CN212417796U - A emulsification equipment for preparing liposome medicine - Google Patents
A emulsification equipment for preparing liposome medicine Download PDFInfo
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- CN212417796U CN212417796U CN201922389274.5U CN201922389274U CN212417796U CN 212417796 U CN212417796 U CN 212417796U CN 201922389274 U CN201922389274 U CN 201922389274U CN 212417796 U CN212417796 U CN 212417796U
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Abstract
The utility model discloses an emulsification device for preparing liposome medicine, include: a dissolving device, wherein an oil phase solution is contained in the dissolving device; the emulsifying device is internally provided with an aqueous phase solution, and the bottom of the emulsifying device is also provided with a spraying disc which comprises a plurality of needle holes; the conveying pipeline is used for communicating the dissolving device to the injection disc of the emulsifying device and is provided with a peristaltic pump; the emulsifying device is used for emulsifying the oil phase solution extruded by the pinholes of the jet disk in the water phase solution to form a multi-chamber liposome. This emulsification equipment can carry out the volume production to the liposome to through set up the injection dish that has a plurality of pinholes in emulsification device, can obtain the multi-chambered liposome of small particle size and narrower distribution, in order to do benefit to follow-up whole grain technology.
Description
Technical Field
The utility model relates to an emulsification equipment for preparing liposome medicine.
Background
In the preparation of liposome drugs, the oil phase solution and the water phase solution need to be emulsified to form liposomes. In laboratory experimental preparation, a multi-compartment liposome solution is usually obtained by rapidly injecting an oil-phase solution into an aqueous-phase solution under pressure using a syringe needle to emulsify. However, in industrial production, such laboratory miniaturization tests cannot meet the requirements of mass production. Therefore, the process of the laboratory lab bench needs to be improved in design so as to realize linear amplification of the emulsification process. Not only the mass production of the emulsification process is realized, but also the size of the formed liposome is ensured to meet the requirement.
SUMMERY OF THE UTILITY MODEL
In order to overcome the defect in the prior art, the embodiment of the utility model provides an emulsification equipment for preparing liposome medicine, this emulsification equipment can carry out the volume production. The emulsifying device for preparing liposome medicine comprises:
a dissolving device, wherein an oil phase solution is contained in the dissolving device;
the emulsifying device is internally provided with an aqueous phase solution, and the bottom of the emulsifying device is also provided with a spraying disc which comprises a plurality of needle holes;
the conveying pipeline is used for communicating the dissolving device to the injection disc of the emulsifying device and is provided with a peristaltic pump;
the emulsifying device is used for emulsifying the oil phase solution extruded by the pinholes of the jet disk in the water phase solution to form a multi-chamber liposome.
Further, the volumes of the oil phase solution and the water phase solution are in direct proportion to the number of the pinholes.
Further, the diameter of the pinhole of the spray disk is 0.5-2 mm.
Further, the number of the pinholes is 10-50.
Further, the oil phase solution contained in the dissolving device is a phospholipid solution dissolved in ethanol.
Further, the dissolving device and the emulsifying device are both sealing devices.
Furthermore, a pressure pipeline is arranged at the tank opening of the dissolving device, external air is used for pressurizing the dissolving device through the pressure pipeline, and the phospholipid solution can be quickly injected into the aqueous phase solution for emulsification.
Further, the air pressure introduced into the dissolving device is 0.1-0.5 MPa.
Furthermore, stirring paddles are respectively arranged in the dissolving device and the emulsifying device.
Further, the volumes of the dissolving device and the emulsifying device are 0.5-5L.
The utility model has the advantages as follows:
this emulsification equipment has realized changing the laboratory method of the little experiment of liposome medicine emulsification to the method of quantization production, can carry out the volume production emulsification to the liposome medicine to through set up the injection dish that has a plurality of pinholes in emulsification device, can obtain the multi-chambered liposome of small particle size and distribution narrower, in order to do benefit to follow-up whole grain technology.
In order to make the aforementioned and other objects, features and advantages of the present invention comprehensible, preferred embodiments accompanied with figures are described in detail below.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
Fig. 1 is a schematic diagram of an emulsification device in an embodiment of the present invention.
Reference numerals of the above figures: a dissolving device-1; a pressure line-11; a stirring paddle-12; an emulsifying device-2; an ejection disk-21; pinhole-22; a transmission pipeline-3; peristaltic pump-31.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
In the description of the present invention, it should be noted that the terms "upper", "lower", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature.
To achieve the above objects, the present invention provides an emulsifying apparatus for preparing liposome medicine, as shown in fig. 1. The emulsifying device comprises a dissolving device 1, an emulsifying device 2 and a conveying pipeline 3. The dissolving device 1 contains an oil phase solution, which is a phospholipid solution dissolved in ethanol in this embodiment. The emulsification device 2 contains aqueous phase solution, the bottom of emulsification device 2 still is provided with sprays dish 21, it includes a plurality of pinholes 22 to spray dish 21. The conveying pipeline 3 is used for communicating the dissolving device 1 to the injection disc 21 of the emulsifying device 2, and a peristaltic pump 31 is arranged on the conveying pipeline 3. The peristaltic pump 31 provides a power source for the delivery of the phospholipid solution. The emulsifying device 2 is used for emulsifying the oil phase solution extruded by the pinholes 22 of the injection disk 21 in the water phase solution to form multi-chamber liposome.
The emulsification equipment realizes the conversion of a laboratory method of a small experiment for emulsifying liposome medicines into a quantitative production method, is different from the method of quickly injecting an oil phase solution into an aqueous phase solution for emulsification by adopting a syringe needle in a laboratory, and adopts the peristaltic pump 31 to convey the oil phase solution in the dissolving device 1 into the aqueous phase solution in the emulsification device 2 through the transmission pipeline 3 for emulsification, so that the mass production of liposomes is realized, the industrial expansion can be met, and the industrialization is realized. Only a single liposome can be produced by using a syringe needle in a laboratory, but a plurality of liposomes can be produced simultaneously by arranging the injection disk 21 with a plurality of needle holes 22 in the emulsifying device 2, so that the production efficiency is greatly improved. In addition, the oil phase solution is extruded through the pinholes 22 of the injection disc 21, so that multi-chamber liposomes with small particle sizes and narrow distribution can be obtained, the diameter size of the liposomes in a laboratory can be more approximate, the production requirement is met, and the subsequent whole grain process is facilitated.
On the other hand, in order to obtain a satisfactory liposome, the volumes of the oil-phase solution and the aqueous-phase solution are required to be proportional to the number of the pinholes. When the volumes of the oil phase solution and the aqueous phase solution are amplified in proportion to the number of the pinholes 22, the linear amplification of the number of the liposomes can be realized by fixing the volumes of the oil phase solution and the aqueous phase solution or the number of the pinholes 22. Specifically, in this embodiment, the volumes of the dissolving device 1 and the emulsifying device 2 are 0.5 to 5L. The diameter of the pinhole 22 of the injection disc 21 is 0.5-2mm, and the number of the pinholes 22 is 10-50. Preferably, the size of the diameter of the multilamellar liposome formed by emulsification of the needle hole 22 with the aqueous solvent is about 100 nm.
The dissolving device 1 and the emulsifying device 2 are both sealing devices, so that the pollution of other substances is avoided, and the quality of the finally formed multi-chamber liposome is improved. The tank mouth of the dissolving device 1 is provided with a pressure pipeline 11, external air pressurizes the dissolving device 1 through the pressure pipeline 11, and the phospholipid solution can be rapidly injected into the water phase solution for emulsification. The air pressure introduced into the dissolving device 1 is 0.1-0.5MPa, and the transportation of the phospholipid solution can be selectively controlled.
Preferably, stirring paddles 12 are respectively arranged in the dissolving device 1 and the emulsifying device 2. The stirring paddle 12 in the dissolving apparatus 1 is used to uniformly dissolve the phospholipid in the ethanol solution, and needs to be heated. The stirring paddle 12 in the emulsifying device 2 is used for accelerating the emulsification of the phospholipid solution and the aqueous phase solution.
The present invention has been explained by using specific embodiments, and the explanation of the above embodiments is only used to help understand the method and the core idea of the present invention; meanwhile, for the general technical personnel in the field, according to the idea of the present invention, there are changes in the specific implementation and application scope, to sum up, the content of the present specification should not be understood as the limitation of the present invention.
Claims (9)
1. An emulsification device for preparing a liposomal drug, comprising:
a dissolving device, wherein an oil phase solution is contained in the dissolving device;
the emulsifying device is internally provided with an aqueous phase solution, and the bottom of the emulsifying device is also provided with a spraying disc which comprises a plurality of needle holes;
the conveying pipeline is used for communicating the dissolving device to the injection disc of the emulsifying device and is provided with a peristaltic pump;
the emulsifying device is used for emulsifying the oil phase solution extruded by the pinholes of the jet disk in the water phase solution to form a multi-chamber liposome.
2. The emulsification device for preparing a liposomal drug of claim 1, wherein the volume of the oil phase solution and the aqueous phase solution is proportional to the number of the pinholes.
3. The emulsifying apparatus for preparing a liposomal drug according to claim 2, wherein the diameter of the pinhole of the jet disk is 0.5-2 mm.
4. The emulsification device for preparing a liposomal drug of claim 3, wherein the number of pinholes is 10-50.
5. The emulsification device for preparing a liposomal drug according to claim 4, wherein the dissolving means and the emulsification means are both sealing means.
6. The emulsification device for preparing liposome drug according to claim 5, wherein the mouth of the dissolving device is provided with a pressure pipeline, and external gas pressurizes the dissolving device through the pressure pipeline, so that the oil phase solution can be rapidly injected into the water phase solution for emulsification.
7. The emulsification device for preparing a liposomal drug according to claim 6, wherein the air pressure introduced into the dissolution apparatus is between 0.1-0.5 MPa.
8. The emulsification device for preparing a liposomal drug according to claim 1, wherein stirring paddles are disposed in the dissolution device and the emulsification device, respectively.
9. The emulsification device for preparing a liposomal drug according to claim 1, wherein the volume of the dissolution means and the emulsification means is 0.5-5L.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922389274.5U CN212417796U (en) | 2019-12-27 | 2019-12-27 | A emulsification equipment for preparing liposome medicine |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201922389274.5U CN212417796U (en) | 2019-12-27 | 2019-12-27 | A emulsification equipment for preparing liposome medicine |
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| CN212417796U true CN212417796U (en) | 2021-01-29 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114887507A (en) * | 2022-05-07 | 2022-08-12 | 成都科建生物医药有限公司 | Liposome preparation device and method suitable for industrial production |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114887507A (en) * | 2022-05-07 | 2022-08-12 | 成都科建生物医药有限公司 | Liposome preparation device and method suitable for industrial production |
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