ES2160495B1 - Treatment of endotoxic shock by inhibiting production of pro-inflammatory cytokines - Google Patents
Treatment of endotoxic shock by inhibiting production of pro-inflammatory cytokinesInfo
- Publication number
- ES2160495B1 ES2160495B1 ES9901235A ES9901235A ES2160495B1 ES 2160495 B1 ES2160495 B1 ES 2160495B1 ES 9901235 A ES9901235 A ES 9901235A ES 9901235 A ES9901235 A ES 9901235A ES 2160495 B1 ES2160495 B1 ES 2160495B1
- Authority
- ES
- Spain
- Prior art keywords
- production
- pro
- treatment
- inflammatory cytokines
- endotoxic shock
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Treatment of endotoxic shock in a mammal comprises administering, in a vehicle, an agent (I) that inhibits production of tumor necrosis factor (TNF) or interleukin-6 (IL-6). ACTIVITY : Antiinflammatory; antibacterial; immunosuppressive. MECHANISM OF ACTION : Inhibiting production of pro-inflammatory cytokines. Murine peritoneal macrophages were stimulated with lipopolysaccharide (LPS; 10 ng/ml) in presence of 0.001 mu M vasoactive intestinal peptide (VIP). The production of IL-6 was about 800 ng/ml in absence of VIP but only about 160 ng/ml in its presence. Production of TNF by the same cells was also suppressed, e.g. the maximum level was reduced from about 1400 pg/ml to about 600 pg/ml.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9901235A ES2160495B1 (en) | 1998-04-17 | 1999-06-04 | Treatment of endotoxic shock by inhibiting production of pro-inflammatory cytokines |
EP00931296A EP1103270B1 (en) | 1999-06-04 | 2000-06-02 | Treatment of autoimmune diseases in mammals |
CA002345030A CA2345030A1 (en) | 1999-06-04 | 2000-06-02 | Composition and method for the treatment of endotoxic shock and inflammatory and autoimmune diseases in mammals |
DE60002143T DE60002143T2 (en) | 1999-06-04 | 2000-06-02 | TREATMENT OF AUTOIMMUNE DISEASES IN MAMMALS |
PCT/ES2000/000197 WO2000074708A1 (en) | 1999-06-04 | 2000-06-02 | Method for treating endotoxic shock and inflammatory and autoimmune diseases in mammals |
AU49277/00A AU4927700A (en) | 1999-06-04 | 2000-06-02 | Method for treating endotoxic shock and inflammatory and autoimmune diseases in mammals |
PT00931296T PT1103270E (en) | 1999-06-04 | 2000-06-02 | TREATMENT OF AUTO-IMMUNE DISEASES IN MAMMALS |
AT00931296T ATE237347T1 (en) | 1999-06-04 | 2000-06-02 | TREATMENT OF AUTOIMMUNE DISEASES IN MAMMALS |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009800814A ES2138561B1 (en) | 1998-04-17 | 1998-04-17 | USE OF VIP PEPTIDES AND PACAP IN THE TREATMENT OF ENDOTOXIC SHOCK IN MAMMALS. |
ES9901235A ES2160495B1 (en) | 1998-04-17 | 1999-06-04 | Treatment of endotoxic shock by inhibiting production of pro-inflammatory cytokines |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2160495A1 ES2160495A1 (en) | 2001-11-01 |
ES2160495B1 true ES2160495B1 (en) | 2002-09-16 |
Family
ID=26155143
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9901235A Expired - Fee Related ES2160495B1 (en) | 1998-04-17 | 1999-06-04 | Treatment of endotoxic shock by inhibiting production of pro-inflammatory cytokines |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2160495B1 (en) |
-
1999
- 1999-06-04 ES ES9901235A patent/ES2160495B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2160495A1 (en) | 2001-11-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2001098331A3 (en) | Glucagon-like peptide-1 analogs | |
GB2249268B (en) | Double tank pinch trigger pump water gun | |
IL138665A0 (en) | Peptide factor | |
CA2329922A1 (en) | Imidazo pyridine derivatives which inhibit gastric acid secretion | |
NO954281L (en) | Water Purification System | |
EP1992641A3 (en) | GLP-1 analogues | |
CA2123593A1 (en) | Method of Treating TNF-Dependent Inflammation Using Tumor Necrosis Factor Antagonists | |
WO1998009618A3 (en) | Graft survival prolongation with porphyrins | |
HK1033548A1 (en) | Cd154 blockade therapy for pancreatic islet tissuetransplantation in primates | |
ES2160495B1 (en) | Treatment of endotoxic shock by inhibiting production of pro-inflammatory cytokines | |
EP0604647A4 (en) | Alleviation of symptoms associated with inflammatory disease states. | |
NO20053364L (en) | CC chemokine mutants for liver disease. | |
EP0971725A4 (en) | Methods for treatment of scar tissue | |
AU1351302A (en) | Inhibition or reversal of skin aging by actin-sequestering peptides | |
HUP0101514A2 (en) | Composition for and treatment of inflammatory bowel disease by colon administration of n-acetylglucosamine | |
CA2114862A1 (en) | Process for the synthesis of semi-synthetic glycosaminoglycans with heparin or heparan structure modified in position 2 of the .alpha.-l-iduronic-2-0-sulfate acid | |
EP1287832A3 (en) | Use of leukemia inhibitory factor antagonist | |
EP0653209A4 (en) | Remedy for inflammatory intestinal diseases. | |
IT1284143B1 (en) | SEMI-SYNTHETIC HEPARANSULPHATES WITH HIGH ANTIMETASTIC ACTIVITY AND REDUCED HEMORRAGIC RISK | |
IT8722871A0 (en) | MODULAR LOW VOLTAGE ELECTRICAL PANEL, FOR MODULAR EQUIPMENT. | |
HAYASHI | Role of human engineering on the robotization | |
Podgorski | Classical Hinduism Documenta Missionalia | |
EP0937718A4 (en) | Antibiotic tkr2648 and process for producing the same | |
李胜利 et al. | Study on structural stability of RE/Fe multilayers | |
UA88862C2 (en) | Glucagon-like peptide-1 analogs |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20011101 Kind code of ref document: A1 Effective date: 20011101 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20190926 |