (1) | CA2227732A1 (es) |
| DK (1) | DK0839153T3 (es) |
| ES (1) | ES2160827T3 (es) |
| WO (1) | WO1997003091A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19903268A1 (de) * | 1999-01-28 | 2000-08-03 | Degussa | Verfahren zur Decarbamoylierung von N-carbamoylgeschützten Verbindungen, neue Carbonsäureanhydride und deren Verwendung |
| CN1939529A (zh) * | 2002-01-29 | 2007-04-04 | Wyeth公司 | 用于调节连接蛋白半通道的组合物和方法 |
| US20040052928A1 (en) * | 2002-09-06 | 2004-03-18 | Ehud Gazit | Peptides and methods using same for diagnosing and treating amyloid-associated diseases |
| US7781396B2 (en) * | 2002-01-31 | 2010-08-24 | Tel Aviv University Future Technology Development L.P. | Peptides directed for diagnosis and treatment of amyloid-associated disease |
| US7491699B2 (en) | 2002-12-09 | 2009-02-17 | Ramot At Tel Aviv University Ltd. | Peptide nanostructures and methods of generating and using the same |
| DE602004020179D1 (de) | 2003-01-07 | 2009-05-07 | Univ Ramot | Peptidenanostrukturen die fremdmaterial enthalten, und verfahren zur herstellung derselben |
| KR101215821B1 (ko) | 2003-06-30 | 2012-12-28 | 텔 아비브 유니버시티 퓨쳐 테크놀로지 디벨롭먼트 엘.피. | 아밀로이드 관련 질환을 진단 및 처치하기 위한 펩타이드, 그것에 대한 항체, 및 그 사용방법 |
| WO2005027901A1 (en) * | 2003-09-25 | 2005-03-31 | Tel Aviv University Future Technology Development L.P. | Compositions and methods using same for treating amyloid-associated diseases |
| US7625707B2 (en) * | 2003-10-02 | 2009-12-01 | Ramot At Tel Aviv University Ltd. | Antibacterial agents and methods of identifying and utilizing same |
| US20090156471A1 (en) * | 2004-07-15 | 2009-06-18 | Ramot At Tel Aviv University Ltd. | Use of anti-amyloid agents for treating and typing pathogen infections |
| WO2006013552A2 (en) | 2004-08-02 | 2006-02-09 | Ramot At Tel Aviv University Ltd. | Articles of peptide nanostructures and method of forming the same |
| US7732479B2 (en) | 2004-08-19 | 2010-06-08 | Tel Aviv University Future Technology Development L.P. | Compositions for treating amyloid associated diseases |
| WO2006027780A2 (en) | 2004-09-08 | 2006-03-16 | Ramot At Tel Aviv University Ltd. | Peptide nanostructures containing end-capping modified peptides and methods of generating and using the same |
| WO2007043048A2 (en) * | 2005-10-11 | 2007-04-19 | Ramot At Tel Aviv University Ltd. | Self-assembled fmoc-ff hydrogels |
| US7879212B2 (en) * | 2005-11-03 | 2011-02-01 | Ramot At Tel-Aviv University Ltd. | Peptide nanostructure-coated electrodes |
| US20100020756A1 (en) * | 2008-07-24 | 2010-01-28 | Adapt4, Llc | Dynamically transformed channel set quality of service |
| JP5652159B2 (ja) | 2009-11-30 | 2015-01-14 | 住友化学株式会社 | ５−（アミノメチル）−２−クロロチアゾールの製造方法 |
| CN102796165B (zh) * | 2011-05-24 | 2014-02-26 | 首都医科大学 | 京都酚逆序列修饰的脂肪胺/醇衍生物及其制备方法和应用 |
| CN109896980B (zh) * | 2017-12-07 | 2022-04-08 | 浙江九洲药业股份有限公司 | 一种西格列汀中间体的生物合成方法 |
| JP6564539B1 (ja) | 2018-09-14 | 2019-08-21 | 長瀬産業株式会社 | スルホン酸化合物によるペプチド精製方法 |
| US12036286B2 (en) | 2021-03-18 | 2024-07-16 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3607194A1 (de) * | 1986-03-05 | 1987-09-10 | Merck Patent Gmbh | Carbamoylphenothiazine |
| US5350681A (en) * | 1986-08-18 | 1994-09-27 | The Coca-Cola Company | Enzymatic membrane method for the synthesis and separation of peptides |
| GB8621377D0 (en) * | 1986-09-04 | 1986-10-15 | Celltech Ltd | Enzymatic process |
| DE4214157C1 (es) * | 1992-04-29 | 1993-08-05 | Degussa Ag, 6000 Frankfurt, De | |
| WO1994000577A1 (en) * | 1992-06-30 | 1994-01-06 | Smithkline Beecham P.L.C. | D-n-carbamoyl-amino acid amidohydrolase and hydantoinase |
| DE4316928C2 (de) * | 1993-05-19 | 1995-03-16 | Degussa | Neue Mikroorganismen, deren Verwendung und Verfahren zur Herstellung von L-alpha-Aminosäuren |
| DE19519717C1 (de) * | 1995-05-30 | 1996-08-22 | Degussa | Neuer Mikroorganismus, dessen Verwendung und Verfahren zur Herstellung von L-alpha-Aminosäuren |
-
1996
- 1996-06-26 WO PCT/EP1996/002782 patent/WO1997003091A1/de not_active Ceased
- 1996-06-26 EP EP96923933A patent/EP0839153B1/de not_active Expired - Lifetime
- 1996-06-26 AT AT96923933T patent/ATE204291T1/de not_active IP Right Cessation
- 1996-06-26 AU AU64165/96A patent/AU6416596A/en not_active Abandoned
- 1996-06-26 ES ES96923933T patent/ES2160827T3/es not_active Expired - Lifetime
- 1996-06-26 CN CN96195353A patent/CN1190406A/zh active Pending
- 1996-06-26 JP JP9505455A patent/JPH11508452A/ja active Pending
- 1996-06-26 US US09/011,859 patent/US6251625B1/en not_active Expired - Fee Related
- 1996-06-26 DK DK96923933T patent/DK0839153T3/da active
- 1996-06-26 CA CA002227732A patent/CA2227732A1/en not_active Abandoned
- 1996-07-10 AR ARP960103520A patent/AR002798A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR002798A1 (es) | 1998-04-29 |
| EP0839153B1 (de) | 2001-08-16 |
| EP0839153A1 (de) | 1998-05-06 |
| CN1190406A (zh) | 1998-08-12 |
| CA2227732A1 (en) | 1997-01-30 |
| JPH11508452A (ja) | 1999-07-27 |
| DK0839153T3 (da) | 2001-11-05 |
| ATE204291T1 (de) | 2001-09-15 |
| AU6416596A (en) | 1997-02-10 |
| WO1997003091A1 (de) | 1997-01-30 |
| US6251625B1 (en) | 2001-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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