ES2160089A1 - Method and device for the production of microparticles for controlled release of water-soluble pharmaceuticals and viral vectors. application to the administration of plasmid dna and defective recombinant adenovirus - Google Patents

Method and device for the production of microparticles for controlled release of water-soluble pharmaceuticals and viral vectors. application to the administration of plasmid dna and defective recombinant adenovirus

Info

Publication number
ES2160089A1
ES2160089A1 ES200000629A ES200000629A ES2160089A1 ES 2160089 A1 ES2160089 A1 ES 2160089A1 ES 200000629 A ES200000629 A ES 200000629A ES 200000629 A ES200000629 A ES 200000629A ES 2160089 A1 ES2160089 A1 ES 2160089A1
Authority
ES
Spain
Prior art keywords
plasmid dna
production
viral vectors
water
recombinant adenovirus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200000629A
Other languages
Spanish (es)
Other versions
ES2160089B1 (en
Inventor
Del Barrio Guillermo Garcia
Villaverde Francisco J Novo
Flamarique Felix Juan Recarte
Omaecheverria M Jesus Renedo
Garreta Juan Manuel Irache
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST CIENTIFICO Y TECNOCLOGICO
Original Assignee
INST CIENTIFICO Y TECNOCLOGICO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INST CIENTIFICO Y TECNOCLOGICO filed Critical INST CIENTIFICO Y TECNOCLOGICO
Priority to ES200000629A priority Critical patent/ES2160089B1/en
Priority to AU40700/01A priority patent/AU4070001A/en
Priority to PCT/ES2001/000100 priority patent/WO2001068059A1/en
Publication of ES2160089A1 publication Critical patent/ES2160089A1/en
Application granted granted Critical
Publication of ES2160089B1 publication Critical patent/ES2160089B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The method involves obtaining a multiple emulsion by injecting immiscible liquid phases under high turbulence. The device used for said purpose, which is called TROMS or "Total Recirculation One-Machine System", comprises a pumping system (1) that is connected to a Rehodine valve (2) from which two needles (3, 4) having different inner diameters stick out. The first needle is inserted into the first mixing vessel (5) and the other needle is inserted into the second mixing vessel (6). The organic phase is introduced into the system by means of a glass syringe with a Teflon plunger (7). The mixing vessels are connected to the pump by two valves (8 and 9). The method and device used are suitable for the production of homogenous microcapsule or heterogeneous microsphere type microparticles that are suitable for the encapsulation of water-soluble pharmaceuticals including plasmid DNA, RNA, genes, oligonucleotides, peptides, proteins and viral vectors used in genic therapy and defective recombinant adenovirus.
ES200000629A 2000-03-15 2000-03-15 PROCEDURE AND APPARATUS FOR THE PRODUCTION OF MICROPARTICLES FOR THE CONTROLLED RELEASE OF HYDROSOLUBLE DRUGS AND VIRAL VECTORS. APPLICATION TO THE ADMINISTRATION OF PLASMIDIC DNA AND DEFECTIVE RECOMBINANT ADENOVIRUS. Expired - Fee Related ES2160089B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES200000629A ES2160089B1 (en) 2000-03-15 2000-03-15 PROCEDURE AND APPARATUS FOR THE PRODUCTION OF MICROPARTICLES FOR THE CONTROLLED RELEASE OF HYDROSOLUBLE DRUGS AND VIRAL VECTORS. APPLICATION TO THE ADMINISTRATION OF PLASMIDIC DNA AND DEFECTIVE RECOMBINANT ADENOVIRUS.
AU40700/01A AU4070001A (en) 2000-03-15 2001-03-15 Method and device for the production of microparticles for controlled release of water-soluble pharmaceuticals and viral vectors. Application to the administration of plasmid DNA and defective recombinant adenovirus
PCT/ES2001/000100 WO2001068059A1 (en) 2000-03-15 2001-03-15 Method and device for the production of microparticles for controlled release of water-soluble pharmaceuticals and viral vectors. application to the administration of plasmid dna and defective recombinant adenovirus

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200000629A ES2160089B1 (en) 2000-03-15 2000-03-15 PROCEDURE AND APPARATUS FOR THE PRODUCTION OF MICROPARTICLES FOR THE CONTROLLED RELEASE OF HYDROSOLUBLE DRUGS AND VIRAL VECTORS. APPLICATION TO THE ADMINISTRATION OF PLASMIDIC DNA AND DEFECTIVE RECOMBINANT ADENOVIRUS.

Publications (2)

Publication Number Publication Date
ES2160089A1 true ES2160089A1 (en) 2001-10-16
ES2160089B1 ES2160089B1 (en) 2002-05-16

Family

ID=8492720

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200000629A Expired - Fee Related ES2160089B1 (en) 2000-03-15 2000-03-15 PROCEDURE AND APPARATUS FOR THE PRODUCTION OF MICROPARTICLES FOR THE CONTROLLED RELEASE OF HYDROSOLUBLE DRUGS AND VIRAL VECTORS. APPLICATION TO THE ADMINISTRATION OF PLASMIDIC DNA AND DEFECTIVE RECOMBINANT ADENOVIRUS.

Country Status (3)

Country Link
AU (1) AU4070001A (en)
ES (1) ES2160089B1 (en)
WO (1) WO2001068059A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105434504B (en) * 2014-08-29 2021-10-15 黑龙江科伦制药有限公司 Fat emulsion tail liquid treatment device and method
CN108770945A (en) * 2018-05-22 2018-11-09 祖名豆制品股份有限公司 A kind of manufacture craft and soybean protein isolate exquisiteness processing unit of bean curd
CN111594423B (en) * 2020-04-21 2021-08-17 通用生物系统（安徽）有限公司 Fluid control device for gene synthesis and working method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011010A1 (en) * 1993-10-22 1995-04-27 Genentech, Inc. Methods and compositions for microencapsulation of antigens for use as vaccines
ES2134130A1 (en) * 1997-02-05 1999-09-16 Inst Cientifico Tecnol Navarra Procedure and apparatus for the production of non- biological vectors for transport of substances by turbulent coaxial injection.
WO1999053903A1 (en) * 1998-04-23 1999-10-28 The Regents Of The University Of Michigan Microspheres containing condensed polyanionic bioactive agents and methods for their production

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2172507C (en) * 1993-10-22 2008-12-02 Jeffrey L. Cleland Methods and compositions for microencapsulation of antigens for use as vaccines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011010A1 (en) * 1993-10-22 1995-04-27 Genentech, Inc. Methods and compositions for microencapsulation of antigens for use as vaccines
ES2134130A1 (en) * 1997-02-05 1999-09-16 Inst Cientifico Tecnol Navarra Procedure and apparatus for the production of non- biological vectors for transport of substances by turbulent coaxial injection.
WO1999053903A1 (en) * 1998-04-23 1999-10-28 The Regents Of The University Of Michigan Microspheres containing condensed polyanionic bioactive agents and methods for their production

Also Published As

Publication number Publication date
AU4070001A (en) 2001-09-24
WO2001068059A1 (en) 2001-09-20
ES2160089B1 (en) 2002-05-16

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